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Q23629

- DHTK1_CAEEL

UniProt

Q23629 - DHTK1_CAEEL

Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial

Gene

ZK836.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 4 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial (EC:1.2.4.2)
    Gene namesi
    ORF Names:ZK836.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiZK836.2a; CE35706; WBGene00014098.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 911Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrialPRO_0000307942
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiQ23629.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.ZK836.2.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ23629.
    SMRiQ23629. Positions 56-910.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0567.
    GeneTreeiENSGT00530000063092.
    HOGENOMiHOG000259588.
    InParanoidiQ23629.
    KOiK15791.
    OMAiLCSGKHY.
    PhylomeDBiQ23629.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q23629-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMLRSAGGSI RRAITQRQNQ HRFYRPGHGV FGHLPDPPKR VFENQGGLTP    50
    ENAQRVHLIN AFRRYGYLEA DLDPLGLRKV ESVAELDPAI YGLSLDENVK 100
    GNFSLHDLAE QLRHIYCGPT AIEFMHINNW EERQWISQNF ENCIAEELRK 150
    EELLRIGDLM LKCENFDKFL STKFPTLKRY GAEGAESMFA FFSELFEGAA 200
    EKQVEEIIIG IAHRGRLNLL TQLMDFPPVH MFRKIKGRAE FPESADAAGD 250
    VLSHLVSSFD YKGSEGNVHV TMLPNPSHLE AVNPVAMGKA RARAWSMNKG 300
    DYSPDERSAR AGDSVLNVLV HGDGAFTGQG VVWESIALSQ APHFRLGGTV 350
    HLVTNNQIAF TAESSVGRSS THCTDIAKAF EYPVIHVNGD HPEEVVKATR 400
    LALAYRERFR KDVFINLVCF RRWGHNELDD PTFTSPVMYK EVEARESVPR 450
    LFLDRLVEEG FTTEEAVKEQ LQKHTEQLNN ELKKVDSTVP IDISHRGRWE 500
    GFKQAPKAIE SWDTGVATDL LRFIGAGSVK VPEDFDTHKH LYKMHIDSRM 550
    QKMQTGEGID WATAEAMAFG SILLEGNDVR ISGQDVGRGT FCHRHAMMVD 600
    QSTDHIHIPL NELVEEQKNQ LEVANNLLSE EAILGFEWGF SSENPRRLCI 650
    WEAQFGDFFN GAQIIIDTFL ASAESKWLTS SGLTMLLPHG FDGAGPEHSS 700
    CRMERFLQLC DSREDQTPVD GENVNMRVAN PTTSAQYFHL LRRQVVPNYR 750
    KPLIVVGPKI LLRHPKAAST INEFGPGTTY QNVISEEHAT SSQKIKKVIF 800
    VSGKHWINVE KARDERGLKD SVAIVRVEML CPFPVVDLQA VLKKYPGAQD 850
    FVWSQEEPRN AGAWSFVRPR FENALGVRLK FAGRPELAWT ATAIGEHHTK 900
    EAEEVINQTF A 911
    Length:911
    Mass (Da):102,731
    Last modified:July 5, 2004 - v4
    Checksum:iD935381071E95A85
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z78201, Z78019 Genomic DNA. Translation: CAB01590.2.
    PIRiT28034.
    RefSeqiNP_001256410.1. NM_001269481.1.
    UniGeneiCel.5653.

    Genome annotation databases

    EnsemblMetazoaiZK836.2a; ZK836.2a; WBGene00014098.
    GeneIDi179674.
    KEGGicel:CELE_ZK836.2.
    UCSCiZK836.2.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z78201 , Z78019 Genomic DNA. Translation: CAB01590.2 .
    PIRi T28034.
    RefSeqi NP_001256410.1. NM_001269481.1.
    UniGenei Cel.5653.

    3D structure databases

    ProteinModelPortali Q23629.
    SMRi Q23629. Positions 56-910.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.ZK836.2.1.

    Proteomic databases

    PaxDbi Q23629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZK836.2a ; ZK836.2a ; WBGene00014098 .
    GeneIDi 179674.
    KEGGi cel:CELE_ZK836.2.
    UCSCi ZK836.2.1. c. elegans.

    Organism-specific databases

    CTDi 179674.
    WormBasei ZK836.2a ; CE35706 ; WBGene00014098 .

    Phylogenomic databases

    eggNOGi COG0567.
    GeneTreei ENSGT00530000063092.
    HOGENOMi HOG000259588.
    InParanoidi Q23629.
    KOi K15791.
    OMAi LCSGKHY.
    PhylomeDBi Q23629.

    Miscellaneous databases

    NextBioi 906402.
    PROi Q23629.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiDHTK1_CAEEL
    AccessioniPrimary (citable) accession number: Q23629
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3