Reviewed, UniProtKB/Swiss-Prot Q23711 (G6PD_CULPI)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49
Alternative name(s):
    Zwischenferment

Gene names

Name:

ZW

Organism

Culex pipiens (House mosquito)

Taxonomic identifier

7175 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Culicini › Culex › Culex

Protein attributes

Sequence length	153 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›153	›153	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068091
Sites
	Binding site	21	1	NADP By similarity
	Binding site	150	1	Substrate By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	153	1

Sequences

	Sequence		Length	Mass (Da)
	Q23711-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F82E2F41C39C82E6	FASTA	153	17,999
	10 20 30 40 50 60 LWWLFRDNLL PSVTKFVGYA RTKLTVAELK EKCHPYMKVD AAHEEKYDEF WALNFYVAGS 70 80 90 100 110 120 YDGRRDFELL NQEIGKFEVG KTANRLFYLR LPPSVFETVT VHIRNTCMGL KGWNRIIVEK 130 140 150 PFGRDADSSN KLSEHLAKLF TEDQLYRIDH YLG

References

[1]	"Phylogenetic utility of partial DNA sequences of G6PDH at different taxonomic levels in Hexapoda with emphasis on Diptera." Soto-Adames F.N., Robertson H.M., Berlocher S.H. Ann. Entomol. Soc. Am. 87:723-736(1994) [Agricola: IND20440286] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U09034 mRNA. Translation: AAB02778.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF00479. G6PD_N. 1 hit. [Graphical view]
PRINTS	PR00079. G6PDHDRGNASE.
PROSITE	PS00069. G6P_DEHYDROGENASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_CULPI

Accession

Primary (citable) accession number: Q23711

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)