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Q23W20 (Q23W20_TETTS) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
ORF Names:TTHERM_00794110 EMBL EAS00685.3
OrganismTetrahymena thermophila (strain SB210) [Reference proteome] EMBL EAS00685.3
Taxonomic identifier312017 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR000108-3 PIRNR PIRNR000108

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding78 – 803NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding311 – 3166NADP By similarity PIRSR PIRSR000108-4
Region97 – 1037Substrate binding By similarity
Region143 – 1497Substrate binding By similarity

Sites

Metal binding2541Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2771Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site801Substrate By similarity PIRSR PIRSR000108-2
Binding site851NADP By similarity PIRSR PIRSR000108-4
Binding site1121Substrate By similarity
Binding site1261Substrate By similarity
Binding site1351Substrate By similarity
Binding site1581Substrate By similarity
Binding site2621NADP By similarity PIRSR PIRSR000108-4
Binding site3291NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1421Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2141Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
Q23W20 [UniParc].

Last modified April 16, 2014. Version 3.
Checksum: 91ED2EC90E256C3B

FASTA41747,211
        10         20         30         40         50         60 
MAELQKIKVT NPVTELDGDE MTRVIWQLIK DKLILPYLDL NIKYFDLGME YRDQTDDKVT 

        70         80         90        100        110        120 
LDAAQSIVET KVGIKCATIT PDEARVKEFN LKKMWKSPNG TIRNHIGGTV FREPILMKNV 

       130        140        150        160        170        180 
PRLVPAWTKP IVIGRHAFGD QYRATDFKVE EAGTFEIVFT PKNGGEKKVM KVFDYPAGGV 

       190        200        210        220        230        240 
GMGMYNTDES ITEFAHSSFK YALDRKMPLY LSTKNTILKA YDGKFKDIFQ AIYDKQYKEE 

       250        260        270        280        290        300 
FTKAGIWYEH RLIDDMVAYM MKSEGGFMWA CKNYDGDVQS DCLAQGFGSL GLMTSVLVGP 

       310        320        330        340        350        360 
NDIIEAEAAH GTVTRHFRQH QKGQETSTNS IASIFAWTQG LLHRAKLDNN KELDLFCKTL 

       370        380        390        400        410 
ESSVIETVET GFMTKDLAIC IQGSNDVPRS KYLTTQEFID KVAETLRKNL VAAKSNL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG662609 Genomic DNA. Translation: EAS00685.3.
UniGeneTth.2460.

3D structure databases

ProteinModelPortalQ23W20.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5911.XP_001020930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsEAS00685; EAS00685; TTHERM_00794110.
KEGGtet:TTHERM_00794110.

Phylogenomic databases

KOK00031.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ23W20_TETTS
AccessionPrimary (citable) accession number: Q23W20
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 16, 2014
Last modified: July 9, 2014
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)