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Protein

Dorsal-ventral patterning protein Sog

Gene

sog

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative negative growth factor (PubMed:7958919). Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg (PubMed:7958919). Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa (PubMed:11260716).2 Publications

GO - Molecular functioni

  • collagen binding Source: FlyBase
  • growth factor activity Source: UniProtKB-KW

GO - Biological processi

  • amnioserosa formation Source: FlyBase
  • BMP signaling pathway Source: FlyBase
  • ectoderm development Source: FlyBase
  • imaginal disc-derived wing vein morphogenesis Source: FlyBase
  • maternal specification of dorsal/ventral axis, oocyte, soma encoded Source: FlyBase
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: FlyBase
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: FlyBase
  • posterior Malpighian tubule development Source: FlyBase
  • regulation of BMP signaling pathway Source: FlyBase
  • regulation of growth Source: UniProtKB-KW
  • ring gland development Source: FlyBase
  • terminal region determination Source: FlyBase
  • torso signaling pathway Source: FlyBase
  • zygotic determination of anterior/posterior axis, embryo Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, Growth factor
Biological processGrowth regulation

Enzyme and pathway databases

ReactomeiR-DME-201451. Signaling by BMP.
R-DME-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-DME-8957275. Post-translational protein phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Dorsal-ventral patterning protein Sog
Alternative name(s):
Short gastrulation protein
Gene namesi
Name:sog
ORF Names:CG9224
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003463. sog.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 53CytoplasmicSequence analysisAdd BLAST53
Transmembranei54 – 74Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini75 – 1038ExtracellularSequence analysisAdd BLAST964

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27C → S: No change in baseline secretion but eliminates increased secretion normally caused by coexpression with Hip14 and reduces intracellular levels of Sog. 1 Publication1
Mutagenesisi28C → S: No effect on secretion when coexpressed with Hip14. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190891 – 1038Dorsal-ventral patterning protein SogAdd BLAST1038

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi666N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi821N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoylated, probably by Hip14.1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ24025.
PRIDEiQ24025.

Expressioni

Tissue specificityi

Abuts the dorsal dpp-expressing cells in a lateral stripe 14-16 cells wide. Later in embryogenesis it is expressed in neuroectoderm and in the endoderm spaced along the anterior-posterior axis of the developing gut.1 Publication

Developmental stagei

Embryogenesis.1 Publication

Gene expression databases

BgeeiFBgn0003463.
ExpressionAtlasiQ24025. differential.
GenevisibleiQ24025. DM.

Interactioni

Subunit structurei

Component of a complex composed of dpp, sog and tsg (PubMed:11260716). Interacts with palmitoyltransferase Hip14 (PubMed:20599894).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
vkgO184072EBI-184947,EBI-15721782

GO - Molecular functioni

  • collagen binding Source: FlyBase
  • growth factor activity Source: UniProtKB-KW

Protein-protein interaction databases

BioGridi58848. 28 interactors.
DIPiDIP-20760N.
IntActiQ24025. 5 interactors.
MINTiMINT-299642.
STRINGi7227.FBpp0304150.

Structurei

3D structure databases

ProteinModelPortaliQ24025.
SMRiQ24025.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 175VWFC 1Add BLAST76
Domaini197 – 337CHRD 1Add BLAST141
Domaini339 – 471CHRD 2Add BLAST133
Domaini474 – 588CHRD 3Add BLAST115
Domaini592 – 713CHRD 4Add BLAST122
Domaini742 – 804VWFC 2Add BLAST63
Domaini830 – 899VWFC 3Add BLAST70
Domaini939 – 1020VWFC 4Add BLAST82

Sequence similaritiesi

Belongs to the chordin family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEDE. Eukaryota.
ENOG410XSBA. LUCA.
GeneTreeiENSGT00730000110792.
InParanoidiQ24025.
KOiK04657.
OMAiQSWHPSV.
OrthoDBiEOG091G11A0.
PhylomeDBiQ24025.

Family and domain databases

InterProiView protein in InterPro
IPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_dom.
PfamiView protein in Pfam
PF07452. CHRD. 2 hits.
PF00093. VWC. 4 hits.
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiView protein in SMART
SM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
PROSITEiView protein in PROSITE
PS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q24025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKLRKSNA IEWATATGTV PLLERSCCHS EDAALEPQAS KTSHREQAPI
60 70 80 90 100
LRHLSQLSHL LIIAGLLIVC LAGVTEGRRH APLMFEESDT GRRSNRPAVT
110 120 130 140 150
ECQFGKVLRE LGSTWYADLG PPFGVMYCIK CECVAIPKKR RIVARVQCRN
160 170 180 190 200
IKNECPPAKC DDPISLPGKC CKTCPGDRND TDVALDVPVP NEEEERNMKH
210 220 230 240 250
YAALLTGRTS YFLKGEEMKS MYTTYNPQNV VATARFLFHK KNLYYSFYTS
260 270 280 290 300
SRIGRPRAIQ FVDDAGVILE EHQLETTLAG TLSVYQNATG KICGVWRRVP
310 320 330 340 350
RDYKRILRDD RLHVVLLWGN KQQAELALAG KVAKYTALQT ELFSSLLEAP
360 370 380 390 400
LPDGKTDPQL AGAGGTAIVS TSSGAASSMH LTLVFNGVFG AEEYADAALS
410 420 430 440 450
VKIELAERKE VIFDEIPRVR KPSAEINVLE LSSPISIQNL RLMSRGKLLL
460 470 480 490 500
TVESKKYPHL RIQGHIVTRA SCEIFQTLLA PHSAESSTKS SGLAWVYLNT
510 520 530 540 550
DGSLAYNIET EHVNTRDRPN ISLIEEQGKR KAKLEDLTPS FNFNQAIGSV
560 570 580 590 600
EKLGPKVLES LYAGELGVNV ATEHETSLIR GRLVPRPVAD ARDSAEPILL
610 620 630 640 650
KRQEHTDAQN PHAVGMAWMS IDNECNLHYE VTLNGVPAQD LQLYLEEKPI
660 670 680 690 700
EAIGAPVTRK LLEEFNGSYL EGFFLSMPSA ELIKLEMSVC YLEVHSKHSK
710 720 730 740 750
QLLLRGKLKS TKVPGHCFPV YTDNNVPVPG DHNDNHLVNG ETKCFHSGRF
760 770 780 790 800
YNESEQWRSA QDSCQMCACL RGQSSCEVIK CPALKCKSTE QLLQRDGECC
810 820 830 840 850
PSCVPKKEAA DYSAQSSPAT NATDLLQQRR GCRLGEQFHP AGASWHPFLP
860 870 880 890 900
PNGFDTCTTC SCDPLTLEIR CPRLVCPPLQ CSEKLAYRPD KKACCKICPE
910 920 930 940 950
GKQSSSNGHK TTPNNPNVLQ DQAMQRSPSH SAEEVLANGG CKVVNKVYEN
960 970 980 990 1000
GQEWHPILMS HGEQKCIKCR CKDSKVNCDR KRCSRSTCQQ QTRVTSKRRL
1010 1020 1030
FEKPDAAAPA IDECCSTQCR RSRRHHKRQP HHQQRSSS
Length:1,038
Mass (Da):115,515
Last modified:November 1, 1996 - v1
Checksum:iB0E833AFD79A9037
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18774 mRNA. Translation: AAA89117.1.
AE014298 Genomic DNA. Translation: AAF48481.1.
BT053679 mRNA. Translation: ACK77594.1.
PIRiT13177.
RefSeqiNP_001259576.1. NM_001272647.2.
NP_001259578.1. NM_001272649.2.
NP_476736.1. NM_057388.4.
UniGeneiDm.3944.

Genome annotation databases

EnsemblMetazoaiFBtr0074063; FBpp0073879; FBgn0003463.
FBtr0331760; FBpp0304148; FBgn0003463.
FBtr0340346; FBpp0309304; FBgn0003463.
GeneIDi32498.
KEGGidme:Dmel_CG9224.

Similar proteinsi

Entry informationi

Entry nameiSOG_DROME
AccessioniPrimary (citable) accession number: Q24025
Secondary accession number(s): B7FNI9, Q9VXS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families