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Protein

Twitchin

Gene

unc-22

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Enzyme regulationi

Forces generated by the contraction/relaxation cycles of muscle activity separate the regulatory domain from the catalytic core, activating the enzyme. At rest, the kinase domain is in a closed conformation. The active site is occupied by the autoinhibitory region, which makes extensive contact with the catalytic site, blocking substrate binding. At low forces the regulatory tail will unravel reversibly and expose the active site to its substrates, potentially stabilized by binding of Ca/CALM. At high forces the kinase begins to unfold and the integrity of the active site is disrupted.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei6290 – 62901ATPPROSITE-ProRule annotationBy similarity
Active sitei6382 – 63821Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6267 – 62759ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: WormBase

GO - Biological processi

  • negative regulation of cell division Source: UniProtKB
  • peptidyl-serine phosphorylation Source: WormBase
  • peptidyl-threonine phosphorylation Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ23551.

Names & Taxonomyi

Protein namesi
Recommended name:
Twitchin1 Publication (EC:2.7.11.1)
Alternative name(s):
Uncoordinated protein 221 Publication
Gene namesi
Name:unc-22Imported
ORF Names:ZK617.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiZK617.1a; CE33017; WBGene00006759; unc-22.
ZK617.1b; CE33018; WBGene00006759; unc-22.
ZK617.1c; CE47057; WBGene00006759; unc-22.
ZK617.1d; CE44671; WBGene00006759; unc-22.
ZK617.1e; CE44668; WBGene00006759; unc-22.

Subcellular locationi

GO - Cellular componenti

  • A band Source: WormBase
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Body muscles are unable to develop or sustain normal contractions but small regions within the myofilament lattice of individual muscle cells contract transiently in the absence of contraction of the adjacent lattice. This results in a nearly constant body twitching phenotype.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 71587158TwitchinPRO_0000404604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 81PROSITE-ProRule annotation
Disulfide bondi132 ↔ 188PROSITE-ProRule annotation
Disulfide bondi1150 ↔ 1201PROSITE-ProRule annotation
Disulfide bondi5944 ↔ 5995PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ23551.
PaxDbiQ23551.
PeptideAtlasiQ23551.
PRIDEiQ23551.

Expressioni

Tissue specificityi

Localized to the outer portions of the muscle A-bands in the body wall, anal, vulval, and pharyngeal muscles.1 Publication

Gene expression databases

ExpressionAtlasiQ23551. baseline.

Interactioni

Protein-protein interaction databases

BioGridi43229. 1 interaction.
STRINGi6239.ZK617.1b.2.

Structurei

Secondary structure

1
7158
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4158 – 41614Combined sources
Beta strandi4163 – 41653Combined sources
Beta strandi4168 – 41747Combined sources
Beta strandi4180 – 41845Combined sources
Turni4187 – 41893Combined sources
Beta strandi4196 – 42016Combined sources
Beta strandi4204 – 42085Combined sources
Helixi4214 – 42163Combined sources
Beta strandi4218 – 42269Combined sources
Beta strandi4229 – 423911Combined sources
Beta strandi6116 – 61238Combined sources
Beta strandi6128 – 61336Combined sources
Beta strandi6139 – 61413Combined sources
Beta strandi6145 – 615511Combined sources
Beta strandi6159 – 617113Combined sources
Beta strandi6179 – 618810Combined sources
Helixi6206 – 62083Combined sources
Beta strandi6219 – 62213Combined sources
Helixi6234 – 62374Combined sources
Helixi6241 – 62444Combined sources
Beta strandi6253 – 62553Combined sources
Helixi6257 – 62593Combined sources
Beta strandi6261 – 627010Combined sources
Beta strandi6273 – 62808Combined sources
Turni6281 – 62833Combined sources
Beta strandi6286 – 62938Combined sources
Helixi6297 – 631216Combined sources
Beta strandi6321 – 63266Combined sources
Beta strandi6328 – 63369Combined sources
Helixi6343 – 63475Combined sources
Helixi6356 – 637520Combined sources
Helixi6385 – 63873Combined sources
Beta strandi6388 – 63947Combined sources
Beta strandi6398 – 64003Combined sources
Beta strandi6413 – 64186Combined sources
Helixi6422 – 64243Combined sources
Helixi6427 – 64304Combined sources
Helixi6437 – 645317Combined sources
Helixi6463 – 64719Combined sources
Helixi6480 – 64823Combined sources
Helixi6487 – 64948Combined sources
Helixi6501 – 65033Combined sources
Helixi6507 – 65126Combined sources
Turni6514 – 65163Combined sources
Turni6522 – 65254Combined sources
Helixi6530 – 65334Combined sources
Helixi6534 – 654310Combined sources
Turni6544 – 65463Combined sources
Helixi6553 – 65597Combined sources
Helixi6562 – 65665Combined sources
Turni6568 – 65725Combined sources
Beta strandi6573 – 65786Combined sources
Helixi6580 – 65834Combined sources
Beta strandi6586 – 65894Combined sources
Beta strandi6594 – 65974Combined sources
Beta strandi6602 – 66098Combined sources
Beta strandi6615 – 66206Combined sources
Beta strandi6627 – 663610Combined sources
Beta strandi6639 – 66446Combined sources
Helixi6649 – 66513Combined sources
Beta strandi6653 – 66619Combined sources
Beta strandi6664 – 667512Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KOAX-ray3.30A6209-6699[»]
1WITNMR-A4148-4240[»]
1WIUNMR-A4148-4240[»]
3UTOX-ray2.40A/B6108-6675[»]
ProteinModelPortaliQ23551.
SMRiQ23551. Positions 4148-4240, 6112-6675.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ23551.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 9793Ig-like 1Sequence analysisAdd
BLAST
Domaini111 – 20494Ig-like 2Sequence analysisAdd
BLAST
Domaini377 – 46690Ig-like 3Sequence analysisAdd
BLAST
Repeati718 – 76447Kelch 1Sequence analysisAdd
BLAST
Domaini980 – 107293Ig-like 4Sequence analysisAdd
BLAST
Domaini1122 – 121392Ig-like 5Sequence analysisAdd
BLAST
Domaini1217 – 130690Ig-like 6Sequence analysisAdd
BLAST
Domaini1312 – 139887Ig-like 7Sequence analysisAdd
BLAST
Domaini1598 – 169093Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini1696 – 179196Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini1891 – 198898Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini1994 – 208794Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Repeati2014 – 205845Kelch 2Sequence analysisAdd
BLAST
Domaini2086 – 218196Ig-like 8Sequence analysisAdd
BLAST
Domaini2189 – 228294Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Repeati2207 – 225347Kelch 3Sequence analysisAdd
BLAST
Domaini2288 – 238396Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini2483 – 257694Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Repeati2502 – 254746Kelch 4Sequence analysisAdd
BLAST
Domaini2579 – 267597Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini2679 – 276385Ig-like 9Sequence analysisAdd
BLAST
Domaini2775 – 286894Fibronectin type-III 9PROSITE-ProRule annotationAdd
BLAST
Repeati2793 – 283947Kelch 5Sequence analysisAdd
BLAST
Domaini2874 – 296895Fibronectin type-III 10PROSITE-ProRule annotationAdd
BLAST
Domaini2972 – 306291Ig-like 10Sequence analysisAdd
BLAST
Domaini3070 – 316596Fibronectin type-III 11PROSITE-ProRule annotationAdd
BLAST
Repeati3089 – 313446Kelch 6Sequence analysisAdd
BLAST
Domaini3171 – 326595Fibronectin type-III 12PROSITE-ProRule annotationAdd
BLAST
Domaini3268 – 335891Ig-like 11Sequence analysisAdd
BLAST
Domaini3365 – 345995Fibronectin type-III 13PROSITE-ProRule annotationAdd
BLAST
Repeati3384 – 343047Kelch 7Sequence analysisAdd
BLAST
Domaini3465 – 355995Fibronectin type-III 14PROSITE-ProRule annotationAdd
BLAST
Domaini3563 – 365391Ig-like 12Sequence analysisAdd
BLAST
Domaini3661 – 375393Fibronectin type-III 15PROSITE-ProRule annotationAdd
BLAST
Domaini3759 – 385395Fibronectin type-III 16PROSITE-ProRule annotationAdd
BLAST
Domaini3954 – 404794Fibronectin type-III 17PROSITE-ProRule annotationAdd
BLAST
Repeati3972 – 401847Kelch 8Sequence analysisAdd
BLAST
Domaini4053 – 414694Fibronectin type-III 18PROSITE-ProRule annotationAdd
BLAST
Domaini4246 – 434095Fibronectin type-III 19PROSITE-ProRule annotationAdd
BLAST
Repeati4265 – 431046Kelch 9Sequence analysisAdd
BLAST
Domaini4346 – 444095Fibronectin type-III 20PROSITE-ProRule annotationAdd
BLAST
Repeati4365 – 441046Kelch 10Sequence analysisAdd
BLAST
Domaini4445 – 453187Ig-like 13Sequence analysisAdd
BLAST
Domaini4538 – 463194Fibronectin type-III 21PROSITE-ProRule annotationAdd
BLAST
Repeati4557 – 460246Kelch 11Sequence analysisAdd
BLAST
Domaini4637 – 473397Fibronectin type-III 22PROSITE-ProRule annotationAdd
BLAST
Domaini4739 – 483496Fibronectin type-III 23PROSITE-ProRule annotationAdd
BLAST
Domaini4936 – 502893Fibronectin type-III 24PROSITE-ProRule annotationAdd
BLAST
Domaini5034 – 512996Fibronectin type-III 25PROSITE-ProRule annotationAdd
BLAST
Domaini5231 – 532696Fibronectin type-III 26PROSITE-ProRule annotationAdd
BLAST
Repeati5287 – 533549Kelch 12Sequence analysisAdd
BLAST
Domaini5333 – 542795Fibronectin type-III 27PROSITE-ProRule annotationAdd
BLAST
Domaini5430 – 552899Fibronectin type-III 28PROSITE-ProRule annotationAdd
BLAST
Domaini5533 – 562189Ig-like 14Sequence analysisAdd
BLAST
Domaini5723 – 581795Fibronectin type-III 29PROSITE-ProRule annotationAdd
BLAST
Repeati5742 – 578746Kelch 13Sequence analysisAdd
BLAST
Domaini5823 – 591997Fibronectin type-III 30PROSITE-ProRule annotationAdd
BLAST
Domaini5923 – 601189Ig-like 15Sequence analysisAdd
BLAST
Domaini6016 – 610792Ig-like 16Sequence analysisAdd
BLAST
Domaini6114 – 620794Fibronectin type-III 31PROSITE-ProRule annotationAdd
BLAST
Domaini6261 – 6516256Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini6585 – 667389Ig-like 17Sequence analysisAdd
BLAST
Domaini6696 – 6795100Ig-like 18Sequence analysisAdd
BLAST
Domaini6863 – 695290Ig-like 19Sequence analysisAdd
BLAST
Domaini6958 – 7059102Ig-like 20Sequence analysisAdd
BLAST
Domaini7067 – 714983Ig-like 21Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1096 – 110611Poly-GlySequence analysisAdd
BLAST

Sequence similaritiesi

Contains 31 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 21 Ig-like (immunoglobulin-like) domains.Sequence analysis
Contains 13 Kelch repeats.Sequence analysis
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0613. Eukaryota.
ENOG410XQFD. LUCA.
GeneTreeiENSGT00840000129685.
InParanoidiQ23551.
OMAiKYEFRVM.
PhylomeDBiQ23551.

Family and domain databases

Gene3Di2.60.40.10. 61 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00041. fn3. 31 hits.
PF07679. I-set. 27 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 32 hits.
SM00409. IG. 30 hits.
SM00408. IGc2. 24 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 30 hits.
SSF49265. SSF49265. 17 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 31 hits.
PS50835. IG_LIKE. 20 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b1 Publication (identifier: Q23551-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGAPRFTQK PSIQQTPTGD LLMECHLEAD PQPTIAWQHS GNLLEPSGRV
60 70 80 90 100
VQTLTPLGGS LYKATLVIKE PNAGDGGAYK CTARNQLGES NANINLNFAG
110 120 130 140 150
AGGDEAKSRG PSFVGKPRII PKDGGALIVM ECKVKSASTP VAKWMKDGVP
160 170 180 190 200
LSMGGLYHAI FSDLGDQTYL CQLEIRGPSS SDAGQYRCNI RNDQGETNAN
210 220 230 240 250
LALNFEEPDP SERQERKRST ASPRPSSRGP GSRPSSPKKS MKSREGTPKR
260 270 280 290 300
TLKPREGSPS KKLRSRTSTP VNEEVSQSES RRSSRTDKME VDQVSGASKR
310 320 330 340 350
KPDGLPPPGG DEKKLRAGSP STRKSPSRKS ASPTPSRKGS SAGGAASGTT
360 370 380 390 400
GASASATSAT SGGSASSDAS RDKYTRPPIV LEASRSQTGR IGGSVVLEVQ
410 420 430 440 450
WQCHSSTIIE WYRDGTLVRN SSEYSQSFNG SIAKLQVNKL TEEKSGLYKC
460 470 480 490 500
HAKCDYGEGQ SSAMVKIEQS DVEEELMKHR KDAEDEYQKE EQKSQTLQAE
510 520 530 540 550
TKKRVARRSK SKSKSPAPQA KKSTTSESGR QEASEVEHKR SSSVRPDPDE
560 570 580 590 600
ESQLDEIPSS GLTIPEERRR ELLGQVGESD DEVSESISEL PSFAGGKPRR
610 620 630 640 650
KTDSPPKQDD MFSRDTLLRK TTTSTKNESS TVEEKTKLRK TVKKVDGELD
660 670 680 690 700
FKAMVKLKKV KKEEGGTTEK SGFPLDHADS TSSVLSQESR SRRGSNAPFA
710 720 730 740 750
KDGLPEQPAN PFAQLKKVKS GAGGLEKSDS MASLKKLDLK KGKIDDNSDG
760 770 780 790 800
AFKVQLKKVV KKEVKESTIS VKEKNGTESG IKTEFKMEKR ERTTLQKYEK
810 820 830 840 850
TDSDGSKKED KPKKVSIAPV STNKSSDDEP STPRHHKEVE EKSTSEELKA
860 870 880 890 900
KVAGRQVGQK RNGAQKPEEP KNLLSQIQLK KVTKKAHDDT NELEGIKLKK
910 920 930 940 950
VTTVPKHVAD DDSQSESESR RGSVFGELRR GSRAPRDSAD NSRRDSIRRS
960 970 980 990 1000
SIDMRRESVQ EILEKTSTPL VPSGASGSAP KIVEVPENVT VVENETAILT
1010 1020 1030 1040 1050
CKVSGSPAPT FRWFKGSREV ISGGRFKHIT DGKEHTVALA LLKCRSQDEG
1060 1070 1080 1090 1100
PYTLTIENVH GTDSADVKLL VTSDNGLDFR AMLKHRESQA GFQKDGEGGG
1110 1120 1130 1140 1150
AGGGGGEKKP MTEAERRQSL FPGKKVEKWD IPLPEKTVQQ QVDKICEWKC
1160 1170 1180 1190 1200
TYSRPNAKIR WYKDRKEIFS GGLKYKIVIE KNVCTLIINN PEVDDTGKYT
1210 1220 1230 1240 1250
CEANGVPTHA QLTVLEPPMK YSFLNPLPNT QEIYRTKQAV LTCKVNTPRA
1260 1270 1280 1290 1300
PLVWYRGSKA IQEGDPRFII EKDAVGRCTL TIKEVEEDDQ AEWTARITQD
1310 1320 1330 1340 1350
VFSKVQVYVE EPRHTFVVPM KSQKVNESDL ATLETDVNDK DAEVVWWHDG
1360 1370 1380 1390 1400
KRIDIDGVKF KVESSNRKRR LIINGARIED HGEYKCTTKD DRTMAQLIVD
1410 1420 1430 1440 1450
AKNKFIVALK DTEVIEKDDV TLMCQTKDTK TPGIWFRNGK QISSMPGGKF
1460 1470 1480 1490 1500
ETQSRNGTHT LKIGKIEMNE ADVYEIDQAG LRGSCNVTVL EAEKRPILNW
1510 1520 1530 1540 1550
KPKKIEAKAG EPCVVKVPFQ IKGTRRGDPK AQILKNGKPI DEEMRKLVEV
1560 1570 1580 1590 1600
IIKDDVAEIV FKNPQLADTG KWALELGNSA GTALAPFELF VKDKPKPPKG
1610 1620 1630 1640 1650
PLETKNVTAE GLDLVWGTPD PDEGAPVKAY IIEMQEGRSG NWAKVGETKG
1660 1670 1680 1690 1700
TDFKVKDLKE HGEYKFRVKA LNECGLSDPL TGESVLAKNP YGVPGKPKNM
1710 1720 1730 1740 1750
DAIDVDKDHC TLAWEPPEED GGAPITGYII ERREKSEKDW HQVGQTKPDC
1760 1770 1780 1790 1800
CELTDKKVVE DKEYLYRVKA VNKAGPGDPC DHGKPIKMKA KKASPEFTGG
1810 1820 1830 1840 1850
GIKDLRLKVG ETIKYDVPIS GEPLPECLWV VNGKPLKAVG RVKMSSERGK
1860 1870 1880 1890 1900
HIMKIENAVR ADSGKFTITL KNSSGSCDST ATVTVVGRPT PPKGPLDIAD
1910 1920 1930 1940 1950
VCADGATLSW NPPDDDGGDP LTGYIVEAQD MDNKGKYIEV GKVDPNTTTL
1960 1970 1980 1990 2000
KVNGLRNKGN YKFRVKAVNN EGESEPLSAD QYTQIKDPWD EPGKPGRPEI
2010 2020 2030 2040 2050
TDFDADRIDI AWEPPHKDGG APIEEYIVEV RDPDTKEWKE VKRVPDTNAS
2060 2070 2080 2090 2100
ISGLKEGKEY QFRVRAVNKA GPGQPSEPSE KQLAKPKFIP AWLKHDNLKS
2110 2120 2130 2140 2150
ITVKAGATVR WEVKIGGEPI PEVKWFKGNQ QLENGIQLTI DTRKNEHTIL
2160 2170 2180 2190 2200
CIPSAMRSDV GEYRLTVKNS HGADEEKANL TVLDRPSKPN GPLEVSDVFE
2210 2220 2230 2240 2250
DNLNLSWKPP DDDGGEPIEY YEVEKLDTAT GRWVPCAKVK DTKAHIDGLK
2260 2270 2280 2290 2300
KGQTYQFRVK AVNKEGASDA LSTDKDTKAK NPYDEPGKTG TPDVVDWDAD
2310 2320 2330 2340 2350
RVSLEWEPPK SDGGAPITQY VIEKKGKHGR DWQECGKVSG DQTNAEILGL
2360 2370 2380 2390 2400
KEGEEYQFRV KAVNKAGPGE ASDPSRKVVA KPRNLKPWID REAMKTITIK
2410 2420 2430 2440 2450
VGNDVEFDVP VRGEPPPKKE WIFNEKPVDD QKIRIESEDY KTRFVLRGAT
2460 2470 2480 2490 2500
RKHAGLYTLT ATNASGSDKH SVEVIVLGKP SSPLGPLEVS NVYEDRADLE
2510 2520 2530 2540 2550
WKVPEDDGGA PIDHYEIEKM DLATGRWVPC GRSETTKTTV PNLQPGHEYK
2560 2570 2580 2590 2600
FRVRAVNKEG ESDPLTTNTA ILAKNPYEVP GKVDKPELVD WDKDHVDLAW
2610 2620 2630 2640 2650
NAPDDGGAPI EAFVIEKKDK NGRWEEALVV PGDQKTATVP NLKEGEEYQF
2660 2670 2680 2690 2700
RISARNKAGT GDPSDPSDRV VAKPRNLAPR IHREDLSDTT VKVGATLKFI
2710 2720 2730 2740 2750
VHIDGEPAPD VTWSFNGKGI GESKAQIENE PYISRFALPK ALRKQSGKYT
2760 2770 2780 2790 2800
ITATNINGTD SVTINIKVKS KPTKPKGPIE VTDVFEDRAT LDWKPPEDDG
2810 2820 2830 2840 2850
GEPIEFYEIE KMNTKDGIWV PCGRSGDTHF TVDSLNKGDH YKFRVKAVNS
2860 2870 2880 2890 2900
EGPSDPLETE TDILAKNPFD RPDRPGRPEP TDWDSDHVDL KWDPPLSDGG
2910 2920 2930 2940 2950
APIEEYQIEK RTKYGRWEPA ITVPGGQTTA TVPDLTPNEE YEFRVVAVNK
2960 2970 2980 2990 3000
GGPSDPSDAS KAVIAKPRNL KPHIDRDALK NLTIKAGQSI SFDVPVSGEP
3010 3020 3030 3040 3050
APTVTWHWPD NREIRNGGRV KLDNPEYQSK LVVKQMERGD SGTFTIKAVN
3060 3070 3080 3090 3100
ANGEDEATVK INVIDKPTSP NGPLDVSDVH GDHVTLNWRA PDDDGGIPIE
3110 3120 3130 3140 3150
NYVIEKYDTA SGRWVPAAKV AGDKTTAVVD GLIPGHEYKF RVAAVNAEGE
3160 3170 3180 3190 3200
SDPLETFGTT LAKDPFDKPG KTNAPEITDW DKDHVDLEWK PPANDGGAPI
3210 3220 3230 3240 3250
EEYVVEMKDE FSPFWNDVAH VPAGQTNATV GNLKEGSKYE FRIRAKNKAG
3260 3270 3280 3290 3300
LGDPSDSASA VAKARNVPPV IDRNSIQEIK VKAGQDFSLN IPVSGEPTPT
3310 3320 3330 3340 3350
ITWTFEGTPV ESDDRMKLNN EDGKTKFHVK RALRSDTGTY IIKAENENGT
3360 3370 3380 3390 3400
DTAEVKVTVL DHPSSPRGPL DVTNIVKDGC DLAWKEPEDD GGAEISHYVI
3410 3420 3430 3440 3450
EKQDAATGRW TACGESKDTN FHVDDLTQGH EYKFRVKAVN RHGDSDPLEA
3460 3470 3480 3490 3500
REAIIAKDPF DRADKPGTPE IVDWDKDHAD LKWTPPADDG GAPIEGYLVE
3510 3520 3530 3540 3550
MRTPSGDWVP AVTVGAGELT ATVDGLKPGQ TYQFRVKALN KAGESTPSDP
3560 3570 3580 3590 3600
SRTMVAKPRH LAPKINRDMF VAQRVKAGQT LNFDVNVEGE PAPKIEWFLN
3610 3620 3630 3640 3650
GSPLSSGGNT HIDNNTDNNT KLTTKSTARA DSGKYKIVAT NESGKDEHEV
3660 3670 3680 3690 3700
DVNILDIPGA PEGPLRHKDI TKESVVLKWD EPLDDGGSPI TNYVVEKQED
3710 3720 3730 3740 3750
GGRWVPCGET SDTSLKVNKL SEGHEYKFRV KAVNRQGTSA PLTSDHAIVA
3760 3770 3780 3790 3800
KNPFDEPDAP TDVTPVDWDK DHVDLEWKPP ANDGGAPIDA YIVEKKDKFG
3810 3820 3830 3840 3850
DWVECARVDG KTTKATADNL TPGETYQFRV KAVNKAGPGK PSDPTGNVVA
3860 3870 3880 3890 3900
KPRRMAPKLN LAGLLDLRIK AGTPIKLDIA FEGEPAPVAK WKANDATIDT
3910 3920 3930 3940 3950
GARADVTNTP TSSAIHIFSA VRGDTGVYKI IVENEHGKDT AQCNVTVLDV
3960 3970 3980 3990 4000
PGTPEGPLKI DEIHKEGCTL NWKPPTDNGG TDVLHYIVEK MDTSRGTWQE
4010 4020 4030 4040 4050
VGTFPDCTAK VNKLVPGKEY AFRVKAVNLQ GESKPLEAEE PIIAKNQFDV
4060 4070 4080 4090 4100
PDPVDKPEVT DWDKDRIDIK WNPTANNGGA PVTGYIVEKK EKGSAIWTEA
4110 4120 4130 4140 4150
GKTPGTTFSA DNLKPGVEYE FRVIAVNAAG PSDPSDPTDP QITKARYLKP
4160 4170 4180 4190 4200
KILTASRKIK IKAGFTHNLE VDFIGAPDPT ATWTVGDSGA ALAPELLVDA
4210 4220 4230 4240 4250
KSSTTSIFFP SAKRADSGNY KLKVKNELGE DEAIFEVIVQ DRPSAPEGPL
4260 4270 4280 4290 4300
EVSDVTKDSC VLNWKPPKDD GGAEISNYVV EKRDTKTNTW VPVSAFVTGT
4310 4320 4330 4340 4350
SITVPKLTEG HEYEFRVMAE NTFGRSDSLN TDEPVLAKDP FGTPGKPGRP
4360 4370 4380 4390 4400
EIVDTDNDHI DIKWDPPRDN GGSPVDHYDI ERKDAKTGRW IKVNTSPVQG
4410 4420 4430 4440 4450
TAFSDTRVQK GHTYEYRVVA VNKAGPGQPS DSSAAATAKP MHEAPKFDLD
4460 4470 4480 4490 4500
LDGKEFRVKA GEPLVITIPF TASPQPDISW TKEGGKPLAG VETTDSQTKL
4510 4520 4530 4540 4550
VIPSTRRSDS GPVKIKAVNP YGEAEANIKI TVIDKPGAPE NITYPAVSRH
4560 4570 4580 4590 4600
TCTLNWDAPK DDGGAEIAGY KIEYQEVGSQ IWDKVPGLIS GTAYTVRGLE
4610 4620 4630 4640 4650
HGQQYRFRIR AENAVGLSDY CQGVPVVIKD PFDPPGAPST PEITGYDTNQ
4660 4670 4680 4690 4700
VSLAWNPPRD DGGSPILGYV VERFEKRGGG DWAPVKMPMV KGTECIVPGL
4710 4720 4730 4740 4750
HENETYQFRV RAVNAAGHGE PSNGSEPVTC RPYVEKPGAP DAPRVGKITK
4760 4770 4780 4790 4800
NSAELTWNRP LRDGGAPIDG YIVEKKKLGD NDWTRCNDKP VRDTAFEVKN
4810 4820 4830 4840 4850
LGEKEEYEFR VIAVNSAGEG EPSKPSDLVL IEEQPGRPIF DINNLKDITV
4860 4870 4880 4890 4900
RAGETIQIRI PYAGGNPKPI IDLFNGNSPI FENERTVVDV NPGEIVITTT
4910 4920 4930 4940 4950
GSKRSDAGPY KISATNKYGK DTCKLNVFVL DAPGKPTGPI RATDIQADAM
4960 4970 4980 4990 5000
TLSWRPPKDN GGDAITNYVV EKRTPGGDWV TVGHPVGTTL RVRNLDANTP
5010 5020 5030 5040 5050
YEFRVRAENQ YGVGEPLETD DAIVAKNPFD TPGAPGQPEA VETSEEAITL
5060 5070 5080 5090 5100
QWTRPTSDGG APIQGYVIEK REVGSTEWTK AAFGNILDTK HRVTGLTPKK
5110 5120 5130 5140 5150
TYEFRVAAYN AAGQGEYSVN SVPITADNAP TRPKINMGML TRDILAYAGE
5160 5170 5180 5190 5200
RAKILVPFAA SPAPKVTFSK GENKISPTDP RVKVEYSDFL ATLTIEKSEL
5210 5220 5230 5240 5250
TDGGLYFVEL ENSQGSDSAS IRLKVVDKPA SPQHIRVEDI APDCCTLYWM
5260 5270 5280 5290 5300
PPSSDGGSPI TNYIVEKLDL RHSDGKWEKV SSFVRNLNYT VGGLIKDNRY
5310 5320 5330 5340 5350
RFRVRAETQY GVSEPCELAD VVVAKYQFEV PNQPEAPTVR DKDSTWAELE
5360 5370 5380 5390 5400
WDPPRDGGSK IIGYQVQYRD TSSGRWINAK MDLSEQCHAR VTGLRQNGEF
5410 5420 5430 5440 5450
EFRIIAKNAA GFSKPSPPSE RCQLKSRFGP PGPPIHVGAK SIGRNHCTIT
5460 5470 5480 5490 5500
WMAPLEDGGS KITGYNVEIR EYGSTLWTVA SDYNVREPEF TVDKLREFND
5510 5520 5530 5540 5550
YEFRVVAINA AGKGIPSLPS GPIKIQESGG SRPQIVVKPE DTAQPYNRRA
5560 5570 5580 5590 5600
VFTCEAVGRP EPTARWLRNG RELPESSRYR FEASDGVYKF TIKEVWDIDA
5610 5620 5630 5640 5650
GEYTVEVSNP YGSDTATANL VVQAPPVIEK DVPNTILPSG DLVRLKIYFS
5660 5670 5680 5690 5700
GTAPFRHSLV LNREEIDMDH PTIRIVEFDD HILITIPALS VREAGRYEYT
5710 5720 5730 5740 5750
VSNDSGEATT GFWLNVTGLP EAPQGPLHIS NIGPSTATLS WRPPVTDGGS
5760 5770 5780 5790 5800
KITSYVVEKR DLSKDEWVTV TSNVKDMNYI VTGLFENHEY EFRVSAQNEN
5810 5820 5830 5840 5850
GIGAPLVSEH PIIARLPFDP PTSPLNLEIV QVGGDYVTLS WQRPLSDGGG
5860 5870 5880 5890 5900
RLRGYIVEKQ EEEHDEWFRC NQNPSPPNNY NVPNLIDGRK YRYRVFAVND
5910 5920 5930 5940 5950
AGLSDLAELD QTLFQASGSG EGPKIVSPLS DLNEEVGRCV TFECEISGSP
5960 5970 5980 5990 6000
RPEYRWFKGC KELVDTSKYT LINKGDKQVL IINDLTSDDA DEYTCRATNS
6010 6020 6030 6040 6050
SGTRSTRANL RIKTKPRVFI PPKYHGGYEA QKGETIELKI PYKAYPQGEA
6060 6070 6080 6090 6100
RWTKDGEKIE NNSKFSITTD DKFATLRISN ASREDYGEYR VVVENSVGSD
6110 6120 6130 6140 6150
SGTVNVTVAD VPEPPRFPII ENILDEAVIL SWKPPALDGG SLVTNYTIEK
6160 6170 6180 6190 6200
REAMGGSWSP CAKSRYTYTT IEGLRAGKQY EFRIIAENKH GQSKPCEPTA
6210 6220 6230 6240 6250
PVLIPGDERK RRRGYDVDEQ GKIVRGKGTV SSNYDNYVFD IWKQYYPQPV
6260 6270 6280 6290 6300
EIKHDHVLDH YDIHEELGTG AFGVVHRVTE RATGNNFAAK FVMTPHESDK
6310 6320 6330 6340 6350
ETVRKEIQTM SVLRHPTLVN LHDAFEDDNE MVMIYEFMSG GELFEKVADE
6360 6370 6380 6390 6400
HNKMSEDEAV EYMRQVCKGL CHMHENNYVH LDLKPENIMF TTKRSNELKL
6410 6420 6430 6440 6450
IDFGLTAHLD PKQSVKVTTG TAEFAAPEVA EGKPVGYYTD MWSVGVLSYI
6460 6470 6480 6490 6500
LLSGLSPFGG ENDDETLRNV KSCDWNMDDS AFSGISEDGK DFIRKLLLAD
6510 6520 6530 6540 6550
PNTRMTIHQA LEHPWLTPGN APGRDSQIPS SRYTKIRDSI KTKYDAWPEP
6560 6570 6580 6590 6600
LPPLGRISNY SSLRKHRPQE YSIRDAFWDR SEAQPRFIVK PYGTEVGEGQ
6610 6620 6630 6640 6650
SANFYCRVIA SSPPVVTWHK DDRELKQSVK YMKRYNGNDY GLTINRVKGD
6660 6670 6680 6690 6700
DKGEYTVRAK NSYGTKEEIV FLNVTRHSEP LKFEPLEPMK KAPSPPRVEE
6710 6720 6730 6740 6750
FKERRSAPFF TFHLRNRLIQ KNHQCKLTCS LQGNPNPTIE WMKDGHPVDE
6760 6770 6780 6790 6800
DRVQVSFRSG VCSLEIFNAR VDDAGTYTVT ATNDLGVDVS ECVLTVQTKG
6810 6820 6830 6840 6850
GEPIPRVSSF RPRRAYDTLS TGTDVERSHS YADMRRRSLI RDVSPDVRSA
6860 6870 6880 6890 6900
ADDLKTKITN ELPSFTAQLS DSETEVGGSA EFSAAVSGQP EPLIEWLHNG
6910 6920 6930 6940 6950
ERISESDSRF RASYVAGKAT LRISDAKKSD EGQYLCRASN SAGQEQTRAT
6960 6970 6980 6990 7000
LTVKGDQPLL NGHAGQAVES ELRVTKHLGG EIVNNGESVT FEARVQGTPE
7010 7020 7030 7040 7050
EVLWMRNGQE LTNGDKTSIS QDGETLSFTI NSADASDAGH YQLEVRSKGT
7060 7070 7080 7090 7100
NLVSVASLVV VGEKADPPVT RLPSSVSAPL GGSTAFTIEF ENVEGLTVQW
7110 7120 7130 7140 7150
FRGSEKIEKN ERVKSVKTGN TFKLDIKNVE QDDDGIYVAK VVKEKKAIAK

YAAALLLV
Note: No experimental confirmation available.Curated
Length:7,158
Mass (Da):788,953
Last modified:June 1, 2003 - v3
Checksum:i561EF9DB13387505
GO
Isoform a3 Publications (identifier: Q23551-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     604-809: Missing.
     835-947: Missing.

Show »
Length:6,839
Mass (Da):753,500
Checksum:i0C911B40FAB7C7E9
GO
Isoform c1 Publication (identifier: Q23551-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-539: Missing.
     540-550: RSSSVRPDPDE → MGQDFDSDSDS

Note: No experimental confirmation available.Curated
Show »
Length:6,619
Mass (Da):730,955
Checksum:iE21C47A68CE46B4A
GO
Isoform d1 Publication (identifier: Q23551-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-809: ESQLDEIPSS...KTDSDGSKKE → NLLKKSASND...AGGKPRRKTD
     835-947: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:6,992
Mass (Da):769,712
Checksum:i325601B31C3A275A
GO
Isoform e1 Publication (identifier: Q23551-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     835-947: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:6,435
Mass (Da):710,556
Checksum:iF1CFD61E8AFE870D
GO

Sequence cautioni

The sequence CAA33463.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 610610Missing in isoform e. 1 PublicationVSP_040605Add
BLAST
Alternative sequencei1 – 539539Missing in isoform c. 1 PublicationVSP_040606Add
BLAST
Alternative sequencei540 – 55011RSSSVRPDPDE → MGQDFDSDSDS in isoform c. 1 PublicationVSP_040607Add
BLAST
Alternative sequencei551 – 809259ESQLD…GSKKE → NLLKKSASNDGSDHGASPSS STSSSSRRLPPRPPLESSHS ASSPSSSNGGPRRMFNLRSA SDRQGASRPTGGQTPNPLNM RSANSSGQDLHKISQIHAFI LSKMPEGEAKERFLRSILDL EGPDSRRGSRDDVGSPNMLK KTNSKSSVNSSSNESQLDEI PSSGLTIPEERRRELLGQVG ESDDEVSESISELPSFAGGK PRRKTD in isoform d. 1 PublicationVSP_040608Add
BLAST
Alternative sequencei604 – 809206Missing in isoform a. 2 PublicationsVSP_040609Add
BLAST
Alternative sequencei835 – 947113Missing in isoform a, isoform d and isoform e. 2 PublicationsVSP_040611Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15423 Genomic DNA. Translation: CAA33463.1. Sequence problems.
Z73897, Z73899 Genomic DNA. Translation: CAA98064.2.
Z73897, Z73899 Genomic DNA. Translation: CAA98065.2.
Z73897, Z73899 Genomic DNA. Translation: CAM35838.2.
Z73897, Z73899 Genomic DNA. Translation: CBK19522.1.
Z73897, Z73899 Genomic DNA. Translation: CBK19523.1.
PIRiA88852.
S57242.
T27935.
RefSeqiNP_001122835.2. NM_001129363.2. [Q23551-3]
NP_001255603.2. NM_001268674.2.
NP_001255604.1. NM_001268675.1. [Q23551-5]
NP_502273.2. NM_069872.5. [Q23551-2]
NP_502274.2. NM_069873.4. [Q23551-1]
UniGeneiCel.23028.

Genome annotation databases

EnsemblMetazoaiZK617.1b.1; ZK617.1b.1; WBGene00006759. [Q23551-1]
ZK617.1b.2; ZK617.1b.2; WBGene00006759. [Q23551-1]
GeneIDi178135.
UCSCiZK617.1a.2. c. elegans.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15423 Genomic DNA. Translation: CAA33463.1. Sequence problems.
Z73897, Z73899 Genomic DNA. Translation: CAA98064.2.
Z73897, Z73899 Genomic DNA. Translation: CAA98065.2.
Z73897, Z73899 Genomic DNA. Translation: CAM35838.2.
Z73897, Z73899 Genomic DNA. Translation: CBK19522.1.
Z73897, Z73899 Genomic DNA. Translation: CBK19523.1.
PIRiA88852.
S57242.
T27935.
RefSeqiNP_001122835.2. NM_001129363.2. [Q23551-3]
NP_001255603.2. NM_001268674.2.
NP_001255604.1. NM_001268675.1. [Q23551-5]
NP_502273.2. NM_069872.5. [Q23551-2]
NP_502274.2. NM_069873.4. [Q23551-1]
UniGeneiCel.23028.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KOAX-ray3.30A6209-6699[»]
1WITNMR-A4148-4240[»]
1WIUNMR-A4148-4240[»]
3UTOX-ray2.40A/B6108-6675[»]
ProteinModelPortaliQ23551.
SMRiQ23551. Positions 4148-4240, 6112-6675.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43229. 1 interaction.
STRINGi6239.ZK617.1b.2.

Proteomic databases

EPDiQ23551.
PaxDbiQ23551.
PeptideAtlasiQ23551.
PRIDEiQ23551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK617.1b.1; ZK617.1b.1; WBGene00006759. [Q23551-1]
ZK617.1b.2; ZK617.1b.2; WBGene00006759. [Q23551-1]
GeneIDi178135.
UCSCiZK617.1a.2. c. elegans.

Organism-specific databases

CTDi178135.
WormBaseiZK617.1a; CE33017; WBGene00006759; unc-22.
ZK617.1b; CE33018; WBGene00006759; unc-22.
ZK617.1c; CE47057; WBGene00006759; unc-22.
ZK617.1d; CE44671; WBGene00006759; unc-22.
ZK617.1e; CE44668; WBGene00006759; unc-22.

Phylogenomic databases

eggNOGiKOG0613. Eukaryota.
ENOG410XQFD. LUCA.
GeneTreeiENSGT00840000129685.
InParanoidiQ23551.
OMAiKYEFRVM.
PhylomeDBiQ23551.

Enzyme and pathway databases

SignaLinkiQ23551.

Miscellaneous databases

EvolutionaryTraceiQ23551.
PROiQ23551.

Gene expression databases

ExpressionAtlasiQ23551. baseline.

Family and domain databases

Gene3Di2.60.40.10. 61 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00041. fn3. 31 hits.
PF07679. I-set. 27 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 32 hits.
SM00409. IG. 30 hits.
SM00408. IGc2. 24 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 30 hits.
SSF49265. SSF49265. 17 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 31 hits.
PS50835. IG_LIKE. 20 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans."
    Benian G.M., Kiff J.E., Neckelmann N., Moerman D.G., Waterston R.H.
    Nature 342:45-50(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. "Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegans."
    Benian G.M., L'Hernault S.W., Morris M.E.
    Genetics 134:1097-1104(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO N-TERMINUS.
    Strain: Bristol N21 Publication.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2Imported.
  4. "Mutants with altered muscle structure of Caenorhabditis elegans."
    Waterston R.H., Thomson J.N., Brenner S.
    Dev. Biol. 77:271-302(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. "Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans."
    Moerman D.G., Benian G.M., Barstead R.J., Schriefer L.A., Waterston R.H.
    Genes Dev. 2:93-105(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "A mutational analysis of Caenorhabditis elegans in space."
    Zhao Y., Lai K., Cheung I., Youds J., Tarailo M., Tarailo S., Rose A.
    Mutat. Res. 601:19-29(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. "Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains."
    Greene D.N., Garcia T., Sutton R.B., Gernert K.M., Benian G.M., Oberhauser A.F.
    Biophys. J. 95:1360-1370(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION.
  8. "Insights into autoregulation from the crystal structure of twitchin kinase."
    Hu S.H., Parker M.W., Lei J.Y., Wilce M.C., Benian G.M., Kemp B.E.
    Nature 369:581-584(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 6211-6699, ENZYME REGULATION.
  9. "Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans."
    Fong S., Hamill S.J., Proctor M., Freund S.M., Benian G.M., Chothia C., Bycroft M., Clarke J.
    J. Mol. Biol. 264:624-639(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 4148-4240.

Entry informationi

Entry nameiUNC22_CAEEL
AccessioniPrimary (citable) accession number: Q23551
Secondary accession number(s): A3RMU0
, D3YT57, D3YT58, Q23020, Q23550, Q27232, Q7JN85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

Determination of the mutation frequency of the unc-22 gene has been used to study the biological effects of short duration spaceflight.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.