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Q23534

- ACP1_CAEEL

UniProt

Q23534 - ACP1_CAEEL

Protein

Putative acid phosphatase 1

Gene

apc-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei29 – 291NucleophileBy similarity
    Active sitei276 – 2761Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative acid phosphatase 1 (EC:3.1.3.2)
    Gene namesi
    Name:apc-1
    ORF Names:ZK563.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiZK563.6; CE28192; WBGene00022770; acp-1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 426408Putative acid phosphatase 1PRO_0000248567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)2 Publications
    Disulfide bondi133 ↔ 369By similarity
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ23534.

    Interactioni

    Protein-protein interaction databases

    IntActiQ23534. 1 interaction.
    STRINGi6239.ZK563.6.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ23534.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 388370ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini410 – 42617CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei389 – 40921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG306642.
    GeneTreeiENSGT00530000062956.
    HOGENOMiHOG000115658.
    InParanoidiQ23534.
    OMAiVERCLMT.
    PhylomeDBiQ23534.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q23534-1 [UniParc]FASTAAdd to Basket

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    MRVLFYVSIL VIIASVHTQL ISVHVIFRHG ARAPVLNVTS EEAKSYFYRG    50
    LGQLTDEGFE QARLMGKVLR DRYVNSFVDA RMLSSQLLFR SSPVERCLMT 100
    LQTVGNTMFP NATPPVQTVA KPDDFLLVPK LDCDFQLGEW DNYFNLTESD 150
    KKMARKNPWF VSDKALRKAV TKTDFLQDRG GENLPALILE KEAGLAVPSW 200
    FNEGAYKESL HVFYSALAVM SSVGEYKSSK GIRIKSGLLM EKVFNDIQEK 250
    VRCHEKKEVS NIKCDIHKLQ VFSSHDLLIL PILETLGIRE EVLGKDMPPE 300
    FMSTIIIETM IVDNSPVVKV LFRKNPREIT LRDVTGFVKN CPPGQPLCPV 350
    QRFTSCCNEF ITSDPKSECY AETTVEKQSE WVMTPLSWII VAIAILLLIA 400
    LILMTYFVIR YKNRSIVNIK KLSLEN 426
    Length:426
    Mass (Da):48,431
    Last modified:October 1, 2001 - v2
    Checksum:iDCE8B129219A498C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080346 Genomic DNA. Translation: CCD63046.1.
    PIRiT27918.
    RefSeqiNP_508585.1. NM_076184.4.
    UniGeneiCel.9217.

    Genome annotation databases

    EnsemblMetazoaiZK563.6.1; ZK563.6.1; WBGene00022770.
    ZK563.6.2; ZK563.6.2; WBGene00022770.
    GeneIDi180627.
    KEGGicel:CELE_ZK563.6.
    UCSCiZK563.6.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080346 Genomic DNA. Translation: CCD63046.1 .
    PIRi T27918.
    RefSeqi NP_508585.1. NM_076184.4.
    UniGenei Cel.9217.

    3D structure databases

    ProteinModelPortali Q23534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q23534. 1 interaction.
    STRINGi 6239.ZK563.6.1.

    Proteomic databases

    PaxDbi Q23534.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZK563.6.1 ; ZK563.6.1 ; WBGene00022770 .
    ZK563.6.2 ; ZK563.6.2 ; WBGene00022770 .
    GeneIDi 180627.
    KEGGi cel:CELE_ZK563.6.
    UCSCi ZK563.6.1. c. elegans.

    Organism-specific databases

    CTDi 180627.
    WormBasei ZK563.6 ; CE28192 ; WBGene00022770 ; acp-1.

    Phylogenomic databases

    eggNOGi NOG306642.
    GeneTreei ENSGT00530000062956.
    HOGENOMi HOG000115658.
    InParanoidi Q23534.
    OMAi VERCLMT.
    PhylomeDBi Q23534.

    Miscellaneous databases

    NextBioi 910178.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins."
      Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J., Kasai K., Takahashi N., Isobe T.
      Nat. Biotechnol. 21:667-672(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Bristol N2.
    3. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
      Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
      Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiACP1_CAEEL
    AccessioniPrimary (citable) accession number: Q23534
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3