Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase

Gene

CELE_ZK622.1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ23554.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
ORF Names:CELE_ZK622.1Imported, ZK622.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK622.1; CE05098; WBGene00022780.

PTM / Processingi

Proteomic databases

PaxDbiQ23554.
PRIDEiQ23554.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK622.1.

Structurei

3D structure databases

ProteinModelPortaliQ23554.
SMRiQ23554. Positions 32-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12695SH2InterPro annotationAdd
BLAST
Domaini138 – 402265Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ23554.
KOiK08253.
OMAiPINKQDW.
OrthoDBiEOG708VXW.
PhylomeDBiQ23554.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGKQDSHRA QKTVEASLRS DGTRKKHQDM DWYHGLLPRA DINTLLENDG
60 70 80 90 100
DFLVRTSHIV GQDSAKTVLS VKWKGKCHHW QLQEKEDGSI VIEERKFESV
110 120 130 140 150
LDMVTTLRMK RLPVSANCPA LLLNPINKQD WELRHDQIKL GKMLGEGAFG
160 170 180 190 200
GVYKAAFYCK GEKRMVAVKV NKGNEKISTR AMIEDVCKEA RIMRQYQHPN
210 220 230 240 250
VVCFFGVCVE KEPIMLVMEL ASQGALDSFL KNEKNNVSLR DKLKYSFDAS
260 270 280 290 300
KGLEYLHQHG CIHRDVAARN FLMHKNVVKI TDFGLSKQLS DLAHKYKLKD
310 320 330 340 350
IQAKLPIRWL APEVIVTATY TFKSDVYSFG ILLWEIFMDG AIPYPGMKLA
360 370 380 390 400
EVKQKVKNGY RMDAPDRMPA FVRNIMISQC WPQNPEDRGN MNEIRLAMES
410
VLDGKVAASN NRSVYYKSS
Length:419
Mass (Da):47,901
Last modified:November 1, 1996 - v1
Checksum:i7BF7CEAFDD5F7B48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD68003.1.
PIRiT27938.
RefSeqiNP_494994.1. NM_062593.1.
UniGeneiCel.28648.

Genome annotation databases

EnsemblMetazoaiZK622.1; ZK622.1; WBGene00022780.
GeneIDi191366.
KEGGicel:CELE_ZK622.1.
UCSCiZK622.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD68003.1.
PIRiT27938.
RefSeqiNP_494994.1. NM_062593.1.
UniGeneiCel.28648.

3D structure databases

ProteinModelPortaliQ23554.
SMRiQ23554. Positions 32-401.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK622.1.

Proteomic databases

PaxDbiQ23554.
PRIDEiQ23554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK622.1; ZK622.1; WBGene00022780.
GeneIDi191366.
KEGGicel:CELE_ZK622.1.
UCSCiZK622.1. c. elegans.

Organism-specific databases

CTDi191366.
WormBaseiZK622.1; CE05098; WBGene00022780.

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ23554.
KOiK08253.
OMAiPINKQDW.
OrthoDBiEOG708VXW.
PhylomeDBiQ23554.

Enzyme and pathway databases

SignaLinkiQ23554.

Miscellaneous databases

NextBioi948908.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ23554_CAEEL
AccessioniPrimary (citable) accession number: Q23554
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.