Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q23711

- G6PD_CULPI

UniProt

Q23711 - G6PD_CULPI

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

ZW

Organism
Culex pipiens (House mosquito)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei21 – 211NADP 1By similarity
    Binding sitei120 – 1201NADP 1; via carbonyl oxygenBy similarity
    Binding sitei120 – 1201SubstratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glucose 6-phosphate metabolic process Source: UniProtKB
    2. NADP metabolic process Source: UniProtKB
    3. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Alternative name(s):
    Zwischenferment
    Gene namesi
    Name:ZW
    OrganismiCulex pipiens (House mosquito)
    Taxonomic identifieri7175 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›153›153Glucose-6-phosphate 1-dehydrogenasePRO_0000068091Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7176.CPIJ006761-PA.

    Structurei

    3D structure databases

    ProteinModelPortaliQ23711.
    SMRiQ23711. Positions 1-153.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni150 – 1534Substrate binding

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR001282. G6P_DH.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF00479. G6PD_N. 1 hit.
    [Graphical view]
    PRINTSiPR00079. G6PDHDRGNASE.

    Sequencei

    Sequence statusi: Fragment.

    Q23711-1 [UniParc]FASTAAdd to Basket

    « Hide

    LWWLFRDNLL PSVTKFVGYA RTKLTVAELK EKCHPYMKVD AAHEEKYDEF    50
    WALNFYVAGS YDGRRDFELL NQEIGKFEVG KTANRLFYLR LPPSVFETVT 100
    VHIRNTCMGL KGWNRIIVEK PFGRDADSSN KLSEHLAKLF TEDQLYRIDH 150
    YLG 153
    Length:153
    Mass (Da):17,999
    Last modified:November 1, 1996 - v1
    Checksum:iF82E2F41C39C82E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei153 – 1531

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09034 mRNA. Translation: AAB02778.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09034 mRNA. Translation: AAB02778.1 .

    3D structure databases

    ProteinModelPortali Q23711.
    SMRi Q23711. Positions 1-153.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7176.CPIJ006761-PA.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR001282. G6P_DH.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00079. G6PDHDRGNASE.
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenetic utility of partial DNA sequences of G6PDH at different taxonomic levels in Hexapoda with emphasis on Diptera."
      Soto-Adames F.N., Robertson H.M., Berlocher S.H.
      Ann. Entomol. Soc. Am. 87:723-736(1994)
      [AGRICOLA] [Europe PMC]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiG6PD_CULPI
    AccessioniPrimary (citable) accession number: Q23711
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3