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Q23K14

- Q23K14_TETTS

UniProt

Q23K14 - Q23K14_TETTS

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Protein
Isocitrate dehydrogenase [NADP]
Gene
TTHERM_00196200
Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931Substrate By similarityUniRule annotation
Binding sitei98 – 981NADP By similarity
Binding sitei125 – 1251Substrate By similarityUniRule annotation
Binding sitei148 – 1481Substrate By similarityUniRule annotation
Sitei155 – 1551Critical for catalysis By similarityUniRule annotation
Sitei228 – 2281Critical for catalysis By similarityUniRule annotation
Metal bindingi268 – 2681Magnesium or manganese By similarityUniRule annotation
Binding sitei276 – 2761NADP By similarity
Metal bindingi291 – 2911Magnesium or manganese By similarityUniRule annotation
Binding sitei343 – 3431NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi91 – 933NADP By similarity
Nucleotide bindingi325 – 3306NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:TTHERM_00196200Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi5911.XP_001017274.

Structurei

3D structure databases

ProteinModelPortaliQ23K14.
SMRiQ23K14. Positions 16-419.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 1167Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23K14-1 [UniParc]FASTAAdd to Basket

« Hide

MMNQTIKNAA SKYKYAGNKI NVKNPIVDLD GDEMTRIIWK MIKDKLILPF    50
ISADIRYYDL SIENRDATND QVTFDAAYAI REHKVGIKCA TITADEARVK 100
EFKLKKMWPS PNGTIRNILD GTVFREPIVC QNIPRLVPGW TKPIIIGRHS 150
FGDQYKCTNF KVQGPGKLEI SFKPQDGGEE IRKTVFEFSG KGGVAMGMYN 200
TIESIESFAN SCFKYALNRQ YPLYFSSKNT ILKQYDGLFK DIFEELYTTK 250
YKQQFEKSGL WYEHRLIDDM VAQVLKGDGG IVWACKNYDG DVQSDIIAQG 300
YGSLGMMTSE LVNNDNVYEA EAAHGTVTRH YRQHQKGQET STNSVASIYA 350
WSRGLRHRAK LDNNQDLLTF SQCIEESVLD CISNGKMTKD LAILVYGQDN 400
IKGKYLNTEE FIDAVAYRLK SQIHIEK 427
Length:427
Mass (Da):48,673
Last modified:April 18, 2006 - v1
Checksum:iBF378B6922FB9CC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662673 Genomic DNA. Translation: EAR97029.1.
RefSeqiXP_001017274.1. XM_001017274.1.
UniGeneiTth.28000.

Genome annotation databases

EnsemblProtistsiEAR97029; EAR97029; TTHERM_00196200.
GeneIDi7825818.
KEGGitet:TTHERM_00196200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662673 Genomic DNA. Translation: EAR97029.1 .
RefSeqi XP_001017274.1. XM_001017274.1.
UniGenei Tth.28000.

3D structure databases

ProteinModelPortali Q23K14.
SMRi Q23K14. Positions 16-419.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5911.XP_001017274.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi EAR97029 ; EAR97029 ; TTHERM_00196200 .
GeneIDi 7825818.
KEGGi tet:TTHERM_00196200.

Phylogenomic databases

KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210.

Entry informationi

Entry nameiQ23K14_TETTS
AccessioniPrimary (citable) accession number: Q23K14
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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