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Protein

DNA ligase

Gene

TTHERM_00387050

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: GO_Central

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation Source: GO_Central
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-KW
  5. double-strand break repair via nonhomologous end joining Source: GO_Central
  6. lagging strand elongation Source: GO_Central
  7. nucleotide-excision repair Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:TTHERM_00387050Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: GO_Central
  2. DNA ligase IV complex Source: GO_Central
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5911.XP_001019308.

Structurei

3D structure databases

ProteinModelPortaliQ23RI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiQ23RI5.
KOiK10777.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23RI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNYYKWHKI KQEQNQELSV NIKPISSSKM KQSDISTRKK KAQEYNMDFD
60 70 80 90 100
EFQQEDSKIN QNSDNFHFGD SADEYGIDSP KMKREKAVKE EDNTFRLEIK
110 120 130 140 150
KSPILEKTLF SFLVKFYNQV QQSKKGQRKK FVQRFIDSTF KTNRCPSYTF
160 170 180 190 200
TILRLIMPHH DKQRLNYGLN YKNLAKVLSE VFALSEDKRQ QLLNYKRPLK
210 220 230 240 250
DNQQVVGDFG EVVQNVLQAF TQKATLTIND VDRCLDELAQ PQNRDLASKE
260 270 280 290 300
KVLRNCLKNA TSEEIKWISR LILKDLNLGI NHEIILALFH PDAVVLFNST
310 320 330 340 350
SSLWEVCKEF VDPNHKLSNV LRLFHPIKPM LAGRKTLKSI EAILKGKNYL
360 370 380 390 400
VETKFDGERI QCHVSPESLM FFTRNSNNYT NIYERMIEHV RRSLKDAVHS
410 420 430 440 450
CILDGEMVVV NKITGQRVQF GLNKTVAMER EDDELCICYK IFDILYLKTK
460 470 480 490 500
DNKEYALTEY TLQYRKKILE NLIDNQQDRV EVIFGREYSD INDILTEFNE
510 520 530 540 550
AIHRNDEGIV IKQLDTLYYP DDRSDKWIKM KGDYYEGIID TLDLIVIGGY
560 570 580 590 600
FGEKSYKING IGDWTDHITH YLVAVAKKID LQNPSNSILV PFAKVGAGFT
610 620 630 640 650
ARDYADIKAR MRDQWVRTNH SNKTPSFIIQ NWKPGEKDKP DAYILSPQNS
660 670 680 690 700
LILEIRATEI IQSSQYPTNY TLRFPRFEKF RRDKDWFDCM KFNEIIEMTQ
710 720 730 740 750
NLKKKEQKES DKEDNASDEE QDENGGKLKK KRKGQNGEEI EVNRQGRKPN
760 770 780 790 800
WKTNKVMAQY LDIDVSDVKV ESNIFNNFVF NIINLPHEVS LSEEKILLEK
810 820 830 840 850
AQIEKGIVAN GGKKVQNDSN LVTHYIASHY DFKVQVIGDH YKVNVLSLQW
860 870 880 890 900
VKDCIKKKTL LDYSPRYIIY GQDQLLERNK LLYDQYGDSY YKDVDEDELL
910 920 930 940 950
DILKSMKIDQ IEEEFQENEE FEEAVKDIIS MKNQLFKECF PQGQTYCFYN
960 970 980 990 1000
ANDKLNSDID LRYLVDLIQF SGNQVVFDLQ DEIDYIVALD YSEAENEKII
1010 1020
TFREKNRSME VITPKNLLNN FGIALE
Length:1,026
Mass (Da):120,320
Last modified:April 17, 2006 - v1
Checksum:iC110753492BAE3B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662644 Genomic DNA. Translation: EAR99063.1.
RefSeqiXP_001019308.1. XM_001019308.1.
UniGeneiTth.9167.

Genome annotation databases

EnsemblProtistsiEAR99063; EAR99063; TTHERM_00387050.
GeneIDi7825974.
KEGGitet:TTHERM_00387050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662644 Genomic DNA. Translation: EAR99063.1.
RefSeqiXP_001019308.1. XM_001019308.1.
UniGeneiTth.9167.

3D structure databases

ProteinModelPortaliQ23RI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5911.XP_001019308.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAR99063; EAR99063; TTHERM_00387050.
GeneIDi7825974.
KEGGitet:TTHERM_00387050.

Phylogenomic databases

InParanoidiQ23RI5.
KOiK10777.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210Imported.

Entry informationi

Entry nameiQ23RI5_TETTS
AccessioniPrimary (citable) accession number: Q23RI5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 17, 2006
Last sequence update: April 17, 2006
Last modified: February 3, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.