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Q24025

- SOG_DROME

UniProt

Q24025 - SOG_DROME

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Protein
Dorsal-ventral patterning protein Sog
Gene
sog, CG9224
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Putative negative growth factor. Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg. Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa.2 Publications

GO - Molecular functioni

  1. collagen binding Source: FlyBase

GO - Biological processi

  1. BMP signaling pathway Source: FlyBase
  2. amnioserosa formation Source: FlyBase
  3. ectoderm development Source: FlyBase
  4. imaginal disc-derived wing vein morphogenesis Source: FlyBase
  5. maternal specification of dorsal/ventral axis, oocyte, soma encoded Source: FlyBase
  6. negative regulation of transforming growth factor beta receptor signaling pathway Source: FlyBase
  7. positive regulation of transforming growth factor beta receptor signaling pathway Source: FlyBase
  8. posterior Malpighian tubule development Source: FlyBase
  9. regulation of BMP signaling pathway Source: FlyBase
  10. regulation of growth Source: UniProtKB-KW
  11. ring gland development Source: FlyBase
  12. terminal region determination Source: FlyBase
  13. torso signaling pathway Source: FlyBase
  14. zygotic determination of anterior/posterior axis, embryo Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Keywords - Biological processi

Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Dorsal-ventral patterning protein Sog
Alternative name(s):
Short gastrulation protein
Gene namesi
Name:sog
ORF Names:CG9224
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003463. sog.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei54 – 7421Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini75 – 1038964Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10381038Dorsal-ventral patterning protein Sog
PRO_0000219089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi287 – 2871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi520 – 5201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi666 – 6661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi752 – 7521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi821 – 8211N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ24025.

Expressioni

Tissue specificityi

Abuts the dorsal dpp-expressing cells in a lateral stripe 14-16 cells wide. Later in embryogenesis it is expressed in neuroectoderm and in the endoderm spaced along the anterior-posterior axis of the developing gut.1 Publication

Developmental stagei

Embryogenesis.1 Publication

Gene expression databases

BgeeiQ24025.

Interactioni

Subunit structurei

Component of a complex composed of dpp, sog and tsg.

Protein-protein interaction databases

BioGridi58848. 14 interactions.
DIPiDIP-20760N.
IntActiQ24025. 3 interactions.
MINTiMINT-299642.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 17576VWFC 1
Add
BLAST
Domaini197 – 337141CHRD 1
Add
BLAST
Domaini339 – 471133CHRD 2
Add
BLAST
Domaini474 – 588115CHRD 3
Add
BLAST
Domaini592 – 713122CHRD 4
Add
BLAST
Domaini742 – 80463VWFC 2
Add
BLAST
Domaini830 – 89970VWFC 3
Add
BLAST
Domaini939 – 102082VWFC 4
Add
BLAST

Sequence similaritiesi

Belongs to the chordin family.
Contains 4 CHRD domains.
Contains 4 VWFC domains.

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85639.
GeneTreeiENSGT00730000110792.
InParanoidiQ24025.
KOiK04657.
OMAiRDPGEGC.
OrthoDBiEOG7QNVK7.
PhylomeDBiQ24025.

Family and domain databases

InterProiIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07452. CHRD. 4 hits.
PF00093. VWC. 4 hits.
[Graphical view]
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiSM00754. CHRD. 4 hits.
SM00214. VWC. 3 hits.
[Graphical view]
PROSITEiPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24025-1 [UniParc]FASTAAdd to Basket

« Hide

MANKLRKSNA IEWATATGTV PLLERSCCHS EDAALEPQAS KTSHREQAPI     50
LRHLSQLSHL LIIAGLLIVC LAGVTEGRRH APLMFEESDT GRRSNRPAVT 100
ECQFGKVLRE LGSTWYADLG PPFGVMYCIK CECVAIPKKR RIVARVQCRN 150
IKNECPPAKC DDPISLPGKC CKTCPGDRND TDVALDVPVP NEEEERNMKH 200
YAALLTGRTS YFLKGEEMKS MYTTYNPQNV VATARFLFHK KNLYYSFYTS 250
SRIGRPRAIQ FVDDAGVILE EHQLETTLAG TLSVYQNATG KICGVWRRVP 300
RDYKRILRDD RLHVVLLWGN KQQAELALAG KVAKYTALQT ELFSSLLEAP 350
LPDGKTDPQL AGAGGTAIVS TSSGAASSMH LTLVFNGVFG AEEYADAALS 400
VKIELAERKE VIFDEIPRVR KPSAEINVLE LSSPISIQNL RLMSRGKLLL 450
TVESKKYPHL RIQGHIVTRA SCEIFQTLLA PHSAESSTKS SGLAWVYLNT 500
DGSLAYNIET EHVNTRDRPN ISLIEEQGKR KAKLEDLTPS FNFNQAIGSV 550
EKLGPKVLES LYAGELGVNV ATEHETSLIR GRLVPRPVAD ARDSAEPILL 600
KRQEHTDAQN PHAVGMAWMS IDNECNLHYE VTLNGVPAQD LQLYLEEKPI 650
EAIGAPVTRK LLEEFNGSYL EGFFLSMPSA ELIKLEMSVC YLEVHSKHSK 700
QLLLRGKLKS TKVPGHCFPV YTDNNVPVPG DHNDNHLVNG ETKCFHSGRF 750
YNESEQWRSA QDSCQMCACL RGQSSCEVIK CPALKCKSTE QLLQRDGECC 800
PSCVPKKEAA DYSAQSSPAT NATDLLQQRR GCRLGEQFHP AGASWHPFLP 850
PNGFDTCTTC SCDPLTLEIR CPRLVCPPLQ CSEKLAYRPD KKACCKICPE 900
GKQSSSNGHK TTPNNPNVLQ DQAMQRSPSH SAEEVLANGG CKVVNKVYEN 950
GQEWHPILMS HGEQKCIKCR CKDSKVNCDR KRCSRSTCQQ QTRVTSKRRL 1000
FEKPDAAAPA IDECCSTQCR RSRRHHKRQP HHQQRSSS 1038
Length:1,038
Mass (Da):115,515
Last modified:November 1, 1996 - v1
Checksum:iB0E833AFD79A9037
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18774 mRNA. Translation: AAA89117.1.
AE014298 Genomic DNA. Translation: AAF48481.1.
BT053679 mRNA. Translation: ACK77594.1.
PIRiT13177.
RefSeqiNP_001259576.1. NM_001272647.1.
NP_001259578.1. NM_001272649.1.
NP_476736.1. NM_057388.3.
UniGeneiDm.3944.

Genome annotation databases

EnsemblMetazoaiFBtr0074063; FBpp0073879; FBgn0003463.
FBtr0331760; FBpp0304148; FBgn0003463.
FBtr0331762; FBpp0304150; FBgn0003463.
GeneIDi32498.
KEGGidme:Dmel_CG9224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18774 mRNA. Translation: AAA89117.1 .
AE014298 Genomic DNA. Translation: AAF48481.1 .
BT053679 mRNA. Translation: ACK77594.1 .
PIRi T13177.
RefSeqi NP_001259576.1. NM_001272647.1.
NP_001259578.1. NM_001272649.1.
NP_476736.1. NM_057388.3.
UniGenei Dm.3944.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 58848. 14 interactions.
DIPi DIP-20760N.
IntActi Q24025. 3 interactions.
MINTi MINT-299642.

Proteomic databases

PRIDEi Q24025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0074063 ; FBpp0073879 ; FBgn0003463 .
FBtr0331760 ; FBpp0304148 ; FBgn0003463 .
FBtr0331762 ; FBpp0304150 ; FBgn0003463 .
GeneIDi 32498.
KEGGi dme:Dmel_CG9224.

Organism-specific databases

CTDi 32498.
FlyBasei FBgn0003463. sog.

Phylogenomic databases

eggNOGi NOG85639.
GeneTreei ENSGT00730000110792.
InParanoidi Q24025.
KOi K04657.
OMAi RDPGEGC.
OrthoDBi EOG7QNVK7.
PhylomeDBi Q24025.

Miscellaneous databases

GenomeRNAii 32498.
NextBioi 778773.
PROi Q24025.

Gene expression databases

Bgeei Q24025.

Family and domain databases

InterProi IPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07452. CHRD. 4 hits.
PF00093. VWC. 4 hits.
[Graphical view ]
PIRSFi PIRSF002496. Chordin. 1 hit.
SMARTi SM00754. CHRD. 4 hits.
SM00214. VWC. 3 hits.
[Graphical view ]
PROSITEi PS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene."
    Francois V., Solloway M., O'Neill J.W., Emery J., Bier E.
    Genes Dev. 8:2602-2616(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
  5. Cited for: FUNCTION, INTERACTION WITH DPP AND TSG.

Entry informationi

Entry nameiSOG_DROME
AccessioniPrimary (citable) accession number: Q24025
Secondary accession number(s): B7FNI9, Q9VXS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi