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Q23W20

- Q23W20_TETTS

UniProt

Q23W20 - Q23W20_TETTS

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Protein
Isocitrate dehydrogenase [NADP]
Gene
TTHERM_00794110
Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801Substrate By similarityUniRule annotation
Binding sitei85 – 851NADP By similarityUniRule annotation
Binding sitei112 – 1121Substrate By similarity
Binding sitei126 – 1261Substrate By similarity
Binding sitei135 – 1351Substrate By similarity
Sitei142 – 1421Critical for catalysis By similarityUniRule annotation
Binding sitei158 – 1581Substrate By similarity
Sitei214 – 2141Critical for catalysis By similarityUniRule annotation
Metal bindingi254 – 2541Magnesium or manganese By similarityUniRule annotation
Binding sitei262 – 2621NADP By similarityUniRule annotation
Metal bindingi277 – 2771Magnesium or manganese By similarityUniRule annotation
Binding sitei329 – 3291NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 803NADP By similarityUniRule annotation
Nucleotide bindingi311 – 3166NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:TTHERM_00794110Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi5911.XP_001020930.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 1037Substrate binding By similarity
Regioni143 – 1497Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23W20-1 [UniParc]FASTAAdd to Basket

« Hide

MAELQKIKVT NPVTELDGDE MTRVIWQLIK DKLILPYLDL NIKYFDLGME    50
YRDQTDDKVT LDAAQSIVET KVGIKCATIT PDEARVKEFN LKKMWKSPNG 100
TIRNHIGGTV FREPILMKNV PRLVPAWTKP IVIGRHAFGD QYRATDFKVE 150
EAGTFEIVFT PKNGGEKKVM KVFDYPAGGV GMGMYNTDES ITEFAHSSFK 200
YALDRKMPLY LSTKNTILKA YDGKFKDIFQ AIYDKQYKEE FTKAGIWYEH 250
RLIDDMVAYM MKSEGGFMWA CKNYDGDVQS DCLAQGFGSL GLMTSVLVGP 300
NDIIEAEAAH GTVTRHFRQH QKGQETSTNS IASIFAWTQG LLHRAKLDNN 350
KELDLFCKTL ESSVIETVET GFMTKDLAIC IQGSNDVPRS KYLTTQEFID 400
KVAETLRKNL VAAKSNL 417
Length:417
Mass (Da):47,211
Last modified:April 16, 2014 - v3
Checksum:i91ED2EC90E256C3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662609 Genomic DNA. Translation: EAS00685.3.
UniGeneiTth.2460.

Genome annotation databases

EnsemblProtistsiEAS00685; EAS00685; TTHERM_00794110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662609 Genomic DNA. Translation: EAS00685.3 .
UniGenei Tth.2460.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5911.XP_001020930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi EAS00685 ; EAS00685 ; TTHERM_00794110 .

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210.

Entry informationi

Entry nameiQ23W20_TETTS
AccessioniPrimary (citable) accession number: Q23W20
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 16, 2014
Last modified: September 3, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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