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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

TTHERM_00047080

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (TTHERM_00047080)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein, UbiquinoneImported

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:TTHERM_00047080Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
Proteomesi
  • UP000009168 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5911.EAR94519

Structurei

3D structure databases

ProteinModelPortaliQ23DI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 446FAD_binding_2InterPro annotationAdd BLAST397
Domaini501 – 636Succ_DH_flav_CInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

InParanoidiQ23DI3
KOiK00234
OMAiGDSPWEH

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q23DI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKYLSKIQR VTLHSKVSKN FAVLSKDHPE KGPSQGHLTD KYTVIDHTYD
60 70 80 90 100
AIVVGAGGAG LRAAFGLVEE GFKTACITKL FPTRSHTVAA QGGINAALGN
110 120 130 140 150
MTEDDWKWHF YDTVKGSDWL GDQDAIQYMT REAPAAVLEL ESYGLPFSRT
160 170 180 190 200
PEGKIYQRAF GGQSLKFGKG GQARRTACAA DRTGHAMLHT LFGRSLAYNC
210 220 230 240 250
NFFIEYFVID LIMDEEGACR GVICMSMADG SIHRIRAHYT VLAAGGYGRS
260 270 280 290 300
YLSCTAAHTC TGDGMALATR AGLPLEDPEF VQFHPTGIYG SGCLMTEGCR
310 320 330 340 350
GEGGILVNSN GEAFMEKYAP TAKDLASRDV VSRAMTIEIL EGRGVGPKKD
360 370 380 390 400
HIFLQLHHLS PETLHQRLPG ISETARIFAG VDVTKEPAPV VPTVHYNMGG
410 420 430 440 450
VPTNWKTEVI TQDKNGKDKI VPGLLAAGEN ACASVHGANR LGANSLLDIV
460 470 480 490 500
VFGRAAAKLV KEKLKPGTPH KDLPKNAGEQ ALARLDKYRF ANGEYTTHHV
510 520 530 540 550
RTAMQETMQR HAAVFRIEKL MAEGVQKLDH IYEQSKSLKT FDRGLVWNTD
560 570 580 590 600
LIETLELENL LLCSKQTLLA GLLRKESRGA HARDDFKERD DKNWMKHSLT
610 620 630
WIKDVNTGKT EVTYRDVINH TLDSEVTPVP PAKRSY
Length:636
Mass (Da):69,980
Last modified:May 29, 2007 - v2
Checksum:i6FAA059568A0A8D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662712 Genomic DNA Translation: EAR94519.2
RefSeqiXP_001014703.2, XM_001014703.3

Genome annotation databases

EnsemblProtistsiEAR94519; EAR94519; TTHERM_00047080
GeneIDi7844993
KEGGitet:TTHERM_00047080

Similar proteinsi

Entry informationi

Entry nameiQ23DI3_TETTS
AccessioniPrimary (citable) accession number: Q23DI3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health