ID   G6PD_CULPI              Reviewed;         153 AA.
AC   Q23711;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 53.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase;
DE            Short=G6PD;
DE            EC=1.1.1.49;
DE   AltName: Full=Zwischenferment;
DE   Flags: Fragment;
GN   Name=ZW;
OS   Culex pipiens (House mosquito).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7175;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   AGRICOLA=IND20440286;
RA   Soto-Adames F.N., Robertson H.M., Berlocher S.H.;
RT   "Phylogenetic utility of partial DNA sequences of G6PDH at different
RT   taxonomic levels in Hexapoda with emphasis on Diptera.";
RL   Ann. Entomol. Soc. Am. 87:723-736(1994).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = D-glucono-
CC       1,5-lactone 6-phosphate + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family.
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DR   EMBL; U09034; AAB02778.1; -; mRNA.
DR   HSSP; P11413; 1QKI.
DR   BRENDA; 1.1.1.49; 263356.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:EC.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001282; Glc-6-P_DH.
DR   InterPro; IPR019796; Glc-6-P_DH_AS.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR23429; G6PDH; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   PROSITE; PS00069; G6P_DEHYDROGENASE; PARTIAL.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Glucose metabolism; NADP; Oxidoreductase.
FT   CHAIN        <1   >153       Glucose-6-phosphate 1-dehydrogenase.
FT                                /FTId=PRO_0000068091.
FT   BINDING      21     21       NADP (By similarity).
FT   BINDING     150    150       Substrate (By similarity).
FT   NON_TER       1      1
FT   NON_TER     153    153
SQ   SEQUENCE   153 AA;  17999 MW;  F82E2F41C39C82E6 CRC64;
     LWWLFRDNLL PSVTKFVGYA RTKLTVAELK EKCHPYMKVD AAHEEKYDEF WALNFYVAGS
     YDGRRDFELL NQEIGKFEVG KTANRLFYLR LPPSVFETVT VHIRNTCMGL KGWNRIIVEK
     PFGRDADSSN KLSEHLAKLF TEDQLYRIDH YLG
//