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Q23RI5

- Q23RI5_TETTS

UniProt

Q23RI5 - Q23RI5_TETTS

Protein

DNA ligase

Gene

TTHERM_00387050

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: RefGenome

    GO - Biological processi

    1. DNA ligation Source: RefGenome
    2. DNA ligation involved in DNA repair Source: InterPro
    3. DNA recombination Source: UniProtKB-KW
    4. double-strand break repair via nonhomologous end joining Source: RefGenome
    5. lagging strand elongation Source: RefGenome
    6. nucleotide-excision repair Source: RefGenome

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    ORF Names:TTHERM_00387050Imported
    OrganismiTetrahymena thermophila (strain SB210)Imported
    Taxonomic identifieri312017 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
    ProteomesiUP000009168: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome Source: RefGenome
    2. DNA ligase IV complex Source: RefGenome

    Interactioni

    Protein-protein interaction databases

    STRINGi5911.XP_001019308.

    Structurei

    3D structure databases

    ProteinModelPortaliQ23RI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK10777.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.10190. 1 hit.
    InterProiIPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR021536. DNA_ligase_IV_dom.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF11411. DNA_ligase_IV. 1 hit.
    [Graphical view]
    SMARTiSM00292. BRCT. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS50172. BRCT. 1 hit.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q23RI5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQNYYKWHKI KQEQNQELSV NIKPISSSKM KQSDISTRKK KAQEYNMDFD     50
    EFQQEDSKIN QNSDNFHFGD SADEYGIDSP KMKREKAVKE EDNTFRLEIK 100
    KSPILEKTLF SFLVKFYNQV QQSKKGQRKK FVQRFIDSTF KTNRCPSYTF 150
    TILRLIMPHH DKQRLNYGLN YKNLAKVLSE VFALSEDKRQ QLLNYKRPLK 200
    DNQQVVGDFG EVVQNVLQAF TQKATLTIND VDRCLDELAQ PQNRDLASKE 250
    KVLRNCLKNA TSEEIKWISR LILKDLNLGI NHEIILALFH PDAVVLFNST 300
    SSLWEVCKEF VDPNHKLSNV LRLFHPIKPM LAGRKTLKSI EAILKGKNYL 350
    VETKFDGERI QCHVSPESLM FFTRNSNNYT NIYERMIEHV RRSLKDAVHS 400
    CILDGEMVVV NKITGQRVQF GLNKTVAMER EDDELCICYK IFDILYLKTK 450
    DNKEYALTEY TLQYRKKILE NLIDNQQDRV EVIFGREYSD INDILTEFNE 500
    AIHRNDEGIV IKQLDTLYYP DDRSDKWIKM KGDYYEGIID TLDLIVIGGY 550
    FGEKSYKING IGDWTDHITH YLVAVAKKID LQNPSNSILV PFAKVGAGFT 600
    ARDYADIKAR MRDQWVRTNH SNKTPSFIIQ NWKPGEKDKP DAYILSPQNS 650
    LILEIRATEI IQSSQYPTNY TLRFPRFEKF RRDKDWFDCM KFNEIIEMTQ 700
    NLKKKEQKES DKEDNASDEE QDENGGKLKK KRKGQNGEEI EVNRQGRKPN 750
    WKTNKVMAQY LDIDVSDVKV ESNIFNNFVF NIINLPHEVS LSEEKILLEK 800
    AQIEKGIVAN GGKKVQNDSN LVTHYIASHY DFKVQVIGDH YKVNVLSLQW 850
    VKDCIKKKTL LDYSPRYIIY GQDQLLERNK LLYDQYGDSY YKDVDEDELL 900
    DILKSMKIDQ IEEEFQENEE FEEAVKDIIS MKNQLFKECF PQGQTYCFYN 950
    ANDKLNSDID LRYLVDLIQF SGNQVVFDLQ DEIDYIVALD YSEAENEKII 1000
    TFREKNRSME VITPKNLLNN FGIALE 1026
    Length:1,026
    Mass (Da):120,320
    Last modified:April 18, 2006 - v1
    Checksum:iC110753492BAE3B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG662644 Genomic DNA. Translation: EAR99063.1.
    RefSeqiXP_001019308.1. XM_001019308.1.
    UniGeneiTth.9167.

    Genome annotation databases

    EnsemblProtistsiEAR99063; EAR99063; TTHERM_00387050.
    GeneIDi7825974.
    KEGGitet:TTHERM_00387050.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG662644 Genomic DNA. Translation: EAR99063.1 .
    RefSeqi XP_001019308.1. XM_001019308.1.
    UniGenei Tth.9167.

    3D structure databases

    ProteinModelPortali Q23RI5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5911.XP_001019308.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi EAR99063 ; EAR99063 ; TTHERM_00387050 .
    GeneIDi 7825974.
    KEGGi tet:TTHERM_00387050.

    Phylogenomic databases

    KOi K10777.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.10190. 1 hit.
    InterProi IPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR021536. DNA_ligase_IV_dom.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF11411. DNA_ligase_IV. 1 hit.
    [Graphical view ]
    SMARTi SM00292. BRCT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS50172. BRCT. 1 hit.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
      Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
      , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
      PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SB210Imported.

    Entry informationi

    Entry nameiQ23RI5_TETTS
    AccessioniPrimary (citable) accession number: Q23RI5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3