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Protein
Submitted name:

FI02843p

Gene

fzy

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • anaphase-promoting complex-dependent catabolic process Source: FlyBase
  • female meiosis I Source: FlyBase
  • female meiosis II Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • mitotic cell cycle Source: FlyBase
  • mitotic nuclear division Source: FlyBase
  • negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation Source: FlyBase
  • negative regulation of necrotic cell death Source: FlyBase
  • neurogenesis Source: FlyBase
  • neuronal stem cell population maintenance Source: FlyBase
  • phagocytosis Source: FlyBase
  • positive regulation of ubiquitin protein ligase activity Source: FlyBase
  • protein catabolic process Source: FlyBase
  • regulation of exit from mitosis Source: FlyBase
  • regulation of proteolysis Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-141405. Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components.
R-DME-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-DME-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174154. APC/C:Cdc20 mediated degradation of Securin.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-DME-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-DME-179409. APC-Cdc20 mediated degradation of Nek2A.
R-DME-2467813. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Submitted name:
FI02843pImported
Submitted name:
FizzyImported
Submitted name:
LD44795pImported
Gene namesi
Name:fzyImported
Synonyms:fzy-RAImported
ORF Names:CG4274Imported, Dmel_CG4274Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001086. fzy.

Subcellular locationi

GO - Cellular componenti

  • anaphase-promoting complex Source: FlyBase
  • centrosome Source: FlyBase
  • cytoplasm Source: FlyBase
  • kinetochore Source: FlyBase
  • spindle Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

DIPiDIP-60667N.
MINTiMINT-922907.
STRINGi7227.FBpp0080391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini232 – 507276WD_REPEATS_REGIONInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatUniRule annotationSAAS annotation, WD repeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
GeneTreeiENSGT00840000129804.
KOiK03363.
OMAiWQPNTLA.
OrthoDBiEOG76X602.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19918. PTHR19918. 1 hit.
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQFNFVSDL QNALIMDGET RGPAPRWKKK LEASLNGSVN TTRSVLSVSY
60 70 80 90 100
NTSFSGVQAP TKTPGKSSEG KTKKSNTTPS KTPGGGDRFI PNRAATNFEL
110 120 130 140 150
AHFLVNKDSG DKSDEENDKA TSSNSNESNV QASAHKGDRQ KLISEVAQVG
160 170 180 190 200
DSKGGRILCY QNKAPAAPET HNNPLKVVYS IKTPISTKSG SRYIPTTSER
210 220 230 240 250
ILDAPDFIND YYLNLMDWSA DNIVAVALGS CVYLWNAQTG NIEQLTEFEE
260 270 280 290 300
GDYAGSLSWI QEGQILAIGN STGAVELWDC SKVKRLRVMD GHSARVGSLA
310 320 330 340 350
WNSFLVSSGS RDGTIVHHDV RAREHKLSTL SGHTQEVCGL KWSTDFKYLA
360 370 380 390 400
SGGNDNLVNV WSAASGGVGT ATDPLHKFND HQAAVRALAW CPWQPSTLAS
410 420 430 440 450
GGGTADRCIK FWNVNNGTLM KSVDSKSQVC SLLFSRHYKE LISAHGFANN
460 470 480 490 500
QLTIWKYPTM VKQADLTGHT SRVLQMAMSP DGSTVISAGA DETLRLWNCF
510 520
APDPLASKKA VSTSKGKQSV FRQSIR
Length:526
Mass (Da):57,081
Last modified:November 1, 1996 - v1
Checksum:i9948BC4F1B947ED9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22419 mRNA. Translation: AAA83150.1.
AE014134 Genomic DNA. Translation: AAF53523.1.
BT029432 mRNA. Translation: ABK57089.1.
BT056243 mRNA. Translation: ACL68690.1.
RefSeqiNP_477501.1. NM_058153.4.
UniGeneiDm.4066.

Genome annotation databases

EnsemblMetazoaiFBtr0080833; FBpp0080391; FBgn0001086.
GeneIDi34968.
KEGGidme:Dmel_CG4274.
UCSCiCG4274-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22419 mRNA. Translation: AAA83150.1.
AE014134 Genomic DNA. Translation: AAF53523.1.
BT029432 mRNA. Translation: ABK57089.1.
BT056243 mRNA. Translation: ACL68690.1.
RefSeqiNP_477501.1. NM_058153.4.
UniGeneiDm.4066.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60667N.
MINTiMINT-922907.
STRINGi7227.FBpp0080391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080833; FBpp0080391; FBgn0001086.
GeneIDi34968.
KEGGidme:Dmel_CG4274.
UCSCiCG4274-RA. d. melanogaster.

Organism-specific databases

CTDi34968.
FlyBaseiFBgn0001086. fzy.

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
GeneTreeiENSGT00840000129804.
KOiK03363.
OMAiWQPNTLA.
OrthoDBiEOG76X602.

Enzyme and pathway databases

ReactomeiR-DME-141405. Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components.
R-DME-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-DME-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174154. APC/C:Cdc20 mediated degradation of Securin.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-DME-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-DME-179409. APC-Cdc20 mediated degradation of Nek2A.
R-DME-2467813. Separation of Sister Chromatids.

Miscellaneous databases

GenomeRNAii34968.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19918. PTHR19918. 1 hit.
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae."
    Dawson I.A., Roth S., Artavanis-Tsakonas S.
    J. Cell Biol. 129:725-737(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. O'Boyle S.T.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. Stapleton M., Carlson J., Frise E., Kapadia B., Park S., Wan K., Yu C., Celniker S.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  11. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  13. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  14. Millard Andrew
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ24044_DROME
AccessioniPrimary (citable) accession number: Q24044
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.