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Reviewed, UniProtKB/Swiss-Prot Q23883 (NDUS2_DICDI)

Last modified November 25, 2008. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit
    EC=1.6.5.3
    EC=1.6.99.3
Alternative name(s):
    NADH dehydrogenase subunit 7
Gene names
Name: nad7
Synonyms: ndufs2
ORF Names: DDB_G0294030
Encoded onMitochondrion
OrganismDictyostelium discoideum (Slime mold) [Complete proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme By similarity.

Catalytic activity

NADH + ubiquinone = NAD(+) + ubiquinol.

NADH + acceptor = NAD(+) + reduced acceptor.

Subunit structure

Complex I is composed of about 45 different subunits By similarity.

Subcellular location

MitochondrionBy similarity.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406NADH-ubiquinone oxidoreductase 49 kDa subunit
PRO_0000118589

Sequences

Sequence LengthMass (Da)Tools
Q23883-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 581BCF7AD71F86A8

FASTA40646,833
        10         20         30         40         50         60 
MLNISKIFEE VKVMKNFTLN FGPQHPAAHG VLRLIVELES ENVVRVEPHI GLLHRGTEKL 

        70         80         90        100        110        120 
IEGKTYTQAL PYFDRLDYVS MNVQEHAYSL AVERLYLDSL DIELEIPQRA KVIRVLFSEI 

       130        140        150        160        170        180 
TRVLNHIMAT TTHAMDVGAL TPFLWAFEER EKLMEFYERV SGARMHAAYI RPGGVAFDLP 

       190        200        210        220        230        240 
MNISEDIYKF VIQYRKRLEE IEDMLINNRI WKQRLVDIGI VSAEEALNYG FTGPLLRGAG 

       250        260        270        280        290        300 
IVYDIRKNYP YDDYDKYDFK IIIGEENNSY TRFIIRMKEM YQSLSIIEQA LNNLRPGLIK 

       310        320        330        340        350        360 
LEGVNITAPD RAFVKKDMES CINHFKFFSE GFIIPANENY TIVEAPKGEF GIYLNANDTA 

       370        380        390        400 
KPYRCRIKAP GFLHLQGLNM MSKDHLLADV VTLIGTQDIV FGEVDR 

« Hide

References

[1]"Mitochondrial ribosomal protein L11 gene of Dictyostelium discoideum resides not in the nuclear genome but in the mitochondrial genome."
Iwamoto M., Yanagisawa K., Tanaka Y.
DNA Res. 2:129-132(1995) [PubMed: 8581739] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AX3.
[2]"The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization."
Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.
Mol. Gen. Genet. 263:514-519(2000) [PubMed: 10821186] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AX3.

Cross-references

Sequence databases

D21196 Genomic DNA. Translation: BAA04731.1.
AB000109 Genomic DNA. Translation: BAA78067.1.
PIRT43763.
RefSeqNP_050085.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2193913.

Organism-specific databases

dictyBaseDDB_G0294030. nad7.

Family and domain databases

InterProIPR014029. NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219. NADH_DH_1_dsu.
IPR001135. NADH_UbQ_OxRdtase_49kDa.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS2_DICDI
AccessionPrimary (citable) accession number: Q23883
Secondary accession number(s): Q9XPJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 25, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents