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Q23808

- AQP_CICVR

UniProt

Q23808 - AQP_CICVR

Protein

Aquaporin AQPcic

Gene

AQP

Organism
Cicadella viridis (Green leafhopper)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Forms a water-specific channel. May be involved in the transfer of excess sap dietary water from the initial midgut to the terminal midgut and the proximal part of the malpighian tubules.

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aquaporin AQPcic
    Gene namesi
    Name:AQP
    Synonyms:CIC
    OrganismiCicadella viridis (Green leafhopper)
    Taxonomic identifieri36150 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraEuhemipteraMembracoideaCicadellidaeCicadellinaeCicadelliniCicadella

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255Aquaporin AQPcicPRO_0000063975Add
    BLAST

    Expressioni

    Tissue specificityi

    Filter chamber epithelium in the digestive tract. Absent from midgut.

    Interactioni

    Subunit structurei

    Homotetramer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ23808.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini51 – 6010ExtracellularSequence Analysis
    Topological domaini82 – 10322CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini163 – 17210CytoplasmicSequence Analysis
    Topological domaini194 – 21522ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini237 – 25519CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi85 – 873NPA 1
    Motifi201 – 2033NPA 2

    Domaini

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    InterProiIPR023271. Aquaporin-like.
    IPR000425. MIP.
    [Graphical view]
    PANTHERiPTHR19139. PTHR19139. 1 hit.
    PfamiPF00230. MIP. 1 hit.
    [Graphical view]
    PRINTSiPR00783. MINTRINSICP.
    SUPFAMiSSF81338. SSF81338. 1 hit.
    TIGRFAMsiTIGR00861. MIP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q23808-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAADKSVDNT KKIIGIDDIT DTKTIWRCLA AELIGTLLLV LIGTGSCTGV    50
    QISEGDVVVR IALTFGFIIA TMVQCIGHVS GCHINPAVTC GLLVTGHISI 100
    LKAIFYIIVQ CVGAIAGSAI LKVITPAEFR GTLCMTSLAP GVTPPMGFLV 150
    EACITFVLIL LVQSVCDDRR KNLGNAAPVA VGLAITCCHL AAIKYTGSSM 200
    NPARSFGPAV NGDDNWANHW VYWAGPIVGG VVAGITYRAL FRARKPEEEA 250
    SSYDF 255
    Length:255
    Mass (Da):26,885
    Last modified:November 1, 1996 - v1
    Checksum:i66093CF3D1253B1D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti120 – 14627ILKVI…VTPPM → PQGNNPCRVQGHSLYDESRP RCDPAH in CAA54921. (PubMed:7542238)CuratedAdd
    BLAST
    Sequence conflicti165 – 17410VCDDRRKNLG → LRRPPQEPA in CAA54921. (PubMed:7542238)Curated
    Sequence conflicti180 – 1801A → R in CAA54921. (PubMed:7542238)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97159 mRNA. Translation: CAA65799.1.
    X77957 mRNA. Translation: CAA54921.1.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Liquid states - Issue 36 of July 2003

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97159 mRNA. Translation: CAA65799.1 .
    X77957 mRNA. Translation: CAA54921.1 .

    3D structure databases

    ProteinModelPortali Q23808.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    InterProi IPR023271. Aquaporin-like.
    IPR000425. MIP.
    [Graphical view ]
    PANTHERi PTHR19139. PTHR19139. 1 hit.
    Pfami PF00230. MIP. 1 hit.
    [Graphical view ]
    PRINTSi PR00783. MINTRINSICP.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    TIGRFAMsi TIGR00861. MIP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of an insect aquaporin. Functional comparison with aquaporin 1."
      Le Caherec F., Deschamps S., Delamarche C., Pellerin I., Bonnec G., Guillam M.-T., Thomas D., Gouranton J., Hubert J.-F.
      Eur. J. Biochem. 241:707-715(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 245-255.
      Tissue: Filter chamber.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-205.
      Tissue: Filter chamber.

    Entry informationi

    Entry nameiAQP_CICVR
    AccessioniPrimary (citable) accession number: Q23808
    Secondary accession number(s): Q23816
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 3, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3