Q23D89 (Q23D89_TETTS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Proline iminopeptidase RuleBase RU003421
EC=3.4.11.5 RuleBase RU003421

Gene names

ORF Names:

TTHERM_00049020 EMBL EAR94511.1

Organism

Tetrahymena thermophila (strain SB210) [Reference proteome]

Taxonomic identifier

312017 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Hymenostomatida › Tetrahymenina › Tetrahymenidae › Tetrahymena › Tetrahymena thermophila

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Release of N-terminal proline from a peptide. RuleBase RU003421
Sequence similarities	Belongs to the peptidase S33 family. RuleBase RU003421

Ontologies

Keywords
Molecular function	Aminopeptidase RuleBase RU003421 EMBL EAR94511.1 Hydrolase Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	119	1	Nucleophile By similarity PIRSR PIRSR006431-1
	Active site	276	1	By similarity PIRSR PIRSR006431-1
	Active site	304	1	Proton donor By similarity PIRSR PIRSR006431-1

Sequences

	Sequence		Length	Mass (Da)
	Q23D89 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 7BCF5282DFAFBE6B	FASTA	325	37,463
	10 20 30 40 50 60 MNQESENYRK TPFEIKEPFK SGFLKVSEIH TIYWEVSGNP EGKPAIIIHG GPGSQSNPNN 70 80 90 100 110 120 RGFFNPEIYM IVQFDQRGCG KSTPFAVTEE NTTQDLIKDI ETIRDLLKLE VWHTVFGGSW 130 140 150 160 170 180 GSTLAIYYAE TYPQKVKHLI LRGIFTGGQK EMDFFYQNGT NWIFPDYYES FCNALPEVKR 190 200 210 220 230 240 NNLLHNYHQL FNSDVNEETK KQLAIEWTKY ESAISYFKVP DNFQKEIEED QSVLSIAKLE 250 260 270 280 290 300 SHYFANGCFF EKENQLIQDA HLISHIPTII VNGRYDIVTP LKVAWDLHKQ IKNSQLVIVP 310 320 DAGHLASEPG IKEQLIIATQ KFEKN

References

[1]

"Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote." Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M. , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E. PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB210.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG662712 Genomic DNA. Translation: EAR94511.1.
RefSeq	XP_001014797.1. XM_001014797.1.
3D structure databases
ProteinModelPortal	Q23D89.
ModBase	Search...
Protein-protein interaction databases
STRING	5911.XP_001014797.
Protein family/group databases
MEROPS	S33.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	EAR94511; EAR94511; TTHERM_00049020.
GeneID	7839774.
KEGG	tet:TTHERM_00049020.
Phylogenomic databases
KO	K01259.
ProtClustDB	CLSZ2497154.
Family and domain databases
InterPro	IPR000073. AB_hydrolase_1. IPR002410. Peptidase_S33. IPR005944. Pro_iminopeptidase. [Graphical view]
PANTHER	PTHR10992:SF12. PTHR10992:SF12. 1 hit.
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PIRSF	PIRSF006431. Pept_S33. 1 hit.
PRINTS	PR00793. PROAMNOPTASE.
TIGRFAMs	TIGR01249. pro_imino_pep_1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q23D89_TETTS

Accession

Primary (citable) accession number: Q23D89

Entry history

Integrated into UniProtKB/TrEMBL:	April 18, 2006
Last sequence update:	April 18, 2006
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)