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Protein

Homeotic protein ultrabithorax

Gene

Ubx

Organism
Drosophila hydei (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein ultrabithorax
Gene namesi
Name:Ubx
OrganismiDrosophila hydei (Fruit fly)
Taxonomic identifieri7224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Organism-specific databases

FlyBaseiFBgn0012384. Dhyd\Ubx.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›87›87Homeotic protein ultrabithoraxPRO_0000200267Add
BLAST

Expressioni

Tissue specificityi

In the embryo, expression is seen in the epidermis, somatic and visceral mesoderm, and the peripheral and central nervous system.1 Publication

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi22 – 276Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 64Poly-Ala

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.Curated

Keywords - Domaini

Homeobox

Family and domain databases

InterProiIPR001827. Homeobox_Antennapedia_CS.
[Graphical view]
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Fragment.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform IB (identifier: Q23946-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
SGAAAAQTAA ASSLHQASNH TFYPWMAIAG ESTADPIKSK IRSDLTQYGG
60 70 80
ISTDMGKRYS ESLAGSLLPD WLGTNGLRRR GRQTYTR
Length:87
Mass (Da):9,333
Last modified:November 1, 1996 - v1
Checksum:i0EE2E34B246E9FED
GO
Isoform IA (identifier: Q23946-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-38: Missing.

Show »
Length:78
Mass (Da):8,434
Checksum:iBF0ACB21EA7C3086
GO
Isoform IIA (identifier: Q23946-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-55: Missing.

Show »
Length:61
Mass (Da):6,580
Checksum:i7487F77F60DBBB1E
GO
Isoform IIB (identifier: Q23946-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-55: Missing.

Show »
Length:70
Mass (Da):7,479
Checksum:i45DD14002001F131
GO
Isoform IVA (identifier: Q23946-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-72: Missing.

Show »
Length:44
Mass (Da):4,706
Checksum:iE344758B02798AB5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei87 – 871

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei30 – 7243Missing in isoform IVA. CuratedVSP_002403Add
BLAST
Alternative sequencei30 – 5526Missing in isoform IIA. CuratedVSP_002402Add
BLAST
Alternative sequencei30 – 389Missing in isoform IA. CuratedVSP_002401
Alternative sequencei39 – 5517Missing in isoform IIB. CuratedVSP_002404Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03178 mRNA. Translation: AAA03568.1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03178 mRNA. Translation: AAA03568.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0012384. Dhyd\Ubx.

Family and domain databases

InterProiIPR001827. Homeobox_Antennapedia_CS.
[Graphical view]
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila."
    Bomze H.M., Lopez A.J.
    Genetics 136:965-977(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Embryo.

Entry informationi

Entry nameiUBX_DROHY
AccessioniPrimary (citable) accession number: Q23946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.