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Q23RI5

- Q23RI5_TETTS

UniProt

Q23RI5 - Q23RI5_TETTS

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Protein

DNA ligase

Gene
TTHERM_00387050
Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome

GO - Biological processi

  1. DNA ligation Source: RefGenome
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. double-strand break repair via nonhomologous end joining Source: RefGenome
  5. lagging strand elongation Source: RefGenome
  6. nucleotide-excision repair Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:TTHERM_00387050Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: RefGenome
  2. DNA ligase IV complex Source: RefGenome
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5911.XP_001019308.

Structurei

3D structure databases

ProteinModelPortaliQ23RI5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10777.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23RI5-1 [UniParc]FASTAAdd to Basket

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MQNYYKWHKI KQEQNQELSV NIKPISSSKM KQSDISTRKK KAQEYNMDFD     50
EFQQEDSKIN QNSDNFHFGD SADEYGIDSP KMKREKAVKE EDNTFRLEIK 100
KSPILEKTLF SFLVKFYNQV QQSKKGQRKK FVQRFIDSTF KTNRCPSYTF 150
TILRLIMPHH DKQRLNYGLN YKNLAKVLSE VFALSEDKRQ QLLNYKRPLK 200
DNQQVVGDFG EVVQNVLQAF TQKATLTIND VDRCLDELAQ PQNRDLASKE 250
KVLRNCLKNA TSEEIKWISR LILKDLNLGI NHEIILALFH PDAVVLFNST 300
SSLWEVCKEF VDPNHKLSNV LRLFHPIKPM LAGRKTLKSI EAILKGKNYL 350
VETKFDGERI QCHVSPESLM FFTRNSNNYT NIYERMIEHV RRSLKDAVHS 400
CILDGEMVVV NKITGQRVQF GLNKTVAMER EDDELCICYK IFDILYLKTK 450
DNKEYALTEY TLQYRKKILE NLIDNQQDRV EVIFGREYSD INDILTEFNE 500
AIHRNDEGIV IKQLDTLYYP DDRSDKWIKM KGDYYEGIID TLDLIVIGGY 550
FGEKSYKING IGDWTDHITH YLVAVAKKID LQNPSNSILV PFAKVGAGFT 600
ARDYADIKAR MRDQWVRTNH SNKTPSFIIQ NWKPGEKDKP DAYILSPQNS 650
LILEIRATEI IQSSQYPTNY TLRFPRFEKF RRDKDWFDCM KFNEIIEMTQ 700
NLKKKEQKES DKEDNASDEE QDENGGKLKK KRKGQNGEEI EVNRQGRKPN 750
WKTNKVMAQY LDIDVSDVKV ESNIFNNFVF NIINLPHEVS LSEEKILLEK 800
AQIEKGIVAN GGKKVQNDSN LVTHYIASHY DFKVQVIGDH YKVNVLSLQW 850
VKDCIKKKTL LDYSPRYIIY GQDQLLERNK LLYDQYGDSY YKDVDEDELL 900
DILKSMKIDQ IEEEFQENEE FEEAVKDIIS MKNQLFKECF PQGQTYCFYN 950
ANDKLNSDID LRYLVDLIQF SGNQVVFDLQ DEIDYIVALD YSEAENEKII 1000
TFREKNRSME VITPKNLLNN FGIALE 1026
Length:1,026
Mass (Da):120,320
Last modified:April 18, 2006 - v1
Checksum:iC110753492BAE3B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662644 Genomic DNA. Translation: EAR99063.1.
RefSeqiXP_001019308.1. XM_001019308.1.
UniGeneiTth.9167.

Genome annotation databases

EnsemblProtistsiEAR99063; EAR99063; TTHERM_00387050.
GeneIDi7825974.
KEGGitet:TTHERM_00387050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662644 Genomic DNA. Translation: EAR99063.1 .
RefSeqi XP_001019308.1. XM_001019308.1.
UniGenei Tth.9167.

3D structure databases

ProteinModelPortali Q23RI5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5911.XP_001019308.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi EAR99063 ; EAR99063 ; TTHERM_00387050 .
GeneIDi 7825974.
KEGGi tet:TTHERM_00387050.

Phylogenomic databases

KOi K10777.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210.

Entry informationi

Entry nameiQ23RI5_TETTS
AccessioniPrimary (citable) accession number: Q23RI5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3