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Q23534 (ACP1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative acid phosphatase 1

EC=3.1.3.2
Gene names
Name:apc-1
ORF Names:ZK563.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 426408Putative acid phosphatase 1
PRO_0000248567

Regions

Topological domain19 – 388370Extracellular Potential
Transmembrane389 – 40921Helical; Potential
Topological domain410 – 42617Cytoplasmic Potential

Sites

Active site291Nucleophile By similarity
Active site2761Proton donor By similarity

Amino acid modifications

Glycosylation371N-linked (GlcNAc...) Ref.2 Ref.3
Glycosylation1451N-linked (GlcNAc...) Potential
Disulfide bond133 ↔ 369 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q23534 [UniParc].

Last modified October 1, 2001. Version 2.
Checksum: DCE8B129219A498C

FASTA42648,431
        10         20         30         40         50         60 
MRVLFYVSIL VIIASVHTQL ISVHVIFRHG ARAPVLNVTS EEAKSYFYRG LGQLTDEGFE 

        70         80         90        100        110        120 
QARLMGKVLR DRYVNSFVDA RMLSSQLLFR SSPVERCLMT LQTVGNTMFP NATPPVQTVA 

       130        140        150        160        170        180 
KPDDFLLVPK LDCDFQLGEW DNYFNLTESD KKMARKNPWF VSDKALRKAV TKTDFLQDRG 

       190        200        210        220        230        240 
GENLPALILE KEAGLAVPSW FNEGAYKESL HVFYSALAVM SSVGEYKSSK GIRIKSGLLM 

       250        260        270        280        290        300 
EKVFNDIQEK VRCHEKKEVS NIKCDIHKLQ VFSSHDLLIL PILETLGIRE EVLGKDMPPE 

       310        320        330        340        350        360 
FMSTIIIETM IVDNSPVVKV LFRKNPREIT LRDVTGFVKN CPPGQPLCPV QRFTSCCNEF 

       370        380        390        400        410        420 
ITSDPKSECY AETTVEKQSE WVMTPLSWII VAIAILLLIA LILMTYFVIR YKNRSIVNIK 


KLSLEN 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins."
Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J., Kasai K., Takahashi N., Isobe T.
Nat. Biotechnol. 21:667-672(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Bristol N2.
[3]"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080346 Genomic DNA. Translation: CCD63046.1.
PIRT27918.
RefSeqNP_508585.1. NM_076184.4.
UniGeneCel.9217.

3D structure databases

ProteinModelPortalQ23534.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ23534. 1 interaction.
STRING6239.ZK563.6.1.

Proteomic databases

PaxDbQ23534.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK563.6.1; ZK563.6.1; WBGene00022770.
ZK563.6.2; ZK563.6.2; WBGene00022770.
GeneID180627.
KEGGcel:CELE_ZK563.6.
UCSCZK563.6.1. c. elegans.

Organism-specific databases

CTD180627.
WormBaseZK563.6; CE28192; WBGene00022770; acp-1.

Phylogenomic databases

eggNOGNOG306642.
GeneTreeENSGT00530000062956.
HOGENOMHOG000115658.
InParanoidQ23534.
OMAVERCLMT.
PhylomeDBQ23534.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMSSF53254. SSF53254. 1 hit.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio910178.

Entry information

Entry nameACP1_CAEEL
AccessionPrimary (citable) accession number: Q23534
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2001
Last modified: June 11, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase