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Q23K14

- Q23K14_TETTS

UniProt

Q23K14 - Q23K14_TETTS

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Protein

Isocitrate dehydrogenase [NADP]

Gene

TTHERM_00196200

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931SubstrateUniRule annotation
Binding sitei98 – 981NADPUniRule annotation
Binding sitei125 – 1251SubstrateUniRule annotation
Binding sitei148 – 1481SubstrateUniRule annotation
Sitei155 – 1551Critical for catalysisUniRule annotation
Sitei228 – 2281Critical for catalysisUniRule annotation
Metal bindingi268 – 2681Magnesium or manganese
Binding sitei276 – 2761NADPUniRule annotation
Metal bindingi291 – 2911Magnesium or manganese
Binding sitei343 – 3431NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi91 – 933NADPUniRule annotation
Nucleotide bindingi325 – 3306NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:TTHERM_00196200Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi5911.XP_001017274.

Structurei

3D structure databases

ProteinModelPortaliQ23K14.
SMRiQ23K14. Positions 16-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 1167Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

InParanoidiQ23K14.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23K14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMNQTIKNAA SKYKYAGNKI NVKNPIVDLD GDEMTRIIWK MIKDKLILPF
60 70 80 90 100
ISADIRYYDL SIENRDATND QVTFDAAYAI REHKVGIKCA TITADEARVK
110 120 130 140 150
EFKLKKMWPS PNGTIRNILD GTVFREPIVC QNIPRLVPGW TKPIIIGRHS
160 170 180 190 200
FGDQYKCTNF KVQGPGKLEI SFKPQDGGEE IRKTVFEFSG KGGVAMGMYN
210 220 230 240 250
TIESIESFAN SCFKYALNRQ YPLYFSSKNT ILKQYDGLFK DIFEELYTTK
260 270 280 290 300
YKQQFEKSGL WYEHRLIDDM VAQVLKGDGG IVWACKNYDG DVQSDIIAQG
310 320 330 340 350
YGSLGMMTSE LVNNDNVYEA EAAHGTVTRH YRQHQKGQET STNSVASIYA
360 370 380 390 400
WSRGLRHRAK LDNNQDLLTF SQCIEESVLD CISNGKMTKD LAILVYGQDN
410 420
IKGKYLNTEE FIDAVAYRLK SQIHIEK
Length:427
Mass (Da):48,673
Last modified:April 18, 2006 - v1
Checksum:iBF378B6922FB9CC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662673 Genomic DNA. Translation: EAR97029.1.
RefSeqiXP_001017274.1. XM_001017274.1.
UniGeneiTth.28000.

Genome annotation databases

EnsemblProtistsiEAR97029; EAR97029; TTHERM_00196200.
GeneIDi7825818.
KEGGitet:TTHERM_00196200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662673 Genomic DNA. Translation: EAR97029.1 .
RefSeqi XP_001017274.1. XM_001017274.1.
UniGenei Tth.28000.

3D structure databases

ProteinModelPortali Q23K14.
SMRi Q23K14. Positions 16-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5911.XP_001017274.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi EAR97029 ; EAR97029 ; TTHERM_00196200 .
GeneIDi 7825818.
KEGGi tet:TTHERM_00196200.

Phylogenomic databases

InParanoidi Q23K14.
KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210Imported.

Entry informationi

Entry nameiQ23K14_TETTS
AccessioniPrimary (citable) accession number: Q23K14
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3