Reviewed, UniProtKB/Swiss-Prot Q23629 (DHTK1_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial
    EC=1.2.4.2

Gene names

ORF Names:

ZK836.2

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	911 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.
Cofactor	Thiamine pyrophosphate By similarity.
Subcellular location	Mitochondrion Potential.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamin pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 911		Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial		PRO_0000307942

Sequences

	Sequence		Length	Mass (Da)
	Q23629-1 [UniParc]. Last modified July 5, 2004. Version 4. Checksum: D935381071E95A85	FASTA	911	102,731
	10 20 30 40 50 60 MMLRSAGGSI RRAITQRQNQ HRFYRPGHGV FGHLPDPPKR VFENQGGLTP ENAQRVHLIN 70 80 90 100 110 120 AFRRYGYLEA DLDPLGLRKV ESVAELDPAI YGLSLDENVK GNFSLHDLAE QLRHIYCGPT 130 140 150 160 170 180 AIEFMHINNW EERQWISQNF ENCIAEELRK EELLRIGDLM LKCENFDKFL STKFPTLKRY 190 200 210 220 230 240 GAEGAESMFA FFSELFEGAA EKQVEEIIIG IAHRGRLNLL TQLMDFPPVH MFRKIKGRAE 250 260 270 280 290 300 FPESADAAGD VLSHLVSSFD YKGSEGNVHV TMLPNPSHLE AVNPVAMGKA RARAWSMNKG 310 320 330 340 350 360 DYSPDERSAR AGDSVLNVLV HGDGAFTGQG VVWESIALSQ APHFRLGGTV HLVTNNQIAF 370 380 390 400 410 420 TAESSVGRSS THCTDIAKAF EYPVIHVNGD HPEEVVKATR LALAYRERFR KDVFINLVCF 430 440 450 460 470 480 RRWGHNELDD PTFTSPVMYK EVEARESVPR LFLDRLVEEG FTTEEAVKEQ LQKHTEQLNN 490 500 510 520 530 540 ELKKVDSTVP IDISHRGRWE GFKQAPKAIE SWDTGVATDL LRFIGAGSVK VPEDFDTHKH 550 560 570 580 590 600 LYKMHIDSRM QKMQTGEGID WATAEAMAFG SILLEGNDVR ISGQDVGRGT FCHRHAMMVD 610 620 630 640 650 660 QSTDHIHIPL NELVEEQKNQ LEVANNLLSE EAILGFEWGF SSENPRRLCI WEAQFGDFFN 670 680 690 700 710 720 GAQIIIDTFL ASAESKWLTS SGLTMLLPHG FDGAGPEHSS CRMERFLQLC DSREDQTPVD 730 740 750 760 770 780 GENVNMRVAN PTTSAQYFHL LRRQVVPNYR KPLIVVGPKI LLRHPKAAST INEFGPGTTY 790 800 810 820 830 840 QNVISEEHAT SSQKIKKVIF VSGKHWINVE KARDERGLKD SVAIVRVEML CPFPVVDLQA 850 860 870 880 890 900 VLKKYPGAQD FVWSQEEPRN AGAWSFVRPR FENALGVRLK FAGRPELAWT ATAIGEHHTK 910 EAEEVINQTF A

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z78201, Z78019 Genomic DNA. Translation: CAB01590.2. Z78019, Z78201 Genomic DNA. Translation: CAE46691.1.
PIR	T28034.
RefSeq	NP_506060.2.
UniGene	Cel.5653
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ZK836.2. Caenorhabditis elegans. [Contig view]
GeneID	179674.
KEGG	cel:ZK836.2.
Organism-specific databases
WormBase	WBGene00014098. ZK836.2.
WormPep	ZK836.2. CE35706. [WorfDB]
Phylogenomic databases
OMA	Q23629. MIRNFRK.
Enzyme and pathway databases
BRENDA	1.2.4.2. 672.
Gene expression databases
ArrayExpress	Q23629.
Family and domain databases
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase_central-reg. [Graphical view]
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	906402.

Entry information

Entry name

DHTK1_CAEEL

Accession

Primary (citable) accession number: Q23629

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 56 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project