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Q23629 (DHTK1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial

EC=1.2.4.2
Gene names
ORF Names:ZK836.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length911 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subcellular location

Mitochondrion Potential.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandThiamine pyrophosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxoglutarate dehydrogenase (succinyl-transferring) activity

Inferred from electronic annotation. Source: UniProtKB-EC

thiamine pyrophosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 911Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrialPRO_0000307942

Sequences

Sequence LengthMass (Da)Tools
Q23629 [UniParc].

Last modified July 5, 2004. Version 4.
Checksum: D935381071E95A85

FASTA911102,731
        10         20         30         40         50         60 
MMLRSAGGSI RRAITQRQNQ HRFYRPGHGV FGHLPDPPKR VFENQGGLTP ENAQRVHLIN 

        70         80         90        100        110        120 
AFRRYGYLEA DLDPLGLRKV ESVAELDPAI YGLSLDENVK GNFSLHDLAE QLRHIYCGPT 

       130        140        150        160        170        180 
AIEFMHINNW EERQWISQNF ENCIAEELRK EELLRIGDLM LKCENFDKFL STKFPTLKRY 

       190        200        210        220        230        240 
GAEGAESMFA FFSELFEGAA EKQVEEIIIG IAHRGRLNLL TQLMDFPPVH MFRKIKGRAE 

       250        260        270        280        290        300 
FPESADAAGD VLSHLVSSFD YKGSEGNVHV TMLPNPSHLE AVNPVAMGKA RARAWSMNKG 

       310        320        330        340        350        360 
DYSPDERSAR AGDSVLNVLV HGDGAFTGQG VVWESIALSQ APHFRLGGTV HLVTNNQIAF 

       370        380        390        400        410        420 
TAESSVGRSS THCTDIAKAF EYPVIHVNGD HPEEVVKATR LALAYRERFR KDVFINLVCF 

       430        440        450        460        470        480 
RRWGHNELDD PTFTSPVMYK EVEARESVPR LFLDRLVEEG FTTEEAVKEQ LQKHTEQLNN 

       490        500        510        520        530        540 
ELKKVDSTVP IDISHRGRWE GFKQAPKAIE SWDTGVATDL LRFIGAGSVK VPEDFDTHKH 

       550        560        570        580        590        600 
LYKMHIDSRM QKMQTGEGID WATAEAMAFG SILLEGNDVR ISGQDVGRGT FCHRHAMMVD 

       610        620        630        640        650        660 
QSTDHIHIPL NELVEEQKNQ LEVANNLLSE EAILGFEWGF SSENPRRLCI WEAQFGDFFN 

       670        680        690        700        710        720 
GAQIIIDTFL ASAESKWLTS SGLTMLLPHG FDGAGPEHSS CRMERFLQLC DSREDQTPVD 

       730        740        750        760        770        780 
GENVNMRVAN PTTSAQYFHL LRRQVVPNYR KPLIVVGPKI LLRHPKAAST INEFGPGTTY 

       790        800        810        820        830        840 
QNVISEEHAT SSQKIKKVIF VSGKHWINVE KARDERGLKD SVAIVRVEML CPFPVVDLQA 

       850        860        870        880        890        900 
VLKKYPGAQD FVWSQEEPRN AGAWSFVRPR FENALGVRLK FAGRPELAWT ATAIGEHHTK 

       910 
EAEEVINQTF A 

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z78201, Z78019 Genomic DNA. Translation: CAB01590.2.
PIRT28034.
RefSeqNP_001256410.1. NM_001269481.1.
UniGeneCel.5653.

3D structure databases

ProteinModelPortalQ23629.
SMRQ23629. Positions 56-910.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.ZK836.2.1.

Proteomic databases

PaxDbQ23629.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK836.2a; ZK836.2a; ZK836.2.
GeneID179674.
KEGGcel:CELE_ZK836.2.
UCSCZK836.2.1. c. elegans.

Organism-specific databases

CTD179674.
WormBaseZK836.2a; CE35706; WBGene00014098.

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
InParanoidQ23629.
KOK15791.
OMALCSGKHY.
PhylomeDBQ23629.

Family and domain databases

InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Other

NextBio906402.
PROQ23629.

Entry information

Entry nameDHTK1_CAEEL
AccessionPrimary (citable) accession number: Q23629
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 90 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase