Metalloendopeptidase

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium ion binding Source: InterPro
• metalloendopeptidase activity Source: UniProtKB-UniRule
• zinc ion binding Source: InterPro

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• axon guidance Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 17119021
• defasciculation of motor neuron axon Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 16971470
• imaginal disc-derived wing vein morphogenesis Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 15872004
• motor neuron axon guidance Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 16971470
• negative regulation of gene expression Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 16780828
• protein processing Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 17119021

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MRRRRGTPLG VSWTNCVLLL ATGLLVVLIS VHAKNPRPHR GLPAPAPAPV 
        60         70         80         90        100
PASVDQVATE NAHRREPTVD GSVLQRLSGS DRAVDEDEDV DEDEDEGLKH 
       110        120        130        140        150
QHLEHRQQFD AYLGTIRRLR RPYRSKYTIE QLMRLHVTPK VSGDIDMDPC 
       160        170        180        190        200
KAGGFMGDIA LPEGDSGPVV AHTPIDDEEQ ERQEVEQLLA DSPSPVHDPA 
       210        220        230        240        250
SVSGAANSGP TKFNATFQLD LEKLKQEVYH EGLQVEEEGL TDIIRKKTKL 
       260        270        280        290        300
PSSGPVNLKA GQSQSQSQSA NEPVKPGSES PSDYAQASSY KNDVLPPSEQ 
       310        320        330        340        350
RIHTDKPARL TLAEIGPKSS NKTQSLHRNV DTRKIQSDNK DIEDDSGNNF 
       360        370        380        390        400
VAERRPSQIV PTSLPEQRST PAHVYSNAGG NGMQLDDEVD FLHSRGVVRR 
       410        420        430        440        450
RHRRGPKQRR SNQHLEHEAK LQRLREELSR PVIEGHHRQS HHQKQAQHRQ 
       460        470        480        490        500
HHQSHHRKKQ HRQQQHHRRR GQSTTQYVNH SPPGFNQSQQ AQQQSVPEMD 
       510        520        530        540        550
LLKAETSKDE EPLRHRVARA VTAKKERIWD YGVIPYEIDG NFSGIHKALF 
       560        570        580        590        600
KLAMRHWENS TCIKFVERDP EIHPNYIVFT VRSCGCCSFV GKRGNGPQAI 
       610        620        630        640        650
SIGRNCDKFG IVVHELGHVV GFWHEHTRPD REKHVVIEHN NIMKGQDYNF 
       660        670        680        690        700
NMLSPDEVDS LGMAYDYDSI MHYARNTFSK GTYLDTILPI EMKGRKRPEI 
       710        720        730        740        750
GQRLRLSQGD IAQANLLYKC PKCGRTFQES SGIFASPSHY TAGALSNETE 
       760        770        780        790        800
HCEWRITATY GERVELKLEN MNIFKSNNCE TDYLEIRDGY FEKSPLIGRF 
       810        820        830        840        850
CGKVDKEVIR TESSRMLLTY VNTHRIEGFR GFKAEFDVVC GGELSVDDAV 
       860        870        880        890        900
GRLESPNYPL DYLPNKECVW KITVPESYQV ALKFQSFEVE NHDSCVYDYV 
       910        920        930        940        950
EVRDGPGQDA PLIGVFCGYK PPPNMKSSGN SMYVKFVSDT SVQKAGFSAV 
       960        970        980        990       1000
FMKEVDECET QNHGCEHECI NTLGGYECSC RIGFELHSDK KHCEDACGGV 
      1010       1020       1030       1040       1050
IEYPNGTITS PSFPEMYPLL KECIWEIVAP PKHRISLNFT HFDLEGTAHQ 
      1060       1070       1080       1090       1100
QSDCGYDSVT VYSKLGENRL KRIGTFCGSS IPPTATSESN ALRLEFHSDK 
      1110       1120       1130       1140       1150
SIQRSGFAAV FFTDIDECAV NNGGCQHECR NTIGSYICMC HNGYSMHENG 
      1160       1170       1180       1190       1200
HDCKEGECKY EISAPFGTIF SPNYPDSYPP NADCVWHFIT TPGHRIKLIF 
      1210       1220       1230       1240       1250
NEFDVESHQE CTYDNVAVYD GESESSSVLG RFCGDKIPFP ISSTSNQMYM 
      1260       1270       1280       1290       1300
VLKTDKNKQK NGFTASHSTA CGGYLRATSQ VQQFYSHARF GNQDYDDGMD 
      1310       1320       1330       1340       1350
CEWTIAAPDN SYVQLIFLTF DIESSENCTF DYVQVFSDID DVYGQYGPMY 
      1360       1370       1380       1390       1400
GQYCGNVLPQ DINSMTHSLL VRFKTDGSVP MKGFSASYVA VPNSGEYDHS 
      1410       1420       1430       1440       1450
DEDVENSYSS EMVTPFPGSL KSIYIEDTQE ETDEYSDFSG NQLVFNGQYR 
      1460 
GRYSLPNRYY SGKA                                        

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Caution