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Q23883 (NDUS2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
NADH dehydrogenase subunit 7
Gene names
Name:nad7
Synonyms:ndufs2
ORF Names:DDB_G0294030
Encoded onMitochondrion
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme By similarity. HAMAP-Rule MF_01358

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01358

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01358

Subunit structure

Complex I is composed of about 45 different subunits By similarity. Interacts with NDUFAF7. Ref.4

Subcellular location

Mitochondrion By similarity HAMAP-Rule MF_01358.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406NADH-ubiquinone oxidoreductase 49 kDa subunit HAMAP-Rule MF_01358
PRO_0000118589

Sequences

Sequence LengthMass (Da)Tools
Q23883 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 581BCF7AD71F86A8

FASTA40646,833
        10         20         30         40         50         60 
MLNISKIFEE VKVMKNFTLN FGPQHPAAHG VLRLIVELES ENVVRVEPHI GLLHRGTEKL 

        70         80         90        100        110        120 
IEGKTYTQAL PYFDRLDYVS MNVQEHAYSL AVERLYLDSL DIELEIPQRA KVIRVLFSEI 

       130        140        150        160        170        180 
TRVLNHIMAT TTHAMDVGAL TPFLWAFEER EKLMEFYERV SGARMHAAYI RPGGVAFDLP 

       190        200        210        220        230        240 
MNISEDIYKF VIQYRKRLEE IEDMLINNRI WKQRLVDIGI VSAEEALNYG FTGPLLRGAG 

       250        260        270        280        290        300 
IVYDIRKNYP YDDYDKYDFK IIIGEENNSY TRFIIRMKEM YQSLSIIEQA LNNLRPGLIK 

       310        320        330        340        350        360 
LEGVNITAPD RAFVKKDMES CINHFKFFSE GFIIPANENY TIVEAPKGEF GIYLNANDTA 

       370        380        390        400 
KPYRCRIKAP GFLHLQGLNM MSKDHLLADV VTLIGTQDIV FGEVDR 

« Hide

References

« Hide 'large scale' references
[1]"Mitochondrial ribosomal protein L11 gene of Dictyostelium discoideum resides not in the nuclear genome but in the mitochondrial genome."
Iwamoto M., Yanagisawa K., Tanaka Y.
DNA Res. 2:129-132(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AX3.
[2]"The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization."
Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.
Mol. Gen. Genet. 263:514-519(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX3.
[3]Bienvenut W.V., Ura S., Insall R.H.
Submitted (JUL-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 34-45; 115-122; 238-246 AND 261-272, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: AX2.
[4]"MidA is a putative methyltransferase that is required for mitochondrial complex I function."
Carilla-Latorre S., Gallardo M.E., Annesley S.J., Calvo-Garrido J., Grana O., Accari S.L., Smith P.K., Valencia A., Garesse R., Fisher P.R., Escalante R.
J. Cell Sci. 123:1674-1683(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NDUFAF7.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D21196 Genomic DNA. Translation: BAA04731.1.
AB000109 Genomic DNA. Translation: BAA78067.1.
PIRT43763.
RefSeqNP_050085.1. NC_000895.1.

3D structure databases

ProteinModelPortalQ23883.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DidioMp18.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2193913.
KEGGddi:DidioMp18.

Organism-specific databases

dictyBaseDDB_G0294030. nad7.

Phylogenomic databases

eggNOGCOG0649.
KOK03935.
OMAARFTINY.
PhylomeDBQ23883.

Family and domain databases

Gene3D1.10.645.10. 2 hits.
HAMAPMF_01358. NDH1_NuoD.
InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMSSF56762. SSF56762. 1 hit.
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ23883.

Entry information

Entry nameNDUS2_DICDI
AccessionPrimary (citable) accession number: Q23883
Secondary accession number(s): Q9XPJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase