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Q23W20

- Q23W20_TETTS

UniProt

Q23W20 - Q23W20_TETTS

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Protein

Isocitrate dehydrogenase [NADP]

Gene

TTHERM_00794110

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801SubstrateUniRule annotation
Binding sitei85 – 851NADP
Binding sitei112 – 1121SubstrateUniRule annotation
Binding sitei126 – 1261Substrate
Binding sitei135 – 1351SubstrateUniRule annotation
Sitei142 – 1421Critical for catalysisUniRule annotation
Binding sitei158 – 1581Substrate
Sitei214 – 2141Critical for catalysisUniRule annotation
Metal bindingi254 – 2541Magnesium or manganeseUniRule annotation
Binding sitei262 – 2621NADP
Metal bindingi277 – 2771Magnesium or manganeseUniRule annotation
Binding sitei329 – 3291NADP; via amide nitrogen and carbonyl oxygen

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 803NADP
Nucleotide bindingi311 – 3166NADP

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:TTHERM_00794110Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi5911.XP_001020930.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 1037Substrate bindingUniRule annotation
Regioni143 – 1497Substrate binding

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

InParanoidiQ23W20.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23W20-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAELQKIKVT NPVTELDGDE MTRVIWQLIK DKLILPYLDL NIKYFDLGME
60 70 80 90 100
YRDQTDDKVT LDAAQSIVET KVGIKCATIT PDEARVKEFN LKKMWKSPNG
110 120 130 140 150
TIRNHIGGTV FREPILMKNV PRLVPAWTKP IVIGRHAFGD QYRATDFKVE
160 170 180 190 200
EAGTFEIVFT PKNGGEKKVM KVFDYPAGGV GMGMYNTDES ITEFAHSSFK
210 220 230 240 250
YALDRKMPLY LSTKNTILKA YDGKFKDIFQ AIYDKQYKEE FTKAGIWYEH
260 270 280 290 300
RLIDDMVAYM MKSEGGFMWA CKNYDGDVQS DCLAQGFGSL GLMTSVLVGP
310 320 330 340 350
NDIIEAEAAH GTVTRHFRQH QKGQETSTNS IASIFAWTQG LLHRAKLDNN
360 370 380 390 400
KELDLFCKTL ESSVIETVET GFMTKDLAIC IQGSNDVPRS KYLTTQEFID
410
KVAETLRKNL VAAKSNL
Length:417
Mass (Da):47,211
Last modified:April 16, 2014 - v3
Checksum:i91ED2EC90E256C3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662609 Genomic DNA. Translation: EAS00685.3.
UniGeneiTth.2460.

Genome annotation databases

EnsemblProtistsiEAS00685; EAS00685; TTHERM_00794110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662609 Genomic DNA. Translation: EAS00685.3 .
UniGenei Tth.2460.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5911.XP_001020930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi EAS00685 ; EAS00685 ; TTHERM_00794110 .

Phylogenomic databases

InParanoidi Q23W20.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210Imported.

Entry informationi

Entry nameiQ23W20_TETTS
AccessioniPrimary (citable) accession number: Q23W20
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 16, 2014
Last modified: October 29, 2014
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3