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Q23534

- ACP1_CAEEL

UniProt

Q23534 - ACP1_CAEEL

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Protein
Putative acid phosphatase 1
Gene
apc-1, ZK563.6
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei29 – 291Nucleophile By similarity
Active sitei276 – 2761Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acid phosphatase 1 (EC:3.1.3.2)
Gene namesi
Name:apc-1
ORF Names:ZK563.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiZK563.6; CE28192; WBGene00022770; acp-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 388370Extracellular Reviewed prediction
Add
BLAST
Transmembranei389 – 40921Helical; Reviewed prediction
Add
BLAST
Topological domaini410 – 42617Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 426408Putative acid phosphatase 1
PRO_0000248567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)2 Publications
Disulfide bondi133 ↔ 369 By similarity
Glycosylationi145 – 1451N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ23534.

Interactioni

Protein-protein interaction databases

IntActiQ23534. 1 interaction.
STRINGi6239.ZK563.6.1.

Structurei

3D structure databases

ProteinModelPortaliQ23534.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG306642.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000115658.
InParanoidiQ23534.
OMAiVERCLMT.
PhylomeDBiQ23534.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q23534-1 [UniParc]FASTAAdd to Basket

« Hide

MRVLFYVSIL VIIASVHTQL ISVHVIFRHG ARAPVLNVTS EEAKSYFYRG    50
LGQLTDEGFE QARLMGKVLR DRYVNSFVDA RMLSSQLLFR SSPVERCLMT 100
LQTVGNTMFP NATPPVQTVA KPDDFLLVPK LDCDFQLGEW DNYFNLTESD 150
KKMARKNPWF VSDKALRKAV TKTDFLQDRG GENLPALILE KEAGLAVPSW 200
FNEGAYKESL HVFYSALAVM SSVGEYKSSK GIRIKSGLLM EKVFNDIQEK 250
VRCHEKKEVS NIKCDIHKLQ VFSSHDLLIL PILETLGIRE EVLGKDMPPE 300
FMSTIIIETM IVDNSPVVKV LFRKNPREIT LRDVTGFVKN CPPGQPLCPV 350
QRFTSCCNEF ITSDPKSECY AETTVEKQSE WVMTPLSWII VAIAILLLIA 400
LILMTYFVIR YKNRSIVNIK KLSLEN 426
Length:426
Mass (Da):48,431
Last modified:October 1, 2001 - v2
Checksum:iDCE8B129219A498C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080346 Genomic DNA. Translation: CCD63046.1.
PIRiT27918.
RefSeqiNP_508585.1. NM_076184.4.
UniGeneiCel.9217.

Genome annotation databases

EnsemblMetazoaiZK563.6.1; ZK563.6.1; WBGene00022770.
ZK563.6.2; ZK563.6.2; WBGene00022770.
GeneIDi180627.
KEGGicel:CELE_ZK563.6.
UCSCiZK563.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080346 Genomic DNA. Translation: CCD63046.1 .
PIRi T27918.
RefSeqi NP_508585.1. NM_076184.4.
UniGenei Cel.9217.

3D structure databases

ProteinModelPortali Q23534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q23534. 1 interaction.
STRINGi 6239.ZK563.6.1.

Proteomic databases

PaxDbi Q23534.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZK563.6.1 ; ZK563.6.1 ; WBGene00022770 .
ZK563.6.2 ; ZK563.6.2 ; WBGene00022770 .
GeneIDi 180627.
KEGGi cel:CELE_ZK563.6.
UCSCi ZK563.6.1. c. elegans.

Organism-specific databases

CTDi 180627.
WormBasei ZK563.6 ; CE28192 ; WBGene00022770 ; acp-1.

Phylogenomic databases

eggNOGi NOG306642.
GeneTreei ENSGT00530000062956.
HOGENOMi HOG000115658.
InParanoidi Q23534.
OMAi VERCLMT.
PhylomeDBi Q23534.

Miscellaneous databases

NextBioi 910178.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins."
    Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J., Kasai K., Takahashi N., Isobe T.
    Nat. Biotechnol. 21:667-672(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.
  3. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiACP1_CAEEL
AccessioniPrimary (citable) accession number: Q23534
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2001
Last modified: June 11, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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