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Q24025

- SOG_DROME

UniProt

Q24025 - SOG_DROME

Protein

Dorsal-ventral patterning protein Sog

Gene

sog

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Putative negative growth factor. Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg. Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa.2 Publications

    GO - Molecular functioni

    1. collagen binding Source: FlyBase

    GO - Biological processi

    1. amnioserosa formation Source: FlyBase
    2. BMP signaling pathway Source: FlyBase
    3. ectoderm development Source: FlyBase
    4. imaginal disc-derived wing vein morphogenesis Source: FlyBase
    5. maternal specification of dorsal/ventral axis, oocyte, soma encoded Source: FlyBase
    6. negative regulation of transforming growth factor beta receptor signaling pathway Source: FlyBase
    7. positive regulation of transforming growth factor beta receptor signaling pathway Source: FlyBase
    8. posterior Malpighian tubule development Source: FlyBase
    9. regulation of BMP signaling pathway Source: FlyBase
    10. regulation of growth Source: UniProtKB-KW
    11. ring gland development Source: FlyBase
    12. terminal region determination Source: FlyBase
    13. torso signaling pathway Source: FlyBase
    14. zygotic determination of anterior/posterior axis, embryo Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein, Growth factor

    Keywords - Biological processi

    Growth regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dorsal-ventral patterning protein Sog
    Alternative name(s):
    Short gastrulation protein
    Gene namesi
    Name:sog
    ORF Names:CG9224
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0003463. sog.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: FlyBase

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10381038Dorsal-ventral patterning protein SogPRO_0000219089Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi666 – 6661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi752 – 7521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi821 – 8211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ24025.

    Expressioni

    Tissue specificityi

    Abuts the dorsal dpp-expressing cells in a lateral stripe 14-16 cells wide. Later in embryogenesis it is expressed in neuroectoderm and in the endoderm spaced along the anterior-posterior axis of the developing gut.1 Publication

    Developmental stagei

    Embryogenesis.1 Publication

    Gene expression databases

    BgeeiQ24025.

    Interactioni

    Subunit structurei

    Component of a complex composed of dpp, sog and tsg.

    Protein-protein interaction databases

    BioGridi58848. 14 interactions.
    DIPiDIP-20760N.
    IntActiQ24025. 3 interactions.
    MINTiMINT-299642.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5353CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini75 – 1038964ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei54 – 7421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini100 – 17576VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini197 – 337141CHRD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini339 – 471133CHRD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini474 – 588115CHRD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini592 – 713122CHRD 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini742 – 80463VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini830 – 89970VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini939 – 102082VWFC 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the chordin family.Curated
    Contains 4 CHRD domains.PROSITE-ProRule annotation
    Contains 4 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG85639.
    GeneTreeiENSGT00730000110792.
    InParanoidiQ24025.
    KOiK04657.
    OMAiRDPGEGC.
    OrthoDBiEOG7QNVK7.
    PhylomeDBiQ24025.

    Family and domain databases

    InterProiIPR016353. Chordin.
    IPR010895. CHRD.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF07452. CHRD. 4 hits.
    PF00093. VWC. 4 hits.
    [Graphical view]
    PIRSFiPIRSF002496. Chordin. 1 hit.
    SMARTiSM00754. CHRD. 4 hits.
    SM00214. VWC. 3 hits.
    [Graphical view]
    PROSITEiPS50933. CHRD. 4 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q24025-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANKLRKSNA IEWATATGTV PLLERSCCHS EDAALEPQAS KTSHREQAPI     50
    LRHLSQLSHL LIIAGLLIVC LAGVTEGRRH APLMFEESDT GRRSNRPAVT 100
    ECQFGKVLRE LGSTWYADLG PPFGVMYCIK CECVAIPKKR RIVARVQCRN 150
    IKNECPPAKC DDPISLPGKC CKTCPGDRND TDVALDVPVP NEEEERNMKH 200
    YAALLTGRTS YFLKGEEMKS MYTTYNPQNV VATARFLFHK KNLYYSFYTS 250
    SRIGRPRAIQ FVDDAGVILE EHQLETTLAG TLSVYQNATG KICGVWRRVP 300
    RDYKRILRDD RLHVVLLWGN KQQAELALAG KVAKYTALQT ELFSSLLEAP 350
    LPDGKTDPQL AGAGGTAIVS TSSGAASSMH LTLVFNGVFG AEEYADAALS 400
    VKIELAERKE VIFDEIPRVR KPSAEINVLE LSSPISIQNL RLMSRGKLLL 450
    TVESKKYPHL RIQGHIVTRA SCEIFQTLLA PHSAESSTKS SGLAWVYLNT 500
    DGSLAYNIET EHVNTRDRPN ISLIEEQGKR KAKLEDLTPS FNFNQAIGSV 550
    EKLGPKVLES LYAGELGVNV ATEHETSLIR GRLVPRPVAD ARDSAEPILL 600
    KRQEHTDAQN PHAVGMAWMS IDNECNLHYE VTLNGVPAQD LQLYLEEKPI 650
    EAIGAPVTRK LLEEFNGSYL EGFFLSMPSA ELIKLEMSVC YLEVHSKHSK 700
    QLLLRGKLKS TKVPGHCFPV YTDNNVPVPG DHNDNHLVNG ETKCFHSGRF 750
    YNESEQWRSA QDSCQMCACL RGQSSCEVIK CPALKCKSTE QLLQRDGECC 800
    PSCVPKKEAA DYSAQSSPAT NATDLLQQRR GCRLGEQFHP AGASWHPFLP 850
    PNGFDTCTTC SCDPLTLEIR CPRLVCPPLQ CSEKLAYRPD KKACCKICPE 900
    GKQSSSNGHK TTPNNPNVLQ DQAMQRSPSH SAEEVLANGG CKVVNKVYEN 950
    GQEWHPILMS HGEQKCIKCR CKDSKVNCDR KRCSRSTCQQ QTRVTSKRRL 1000
    FEKPDAAAPA IDECCSTQCR RSRRHHKRQP HHQQRSSS 1038
    Length:1,038
    Mass (Da):115,515
    Last modified:November 1, 1996 - v1
    Checksum:iB0E833AFD79A9037
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18774 mRNA. Translation: AAA89117.1.
    AE014298 Genomic DNA. Translation: AAF48481.1.
    BT053679 mRNA. Translation: ACK77594.1.
    PIRiT13177.
    RefSeqiNP_001259576.1. NM_001272647.1.
    NP_001259578.1. NM_001272649.1.
    NP_476736.1. NM_057388.3.
    UniGeneiDm.3944.

    Genome annotation databases

    EnsemblMetazoaiFBtr0074063; FBpp0073879; FBgn0003463.
    FBtr0331760; FBpp0304148; FBgn0003463.
    FBtr0331762; FBpp0304150; FBgn0003463.
    GeneIDi32498.
    KEGGidme:Dmel_CG9224.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18774 mRNA. Translation: AAA89117.1 .
    AE014298 Genomic DNA. Translation: AAF48481.1 .
    BT053679 mRNA. Translation: ACK77594.1 .
    PIRi T13177.
    RefSeqi NP_001259576.1. NM_001272647.1.
    NP_001259578.1. NM_001272649.1.
    NP_476736.1. NM_057388.3.
    UniGenei Dm.3944.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 58848. 14 interactions.
    DIPi DIP-20760N.
    IntActi Q24025. 3 interactions.
    MINTi MINT-299642.

    Proteomic databases

    PRIDEi Q24025.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0074063 ; FBpp0073879 ; FBgn0003463 .
    FBtr0331760 ; FBpp0304148 ; FBgn0003463 .
    FBtr0331762 ; FBpp0304150 ; FBgn0003463 .
    GeneIDi 32498.
    KEGGi dme:Dmel_CG9224.

    Organism-specific databases

    CTDi 32498.
    FlyBasei FBgn0003463. sog.

    Phylogenomic databases

    eggNOGi NOG85639.
    GeneTreei ENSGT00730000110792.
    InParanoidi Q24025.
    KOi K04657.
    OMAi RDPGEGC.
    OrthoDBi EOG7QNVK7.
    PhylomeDBi Q24025.

    Miscellaneous databases

    GenomeRNAii 32498.
    NextBioi 778773.
    PROi Q24025.

    Gene expression databases

    Bgeei Q24025.

    Family and domain databases

    InterProi IPR016353. Chordin.
    IPR010895. CHRD.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF07452. CHRD. 4 hits.
    PF00093. VWC. 4 hits.
    [Graphical view ]
    PIRSFi PIRSF002496. Chordin. 1 hit.
    SMARTi SM00754. CHRD. 4 hits.
    SM00214. VWC. 3 hits.
    [Graphical view ]
    PROSITEi PS50933. CHRD. 4 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene."
      Francois V., Solloway M., O'Neill J.W., Emery J., Bier E.
      Genes Dev. 8:2602-2616(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
    5. Cited for: FUNCTION, INTERACTION WITH DPP AND TSG.

    Entry informationi

    Entry nameiSOG_DROME
    AccessioniPrimary (citable) accession number: Q24025
    Secondary accession number(s): B7FNI9, Q9VXS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3