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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

TTHERM_00047080

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (TTHERM_00047080)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, UbiquinoneImported

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:TTHERM_00047080Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ23DI3.
SMRiQ23DI3. Positions 41-636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

InParanoidiQ23DI3.
KOiK00234.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23DI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKYLSKIQR VTLHSKVSKN FAVLSKDHPE KGPSQGHLTD KYTVIDHTYD
60 70 80 90 100
AIVVGAGGAG LRAAFGLVEE GFKTACITKL FPTRSHTVAA QGGINAALGN
110 120 130 140 150
MTEDDWKWHF YDTVKGSDWL GDQDAIQYMT REAPAAVLEL ESYGLPFSRT
160 170 180 190 200
PEGKIYQRAF GGQSLKFGKG GQARRTACAA DRTGHAMLHT LFGRSLAYNC
210 220 230 240 250
NFFIEYFVID LIMDEEGACR GVICMSMADG SIHRIRAHYT VLAAGGYGRS
260 270 280 290 300
YLSCTAAHTC TGDGMALATR AGLPLEDPEF VQFHPTGIYG SGCLMTEGCR
310 320 330 340 350
GEGGILVNSN GEAFMEKYAP TAKDLASRDV VSRAMTIEIL EGRGVGPKKD
360 370 380 390 400
HIFLQLHHLS PETLHQRLPG ISETARIFAG VDVTKEPAPV VPTVHYNMGG
410 420 430 440 450
VPTNWKTEVI TQDKNGKDKI VPGLLAAGEN ACASVHGANR LGANSLLDIV
460 470 480 490 500
VFGRAAAKLV KEKLKPGTPH KDLPKNAGEQ ALARLDKYRF ANGEYTTHHV
510 520 530 540 550
RTAMQETMQR HAAVFRIEKL MAEGVQKLDH IYEQSKSLKT FDRGLVWNTD
560 570 580 590 600
LIETLELENL LLCSKQTLLA GLLRKESRGA HARDDFKERD DKNWMKHSLT
610 620 630
WIKDVNTGKT EVTYRDVINH TLDSEVTPVP PAKRSY
Length:636
Mass (Da):69,980
Last modified:May 29, 2007 - v2
Checksum:i6FAA059568A0A8D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662712 Genomic DNA. Translation: EAR94519.2.
RefSeqiXP_001014703.2. XM_001014703.2.
UniGeneiTth.2689.

Genome annotation databases

EnsemblProtistsiEAR94519; EAR94519; TTHERM_00047080.
GeneIDi7844993.
KEGGitet:TTHERM_00047080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662712 Genomic DNA. Translation: EAR94519.2.
RefSeqiXP_001014703.2. XM_001014703.2.
UniGeneiTth.2689.

3D structure databases

ProteinModelPortaliQ23DI3.
SMRiQ23DI3. Positions 41-636.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAR94519; EAR94519; TTHERM_00047080.
GeneIDi7844993.
KEGGitet:TTHERM_00047080.

Phylogenomic databases

InParanoidiQ23DI3.
KOiK00234.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210Imported.

Entry informationi

Entry nameiQ23DI3_TETTS
AccessioniPrimary (citable) accession number: Q23DI3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: May 29, 2007
Last modified: July 22, 2015
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.