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Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial

Gene

ZK836.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: GO_Central
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial (EC:1.2.4.2)
Gene namesi
ORF Names:ZK836.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiZK836.2a; CE35706; WBGene00014098.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: GO_Central
  2. oxoglutarate dehydrogenase complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 911Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrialPRO_0000307942
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PaxDbiQ23629.

Expressioni

Gene expression databases

ExpressionAtlasiQ23629. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK836.2.1.

Structurei

3D structure databases

ProteinModelPortaliQ23629.
SMRiQ23629. Positions 56-910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
GeneTreeiENSGT00530000063092.
HOGENOMiHOG000259588.
InParanoidiQ23629.
KOiK15791.
OMAiEHSSCRM.
PhylomeDBiQ23629.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q23629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLRSAGGSI RRAITQRQNQ HRFYRPGHGV FGHLPDPPKR VFENQGGLTP
60 70 80 90 100
ENAQRVHLIN AFRRYGYLEA DLDPLGLRKV ESVAELDPAI YGLSLDENVK
110 120 130 140 150
GNFSLHDLAE QLRHIYCGPT AIEFMHINNW EERQWISQNF ENCIAEELRK
160 170 180 190 200
EELLRIGDLM LKCENFDKFL STKFPTLKRY GAEGAESMFA FFSELFEGAA
210 220 230 240 250
EKQVEEIIIG IAHRGRLNLL TQLMDFPPVH MFRKIKGRAE FPESADAAGD
260 270 280 290 300
VLSHLVSSFD YKGSEGNVHV TMLPNPSHLE AVNPVAMGKA RARAWSMNKG
310 320 330 340 350
DYSPDERSAR AGDSVLNVLV HGDGAFTGQG VVWESIALSQ APHFRLGGTV
360 370 380 390 400
HLVTNNQIAF TAESSVGRSS THCTDIAKAF EYPVIHVNGD HPEEVVKATR
410 420 430 440 450
LALAYRERFR KDVFINLVCF RRWGHNELDD PTFTSPVMYK EVEARESVPR
460 470 480 490 500
LFLDRLVEEG FTTEEAVKEQ LQKHTEQLNN ELKKVDSTVP IDISHRGRWE
510 520 530 540 550
GFKQAPKAIE SWDTGVATDL LRFIGAGSVK VPEDFDTHKH LYKMHIDSRM
560 570 580 590 600
QKMQTGEGID WATAEAMAFG SILLEGNDVR ISGQDVGRGT FCHRHAMMVD
610 620 630 640 650
QSTDHIHIPL NELVEEQKNQ LEVANNLLSE EAILGFEWGF SSENPRRLCI
660 670 680 690 700
WEAQFGDFFN GAQIIIDTFL ASAESKWLTS SGLTMLLPHG FDGAGPEHSS
710 720 730 740 750
CRMERFLQLC DSREDQTPVD GENVNMRVAN PTTSAQYFHL LRRQVVPNYR
760 770 780 790 800
KPLIVVGPKI LLRHPKAAST INEFGPGTTY QNVISEEHAT SSQKIKKVIF
810 820 830 840 850
VSGKHWINVE KARDERGLKD SVAIVRVEML CPFPVVDLQA VLKKYPGAQD
860 870 880 890 900
FVWSQEEPRN AGAWSFVRPR FENALGVRLK FAGRPELAWT ATAIGEHHTK
910
EAEEVINQTF A
Length:911
Mass (Da):102,731
Last modified:July 5, 2004 - v4
Checksum:iD935381071E95A85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78201, Z78019 Genomic DNA. Translation: CAB01590.2.
PIRiT28034.
RefSeqiNP_001256410.1. NM_001269481.1.
UniGeneiCel.5653.

Genome annotation databases

EnsemblMetazoaiZK836.2a; ZK836.2a; WBGene00014098.
GeneIDi179674.
KEGGicel:CELE_ZK836.2.
UCSCiZK836.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78201, Z78019 Genomic DNA. Translation: CAB01590.2.
PIRiT28034.
RefSeqiNP_001256410.1. NM_001269481.1.
UniGeneiCel.5653.

3D structure databases

ProteinModelPortaliQ23629.
SMRiQ23629. Positions 56-910.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK836.2.1.

Proteomic databases

PaxDbiQ23629.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK836.2a; ZK836.2a; WBGene00014098.
GeneIDi179674.
KEGGicel:CELE_ZK836.2.
UCSCiZK836.2.1. c. elegans.

Organism-specific databases

CTDi179674.
WormBaseiZK836.2a; CE35706; WBGene00014098.

Phylogenomic databases

eggNOGiCOG0567.
GeneTreeiENSGT00530000063092.
HOGENOMiHOG000259588.
InParanoidiQ23629.
KOiK15791.
OMAiEHSSCRM.
PhylomeDBiQ23629.

Miscellaneous databases

NextBioi906402.
PROiQ23629.

Gene expression databases

ExpressionAtlasiQ23629. baseline.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiDHTK1_CAEEL
AccessioniPrimary (citable) accession number: Q23629
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 96 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.