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Protein

Aquaporin AQPcic

Gene

AQP

Organism
Cicadella viridis (Green leafhopper)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms a water-specific channel. May be involved in the transfer of excess sap dietary water from the initial midgut to the terminal midgut and the proximal part of the malpighian tubules.

GO - Molecular functioni

  1. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin AQPcic
Gene namesi
Name:AQP
Synonyms:CIC
OrganismiCicadella viridis (Green leafhopper)
Taxonomic identifieri36150 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraEuhemipteraMembracoideaCicadellidaeCicadellinaeCicadelliniCicadella

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 6010ExtracellularSequence Analysis
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini82 – 10322CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 17210CytoplasmicSequence Analysis
Transmembranei173 – 19321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini194 – 21522ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 23621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini237 – 25519CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Aquaporin AQPcicPRO_0000063975Add
BLAST

Expressioni

Tissue specificityi

Filter chamber epithelium in the digestive tract. Absent from midgut.

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliQ23808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi85 – 873NPA 1
Motifi201 – 2033NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q23808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADKSVDNT KKIIGIDDIT DTKTIWRCLA AELIGTLLLV LIGTGSCTGV
60 70 80 90 100
QISEGDVVVR IALTFGFIIA TMVQCIGHVS GCHINPAVTC GLLVTGHISI
110 120 130 140 150
LKAIFYIIVQ CVGAIAGSAI LKVITPAEFR GTLCMTSLAP GVTPPMGFLV
160 170 180 190 200
EACITFVLIL LVQSVCDDRR KNLGNAAPVA VGLAITCCHL AAIKYTGSSM
210 220 230 240 250
NPARSFGPAV NGDDNWANHW VYWAGPIVGG VVAGITYRAL FRARKPEEEA

SSYDF
Length:255
Mass (Da):26,885
Last modified:November 1, 1996 - v1
Checksum:i66093CF3D1253B1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 14627ILKVI…VTPPM → PQGNNPCRVQGHSLYDESRP RCDPAH in CAA54921 (PubMed:7542238).CuratedAdd
BLAST
Sequence conflicti165 – 17410VCDDRRKNLG → LRRPPQEPA in CAA54921 (PubMed:7542238).Curated
Sequence conflicti180 – 1801A → R in CAA54921 (PubMed:7542238).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97159 mRNA. Translation: CAA65799.1.
X77957 mRNA. Translation: CAA54921.1.

Cross-referencesi

Web resourcesi

Protein Spotlight

Liquid states - Issue 36 of July 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97159 mRNA. Translation: CAA65799.1.
X77957 mRNA. Translation: CAA54921.1.

3D structure databases

ProteinModelPortaliQ23808.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of an insect aquaporin. Functional comparison with aquaporin 1."
    Le Caherec F., Deschamps S., Delamarche C., Pellerin I., Bonnec G., Guillam M.-T., Thomas D., Gouranton J., Hubert J.-F.
    Eur. J. Biochem. 241:707-715(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 245-255.
    Tissue: Filter chamber.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-205.
    Tissue: Filter chamber.

Entry informationi

Entry nameiAQP_CICVR
AccessioniPrimary (citable) accession number: Q23808
Secondary accession number(s): Q23816
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.