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Protein

Protein flightless-1

Gene

fliI

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. Alternatively, it may play a structural role in indirect flight muscle. Vital for embryonic development.

GO - Molecular functioni

  • actin binding Source: FlyBase
  • calcium ion binding Source: FlyBase

GO - Biological processi

  • actin filament severing Source: InterPro
  • adult somatic muscle development Source: FlyBase
  • flight behavior Source: FlyBase
  • gastrulation involving germ band extension Source: FlyBase
  • myofibril assembly Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein flightless-1
Alternative name(s):
Flightless-I
Gene namesi
Name:fliI
ORF Names:CG1484
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000709. fliI.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12561256Protein flightless-1PRO_0000218749Add
BLAST

Proteomic databases

PaxDbiQ24020.
PRIDEiQ24020.

Expressioni

Tissue specificityi

Found in ovaries, larval fat bodies, brain and adult thorax.

Developmental stagei

Expressed both maternally and zygotically.

Gene expression databases

BgeeiQ24020.
GenevisibleiQ24020. DM.

Interactioni

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

BioGridi59388. 2 interactions.
IntActiQ24020. 10 interactions.
STRINGi7227.FBpp0076893.

Structurei

3D structure databases

ProteinModelPortaliQ24020.
SMRiQ24020. Positions 4-400, 494-829, 894-1253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 2825LRR 1Add
BLAST
Repeati29 – 5123LRR 2Add
BLAST
Repeati52 – 7423LRR 3Add
BLAST
Repeati75 – 9925LRR 4Add
BLAST
Repeati100 – 12223LRR 5Add
BLAST
Repeati124 – 14522LRR 6Add
BLAST
Repeati147 – 16923LRR 7Add
BLAST
Repeati171 – 19222LRR 8Add
BLAST
Repeati218 – 24124LRR 9Add
BLAST
Repeati243 – 26422LRR 10Add
BLAST
Repeati265 – 28723LRR 11Add
BLAST
Repeati289 – 31224LRR 12Add
BLAST
Repeati313 – 33523LRR 13Add
BLAST
Repeati336 – 35823LRR 14Add
BLAST
Repeati360 – 38122LRR 15Add
BLAST
Repeati499 – 55759Gelsolin-like 1Add
BLAST
Repeati746 – 78944Gelsolin-like 2Add
BLAST
Repeati1064 – 110239Gelsolin-like 3Add
BLAST
Repeati1165 – 120642Gelsolin-like 4Add
BLAST

Domaini

Consists of a leucine-rich N-terminal half, which is likely to be involved in protein-protein interaction, and a C-terminal half which has high sequence similarity to gelsolin and is therefore likely to be involved in actin-binding.

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated
Contains 4 gelsolin-like repeats.Curated
Contains 15 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0444. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000263916.
InParanoidiQ24020.
OMAiQMKADLT.
OrthoDBiEOG7C2R0C.
PhylomeDBiQ24020.

Family and domain databases

Gene3Di3.40.20.10. 6 hits.
3.80.10.10. 3 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR029919. FliI.
IPR007123. Gelsolin-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF42. PTHR11977:SF42. 1 hit.
PfamiPF00626. Gelsolin. 4 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00369. LRR_TYP. 12 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLPFVRGV DFTKNDFSAT FPSSMRQMSR VQWLTLDRTQ LAEIPEELGH
60 70 80 90 100
LQKLEHLSLN HNRLEKIFGE LTELSCLRSL DLRHNQLKNS GIPPELFHLE
110 120 130 140 150
ELTTLDLSHN KLKEVPEGLE RAKNLIVLNL SNNQIESIPT PLFIHLTDLL
160 170 180 190 200
FLDLSHNRLE TLPPQTRRLI NLKTLDLSHN PLELFQLRQL PSLQSLEVLK
210 220 230 240 250
MSGTQRTLLN FPTSIDSLAN LCELDLSHNS LPKLPDCVYN VVTLVRLNLS
260 270 280 290 300
DNELTELTAG VELWQRLESL NLSRNQLVAL PAALCKLPKL RRLLVNDNKL
310 320 330 340 350
NFEGIPSGIG KLGALEVFSA ANNLLEMVPE GLCRCGALKQ LNLSCNRLIT
360 370 380 390 400
LPDAIHLLEG LDQLDLRNNP ELVMPPKPSE ASKATSLEFY NIDFSLQTQL
410 420 430 440 450
RLAGAAVPPS MPSSATPKDS TARKIRLRRG PRSEGDQDAA KVLKGMKDVA
460 470 480 490 500
KDKDNEAGAV PEDGKPESLK PKRWDESLEK PQLDYSKFFE KDDGQLPGLT
510 520 530 540 550
IWEIENFLPN KIEEVVHGKF YEGDCYIVLK TKFDDLGLLD WEIFFWIGNE
560 570 580 590 600
ATLDKRACAA IHAVNLRNFL GARCRTVREE QGDESEQFLS LFETEVIYIE
610 620 630 640 650
GGRTATGFYT IEEMIHITRL YLVHAYGATI HLEPVAPAIT SLDPRHAFVL
660 670 680 690 700
DLGTHIYIWM GERSKNTLNS KARLMAEKIS KTERKNKCEI QLERQGEESA
710 720 730 740 750
EFWQGLGMTS EEADAAEPPK EHVPEDYQPV QPRLYQVQLG MGYLELPQVE
760 770 780 790 800
LPEQKLCHTL LNSKHVYILD CYTDLFVWFG KKSTRLVRAA AVKLSRELFN
810 820 830 840 850
MMDRPDYALV MRVPEGNEMQ IFRTKFAGWD EVMAVDFTRT AKSVAKTGAN
860 870 880 890 900
LTQWARQQET RTDLAALFMP RQSAMPLAEA EQLEEEWNYD LEMMEAFVLE
910 920 930 940 950
NKKFVRLPEE ELGRFYTGEC YVFLCRYCIP IEEPENGSED GANPAADVSK
960 970 980 990 1000
SSANNQPEDE IQCVVYFWQG RNAGNMGWLT FTFTLQKKFK AMFGEELEVV
1010 1020 1030 1040 1050
RIFQQQENLK FMSHFKRKFI IHTGKRKDKA HTAKGKSPVE FFHLRSNGGA
1060 1070 1080 1090 1100
LTTRLIQINP DAVHLNSTFC YILHVPFETE DDSQSGIVYV WIGSKACNEE
1110 1120 1130 1140 1150
AKLVQDIAEQ MFNSPWVSLQ ILNEGDEPEN FFWVALGGRK PYDTDAEYMN
1160 1170 1180 1190 1200
YTRLFRCSNE RGYYTVAEKC ADFCQDDLAD DDIMILDNGE HVFLWMGPRC
1210 1220 1230 1240 1250
SEVEVKLAYK SAQVYIQHMR IKQPERPRKL FLTMKNKESR RFTKCFHGWS

AFKVYL
Length:1,256
Mass (Da):143,682
Last modified:November 1, 1996 - v1
Checksum:iCF0056EFAA88DB92
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1068 – 10681T → A in AAC28407 (PubMed:9520435).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti601 – 6011G → S.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01182 mRNA. Translation: AAC03566.1.
AF017777 Genomic DNA. Translation: AAC28407.1.
AE014298 Genomic DNA. Translation: AAF50830.2.
AF132184 mRNA. Translation: AAD34772.1.
PIRiS60461.
RefSeqiNP_525097.1. NM_080358.3.
UniGeneiDm.1666.

Genome annotation databases

EnsemblMetazoaiFBtr0077192; FBpp0076893; FBgn0000709.
GeneIDi33110.
KEGGidme:Dmel_CG1484.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01182 mRNA. Translation: AAC03566.1.
AF017777 Genomic DNA. Translation: AAC28407.1.
AE014298 Genomic DNA. Translation: AAF50830.2.
AF132184 mRNA. Translation: AAD34772.1.
PIRiS60461.
RefSeqiNP_525097.1. NM_080358.3.
UniGeneiDm.1666.

3D structure databases

ProteinModelPortaliQ24020.
SMRiQ24020. Positions 4-400, 494-829, 894-1253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59388. 2 interactions.
IntActiQ24020. 10 interactions.
STRINGi7227.FBpp0076893.

Proteomic databases

PaxDbiQ24020.
PRIDEiQ24020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077192; FBpp0076893; FBgn0000709.
GeneIDi33110.
KEGGidme:Dmel_CG1484.

Organism-specific databases

CTDi2314.
FlyBaseiFBgn0000709. fliI.

Phylogenomic databases

eggNOGiKOG0444. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000263916.
InParanoidiQ24020.
OMAiQMKADLT.
OrthoDBiEOG7C2R0C.
PhylomeDBiQ24020.

Miscellaneous databases

ChiTaRSifliI. fly.
GenomeRNAii33110.
NextBioi781957.
PROiQ24020.

Gene expression databases

BgeeiQ24020.
GenevisibleiQ24020. DM.

Family and domain databases

Gene3Di3.40.20.10. 6 hits.
3.80.10.10. 3 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR029919. FliI.
IPR007123. Gelsolin-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF42. PTHR11977:SF42. 1 hit.
PfamiPF00626. Gelsolin. 4 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00369. LRR_TYP. 12 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans."
    Campbell H.D., Schimansky T., Claudianos C., Ozsarac N., Kasprzak A.B., Cotsell J.N., Young I.G., de Couet H.G., Miklos G.L.G.
    Proc. Natl. Acad. Sci. U.S.A. 90:11386-11390(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Oregon-R.
    Tissue: Embryo.
  2. "Molecular and mutational analysis of a gelsolin-family member encoded by the flightless I gene of Drosophila melanogaster."
    de Couet H.G., Fong K.S.K., Weeds A.G., McLaughlin P.J., Miklos G.L.G.
    Genetics 141:1049-1059(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-601.
    Strain: Canton-S.
  3. "Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila."
    Maleszka R., de Couet H.G., Miklos G.L.G.
    Proc. Natl. Acad. Sci. U.S.A. 95:3731-3736(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Canton-S.
  4. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  5. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiFLII_DROME
AccessioniPrimary (citable) accession number: Q24020
Secondary accession number(s): Q24088, Q9VRH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.