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Protein

Putative acid phosphatase 1

Gene

acp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei29NucleophileBy similarity1
Active sitei276Proton donorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acid phosphatase 1 (EC:3.1.3.2)
Gene namesi
Name:acp-1Imported
ORF Names:ZK563.6Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiZK563.6; CE28192; WBGene00022770; acp-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 388ExtracellularSequence analysisAdd BLAST370
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 426CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000024856719 – 426Putative acid phosphatase 1Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi133 ↔ 369By similarity
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ23534.
PaxDbiQ23534.
PeptideAtlasiQ23534.

PTM databases

iPTMnetiQ23534.

Expressioni

Gene expression databases

BgeeiWBGene00022770.

Interactioni

Protein-protein interaction databases

IntActiQ23534. 1 interactor.
STRINGi6239.ZK563.6.2.

Structurei

3D structure databases

ProteinModelPortaliQ23534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3720. Eukaryota.
ENOG410ZVBQ. LUCA.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000115658.
InParanoidiQ23534.
OMAiVERCLMT.
OrthoDBiEOG091G0AF7.
PhylomeDBiQ23534.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiView protein in InterPro
IPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
PfamiView protein in Pfam
PF00328. His_Phos_2. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiView protein in PROSITE
PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q23534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLFYVSIL VIIASVHTQL ISVHVIFRHG ARAPVLNVTS EEAKSYFYRG
60 70 80 90 100
LGQLTDEGFE QARLMGKVLR DRYVNSFVDA RMLSSQLLFR SSPVERCLMT
110 120 130 140 150
LQTVGNTMFP NATPPVQTVA KPDDFLLVPK LDCDFQLGEW DNYFNLTESD
160 170 180 190 200
KKMARKNPWF VSDKALRKAV TKTDFLQDRG GENLPALILE KEAGLAVPSW
210 220 230 240 250
FNEGAYKESL HVFYSALAVM SSVGEYKSSK GIRIKSGLLM EKVFNDIQEK
260 270 280 290 300
VRCHEKKEVS NIKCDIHKLQ VFSSHDLLIL PILETLGIRE EVLGKDMPPE
310 320 330 340 350
FMSTIIIETM IVDNSPVVKV LFRKNPREIT LRDVTGFVKN CPPGQPLCPV
360 370 380 390 400
QRFTSCCNEF ITSDPKSECY AETTVEKQSE WVMTPLSWII VAIAILLLIA
410 420
LILMTYFVIR YKNRSIVNIK KLSLEN
Length:426
Mass (Da):48,431
Last modified:October 1, 2001 - v2
Checksum:iDCE8B129219A498C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080346 Genomic DNA. Translation: CCD63046.1.
PIRiT27918.
RefSeqiNP_508585.1. NM_076184.4.
UniGeneiCel.9217.

Genome annotation databases

EnsemblMetazoaiZK563.6.1; ZK563.6.1; WBGene00022770.
ZK563.6.2; ZK563.6.2; WBGene00022770.
GeneIDi180627.
KEGGicel:CELE_ZK563.6.
UCSCiZK563.6.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiACP1_CAEEL
AccessioniPrimary (citable) accession number: Q23534
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2001
Last modified: February 28, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome