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Q23K14 (Q23K14_TETTS) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
ORF Names:TTHERM_00196200 EMBL EAR97029.1
OrganismTetrahymena thermophila (strain SB210) [Reference proteome] EMBL EAR97029.1
Taxonomic identifier312017 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding91 – 933NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding325 – 3306NADP By similarity PIRSR PIRSR000108-4
Region110 – 1167Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2681Magnesium or manganese By similarity
Metal binding2911Magnesium or manganese By similarity
Binding site931Substrate By similarity PIRSR PIRSR000108-2
Binding site981NADP By similarity PIRSR PIRSR000108-4
Binding site1251Substrate By similarity PIRSR PIRSR000108-2
Binding site1481Substrate By similarity PIRSR PIRSR000108-2
Binding site2761NADP By similarity PIRSR PIRSR000108-4
Binding site3431NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1551Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2281Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
Q23K14 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: BF378B6922FB9CC4

FASTA42748,673
        10         20         30         40         50         60 
MMNQTIKNAA SKYKYAGNKI NVKNPIVDLD GDEMTRIIWK MIKDKLILPF ISADIRYYDL 

        70         80         90        100        110        120 
SIENRDATND QVTFDAAYAI REHKVGIKCA TITADEARVK EFKLKKMWPS PNGTIRNILD 

       130        140        150        160        170        180 
GTVFREPIVC QNIPRLVPGW TKPIIIGRHS FGDQYKCTNF KVQGPGKLEI SFKPQDGGEE 

       190        200        210        220        230        240 
IRKTVFEFSG KGGVAMGMYN TIESIESFAN SCFKYALNRQ YPLYFSSKNT ILKQYDGLFK 

       250        260        270        280        290        300 
DIFEELYTTK YKQQFEKSGL WYEHRLIDDM VAQVLKGDGG IVWACKNYDG DVQSDIIAQG 

       310        320        330        340        350        360 
YGSLGMMTSE LVNNDNVYEA EAAHGTVTRH YRQHQKGQET STNSVASIYA WSRGLRHRAK 

       370        380        390        400        410        420 
LDNNQDLLTF SQCIEESVLD CISNGKMTKD LAILVYGQDN IKGKYLNTEE FIDAVAYRLK 


SQIHIEK 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG662673 Genomic DNA. Translation: EAR97029.1.
RefSeqXP_001017274.1. XM_001017274.1.
UniGeneTth.28000.

3D structure databases

ProteinModelPortalQ23K14.
SMRQ23K14. Positions 16-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5911.XP_001017274.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsEAR97029; EAR97029; TTHERM_00196200.
GeneID7825818.
KEGGtet:TTHERM_00196200.

Phylogenomic databases

KOK00031.
ProtClustDBPTZ00435.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ23K14_TETTS
AccessionPrimary (citable) accession number: Q23K14
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 13, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)