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Q23651

- ELP3_CAEEL

UniProt

Q23651 - ELP3_CAEEL

Protein

Probable elongator complex protein 3

Gene

elpc-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Cofactori

    Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi95 – 951Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi105 – 1051Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi108 – 1081Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC
    2. iron-sulfur cluster binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. phosphorylase kinase regulator activity Source: UniProtKB

    GO - Biological processi

    1. embryonic morphogenesis Source: WormBase
    2. olfactory learning Source: WormBase
    3. oocyte development Source: WormBase
    4. regulation of protein kinase activity Source: GOC
    5. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    6. spermatogenesis Source: WormBase
    7. transcription, DNA-templated Source: UniProtKB-KW
    8. translation Source: WormBase
    9. tRNA wobble uridine modification Source: WormBase
    10. vulval development Source: WormBase

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable elongator complex protein 3 (EC:2.3.1.48)
    Gene namesi
    Name:elpc-3
    ORF Names:ZK863.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiZK863.3; CE40344; WBGene00014123; elpc-3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. transcription elongation factor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 547547Probable elongator complex protein 3PRO_0000283994Add
    BLAST

    Proteomic databases

    PaxDbiQ23651.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.By similarity

    Protein-protein interaction databases

    STRINGi6239.ZK863.3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ23651.
    SMRiQ23651. Positions 486-535.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini392 – 547156N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ELP3 family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1243.
    GeneTreeiENSGT00390000013141.
    HOGENOMiHOG000227514.
    InParanoidiQ23651.
    KOiK07739.
    OMAiGYKVVSH.
    PhylomeDBiQ23651.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR01211. ELP3. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q23651-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQKGSQRAL LAQTINEIVK LLIEAHNQKK DVNLNRLKCI VAQKNGLSFQ    50
    PKLVDIIAGV PSDYKDSLLP KLKAKPVRTA SGIAVVAVMS KPHRCPHINF 100
    TGNICVYCPG GPDSDFEYST QSYTGYEPTS MRAIRARYNP YLQTRGRLNQ 150
    LMQLGHSVDK VEFIVMGGTF MSLPEDYRDF FIRNLHDALS GHTSASVEEA 200
    VAYSERSKMK CIGITIETRP DYCLPRHLND MLLYGCTRLE IGVQSTYEDV 250
    ARDTNRGHTV KSVCETFHMA KDTGYKVVIH MMPDLPNVGL ERDKEQFLEL 300
    FESPAFRPDG LKLYPTLVIR GTGLYELWKT GRYQSYPPSV LVDLIATILS 350
    LVPPWTRVYR VQRDIPMPLV SSGVEHGNLR EHAMAKMKEL GLKCRDVRTR 400
    EVGIQEIHNK VRPEDVELIR RDYTANGGWE TFISYEDPKQ DILIGLLRLR 450
    KISDKAHRPE LKGNVSVVRE LHVYGSVVSV ADRDPKKFQH QGYGSLLMEE 500
    AERIAREEHG SDKIAVISGV GTREYYRKLG YELDGPYMSK MLDSAAA 547
    Length:547
    Mass (Da):61,910
    Last modified:September 5, 2006 - v2
    Checksum:i6C7FAAEC59D8C6A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z78019 Genomic DNA. Translation: CAB01454.2.
    PIRiT28062.
    RefSeqiNP_506055.2. NM_073654.4.
    UniGeneiCel.23487.

    Genome annotation databases

    EnsemblMetazoaiZK863.3; ZK863.3; WBGene00014123.
    GeneIDi179669.
    KEGGicel:CELE_ZK863.3.
    UCSCiZK863.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z78019 Genomic DNA. Translation: CAB01454.2 .
    PIRi T28062.
    RefSeqi NP_506055.2. NM_073654.4.
    UniGenei Cel.23487.

    3D structure databases

    ProteinModelPortali Q23651.
    SMRi Q23651. Positions 486-535.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.ZK863.3.

    Proteomic databases

    PaxDbi Q23651.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZK863.3 ; ZK863.3 ; WBGene00014123 .
    GeneIDi 179669.
    KEGGi cel:CELE_ZK863.3.
    UCSCi ZK863.3. c. elegans.

    Organism-specific databases

    CTDi 179669.
    WormBasei ZK863.3 ; CE40344 ; WBGene00014123 ; elpc-3.

    Phylogenomic databases

    eggNOGi COG1243.
    GeneTreei ENSGT00390000013141.
    HOGENOMi HOG000227514.
    InParanoidi Q23651.
    KOi K07739.
    OMAi GYKVVSH.
    PhylomeDBi Q23651.

    Miscellaneous databases

    NextBioi 906382.
    PROi Q23651.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR01211. ELP3. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiELP3_CAEEL
    AccessioniPrimary (citable) accession number: Q23651
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3