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Q23946

- UBX_DROHY

UniProt

Q23946 - UBX_DROHY

Protein

Homeotic protein ultrabithorax

Gene

Ubx

Organism
Drosophila hydei (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeotic protein ultrabithorax
    Gene namesi
    Name:Ubx
    OrganismiDrosophila hydei (Fruit fly)
    Taxonomic identifieri7224 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

    Organism-specific databases

    FlyBaseiFBgn0012384. Dhyd\Ubx.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›87›87Homeotic protein ultrabithoraxPRO_0000200267Add
    BLAST

    Expressioni

    Tissue specificityi

    In the embryo, expression is seen in the epidermis, somatic and visceral mesoderm, and the peripheral and central nervous system.1 Publication

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi22 – 276Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 64Poly-Ala

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.Curated

    Keywords - Domaini

    Homeobox

    Family and domain databases

    InterProiIPR001827. Homeobox_Antennapedia_CS.
    [Graphical view]
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Fragment.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform IB (identifier: Q23946-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    SGAAAAQTAA ASSLHQASNH TFYPWMAIAG ESTADPIKSK IRSDLTQYGG   50
    ISTDMGKRYS ESLAGSLLPD WLGTNGLRRR GRQTYTR 87
    Length:87
    Mass (Da):9,333
    Last modified:November 1, 1996 - v1
    Checksum:i0EE2E34B246E9FED
    GO
    Isoform IA (identifier: Q23946-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         30-38: Missing.

    Show »
    Length:78
    Mass (Da):8,434
    Checksum:iBF0ACB21EA7C3086
    GO
    Isoform IIA (identifier: Q23946-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         30-55: Missing.

    Show »
    Length:61
    Mass (Da):6,580
    Checksum:i7487F77F60DBBB1E
    GO
    Isoform IIB (identifier: Q23946-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         39-55: Missing.

    Show »
    Length:70
    Mass (Da):7,479
    Checksum:i45DD14002001F131
    GO
    Isoform IVA (identifier: Q23946-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         30-72: Missing.

    Show »
    Length:44
    Mass (Da):4,706
    Checksum:iE344758B02798AB5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei87 – 871

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei30 – 7243Missing in isoform IVA. CuratedVSP_002403Add
    BLAST
    Alternative sequencei30 – 5526Missing in isoform IIA. CuratedVSP_002402Add
    BLAST
    Alternative sequencei30 – 389Missing in isoform IA. CuratedVSP_002401
    Alternative sequencei39 – 5517Missing in isoform IIB. CuratedVSP_002404Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03178 mRNA. Translation: AAA03568.1.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03178 mRNA. Translation: AAA03568.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0012384. Dhyd\Ubx.

    Family and domain databases

    InterProi IPR001827. Homeobox_Antennapedia_CS.
    [Graphical view ]
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila."
      Bomze H.M., Lopez A.J.
      Genetics 136:965-977(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiUBX_DROHY
    AccessioniPrimary (citable) accession number: Q23946
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3