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Protein

Proline iminopeptidase

Gene

TTHERM_00049020

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Release of N-terminal proline from a peptide.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191NucleophileUniRule annotation
Active sitei276 – 2761UniRule annotation
Active sitei304 – 3041Proton donorUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

AminopeptidaseUniRule annotation, Hydrolase, Protease

Protein family/group databases

MEROPSiS33.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline iminopeptidaseUniRule annotation (EC:3.4.11.5UniRule annotation)
Gene namesi
ORF Names:TTHERM_00049020Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5911.XP_001014797.

Structurei

3D structure databases

ProteinModelPortaliQ23D89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.UniRule annotation

Phylogenomic databases

InParanoidiQ23D89.
KOiK01259.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR002410. Peptidase_S33.
IPR005944. Pro_iminopeptidase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006431. Pept_S33. 1 hit.
PRINTSiPR00793. PROAMNOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01249. pro_imino_pep_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q23D89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQESENYRK TPFEIKEPFK SGFLKVSEIH TIYWEVSGNP EGKPAIIIHG
60 70 80 90 100
GPGSQSNPNN RGFFNPEIYM IVQFDQRGCG KSTPFAVTEE NTTQDLIKDI
110 120 130 140 150
ETIRDLLKLE VWHTVFGGSW GSTLAIYYAE TYPQKVKHLI LRGIFTGGQK
160 170 180 190 200
EMDFFYQNGT NWIFPDYYES FCNALPEVKR NNLLHNYHQL FNSDVNEETK
210 220 230 240 250
KQLAIEWTKY ESAISYFKVP DNFQKEIEED QSVLSIAKLE SHYFANGCFF
260 270 280 290 300
EKENQLIQDA HLISHIPTII VNGRYDIVTP LKVAWDLHKQ IKNSQLVIVP
310 320
DAGHLASEPG IKEQLIIATQ KFEKN
Length:325
Mass (Da):37,463
Last modified:April 18, 2006 - v1
Checksum:i7BCF5282DFAFBE6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662712 Genomic DNA. Translation: EAR94511.1.
RefSeqiXP_001014797.1. XM_001014797.1.

Genome annotation databases

EnsemblProtistsiEAR94511; EAR94511; TTHERM_00049020.
GeneIDi7839774.
KEGGitet:TTHERM_00049020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662712 Genomic DNA. Translation: EAR94511.1.
RefSeqiXP_001014797.1. XM_001014797.1.

3D structure databases

ProteinModelPortaliQ23D89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5911.XP_001014797.

Protein family/group databases

MEROPSiS33.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAR94511; EAR94511; TTHERM_00049020.
GeneIDi7839774.
KEGGitet:TTHERM_00049020.

Phylogenomic databases

InParanoidiQ23D89.
KOiK01259.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR002410. Peptidase_S33.
IPR005944. Pro_iminopeptidase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006431. Pept_S33. 1 hit.
PRINTSiPR00793. PROAMNOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01249. pro_imino_pep_1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210Imported.

Entry informationi

Entry nameiQ23D89_TETTS
AccessioniPrimary (citable) accession number: Q23D89
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: March 4, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.