ID   NDUS2_DICDI             Reviewed;         406 AA.
AC   Q23883; Q9XPJ8;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 65.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 49 kDa subunit;
DE            EC=1.6.5.3;
DE            EC=1.6.99.3;
DE   AltName: Full=NADH dehydrogenase subunit 7;
GN   Name=nad7; Synonyms=ndufs2; ORFNames=DDB_G0294030;
OS   Dictyostelium discoideum (Slime mold).
OG   Mitochondrion.
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AX3;
RX   MEDLINE=96038265; PubMed=8581739; DOI=10.1093/dnares/2.3.129;
RA   Iwamoto M., Yanagisawa K., Tanaka Y.;
RT   "Mitochondrial ribosomal protein L11 gene of Dictyostelium discoideum
RT   resides not in the nuclear genome but in the mitochondrial genome.";
RL   DNA Res. 2:129-132(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AX3;
RX   MEDLINE=20279206; PubMed=10821186; DOI=10.1007/s004380051196;
RA   Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K.,
RA   Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.;
RT   "The mitochondrial DNA of Dictyostelium discoideum: complete sequence,
RT   gene content and genome organization.";
RL   Mol. Gen. Genet. 263:514-519(2000).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone (By similarity). Component of the iron-sulfur (IP)
CC       fragment of the enzyme. Component of the iron-sulfur (IP) fragment
CC       of the enzyme (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol.
CC   -!- CATALYTIC ACTIVITY: NADH + acceptor = NAD(+) + reduced acceptor.
CC   -!- SUBUNIT: Complex I is composed of about 45 different subunits (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
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DR   EMBL; D21196; BAA04731.1; -; Genomic_DNA.
DR   EMBL; AB000109; BAA78067.1; -; Genomic_DNA.
DR   PIR; T43763; T43763.
DR   RefSeq; NP_050085.1; -.
DR   GeneID; 2193913; -.
DR   dictyBase; DDB_G0294030; nad7.
DR   BRENDA; 1.6.5.3; 424.
DR   BRENDA; 1.6.99.3; 424.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010219; NADH_DH_1_dsu.
DR   InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR   InterPro; IPR014029; NADH_UbQ_OxRdtase_su-49kDa_CS.
DR   Pfam; PF00346; Complex1_49kDa; 1.
DR   TIGRFAMs; TIGR01962; NuoD; 1.
DR   PROSITE; PS00535; COMPLEX1_49K; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Electron transport; Mitochondrion; NAD;
KW   Oxidoreductase; Respiratory chain; Transport; Ubiquinone.
FT   CHAIN         1    406       NADH-ubiquinone oxidoreductase 49 kDa
FT                                subunit.
FT                                /FTId=PRO_0000118589.
SQ   SEQUENCE   406 AA;  46833 MW;  581BCF7AD71F86A8 CRC64;
     MLNISKIFEE VKVMKNFTLN FGPQHPAAHG VLRLIVELES ENVVRVEPHI GLLHRGTEKL
     IEGKTYTQAL PYFDRLDYVS MNVQEHAYSL AVERLYLDSL DIELEIPQRA KVIRVLFSEI
     TRVLNHIMAT TTHAMDVGAL TPFLWAFEER EKLMEFYERV SGARMHAAYI RPGGVAFDLP
     MNISEDIYKF VIQYRKRLEE IEDMLINNRI WKQRLVDIGI VSAEEALNYG FTGPLLRGAG
     IVYDIRKNYP YDDYDKYDFK IIIGEENNSY TRFIIRMKEM YQSLSIIEQA LNNLRPGLIK
     LEGVNITAPD RAFVKKDMES CINHFKFFSE GFIIPANENY TIVEAPKGEF GIYLNANDTA
     KPYRCRIKAP GFLHLQGLNM MSKDHLLADV VTLIGTQDIV FGEVDR
//