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Protein
Submitted name:

FI02843p

Gene

fzy

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • anaphase-promoting complex-dependent catabolic process Source: FlyBase
  • female meiosis I Source: FlyBase
  • female meiosis II Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • mitotic cell cycle Source: FlyBase
  • negative regulation of necrotic cell death Source: FlyBase
  • neuronal stem cell population maintenance Source: FlyBase
  • positive regulation of ubiquitin protein ligase activity Source: FlyBase
  • protein catabolic process Source: FlyBase
  • regulation of exit from mitosis Source: FlyBase
  • regulation of proteolysis Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
R-DME-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-DME-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-DME-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-DME-179409 APC-Cdc20 mediated degradation of Nek2A
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
FI02843pImported
Submitted name:
FizzyImported
Submitted name:
LD44795pImported
Gene namesi
Name:fzyImported
Synonyms:BG:DS02740.14Imported, CDC20Imported, Cdc20Imported, cdc20Imported, Cdc20[fizzy]Imported, Cdc20[Fzy]Imported, dCDC20Imported, dFZYImported, Dmel\CG4274Imported, FizzyImported, fizzyImported, FZYImported, FzyImported, fzy-RAImported
ORF Names:CG4274Imported, Dmel_CG4274Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001086 fzy

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ24044

Expressioni

Gene expression databases

BgeeiFBgn0001086
ExpressionAtlasiQ24044 baseline and differential

Interactioni

Protein-protein interaction databases

DIPiDIP-60667N
IntActiQ24044, 3 interactors
STRINGi7227.FBpp0080391

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 507WD_REPEATS_REGIONInterPro annotationAdd BLAST276
Repeati330 – 366WDPROSITE-ProRule annotationAdd BLAST37
Repeati466 – 498WDPROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

RepeatSAAS annotation, WD repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0305 Eukaryota
ENOG410XQ8I LUCA
GeneTreeiENSGT00870000136444
KOiK03363
OMAiWQSNILA
OrthoDBiEOG091G06FJ

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR033187 CDC20
IPR033010 Cdc20/Fizzy
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19918 PTHR19918, 1 hit
PTHR19918:SF3 PTHR19918:SF3, 1 hit
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q24044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQFNFVSDL QNALIMDGET RGPAPRWKKK LEASLNGSVN TTRSVLSVSY
60 70 80 90 100
NTSFSGVQAP TKTPGKSSEG KTKKSNTTPS KTPGGGDRFI PNRAATNFEL
110 120 130 140 150
AHFLVNKDSG DKSDEENDKA TSSNSNESNV QASAHKGDRQ KLISEVAQVG
160 170 180 190 200
DSKGGRILCY QNKAPAAPET HNNPLKVVYS IKTPISTKSG SRYIPTTSER
210 220 230 240 250
ILDAPDFIND YYLNLMDWSA DNIVAVALGS CVYLWNAQTG NIEQLTEFEE
260 270 280 290 300
GDYAGSLSWI QEGQILAIGN STGAVELWDC SKVKRLRVMD GHSARVGSLA
310 320 330 340 350
WNSFLVSSGS RDGTIVHHDV RAREHKLSTL SGHTQEVCGL KWSTDFKYLA
360 370 380 390 400
SGGNDNLVNV WSAASGGVGT ATDPLHKFND HQAAVRALAW CPWQPSTLAS
410 420 430 440 450
GGGTADRCIK FWNVNNGTLM KSVDSKSQVC SLLFSRHYKE LISAHGFANN
460 470 480 490 500
QLTIWKYPTM VKQADLTGHT SRVLQMAMSP DGSTVISAGA DETLRLWNCF
510 520
APDPLASKKA VSTSKGKQSV FRQSIR
Length:526
Mass (Da):57,081
Last modified:November 1, 1996 - v1
Checksum:i9948BC4F1B947ED9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22419 mRNA Translation: AAA83150.1
AE014134 Genomic DNA Translation: AAF53523.1
BT029432 mRNA Translation: ABK57089.1
BT056243 mRNA Translation: ACL68690.1
RefSeqiNP_477501.1, NM_058153.4
UniGeneiDm.4066

Genome annotation databases

EnsemblMetazoaiFBtr0080833; FBpp0080391; FBgn0001086
GeneIDi34968
KEGGidme:Dmel_CG4274
UCSCiCG4274-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ24044_DROME
AccessioniPrimary (citable) accession number: Q24044
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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