UniProtKB - Q23995 (Q23995_DROME)
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Protein
Metalloendopeptidase
Gene
tok
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Cofactori
Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 614 | Zinc; catalyticUniRule annotation | 1 | |
Active sitei | 615 | UniRule annotation | 1 | |
Metal bindingi | 618 | Zinc; catalyticUniRule annotation | 1 | |
Metal bindingi | 624 | Zinc; catalyticUniRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- metalloendopeptidase activity Source: UniProtKB-UniRule
- zinc ion binding Source: InterPro
GO - Biological processi
- axon guidance Source: FlyBase
- defasciculation of motor neuron axon Source: FlyBase
- imaginal disc-derived wing vein morphogenesis Source: FlyBase
- motor neuron axon guidance Source: FlyBase
- negative regulation of gene expression Source: FlyBase
- protein processing Source: FlyBase
Keywordsi
Molecular function | Hydrolase, MetalloproteaseUniRule annotation, Protease |
Ligand | Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation |
Enzyme and pathway databases
Reactomei | R-DME-1474228. Degradation of the extracellular matrix. R-DME-2243919. Crosslinking of collagen fibrils. |
Protein family/group databases
MEROPSi | M12.011. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:tokImported ORF Names:CG6863Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Organism-specific databases
FlyBasei | FBgn0004885. tok. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | UniRule annotationAdd BLAST | 33 | |
ChainiPRO_5005142869 | 34 – 1464 | MetalloendopeptidaseUniRule annotationAdd BLAST | 1431 |
Keywords - PTMi
Disulfide bondSAAS annotationProteomic databases
PRIDEi | Q23995. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 723 – 839 | CUBInterPro annotationAdd BLAST | 117 | |
Domaini | 840 – 954 | CUBInterPro annotationAdd BLAST | 115 | |
Domaini | 954 – 994 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 997 – 1114 | CUBInterPro annotationAdd BLAST | 118 | |
Domaini | 1114 – 1154 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 1158 – 1270 | CUBInterPro annotationAdd BLAST | 113 | |
Domaini | 1271 – 1391 | CUBInterPro annotationAdd BLAST | 121 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 407 – 427 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotationPhylogenomic databases
eggNOGi | KOG3714. Eukaryota. ENOG410ZPX7. LUCA. |
OrthoDBi | EOG091G009U. |
Family and domain databases
CDDi | cd00041. CUB. 5 hits. cd04281. ZnMc_BMP1_TLD. 1 hit. |
Gene3Di | 2.60.120.290. 5 hits. 3.40.390.10. 1 hit. |
InterProi | View protein in InterPro IPR015446. BMP_1/tolloid-like. IPR000859. CUB_dom. IPR001881. EGF-like_Ca-bd_dom. IPR013032. EGF-like_CS. IPR000742. EGF-like_dom. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR024079. MetalloPept_cat_dom_sf. IPR001506. Peptidase_M12A. IPR006026. Peptidase_Metallo. IPR035914. Sperma_CUB_dom_sf. IPR034036. ZnMP_TLD/BMP1. |
Pfami | View protein in Pfam PF01400. Astacin. 1 hit. PF00431. CUB. 5 hits. |
PIRSFi | PIRSF001199. BMP_1/tolloid-like. 2 hits. |
PRINTSi | PR00480. ASTACIN. |
SMARTi | View protein in SMART SM00042. CUB. 5 hits. SM00181. EGF. 2 hits. SM00179. EGF_CA. 2 hits. SM00235. ZnMc. 1 hit. |
SUPFAMi | SSF49854. SSF49854. 5 hits. |
PROSITEi | View protein in PROSITE PS00010. ASX_HYDROXYL. 2 hits. PS01180. CUB. 5 hits. PS01186. EGF_2. 2 hits. PS50026. EGF_3. 2 hits. PS01187. EGF_CA. 2 hits. |
i Sequence
Sequence statusi: Complete.
Q23995-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRRRGTPLG VSWTNCVLLL ATGLLVVLIS VHAKNPRPHR GLPAPAPAPV
60 70 80 90 100
PASVDQVATE NAHRREPTVD GSVLQRLSGS DRAVDEDEDV DEDEDEGLKH
110 120 130 140 150
QHLEHRQQFD AYLGTIRRLR RPYRSKYTIE QLMRLHVTPK VSGDIDMDPC
160 170 180 190 200
KAGGFMGDIA LPEGDSGPVV AHTPIDDEEQ ERQEVEQLLA DSPSPVHDPA
210 220 230 240 250
SVSGAANSGP TKFNATFQLD LEKLKQEVYH EGLQVEEEGL TDIIRKKTKL
260 270 280 290 300
PSSGPVNLKA GQSQSQSQSA NEPVKPGSES PSDYAQASSY KNDVLPPSEQ
310 320 330 340 350
RIHTDKPARL TLAEIGPKSS NKTQSLHRNV DTRKIQSDNK DIEDDSGNNF
360 370 380 390 400
VAERRPSQIV PTSLPEQRST PAHVYSNAGG NGMQLDDEVD FLHSRGVVRR
410 420 430 440 450
RHRRGPKQRR SNQHLEHEAK LQRLREELSR PVIEGHHRQS HHQKQAQHRQ
460 470 480 490 500
HHQSHHRKKQ HRQQQHHRRR GQSTTQYVNH SPPGFNQSQQ AQQQSVPEMD
510 520 530 540 550
LLKAETSKDE EPLRHRVARA VTAKKERIWD YGVIPYEIDG NFSGIHKALF
560 570 580 590 600
KLAMRHWENS TCIKFVERDP EIHPNYIVFT VRSCGCCSFV GKRGNGPQAI
610 620 630 640 650
SIGRNCDKFG IVVHELGHVV GFWHEHTRPD REKHVVIEHN NIMKGQDYNF
660 670 680 690 700
NMLSPDEVDS LGMAYDYDSI MHYARNTFSK GTYLDTILPI EMKGRKRPEI
710 720 730 740 750
GQRLRLSQGD IAQANLLYKC PKCGRTFQES SGIFASPSHY TAGALSNETE
760 770 780 790 800
HCEWRITATY GERVELKLEN MNIFKSNNCE TDYLEIRDGY FEKSPLIGRF
810 820 830 840 850
CGKVDKEVIR TESSRMLLTY VNTHRIEGFR GFKAEFDVVC GGELSVDDAV
860 870 880 890 900
GRLESPNYPL DYLPNKECVW KITVPESYQV ALKFQSFEVE NHDSCVYDYV
910 920 930 940 950
EVRDGPGQDA PLIGVFCGYK PPPNMKSSGN SMYVKFVSDT SVQKAGFSAV
960 970 980 990 1000
FMKEVDECET QNHGCEHECI NTLGGYECSC RIGFELHSDK KHCEDACGGV
1010 1020 1030 1040 1050
IEYPNGTITS PSFPEMYPLL KECIWEIVAP PKHRISLNFT HFDLEGTAHQ
1060 1070 1080 1090 1100
QSDCGYDSVT VYSKLGENRL KRIGTFCGSS IPPTATSESN ALRLEFHSDK
1110 1120 1130 1140 1150
SIQRSGFAAV FFTDIDECAV NNGGCQHECR NTIGSYICMC HNGYSMHENG
1160 1170 1180 1190 1200
HDCKEGECKY EISAPFGTIF SPNYPDSYPP NADCVWHFIT TPGHRIKLIF
1210 1220 1230 1240 1250
NEFDVESHQE CTYDNVAVYD GESESSSVLG RFCGDKIPFP ISSTSNQMYM
1260 1270 1280 1290 1300
VLKTDKNKQK NGFTASHSTA CGGYLRATSQ VQQFYSHARF GNQDYDDGMD
1310 1320 1330 1340 1350
CEWTIAAPDN SYVQLIFLTF DIESSENCTF DYVQVFSDID DVYGQYGPMY
1360 1370 1380 1390 1400
GQYCGNVLPQ DINSMTHSLL VRFKTDGSVP MKGFSASYVA VPNSGEYDHS
1410 1420 1430 1440 1450
DEDVENSYSS EMVTPFPGSL KSIYIEDTQE ETDEYSDFSG NQLVFNGQYR
1460
GRYSLPNRYY SGKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12634 mRNA. Translation: AAA70057.1. |
Similar proteinsi
Entry informationi
Entry namei | Q23995_DROME | |
Accessioni | Q23995Primary (citable) accession number: Q23995 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1996 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 28, 2018 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |
Miscellaneousi
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation