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Q23711

- G6PD_CULPI

UniProt

Q23711 - G6PD_CULPI

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
ZW
Organism
Culex pipiens (House mosquito)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211NADP 1 By similarity
Binding sitei120 – 1201NADP 1; via carbonyl oxygen By similarity
Binding sitei120 – 1201Substrate By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB

GO - Biological processi

  1. NADP metabolic process Source: UniProtKB
  2. glucose 6-phosphate metabolic process Source: UniProtKB
  3. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Alternative name(s):
Zwischenferment
Gene namesi
Name:ZW
OrganismiCulex pipiens (House mosquito)
Taxonomic identifieri7175 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›153›153Glucose-6-phosphate 1-dehydrogenase
PRO_0000068091Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7176.CPIJ006761-PA.

Structurei

3D structure databases

ProteinModelPortaliQ23711.
SMRiQ23711. Positions 1-153.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 1534Substrate binding

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001282. G6P_DH.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF00479. G6PD_N. 1 hit.
[Graphical view]
PRINTSiPR00079. G6PDHDRGNASE.

Sequencei

Sequence statusi: Fragment.

Q23711-1 [UniParc]FASTAAdd to Basket

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LWWLFRDNLL PSVTKFVGYA RTKLTVAELK EKCHPYMKVD AAHEEKYDEF    50
WALNFYVAGS YDGRRDFELL NQEIGKFEVG KTANRLFYLR LPPSVFETVT 100
VHIRNTCMGL KGWNRIIVEK PFGRDADSSN KLSEHLAKLF TEDQLYRIDH 150
YLG 153
Length:153
Mass (Da):17,999
Last modified:November 1, 1996 - v1
Checksum:iF82E2F41C39C82E6
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei153 – 1531

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09034 mRNA. Translation: AAB02778.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09034 mRNA. Translation: AAB02778.1 .

3D structure databases

ProteinModelPortali Q23711.
SMRi Q23711. Positions 1-153.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7176.CPIJ006761-PA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR001282. G6P_DH.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF00479. G6PD_N. 1 hit.
[Graphical view ]
PRINTSi PR00079. G6PDHDRGNASE.
ProtoNeti Search...

Publicationsi

  1. "Phylogenetic utility of partial DNA sequences of G6PDH at different taxonomic levels in Hexapoda with emphasis on Diptera."
    Soto-Adames F.N., Robertson H.M., Berlocher S.H.
    Ann. Entomol. Soc. Am. 87:723-736(1994)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiG6PD_CULPI
AccessioniPrimary (citable) accession number: Q23711
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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