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Protein

Isocitrate dehydrogenase [NADP]

Gene

TTHERM_00794110

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80SubstrateUniRule annotation1
Binding sitei85NADPUniRule annotation1
Binding sitei112SubstrateUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Sitei142Critical for catalysisUniRule annotation1
Sitei214Critical for catalysisUniRule annotation1
Metal bindingi254Magnesium or manganeseUniRule annotation1
Binding sitei262NADPUniRule annotation1
Metal bindingi277Magnesium or manganeseUniRule annotation1
Binding sitei329NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi78 – 80NADPUniRule annotation3
Nucleotide bindingi311 – 316NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:TTHERM_00794110Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
Proteomesi
  • UP000009168 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 402Iso_dhInterPro annotationAdd BLAST391

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 103Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

InParanoidiQ23W20.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23W20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELQKIKVT NPVTELDGDE MTRVIWQLIK DKLILPYLDL NIKYFDLGME
60 70 80 90 100
YRDQTDDKVT LDAAQSIVET KVGIKCATIT PDEARVKEFN LKKMWKSPNG
110 120 130 140 150
TIRNHIGGTV FREPILMKNV PRLVPAWTKP IVIGRHAFGD QYRATDFKVE
160 170 180 190 200
EAGTFEIVFT PKNGGEKKVM KVFDYPAGGV GMGMYNTDES ITEFAHSSFK
210 220 230 240 250
YALDRKMPLY LSTKNTILKA YDGKFKDIFQ AIYDKQYKEE FTKAGIWYEH
260 270 280 290 300
RLIDDMVAYM MKSEGGFMWA CKNYDGDVQS DCLAQGFGSL GLMTSVLVGP
310 320 330 340 350
NDIIEAEAAH GTVTRHFRQH QKGQETSTNS IASIFAWTQG LLHRAKLDNN
360 370 380 390 400
KELDLFCKTL ESSVIETVET GFMTKDLAIC IQGSNDVPRS KYLTTQEFID
410
KVAETLRKNL VAAKSNL
Length:417
Mass (Da):47,211
Last modified:April 16, 2014 - v3
Checksum:i91ED2EC90E256C3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662609 Genomic DNA. Translation: EAS00685.3.
RefSeqiXP_001020930.3. XM_001020930.3.

Genome annotation databases

EnsemblProtistsiEAS00685; EAS00685; TTHERM_00794110.
GeneIDi7825488.
KEGGitet:TTHERM_00794110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662609 Genomic DNA. Translation: EAS00685.3.
RefSeqiXP_001020930.3. XM_001020930.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAS00685; EAS00685; TTHERM_00794110.
GeneIDi7825488.
KEGGitet:TTHERM_00794110.

Phylogenomic databases

InParanoidiQ23W20.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ23W20_TETTS
AccessioniPrimary (citable) accession number: Q23W20
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 16, 2014
Last modified: June 8, 2016
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.