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Q23946

- UBX_DROHY

UniProt

Q23946 - UBX_DROHY

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Protein
Homeotic protein ultrabithorax
Gene
Ubx
Organism
Drosophila hydei (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein ultrabithorax
Gene namesi
Name:Ubx
OrganismiDrosophila hydei (Fruit fly)
Taxonomic identifieri7224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Organism-specific databases

FlyBaseiFBgn0012384. Dhyd\Ubx.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›87›87Homeotic protein ultrabithorax
PRO_0000200267Add
BLAST

Expressioni

Tissue specificityi

In the embryo, expression is seen in the epidermis, somatic and visceral mesoderm, and the peripheral and central nervous system.1 Publication

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi22 – 276Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 64Poly-Ala

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Family and domain databases

InterProiIPR001827. Homeobox_Antennapedia_CS.
[Graphical view]
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Fragment.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform IB (identifier: Q23946-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

SGAAAAQTAA ASSLHQASNH TFYPWMAIAG ESTADPIKSK IRSDLTQYGG   50
ISTDMGKRYS ESLAGSLLPD WLGTNGLRRR GRQTYTR 87
Length:87
Mass (Da):9,333
Last modified:November 1, 1996 - v1
Checksum:i0EE2E34B246E9FED
GO
Isoform IA (identifier: Q23946-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-38: Missing.

Show »
Length:78
Mass (Da):8,434
Checksum:iBF0ACB21EA7C3086
GO
Isoform IIA (identifier: Q23946-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-55: Missing.

Show »
Length:61
Mass (Da):6,580
Checksum:i7487F77F60DBBB1E
GO
Isoform IIB (identifier: Q23946-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-55: Missing.

Show »
Length:70
Mass (Da):7,479
Checksum:i45DD14002001F131
GO
Isoform IVA (identifier: Q23946-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-72: Missing.

Show »
Length:44
Mass (Da):4,706
Checksum:iE344758B02798AB5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei30 – 7243Missing in isoform IVA.
VSP_002403Add
BLAST
Alternative sequencei30 – 5526Missing in isoform IIA.
VSP_002402Add
BLAST
Alternative sequencei30 – 389Missing in isoform IA.
VSP_002401
Alternative sequencei39 – 5517Missing in isoform IIB.
VSP_002404Add
BLAST

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei87 – 871

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03178 mRNA. Translation: AAA03568.1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03178 mRNA. Translation: AAA03568.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0012384. Dhyd\Ubx.

Family and domain databases

InterProi IPR001827. Homeobox_Antennapedia_CS.
[Graphical view ]
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila."
    Bomze H.M., Lopez A.J.
    Genetics 136:965-977(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Embryo.

Entry informationi

Entry nameiUBX_DROHY
AccessioniPrimary (citable) accession number: Q23946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi