Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein flightless-1

Gene

fliI

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. Alternatively, it may play a structural role in indirect flight muscle. Vital for embryonic development.

GO - Molecular functioni

  • actin binding Source: FlyBase
  • calcium ion binding Source: FlyBase

GO - Biological processi

  • actin filament severing Source: InterPro
  • adult somatic muscle development Source: FlyBase
  • flight behavior Source: FlyBase
  • gastrulation involving germ band extension Source: FlyBase
  • myofibril assembly Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein flightless-1
Alternative name(s):
Flightless-I
Gene namesi
Name:fliI
ORF Names:CG1484
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000709. fliI.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187491 – 1256Protein flightless-1Add BLAST1256

Proteomic databases

PaxDbiQ24020.
PRIDEiQ24020.

Expressioni

Tissue specificityi

Found in ovaries, larval fat bodies, brain and adult thorax.

Developmental stagei

Expressed both maternally and zygotically.

Gene expression databases

BgeeiFBgn0000709.
GenevisibleiQ24020. DM.

Interactioni

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

BioGridi59388. 2 interactors.
IntActiQ24020. 10 interactors.
STRINGi7227.FBpp0076893.

Structurei

3D structure databases

ProteinModelPortaliQ24020.
SMRiQ24020.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 28LRR 1Add BLAST25
Repeati29 – 51LRR 2Add BLAST23
Repeati52 – 74LRR 3Add BLAST23
Repeati75 – 99LRR 4Add BLAST25
Repeati100 – 122LRR 5Add BLAST23
Repeati124 – 145LRR 6Add BLAST22
Repeati147 – 169LRR 7Add BLAST23
Repeati171 – 192LRR 8Add BLAST22
Repeati218 – 241LRR 9Add BLAST24
Repeati243 – 264LRR 10Add BLAST22
Repeati265 – 287LRR 11Add BLAST23
Repeati289 – 312LRR 12Add BLAST24
Repeati313 – 335LRR 13Add BLAST23
Repeati336 – 358LRR 14Add BLAST23
Repeati360 – 381LRR 15Add BLAST22
Repeati499 – 557Gelsolin-like 1Add BLAST59
Repeati746 – 789Gelsolin-like 2Add BLAST44
Repeati1064 – 1102Gelsolin-like 3Add BLAST39
Repeati1165 – 1206Gelsolin-like 4Add BLAST42

Domaini

Consists of a leucine-rich N-terminal half, which is likely to be involved in protein-protein interaction, and a C-terminal half which has high sequence similarity to gelsolin and is therefore likely to be involved in actin-binding.

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated
Contains 4 gelsolin-like repeats.Curated
Contains 15 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0444. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000263916.
InParanoidiQ24020.
OMAiQMKADLT.
OrthoDBiEOG091G00R0.
PhylomeDBiQ24020.

Family and domain databases

Gene3Di3.40.20.10. 6 hits.
3.80.10.10. 3 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR029919. FliI.
IPR007123. Gelsolin-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF42. PTHR11977:SF42. 1 hit.
PfamiPF00626. Gelsolin. 4 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00369. LRR_TYP. 12 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLPFVRGV DFTKNDFSAT FPSSMRQMSR VQWLTLDRTQ LAEIPEELGH
60 70 80 90 100
LQKLEHLSLN HNRLEKIFGE LTELSCLRSL DLRHNQLKNS GIPPELFHLE
110 120 130 140 150
ELTTLDLSHN KLKEVPEGLE RAKNLIVLNL SNNQIESIPT PLFIHLTDLL
160 170 180 190 200
FLDLSHNRLE TLPPQTRRLI NLKTLDLSHN PLELFQLRQL PSLQSLEVLK
210 220 230 240 250
MSGTQRTLLN FPTSIDSLAN LCELDLSHNS LPKLPDCVYN VVTLVRLNLS
260 270 280 290 300
DNELTELTAG VELWQRLESL NLSRNQLVAL PAALCKLPKL RRLLVNDNKL
310 320 330 340 350
NFEGIPSGIG KLGALEVFSA ANNLLEMVPE GLCRCGALKQ LNLSCNRLIT
360 370 380 390 400
LPDAIHLLEG LDQLDLRNNP ELVMPPKPSE ASKATSLEFY NIDFSLQTQL
410 420 430 440 450
RLAGAAVPPS MPSSATPKDS TARKIRLRRG PRSEGDQDAA KVLKGMKDVA
460 470 480 490 500
KDKDNEAGAV PEDGKPESLK PKRWDESLEK PQLDYSKFFE KDDGQLPGLT
510 520 530 540 550
IWEIENFLPN KIEEVVHGKF YEGDCYIVLK TKFDDLGLLD WEIFFWIGNE
560 570 580 590 600
ATLDKRACAA IHAVNLRNFL GARCRTVREE QGDESEQFLS LFETEVIYIE
610 620 630 640 650
GGRTATGFYT IEEMIHITRL YLVHAYGATI HLEPVAPAIT SLDPRHAFVL
660 670 680 690 700
DLGTHIYIWM GERSKNTLNS KARLMAEKIS KTERKNKCEI QLERQGEESA
710 720 730 740 750
EFWQGLGMTS EEADAAEPPK EHVPEDYQPV QPRLYQVQLG MGYLELPQVE
760 770 780 790 800
LPEQKLCHTL LNSKHVYILD CYTDLFVWFG KKSTRLVRAA AVKLSRELFN
810 820 830 840 850
MMDRPDYALV MRVPEGNEMQ IFRTKFAGWD EVMAVDFTRT AKSVAKTGAN
860 870 880 890 900
LTQWARQQET RTDLAALFMP RQSAMPLAEA EQLEEEWNYD LEMMEAFVLE
910 920 930 940 950
NKKFVRLPEE ELGRFYTGEC YVFLCRYCIP IEEPENGSED GANPAADVSK
960 970 980 990 1000
SSANNQPEDE IQCVVYFWQG RNAGNMGWLT FTFTLQKKFK AMFGEELEVV
1010 1020 1030 1040 1050
RIFQQQENLK FMSHFKRKFI IHTGKRKDKA HTAKGKSPVE FFHLRSNGGA
1060 1070 1080 1090 1100
LTTRLIQINP DAVHLNSTFC YILHVPFETE DDSQSGIVYV WIGSKACNEE
1110 1120 1130 1140 1150
AKLVQDIAEQ MFNSPWVSLQ ILNEGDEPEN FFWVALGGRK PYDTDAEYMN
1160 1170 1180 1190 1200
YTRLFRCSNE RGYYTVAEKC ADFCQDDLAD DDIMILDNGE HVFLWMGPRC
1210 1220 1230 1240 1250
SEVEVKLAYK SAQVYIQHMR IKQPERPRKL FLTMKNKESR RFTKCFHGWS

AFKVYL
Length:1,256
Mass (Da):143,682
Last modified:November 1, 1996 - v1
Checksum:iCF0056EFAA88DB92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1068T → A in AAC28407 (PubMed:9520435).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti601G → S.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01182 mRNA. Translation: AAC03566.1.
AF017777 Genomic DNA. Translation: AAC28407.1.
AE014298 Genomic DNA. Translation: AAF50830.2.
AF132184 mRNA. Translation: AAD34772.1.
PIRiS60461.
RefSeqiNP_525097.1. NM_080358.3.
UniGeneiDm.1666.

Genome annotation databases

EnsemblMetazoaiFBtr0077192; FBpp0076893; FBgn0000709.
GeneIDi33110.
KEGGidme:Dmel_CG1484.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01182 mRNA. Translation: AAC03566.1.
AF017777 Genomic DNA. Translation: AAC28407.1.
AE014298 Genomic DNA. Translation: AAF50830.2.
AF132184 mRNA. Translation: AAD34772.1.
PIRiS60461.
RefSeqiNP_525097.1. NM_080358.3.
UniGeneiDm.1666.

3D structure databases

ProteinModelPortaliQ24020.
SMRiQ24020.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59388. 2 interactors.
IntActiQ24020. 10 interactors.
STRINGi7227.FBpp0076893.

Proteomic databases

PaxDbiQ24020.
PRIDEiQ24020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077192; FBpp0076893; FBgn0000709.
GeneIDi33110.
KEGGidme:Dmel_CG1484.

Organism-specific databases

CTDi2314.
FlyBaseiFBgn0000709. fliI.

Phylogenomic databases

eggNOGiKOG0444. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000263916.
InParanoidiQ24020.
OMAiQMKADLT.
OrthoDBiEOG091G00R0.
PhylomeDBiQ24020.

Miscellaneous databases

ChiTaRSifliI. fly.
GenomeRNAii33110.
PROiQ24020.

Gene expression databases

BgeeiFBgn0000709.
GenevisibleiQ24020. DM.

Family and domain databases

Gene3Di3.40.20.10. 6 hits.
3.80.10.10. 3 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR029919. FliI.
IPR007123. Gelsolin-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF42. PTHR11977:SF42. 1 hit.
PfamiPF00626. Gelsolin. 4 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00369. LRR_TYP. 12 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLII_DROME
AccessioniPrimary (citable) accession number: Q24020
Secondary accession number(s): Q24088, Q9VRH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.