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Protein

Probable serine/threonine-protein kinase kinX

Gene

kinX

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei146 – 1461Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 369ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase kinX (EC:2.7.11.1)
Gene namesi
Name:kinX
ORF Names:DDB_G0283391
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283391. kinX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10941094Probable serine/threonine-protein kinase kinXPRO_0000327648Add
BLAST

Proteomic databases

PaxDbiQ23915.
PRIDEiQ23915.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0191487.

Structurei

3D structure databases

ProteinModelPortaliQ23915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 281260Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni676 – 97830340 X 9 AA approximate repeats of V-K-V-E-E-P-V-E-EAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi324 – 3285Poly-Asn
Compositional biasi331 – 34414Poly-AspAdd
BLAST
Compositional biasi374 – 38714Gln-richAdd
BLAST
Compositional biasi441 – 45313Poly-GluAdd
BLAST
Compositional biasi480 – 52344Asp/Glu-rich (Acidic)Add
BLAST
Compositional biasi563 – 58624Poly-GlnAdd
BLAST
Compositional biasi588 – 61023Asp/Glu-rich (Acidic)Add
BLAST
Compositional biasi1033 – 10397Poly-Gln

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZYG. Eukaryota.
COG0515. LUCA.
InParanoidiQ23915.
KOiK05743.
OMAiSTINGQE.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVDTSVPS FDRAWSIKYE DLDFISEIGS GGFGKVFKGE YLGAPVAIKK
60 70 80 90 100
IHILPDDPNR VDLEKFLNRE IETIKLFTHP NVIQFVGISE NNGILFIVTE
110 120 130 140 150
LIEGGDLQYY LKNQSIDLPW FLRANIALDV SLAMSYLHSK SIVHRDLKST
160 170 180 190 200
NLLVDKNWKI KVCDFGFARI VEEDNNKSMT ICGTDNWMSP EMITGLDYDE
210 220 230 240 250
RSDIFSFGIV LLEIISRVKP APYMRDASFG LAEDIVRNQL IPTDCPESLI
260 270 280 290 300
DLTFNCCSVD PNNRPSFKEI SQTLKQIKTT LDSNIVYPEI RDFEQQQKIS
310 320 330 340 350
TTNGNNKQNG GAPKINNLPL QYSNNNNNIY DDDDDDDDDD DDNDSFPRPY
360 370 380 390 400
SDNSNSNVTL ESNSNYNSST INGQEQQEQQ EQQQQQQVKE ERDEGEIEQD
410 420 430 440 450
DDNIEVYDSD YQKKLEEHQK ELLERQNQNQ EGSTDENEVY EQEEEEEEED
460 470 480 490 500
EEEQVISTPA KKRISFGQDT FHTYEAYRTD DEDDDDDEED EEEGDEYDHG
510 520 530 540 550
YDDFDEDDED DEEYDEDEDD EDERQIQYYQ QQLQYQQQLQ KQQEQEYQRQ
560 570 580 590 600
QQLQLQREEE EYQRQLQQQQ QQQQQQQQQQ QQHQQQYDDD DDDDDEEEEE
610 620 630 640 650
YDDVIRHDTD SEEESKDKTP LPWDQHFEKQ KESENKVEQE ETNVVVANSQ
660 670 680 690 700
ETEQQQQQQQ QPKEEEEEEP TKVEDVKVET EEQTKEEHDV KVDEESTKVD
710 720 730 740 750
EPVDEPTKVE ESVEQVKAEE PNKVEELVEE VKVEEEPTNV EEVKAEEPVE
760 770 780 790 800
EVKVEEPVEE VKAEEPVEEV KAEEPVEEVK TEEPVEEVKV EEPVEEVKVE
810 820 830 840 850
EPVEEVEAEE SVQEPVEEVK VDEPTKVEEP TKVEEPIEEV KVEEPTKVEE
860 870 880 890 900
SIEEVKVEEP TKVEEPVEEI KPEEPTKVEE SVEDVKVEDV KVEEVKAEEP
910 920 930 940 950
TKAEESVEDV KVEEPIKVEE PVKVEEPVKV EEPVKVEEPI KVEEPIKVEE
960 970 980 990 1000
PIKVEEPIKV EEPIKVEEPV KVEVASPVVQ EQPPQQEEKP EVVSTSTITI
1010 1020 1030 1040 1050
ASSPQQSSNS PPSTPVKQPQ QQEIEVNSTP IKQQQQQQQT PTQQTQTPTK
1060 1070 1080 1090
QHTEINVQPT PTKTPPLPPQ TNEKIPLISP NNKSNRGCCS CFIQ
Length:1,094
Mass (Da):126,718
Last modified:April 8, 2008 - v2
Checksum:iB109D1B8E8778E0A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti581 – 5811Q → H in CAA86053 (PubMed:7857991).Curated
Sequence conflicti653 – 6531E → D in CAA86053 (PubMed:7857991).Curated
Sequence conflicti1031 – 10311I → L in CAA86053 (PubMed:7857991).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37981 Genomic DNA. Translation: CAA86053.1.
AAFI02000055 Genomic DNA. Translation: EAL65680.1.
PIRiS52076. S49313.
RefSeqiXP_639097.1. XM_634005.1.

Genome annotation databases

EnsemblProtistsiDDB0191487; DDB0191487; DDB_G0283391.
GeneIDi8624121.
KEGGiddi:DDB_G0283391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37981 Genomic DNA. Translation: CAA86053.1.
AAFI02000055 Genomic DNA. Translation: EAL65680.1.
PIRiS52076. S49313.
RefSeqiXP_639097.1. XM_634005.1.

3D structure databases

ProteinModelPortaliQ23915.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0191487.

Proteomic databases

PaxDbiQ23915.
PRIDEiQ23915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0191487; DDB0191487; DDB_G0283391.
GeneIDi8624121.
KEGGiddi:DDB_G0283391.

Organism-specific databases

dictyBaseiDDB_G0283391. kinX.

Phylogenomic databases

eggNOGiENOG410IZYG. Eukaryota.
COG0515. LUCA.
InParanoidiQ23915.
KOiK05743.
OMAiSTINGQE.

Miscellaneous databases

PROiQ23915.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKINX_DICDI
AccessioniPrimary (citable) accession number: Q23915
Secondary accession number(s): Q54QZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 11, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.