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Q23883

- NDUS2_DICDI

UniProt

Q23883 - NDUS2_DICDI

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Protein
NADH-ubiquinone oxidoreductase 49 kDa subunit
Gene
nad7, ndufs2, DDB_G0294030
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme By similarity.UniRule annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation
NADH + acceptor = NAD+ + reduced acceptor.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  3. protein binding Source: dictyBase
  4. quinone binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    NADH dehydrogenase subunit 7
    Gene namesi
    Name:nad7
    Synonyms:ndufs2
    ORF Names:DDB_G0294030
    Encoded oniMitochondrion
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Mitochondrion

    Organism-specific databases

    dictyBaseiDDB_G0294030. nad7.

    Subcellular locationi

    Mitochondrion By similarity UniRule annotation

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406NADH-ubiquinone oxidoreductase 49 kDa subunitUniRule annotation
    PRO_0000118589Add
    BLAST

    Interactioni

    Subunit structurei

    Complex I is composed of about 45 different subunits By similarity. Interacts with NDUFAF7.1 Publication

    Protein-protein interaction databases

    STRINGi44689.DidioMp18.

    Structurei

    3D structure databases

    ProteinModelPortaliQ23883.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0649.
    KOiK03935.
    OMAiARFTINY.
    PhylomeDBiQ23883.

    Family and domain databases

    Gene3Di1.10.645.10. 2 hits.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q23883-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNISKIFEE VKVMKNFTLN FGPQHPAAHG VLRLIVELES ENVVRVEPHI    50
    GLLHRGTEKL IEGKTYTQAL PYFDRLDYVS MNVQEHAYSL AVERLYLDSL 100
    DIELEIPQRA KVIRVLFSEI TRVLNHIMAT TTHAMDVGAL TPFLWAFEER 150
    EKLMEFYERV SGARMHAAYI RPGGVAFDLP MNISEDIYKF VIQYRKRLEE 200
    IEDMLINNRI WKQRLVDIGI VSAEEALNYG FTGPLLRGAG IVYDIRKNYP 250
    YDDYDKYDFK IIIGEENNSY TRFIIRMKEM YQSLSIIEQA LNNLRPGLIK 300
    LEGVNITAPD RAFVKKDMES CINHFKFFSE GFIIPANENY TIVEAPKGEF 350
    GIYLNANDTA KPYRCRIKAP GFLHLQGLNM MSKDHLLADV VTLIGTQDIV 400
    FGEVDR 406
    Length:406
    Mass (Da):46,833
    Last modified:November 1, 1996 - v1
    Checksum:i581BCF7AD71F86A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21196 Genomic DNA. Translation: BAA04731.1.
    AB000109 Genomic DNA. Translation: BAA78067.1.
    PIRiT43763.
    RefSeqiNP_050085.1. NC_000895.1.

    Genome annotation databases

    GeneIDi2193913.
    KEGGiddi:DidioMp18.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21196 Genomic DNA. Translation: BAA04731.1 .
    AB000109 Genomic DNA. Translation: BAA78067.1 .
    PIRi T43763.
    RefSeqi NP_050085.1. NC_000895.1.

    3D structure databases

    ProteinModelPortali Q23883.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 44689.DidioMp18.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2193913.
    KEGGi ddi:DidioMp18.

    Organism-specific databases

    dictyBasei DDB_G0294030. nad7.

    Phylogenomic databases

    eggNOGi COG0649.
    KOi K03935.
    OMAi ARFTINY.
    PhylomeDBi Q23883.

    Miscellaneous databases

    PROi Q23883.

    Family and domain databases

    Gene3Di 1.10.645.10. 2 hits.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Mitochondrial ribosomal protein L11 gene of Dictyostelium discoideum resides not in the nuclear genome but in the mitochondrial genome."
      Iwamoto M., Yanagisawa K., Tanaka Y.
      DNA Res. 2:129-132(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AX3.
    2. "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization."
      Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.
      Mol. Gen. Genet. 263:514-519(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX3.
    3. Bienvenut W.V., Ura S., Insall R.H.
      Submitted (JUL-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 34-45; 115-122; 238-246 AND 261-272, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: AX2.
    4. Cited for: INTERACTION WITH NDUFAF7.

    Entry informationi

    Entry nameiNDUS2_DICDI
    AccessioniPrimary (citable) accession number: Q23883
    Secondary accession number(s): Q9XPJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: June 11, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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