ID   Q23NF3_TETTS            Unreviewed;       507 AA.
AC   Q23NF3;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=Cytochrome P450 family monooxygenase {ECO:0000313|EMBL:EAR98121.2};
GN   ORFNames=TTHERM_00754700 {ECO:0000313|EMBL:EAR98121.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR98121.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR   EMBL; GG662655; EAR98121.2; -; Genomic_DNA.
DR   RefSeq; XP_001018366.2; XM_001018366.3.
DR   AlphaFoldDB; Q23NF3; -.
DR   STRING; 312017.Q23NF3; -.
DR   EnsemblProtists; EAR98121; EAR98121; TTHERM_00754700.
DR   GeneID; 7837526; -.
DR   KEGG; tet:TTHERM_00754700; -.
DR   eggNOG; KOG0157; Eukaryota.
DR   HOGENOM; CLU_001570_5_1_1; -.
DR   InParanoid; Q23NF3; -.
DR   OrthoDB; 3041391at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR24291:SF189; CYTOCHROME P450 4V2; 1.
DR   PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|RuleBase:RU000461};
KW   Monooxygenase {ECO:0000256|RuleBase:RU000461, ECO:0000313|EMBL:EAR98121.2};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   507 AA;  59199 MW;  BA13949F47C91953 CRC64;
     MAFLELIGAS ILAFIIFLVI KYYVLTKMAM RFYANQGIKE YKYYPVTGMA KEWMDYSSSD
     NLKTIKYIKF DDKFKGEDAI LSNLLDRALL IFTNPNLINE FLQNQQNYIK FEAPVVGFKQ
     FLGNGIALEE GEKWKSKRKF ISKLFKFDVV VNYLNSIRKI SKMMLDRVEN DSNFSVQKSF
     EAINSAISVQ IFMGANIDDY KIDGKNPYDA IDTMCFEIFQ HYLNLIPGIL GERFVKLKLR
     KSDRIICEKV QYVRQQMKNI ILDTIKREKS HAEQNKESEN INIIALLIKE GHKLDEEKEI
     IDILELTFSL YFASRDTLAS VLTMMLYYLI KNPDYFKLVE KEVLSLPQNY SFSDIQKLDF
     LQACFKETIR INTSAPILFT REAKVDHKIG NYNIQKGTYV NVGLISNQID ETYFKDPLTF
     NPNRWLDHSA ENIIKENPFV YLPFSGGMRN CIGQHLANLQ AKIVLVEFVK KYQIPQMPND
     FVLEFVIKQN YQIKNPLILN LTKRQAY
//