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Protein

Pyruvate kinase

Gene

pyk-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 2 (gpd-2), Glyceraldehyde-3-phosphate dehydrogenase 4 (gpd-4), Glyceraldehyde-3-phosphate dehydrogenase 3 (gpd-3), Glyceraldehyde-3-phosphate dehydrogenase 1 (gpd-1)
  2. Probable phosphoglycerate kinase (pgk-1)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (ipgm-1)
  4. Enolase (enol-1)
  5. Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.
R-CEL-70171. Glycolysis.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pyk-2Imported
ORF Names:CELE_ZK593.1Imported, ZK593.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiZK593.1a; CE24731; WBGene00014001; pyk-2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiQ23539.
PeptideAtlasiQ23539.

Expressioni

Gene expression databases

BgeeiWBGene00014001.
ExpressionAtlasiQ23539. baseline.

Interactioni

Protein-protein interaction databases

IntActiQ23539. 3 interactors.
MINTiMINT-6669282.
STRINGi6239.ZK593.1a.

Structurei

3D structure databases

ProteinModelPortaliQ23539.
SMRiQ23539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 378PKInterPro annotationAdd BLAST345
Domaini395 – 512PK_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
GeneTreeiENSGT00390000008859.
HOGENOMiHOG000021559.
InParanoidiQ23539.
KOiK00873.
OMAiMIAAPVP.
OrthoDBiEOG091G0597.
PhylomeDBiQ23539.

Family and domain databases

CDDicd00288. Pyruvate_Kinase. 1 hit.
Gene3Di3.40.1380.20. 1 hit.
InterProiView protein in InterPro
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiView protein in Pfam
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00110. PYRUVATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q23539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQDDHIGSE HSSATTNISH LCGLRISERP QKTRKTGVIC TIGPACSDVE
60 70 80 90 100
TLRKMINTGM NIARLNFSHG THEAHAATIK TIREAAENAP FPVAIALDTK
110 120 130 140 150
GPEIRTGMFA NNMKEVQLEN GKSVRVSTDP SMEFAATSSH IYADYRNLPK
160 170 180 190 200
VVQPGSRIYI DDGLISLIVE SCEETAVICT IENGGALGTR KGVNLPGTIV
210 220 230 240 250
DLPAVTSKDI EDLLFGVEQG VDIIFASFIR NADGIHKIRQ VLGEKGKHIY
260 270 280 290 300
IIAKIESEDG VTNCDEIIEA SDGVMVARGD LGIEIPAEKV FLAQKMLIAK
310 320 330 340 350
CNLAGKPVIC ATQMLESMIT KPRPTRAECS DVANAVLDGV DCVMLSGETA
360 370 380 390 400
KGDYPVEALA IMHNICKEAE SAFFHMKHFE ELILHTKKPT GMTHTTAIAA
410 420 430 440 450
VSATITCRAV AIILITTTGK TARLCSRYRP PVPIITVSRD ERISRQLHLH
460 470 480 490 500
RGIFPVYYPK GRIDEWDVDV EERVQYGVNL GKTRGFIHLG DPLIVITGWK
510
QGAGFTNTMR IVVAT
Length:515
Mass (Da):56,159
Last modified:May 1, 2000 - v2
Checksum:i6D7B8BE7E8FA2570
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAA93424.2.
PIRiF88823.
T27928.
RefSeqiNP_001255515.1. NM_001268586.1.
UniGeneiCel.11603.

Genome annotation databases

EnsemblMetazoaiZK593.1a; ZK593.1a; WBGene00014001.
GeneIDi177984.
KEGGicel:CELE_ZK593.1.
UCSCiZK593.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ23539_CAEEL
AccessioniPrimary (citable) accession number: Q23539
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported