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Q23711 (G6PD_CULPI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Alternative name(s):
Zwischenferment
Gene names
Name:ZW
OrganismCulex pipiens (House mosquito)
Taxonomic identifier7175 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex

Protein attributes

Sequence length153 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›153›153Glucose-6-phosphate 1-dehydrogenase
PRO_0000068091

Regions

Region150 – 1534Substrate binding

Sites

Binding site211NADP 1 By similarity
Binding site1201NADP 1; via carbonyl oxygen By similarity
Binding site1201Substrate By similarity

Experimental info

Non-terminal residue11
Non-terminal residue1531

Sequences

Sequence LengthMass (Da)Tools
Q23711 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F82E2F41C39C82E6

FASTA15317,999
        10         20         30         40         50         60 
LWWLFRDNLL PSVTKFVGYA RTKLTVAELK EKCHPYMKVD AAHEEKYDEF WALNFYVAGS 

        70         80         90        100        110        120 
YDGRRDFELL NQEIGKFEVG KTANRLFYLR LPPSVFETVT VHIRNTCMGL KGWNRIIVEK 

       130        140        150 
PFGRDADSSN KLSEHLAKLF TEDQLYRIDH YLG 

« Hide

References

[1]"Phylogenetic utility of partial DNA sequences of G6PDH at different taxonomic levels in Hexapoda with emphasis on Diptera."
Soto-Adames F.N., Robertson H.M., Berlocher S.H.
Ann. Entomol. Soc. Am. 87:723-736(1994) [AGRICOLA] [Europe PMC]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09034 mRNA. Translation: AAB02778.1.

3D structure databases

ProteinModelPortalQ23711.
SMRQ23711. Positions 1-153.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7176.CPIJ006761-PA.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001282. G6P_DH.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF00479. G6PD_N. 1 hit.
[Graphical view]
PRINTSPR00079. G6PDHDRGNASE.
ProtoNetSearch...

Entry information

Entry nameG6PD_CULPI
AccessionPrimary (citable) accession number: Q23711
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways