Reviewed, UniProtKB/Swiss-Prot Q24040 (BGB_DROME)

Names and origin

Protein names

Recommended name:
    Protein big brother

Gene names

Name:	Bgb
ORF Names:	CG7959

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Regulates the DNA-binding properties of Runt.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the CBF-beta family.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription from RNA polymerase II promoter Traceable author statement. Source: FlyBase
Cellular component	nucleus Ref.1 Inferred from direct assay. Source: FlyBase
Molecular function	protein heterodimerization activity Traceable author statement. Source: FlyBase transcription coactivator activity Ref.1 Inferred from direct assay. Source: FlyBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
run	P22814	1	EBI-136112,EBI-868309

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Protein big brother		PRO_0000064920
Experimental info
	Sequence conflict	8	1	A → S Ref.1
	Sequence conflict	24	1	P → K Ref.1
	Sequence conflict	141	1	E → D in AAB03676. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q24040-1 [UniParc]. Last modified January 16, 2004. Version 3. Checksum: 6FC6156136B362AA	FASTA	213	25,177
	10 20 30 40 50 60 MMNEAALANM IPYDTIGLYE QPKPRFIFKM PRVVPDQKSK FESDELFRRL SRESEVRYTG 70 80 90 100 110 120 YRERSIEERQ VRFMNGCREG HTEASFVASG TNLQLVFNAN QNPYLHDKEC DFDKEHGKVH 130 140 150 160 170 180 IKSYFIMNGV CVRFRGWIDL ERLDGVGCLE YDERRAMHED AILRDQIDRY NQRLREFEDT 190 200 210 KRAYRDNRQD EMEAVRRGVA SGGIGVGASM WRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt." Golling G., Li L., Pepling M., Stebbins M., Gergen J.P. Mol. Cell. Biol. 16:932-942(1996) [PubMed: 8622696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U22177 mRNA. Translation: AAB03676.1. Different initiation. AE014296 Genomic DNA. Translation: AAF47533.3. AY058784 mRNA. Translation: AAL14013.1.
RefSeq	NP_477065.3.
UniGene	Dm.4101
3D structure databases
HSSP	HSSP built from PDB template 1E50 based on UniProtKB Q13951.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q24040. 6 interactions.
Genome annotation databases
Ensembl	FBgn0013753. Drosophila melanogaster. [Contig view]
GeneID	38198.
KEGG	dme:Dmel_CG7959.
NMPDR	fig|7227.3.peg.7612.
Organism-specific databases
FlyBase	FBgn0013753. Bgb.
Phylogenomic databases
HOGENOM	Q24040.
OMA	Q24040. RVVPDQK.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-014697-MON.
Gene expression databases
ArrayExpress	Q24040.
GermOnline	CG7959. Drosophila melanogaster.
Family and domain databases
InterPro	IPR003417. CBF_beta. [Graphical view]
Gene3D	G3DSA:2.40.250.10. CBF_beta. 1 hit.
PANTHER	PTHR10276. CBF_beta. 1 hit.
Pfam	PF02312. CBF_beta. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	807472.

Entry information

Entry name

BGB_DROME

Accession

Primary (citable) accession number: Q24040
Secondary accession number(s): Q95TG4, Q9W0B9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 16, 2004
Last modified:	June 16, 2009
This is version 65 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project