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Q23808 (AQP_CICVR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aquaporin AQPcic
Gene names
Name:AQP
Synonyms:CIC
OrganismCicadella viridis (Green leafhopper)
Taxonomic identifier36150 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraEuhemipteraMembracoideaCicadellidaeCicadellinaeCicadelliniCicadella

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Forms a water-specific channel. May be involved in the transfer of excess sap dietary water from the initial midgut to the terminal midgut and the proximal part of the malpighian tubules.

Subunit structure

Homotetramer.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Filter chamber epithelium in the digestive tract. Absent from midgut.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255Aquaporin AQPcic
PRO_0000063975

Regions

Topological domain1 – 2929Cytoplasmic Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 6010Extracellular Potential
Transmembrane61 – 8121Helical; Name=2; Potential
Topological domain82 – 10322Cytoplasmic Potential
Transmembrane104 – 12421Helical; Name=3; Potential
Topological domain125 – 14117Extracellular Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Topological domain163 – 17210Cytoplasmic Potential
Transmembrane173 – 19321Helical; Name=5; Potential
Topological domain194 – 21522Extracellular Potential
Transmembrane216 – 23621Helical; Name=6; Potential
Topological domain237 – 25519Cytoplasmic Potential
Motif85 – 873NPA 1
Motif201 – 2033NPA 2

Experimental info

Sequence conflict120 – 14627ILKVI…VTPPM → PQGNNPCRVQGHSLYDESRP RCDPAH in CAA54921. Ref.2
Sequence conflict165 – 17410VCDDRRKNLG → LRRPPQEPA in CAA54921. Ref.2
Sequence conflict1801A → R in CAA54921. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q23808 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 66093CF3D1253B1D

FASTA25526,885
        10         20         30         40         50         60 
MAADKSVDNT KKIIGIDDIT DTKTIWRCLA AELIGTLLLV LIGTGSCTGV QISEGDVVVR 

        70         80         90        100        110        120 
IALTFGFIIA TMVQCIGHVS GCHINPAVTC GLLVTGHISI LKAIFYIIVQ CVGAIAGSAI 

       130        140        150        160        170        180 
LKVITPAEFR GTLCMTSLAP GVTPPMGFLV EACITFVLIL LVQSVCDDRR KNLGNAAPVA 

       190        200        210        220        230        240 
VGLAITCCHL AAIKYTGSSM NPARSFGPAV NGDDNWANHW VYWAGPIVGG VVAGITYRAL 

       250 
FRARKPEEEA SSYDF 

« Hide

References

[1]"Molecular cloning and characterization of an insect aquaporin. Functional comparison with aquaporin 1."
Le Caherec F., Deschamps S., Delamarche C., Pellerin I., Bonnec G., Guillam M.-T., Thomas D., Gouranton J., Hubert J.-F.
Eur. J. Biochem. 241:707-715(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 245-255.
Tissue: Filter chamber.
[2]"Structural analysis of a MIP family protein from the digestive tract of Cicadella viridis."
Beuron F., Le Caherec F., Guillam M.-T., Cavalier A., Garret A., Tassan J.-P., Delamarche C., Schultz P., Mallouh V., Rolland J.-P., Hubert J.-F., Gouranton J., Thomas D.
J. Biol. Chem. 270:17414-17422(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-205.
Tissue: Filter chamber.

Web resources

Protein Spotlight

Liquid states - Issue 36 of July 2003

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X97159 mRNA. Translation: CAA65799.1.
X77957 mRNA. Translation: CAA54921.1.

3D structure databases

ProteinModelPortalQ23808.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1080.10. 1 hit.
InterProIPR023271. Aquaporin-like.
IPR000425. MIP.
[Graphical view]
PANTHERPTHR19139. PTHR19139. 1 hit.
PfamPF00230. MIP. 1 hit.
[Graphical view]
PRINTSPR00783. MINTRINSICP.
SUPFAMSSF81338. SSF81338. 1 hit.
TIGRFAMsTIGR00861. MIP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAQP_CICVR
AccessionPrimary (citable) accession number: Q23808
Secondary accession number(s): Q23816
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries