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Q23RI5

- Q23RI5_TETTS

UniProt

Q23RI5 - Q23RI5_TETTS

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Protein

DNA ligase

Gene

TTHERM_00387050

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation Source: RefGenome
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-KW
  5. double-strand break repair via nonhomologous end joining Source: RefGenome
  6. lagging strand elongation Source: RefGenome
  7. nucleotide-excision repair Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:TTHERM_00387050Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: RefGenome
  2. DNA ligase IV complex Source: RefGenome
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5911.XP_001019308.

Structurei

3D structure databases

ProteinModelPortaliQ23RI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiQ23RI5.
KOiK10777.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23RI5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQNYYKWHKI KQEQNQELSV NIKPISSSKM KQSDISTRKK KAQEYNMDFD
60 70 80 90 100
EFQQEDSKIN QNSDNFHFGD SADEYGIDSP KMKREKAVKE EDNTFRLEIK
110 120 130 140 150
KSPILEKTLF SFLVKFYNQV QQSKKGQRKK FVQRFIDSTF KTNRCPSYTF
160 170 180 190 200
TILRLIMPHH DKQRLNYGLN YKNLAKVLSE VFALSEDKRQ QLLNYKRPLK
210 220 230 240 250
DNQQVVGDFG EVVQNVLQAF TQKATLTIND VDRCLDELAQ PQNRDLASKE
260 270 280 290 300
KVLRNCLKNA TSEEIKWISR LILKDLNLGI NHEIILALFH PDAVVLFNST
310 320 330 340 350
SSLWEVCKEF VDPNHKLSNV LRLFHPIKPM LAGRKTLKSI EAILKGKNYL
360 370 380 390 400
VETKFDGERI QCHVSPESLM FFTRNSNNYT NIYERMIEHV RRSLKDAVHS
410 420 430 440 450
CILDGEMVVV NKITGQRVQF GLNKTVAMER EDDELCICYK IFDILYLKTK
460 470 480 490 500
DNKEYALTEY TLQYRKKILE NLIDNQQDRV EVIFGREYSD INDILTEFNE
510 520 530 540 550
AIHRNDEGIV IKQLDTLYYP DDRSDKWIKM KGDYYEGIID TLDLIVIGGY
560 570 580 590 600
FGEKSYKING IGDWTDHITH YLVAVAKKID LQNPSNSILV PFAKVGAGFT
610 620 630 640 650
ARDYADIKAR MRDQWVRTNH SNKTPSFIIQ NWKPGEKDKP DAYILSPQNS
660 670 680 690 700
LILEIRATEI IQSSQYPTNY TLRFPRFEKF RRDKDWFDCM KFNEIIEMTQ
710 720 730 740 750
NLKKKEQKES DKEDNASDEE QDENGGKLKK KRKGQNGEEI EVNRQGRKPN
760 770 780 790 800
WKTNKVMAQY LDIDVSDVKV ESNIFNNFVF NIINLPHEVS LSEEKILLEK
810 820 830 840 850
AQIEKGIVAN GGKKVQNDSN LVTHYIASHY DFKVQVIGDH YKVNVLSLQW
860 870 880 890 900
VKDCIKKKTL LDYSPRYIIY GQDQLLERNK LLYDQYGDSY YKDVDEDELL
910 920 930 940 950
DILKSMKIDQ IEEEFQENEE FEEAVKDIIS MKNQLFKECF PQGQTYCFYN
960 970 980 990 1000
ANDKLNSDID LRYLVDLIQF SGNQVVFDLQ DEIDYIVALD YSEAENEKII
1010 1020
TFREKNRSME VITPKNLLNN FGIALE
Length:1,026
Mass (Da):120,320
Last modified:April 18, 2006 - v1
Checksum:iC110753492BAE3B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662644 Genomic DNA. Translation: EAR99063.1.
RefSeqiXP_001019308.1. XM_001019308.1.
UniGeneiTth.9167.

Genome annotation databases

EnsemblProtistsiEAR99063; EAR99063; TTHERM_00387050.
GeneIDi7825974.
KEGGitet:TTHERM_00387050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662644 Genomic DNA. Translation: EAR99063.1 .
RefSeqi XP_001019308.1. XM_001019308.1.
UniGenei Tth.9167.

3D structure databases

ProteinModelPortali Q23RI5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5911.XP_001019308.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi EAR99063 ; EAR99063 ; TTHERM_00387050 .
GeneIDi 7825974.
KEGGi tet:TTHERM_00387050.

Phylogenomic databases

InParanoidi Q23RI5.
KOi K10777.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
PANTHERi PTHR10459:SF7. PTHR10459:SF7. 1 hit.
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210Imported.

Entry informationi

Entry nameiQ23RI5_TETTS
AccessioniPrimary (citable) accession number: Q23RI5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3