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Protein

Tropomyosin

Gene
N/A
Organism
Clonorchis sinensis (Chinese liver fluke)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
OrganismiClonorchis sinensis (Chinese liver fluke)
Taxonomic identifieri79923 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaOpisthorchiidaOpisthorchiataOpisthorchiidaeClonorchis

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056511 – 284TropomyosinAdd BLAST284

Proteomic databases

PRIDEiQ23758.

Structurei

3D structure databases

ProteinModelPortaliQ23758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 284Add BLAST284

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.

Sequencei

Sequence statusi: Complete.

Q23758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGIKKKMIA MKLEKENAME RAVQYEAQLK QKEEEQEKKE TEIGELNNRM
60 70 80 90 100
KQAQTELDEI QEALQDSLNK MEETDKRATN AEAEVARMTR RIRLLEEDLE
110 120 130 140 150
VSSSRLTETL AKFDEASKTA EESERGRKEL EIRSIADDEG LSQLEDQQKE
160 170 180 190 200
GKYIAEDADR KYDEAARKLA IVEVDFERAE SRLEAAESKI VELEEELRVV
210 220 230 240 250
GNNMKALEIS EQESAQREES YEETIRDLTE RLKAAEQRAA EAERQVSKLQ
260 270 280
NEVDHLEDDL LSEKIRYKDL SGGLDQTFAE LTGY
Length:284
Mass (Da):32,786
Last modified:November 1, 1996 - v1
Checksum:iF29E2F7A581137CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43918 mRNA. Translation: AAA70373.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43918 mRNA. Translation: AAA70373.1.

3D structure databases

ProteinModelPortaliQ23758.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ23758.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
ProtoNetiSearch...

Entry informationi

Entry nameiTPM_CLOSI
AccessioniPrimary (citable) accession number: Q23758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.