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Protein

Myosin-IA

Gene

Myo31DF

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in directing the movement of organelles along actin filaments.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1078ATPBy similarity

GO - Molecular functioni

  • actin binding Source: FlyBase
  • ATPase activity, coupled Source: FlyBase
  • ATP binding Source: UniProtKB-KW
  • motor activity Source: FlyBase

GO - Biological processi

  • determination of digestive tract left/right asymmetry Source: FlyBase
  • determination of left/right symmetry Source: FlyBase
  • imaginal disc-derived male genitalia morphogenesis Source: FlyBase
  • mesoderm development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-IA
Short name:
MIA
Alternative name(s):
Brush border myosin IA
Short name:
BBMIA
Gene namesi
Name:Myo31DF
ORF Names:CG7438
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0086347. Myo31DF.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Protein shifts from the basolateral to apical domain in enterocytes and follicle cells.

GO - Cellular componenti

  • cell cortex Source: FlyBase
  • cytoplasm Source: FlyBase
  • myosin complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10111011Myosin-IAPRO_0000123454Add
BLAST

Proteomic databases

PaxDbiQ23978.
PRIDEiQ23978.

Expressioni

Tissue specificityi

In the embryo, expressed in gastric caeca, midgut cells of the proventriculus, and in the mid and hindgut. In the larval gut brush border, expression is in the terminal web domain. In the adult gut brush border, expression remains in the web domain and has also moved into the microvilli. Also expressed at low levels in follicle cells during oogenesis.1 Publication

Developmental stagei

Expressed both maternally and zygotically throughout development to adulthood with highest levels at the end of larval development. Expression in embryogenesis is correlated with the formation of a brush border within the alimentary canal.2 Publications

Gene expression databases

BgeeiFBgn0086347.
ExpressionAtlasiQ23978. differential.
GenevisibleiQ23978. DM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ23978. 7 interactions.
STRINGi7227.FBpp0079625.

Structurei

3D structure databases

ProteinModelPortaliQ23978.
SMRiQ23978. Positions 8-774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 690684Myosin motorAdd
BLAST
Domaini695 – 72127IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini716 – 73621IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini806 – 1007202TH1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni567 – 58923Actin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
InParanoidiQ23978.
KOiK10356.
OMAiNRWRASQ.
OrthoDBiEOG091G0136.
PhylomeDBiQ23978.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMQREAGVQ DFVLLDQVSM EKFMDNLRKR FQNGSIYTYI GEVCVSMNPY
60 70 80 90 100
RQMNIYGPET IRKYKGRELF ENAPHLFAIA DSAYRVLKQR QQDTCILISG
110 120 130 140 150
ESGAGKTEAS KIIMKYIAAV TNAQGQNEIE RVKNVLIQSN AILETFGNAK
160 170 180 190 200
TNRNDNSSRF GKYMDIEFDY KADPVGGIIT NYLLEKSRVV QQQPGERNFH
210 220 230 240 250
SFYQLLRGAN DNELRQYELQ KETGKYHYLN QGSMDILTEK SDYKGTCNAF
260 270 280 290 300
KTLGFSTDEV QTIWRTIAAV LHLGNVEFQT IEDELVISNK QHLKSTAKLL
310 320 330 340 350
QVTETELSTA LTKRVIAAGG NVMQKDHNAT QAEYGKDALA KAIYDRLFTW
360 370 380 390 400
IISRINRAIL FRGSKTQARF NSVIGVLDIY GFEIFDSNSF EQFCINYCNE
410 420 430 440 450
KLQQLFIELV LKQEQEEYQR EGIEWTNIEY FNNKIICDLV EQPHKGIIAI
460 470 480 490 500
MDEACLSVGK VTDDTLLGAM DKNLSKHPHY TSRQLKPTDK ELKHREDFRI
510 520 530 540 550
THYAGDVIYN INGFIEKNKD TLYQDFKRLL HNSKDANLSE MWPEGAQDIK
560 570 580 590 600
KTTKRPLTAG TLFQRSMADL VVTLLKKEPF YVRCIKPNDL KSSTVFDEER
610 620 630 640 650
VEHQVRYLGL LENLRVRRAG FVHRQRYDKF LLRYKMISQY TWPNFRAGSD
660 670 680 690 700
RDGVRVLIEE KKFAQDVKYG HTKIFIRSPR TLFALEHQRN EMIPHIVTLL
710 720 730 740 750
QKRVRGWIVR RNFKKMKAAI TIVRAYKAYK LRSYVQELAN RLRKAKQMRD
760 770 780 790 800
YGKSIQWPQP PLAGRKVEAK LHRMFDFWRA NMILHKYPRS EWPQLRLQII
810 820 830 840 850
AATALAGRRP YWGQARRWVG DYLANSQENS GYEAYNGSIK NIRNHPADGE
860 870 880 890 900
TFQQVLFSSF VKKFNHFNKQ ANRAFIVSDS TIHKLDGIKN KFKDMKRTIK
910 920 930 940 950
IRELTSISVS PGRDQLIVFH SSKNKDLVFS LESEYTPLKE DRIGEVVGIV
960 970 980 990 1000
CKKYHDLTGT ELRVNVTTNI SCRLDGKARI ITVEAASNVE VPNFRPKEGN
1010
IIFEVPAAYC V
Length:1,011
Mass (Da):117,095
Last modified:November 1, 1996 - v1
Checksum:i31206C065B5D5DFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07595 mRNA. Translation: AAA19590.1.
AE014134 Genomic DNA. Translation: AAF52966.1.
AE014134 Genomic DNA. Translation: AAN10756.1.
AY075567 mRNA. Translation: AAL68374.1.
PIRiS45573.
RefSeqiNP_001188784.1. NM_001201855.2.
NP_523538.1. NM_078814.4.
NP_723596.1. NM_164933.3.
UniGeneiDm.5426.

Genome annotation databases

EnsemblMetazoaiFBtr0080035; FBpp0079625; FBgn0086347.
FBtr0080036; FBpp0079626; FBgn0086347.
FBtr0304138; FBpp0293078; FBgn0086347.
GeneIDi34445.
KEGGidme:Dmel_CG7438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07595 mRNA. Translation: AAA19590.1.
AE014134 Genomic DNA. Translation: AAF52966.1.
AE014134 Genomic DNA. Translation: AAN10756.1.
AY075567 mRNA. Translation: AAL68374.1.
PIRiS45573.
RefSeqiNP_001188784.1. NM_001201855.2.
NP_523538.1. NM_078814.4.
NP_723596.1. NM_164933.3.
UniGeneiDm.5426.

3D structure databases

ProteinModelPortaliQ23978.
SMRiQ23978. Positions 8-774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ23978. 7 interactions.
STRINGi7227.FBpp0079625.

Proteomic databases

PaxDbiQ23978.
PRIDEiQ23978.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080035; FBpp0079625; FBgn0086347.
FBtr0080036; FBpp0079626; FBgn0086347.
FBtr0304138; FBpp0293078; FBgn0086347.
GeneIDi34445.
KEGGidme:Dmel_CG7438.

Organism-specific databases

CTDi34445.
FlyBaseiFBgn0086347. Myo31DF.

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
InParanoidiQ23978.
KOiK10356.
OMAiNRWRASQ.
OrthoDBiEOG091G0136.
PhylomeDBiQ23978.

Miscellaneous databases

ChiTaRSiMyo31DF. fly.
GenomeRNAii34445.
PROiQ23978.

Gene expression databases

BgeeiFBgn0086347.
ExpressionAtlasiQ23978. differential.
GenevisibleiQ23978. DM.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMY31D_DROME
AccessioniPrimary (citable) accession number: Q23978
Secondary accession number(s): A4V0K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.