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Protein

Cullin-5

Gene

cul-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-CEL-8863795 Downregulation of ERBB2 signaling
R-CEL-8951664 Neddylation
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Cullin-5
Short name:
CUL-5
Gene namesi
Name:cul-5
ORF Names:ZK856.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiZK856.1 ; CE41096 ; WBGene00000840 ; cul-5

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197841 – 765Cullin-5Add BLAST765

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki709Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)By similarity

Post-translational modificationi

Neddylated; which enhances the ubiquitination activity of SCF-like complex.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ23639
PaxDbiQ23639
PeptideAtlasiQ23639

PTM databases

iPTMnetiQ23639

Expressioni

Gene expression databases

BgeeiWBGene00000840

Interactioni

Subunit structurei

Interacts with rbx-1 and rbx-2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi44444, 1 interactor
DIPiDIP-25847N
IntActiQ23639, 2 interactors
MINTiQ23639
STRINGi6239.ZK856.1

Structurei

3D structure databases

ProteinModelPortaliQ23639
SMRiQ23639
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2285 Eukaryota
COG5647 LUCA
GeneTreeiENSGT00760000119212
HOGENOMiHOG000007610
InParanoidiQ23639
KOiK10612
OMAiQEFAIVK
OrthoDBiEOG091G02MQ
PhylomeDBiQ23639

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016157 Cullin_CS
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR019559 Cullin_neddylation_domain
IPR016159 Cullin_repeat-like_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00888 Cullin, 1 hit
PF10557 Cullin_Nedd8, 1 hit
SMARTiView protein in SMART
SM00182 CULLIN, 1 hit
SM00884 Cullin_Nedd8, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF74788 SSF74788, 1 hit
SSF75632 SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS01256 CULLIN_1, 1 hit
PS50069 CULLIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q23639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFDEEWSKA DPIVHALLHQ KSVTPAAWQD LFYHVYKITS WVDDGPLKIR
60 70 80 90 100
DILTRCINDY VHEANKRIRS LQTDGSLLIG YIKEWNRFYQ QANILPLPFK
110 120 130 140 150
KIDESSRRRS VPETPEESIR TVMLEKWNEI IFMNISEQLL VEALRLVKEE
160 170 180 190 200
RDGNIIDAQN VIGIRESFVA LNDRAGEDPL LVYRQSFERQ FIEQTTEYYK
210 220 230 240 250
KICGNLLNEL GVLEYMVYAD KKLEEEQQRA KRYLEMNSPT SGKHMEKAVI
260 270 280 290 300
ALVESFEDTI LAECSKLIAS KDVERLQRLY RLIRRTRSGI DTVLKCIDTH
310 320 330 340 350
IRTEGLNDMR NNAENLSTDP ERYVQQLLLM FDKFSSLVRE GFCDDARLLT
360 370 380 390 400
ARDKAFRAVV NDSSIFKTEM MNKKGRTLSV ESKCAELLAN YCDLLLRKTQ
410 420 430 440 450
LSKKLTSEEI DEKLNQVLLV LKYVENKDVF MRFHRAHLSR RLILEMSADQ
460 470 480 490 500
EKEEMMVTKL RECGMPSDAV NKLSRMLQDI ELNKDMNSSF KKALTGTNNN
510 520 530 540 550
KSIADSINMK VLNGGAWGRG GSERIRFSLP RELEDFVPEM EAFYKKQHNG
560 570 580 590 600
RKLCWMHHWS SGTMVFGTAN GGRFDLECTT FQMAVLFCFN DRAHDKISLE
610 620 630 640 650
TLRLATELPD AELNRTLLSL VAYPKMRYQI LLCDVPSTTV TARDFTDSTK
660 670 680 690 700
FLINHDFNVV KNGKSQQRGK VNLIGRLQLS LEANAEKEHE SIVALRELRV
710 720 730 740 750
QEGIVKILKT RKTYTLAQLT MELVEILKPL FIPNRKIIKE QIDWLIENKY
760
MERRADDINT FVYIS
Length:765
Mass (Da):88,908
Last modified:January 15, 2008 - v2
Checksum:i2C264BB19B36D04D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70783 Genomic DNA Translation: CAA94852.2
PIRiT28043
RefSeqiNP_505616.2, NM_073215.4
UniGeneiCel.16970

Genome annotation databases

EnsemblMetazoaiZK856.1; ZK856.1; WBGene00000840
GeneIDi179413
KEGGicel:CELE_ZK856.1
UCSCiZK856.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiCUL5_CAEEL
AccessioniPrimary (citable) accession number: Q23639
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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