Q23534 (ACP1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative acid phosphatase 1
EC=3.1.3.2

Gene names

Name:	apc-1
ORF Names:	ZK563.6

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 426	408	Putative acid phosphatase 1		PRO_0000248567
Regions
	Topological domain	19 – 388	370	Extracellular Potential
	Transmembrane	389 – 409	21	Helical; Potential
	Topological domain	410 – 426	17	Cytoplasmic Potential
Sites
	Active site	29	1	Nucleophile By similarity
	Active site	276	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	37	1	N-linked (GlcNAc...) Ref.2 Ref.3
	Glycosylation	145	1	N-linked (GlcNAc...) Potential
	Disulfide bond	133 ↔ 369		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q23534 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: DCE8B129219A498C	FASTA	426	48,431
	10 20 30 40 50 60 MRVLFYVSIL VIIASVHTQL ISVHVIFRHG ARAPVLNVTS EEAKSYFYRG LGQLTDEGFE 70 80 90 100 110 120 QARLMGKVLR DRYVNSFVDA RMLSSQLLFR SSPVERCLMT LQTVGNTMFP NATPPVQTVA 130 140 150 160 170 180 KPDDFLLVPK LDCDFQLGEW DNYFNLTESD KKMARKNPWF VSDKALRKAV TKTDFLQDRG 190 200 210 220 230 240 GENLPALILE KEAGLAVPSW FNEGAYKESL HVFYSALAVM SSVGEYKSSK GIRIKSGLLM 250 260 270 280 290 300 EKVFNDIQEK VRCHEKKEVS NIKCDIHKLQ VFSSHDLLIL PILETLGIRE EVLGKDMPPE 310 320 330 340 350 360 FMSTIIIETM IVDNSPVVKV LFRKNPREIT LRDVTGFVKN CPPGQPLCPV QRFTSCCNEF 370 380 390 400 410 420 ITSDPKSECY AETTVEKQSE WVMTPLSWII VAIAILLLIA LILMTYFVIR YKNRSIVNIK KLSLEN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins." Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J., Kasai K., Takahashi N., Isobe T. Nat. Biotechnol. 21:667-672(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37, MASS SPECTROMETRY. Strain: Bristol N2.
[3]	"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins." Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T. Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37, MASS SPECTROMETRY. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080346 Genomic DNA. Translation: CCD63046.1.
PIR	T27918.
RefSeq	NP_508585.1. NM_076184.4.
3D structure databases
HSSP	HSSP built from PDB template 1ND5 based on UniProtKB P15309.
ProteinModelPortal	Q23534.
SMR	Q23534. Positions 18-372.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q23534. 1 interaction.
Proteomic databases
PaxDb	Q23534.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZK563.6.1; ZK563.6.1; ZK563.6. ZK563.6.2; ZK563.6.2; ZK563.6.
GeneID	180627.
KEGG	cel:CELE_ZK563.6.
UCSC	ZK563.6.1. c. elegans.
Organism-specific databases
CTD	180627.
WormBase	ZK563.6; CE28192; WBGene00022770; acp-1.
Phylogenomic databases
eggNOG	NOG306642.
GeneTree	ENSGT00530000062956.
HOGENOM	HOG000115658.
InParanoid	Q23534.
OMA	VERCLMT.
Family and domain databases
InterPro	IPR000560. His_Pase_superF_clade-2. [Graphical view]
Pfam	PF00328. His_Phos_2. 1 hit. [Graphical view]
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	910178.

Entry information

Entry name

ACP1_CAEEL

Accession

Primary (citable) accession number: Q23534

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	October 1, 2001
Last modified:	April 3, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project