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Q23651

- ELP3_CAEEL

UniProt

Q23651 - ELP3_CAEEL

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Protein

Probable elongator complex protein 3

Gene

elpc-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactori

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi105 – 1051Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi108 – 1081Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. iron-sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. phosphorylase kinase regulator activity Source: UniProtKB

GO - Biological processi

  1. embryonic morphogenesis Source: WormBase
  2. olfactory learning Source: WormBase
  3. oocyte development Source: WormBase
  4. regulation of protein kinase activity Source: GOC
  5. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  6. spermatogenesis Source: WormBase
  7. transcription, DNA-templated Source: UniProtKB-KW
  8. translation Source: WormBase
  9. tRNA wobble uridine modification Source: WormBase
  10. vulval development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:elpc-3
ORF Names:ZK863.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiZK863.3; CE40344; WBGene00014123; elpc-3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Probable elongator complex protein 3PRO_0000283994Add
BLAST

Proteomic databases

PaxDbiQ23651.

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (By similarity).By similarity

Protein-protein interaction databases

STRINGi6239.ZK863.3.

Structurei

3D structure databases

ProteinModelPortaliQ23651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini392 – 547156N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ELP3 family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1243.
GeneTreeiENSGT00390000013141.
HOGENOMiHOG000227514.
InParanoidiQ23651.
KOiK07739.
OMAiGYKVVSH.
PhylomeDBiQ23651.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23651-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQKGSQRAL LAQTINEIVK LLIEAHNQKK DVNLNRLKCI VAQKNGLSFQ
60 70 80 90 100
PKLVDIIAGV PSDYKDSLLP KLKAKPVRTA SGIAVVAVMS KPHRCPHINF
110 120 130 140 150
TGNICVYCPG GPDSDFEYST QSYTGYEPTS MRAIRARYNP YLQTRGRLNQ
160 170 180 190 200
LMQLGHSVDK VEFIVMGGTF MSLPEDYRDF FIRNLHDALS GHTSASVEEA
210 220 230 240 250
VAYSERSKMK CIGITIETRP DYCLPRHLND MLLYGCTRLE IGVQSTYEDV
260 270 280 290 300
ARDTNRGHTV KSVCETFHMA KDTGYKVVIH MMPDLPNVGL ERDKEQFLEL
310 320 330 340 350
FESPAFRPDG LKLYPTLVIR GTGLYELWKT GRYQSYPPSV LVDLIATILS
360 370 380 390 400
LVPPWTRVYR VQRDIPMPLV SSGVEHGNLR EHAMAKMKEL GLKCRDVRTR
410 420 430 440 450
EVGIQEIHNK VRPEDVELIR RDYTANGGWE TFISYEDPKQ DILIGLLRLR
460 470 480 490 500
KISDKAHRPE LKGNVSVVRE LHVYGSVVSV ADRDPKKFQH QGYGSLLMEE
510 520 530 540
AERIAREEHG SDKIAVISGV GTREYYRKLG YELDGPYMSK MLDSAAA
Length:547
Mass (Da):61,910
Last modified:September 5, 2006 - v2
Checksum:i6C7FAAEC59D8C6A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z78019 Genomic DNA. Translation: CAB01454.2.
PIRiT28062.
RefSeqiNP_506055.2. NM_073654.4.
UniGeneiCel.23487.

Genome annotation databases

EnsemblMetazoaiZK863.3; ZK863.3; WBGene00014123.
GeneIDi179669.
KEGGicel:CELE_ZK863.3.
UCSCiZK863.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z78019 Genomic DNA. Translation: CAB01454.2 .
PIRi T28062.
RefSeqi NP_506055.2. NM_073654.4.
UniGenei Cel.23487.

3D structure databases

ProteinModelPortali Q23651.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.ZK863.3.

Proteomic databases

PaxDbi Q23651.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZK863.3 ; ZK863.3 ; WBGene00014123 .
GeneIDi 179669.
KEGGi cel:CELE_ZK863.3.
UCSCi ZK863.3. c. elegans.

Organism-specific databases

CTDi 179669.
WormBasei ZK863.3 ; CE40344 ; WBGene00014123 ; elpc-3.

Phylogenomic databases

eggNOGi COG1243.
GeneTreei ENSGT00390000013141.
HOGENOMi HOG000227514.
InParanoidi Q23651.
KOi K07739.
OMAi GYKVVSH.
PhylomeDBi Q23651.

Miscellaneous databases

NextBioi 906382.
PROi Q23651.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR01211. ELP3. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiELP3_CAEEL
AccessioniPrimary (citable) accession number: Q23651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3