Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative acid phosphatase 1

Gene

apc-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei29NucleophileBy similarity1
Active sitei276Proton donorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acid phosphatase 1 (EC:3.1.3.2)
Gene namesi
Name:apc-1
ORF Names:ZK563.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiZK563.6; CE28192; WBGene00022770; acp-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 388ExtracellularSequence analysisAdd BLAST370
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 426CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000024856719 – 426Putative acid phosphatase 1Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)2 Publications1
Disulfide bondi133 ↔ 369By similarity
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ23534.
PaxDbiQ23534.
PeptideAtlasiQ23534.

Expressioni

Gene expression databases

BgeeiWBGene00022770.

Interactioni

Protein-protein interaction databases

IntActiQ23534. 1 interactor.
STRINGi6239.ZK563.6.2.

Structurei

3D structure databases

ProteinModelPortaliQ23534.
SMRiQ23534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3720. Eukaryota.
ENOG410ZVBQ. LUCA.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000115658.
InParanoidiQ23534.
OMAiVERCLMT.
OrthoDBiEOG091G0AF7.
PhylomeDBiQ23534.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q23534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLFYVSIL VIIASVHTQL ISVHVIFRHG ARAPVLNVTS EEAKSYFYRG
60 70 80 90 100
LGQLTDEGFE QARLMGKVLR DRYVNSFVDA RMLSSQLLFR SSPVERCLMT
110 120 130 140 150
LQTVGNTMFP NATPPVQTVA KPDDFLLVPK LDCDFQLGEW DNYFNLTESD
160 170 180 190 200
KKMARKNPWF VSDKALRKAV TKTDFLQDRG GENLPALILE KEAGLAVPSW
210 220 230 240 250
FNEGAYKESL HVFYSALAVM SSVGEYKSSK GIRIKSGLLM EKVFNDIQEK
260 270 280 290 300
VRCHEKKEVS NIKCDIHKLQ VFSSHDLLIL PILETLGIRE EVLGKDMPPE
310 320 330 340 350
FMSTIIIETM IVDNSPVVKV LFRKNPREIT LRDVTGFVKN CPPGQPLCPV
360 370 380 390 400
QRFTSCCNEF ITSDPKSECY AETTVEKQSE WVMTPLSWII VAIAILLLIA
410 420
LILMTYFVIR YKNRSIVNIK KLSLEN
Length:426
Mass (Da):48,431
Last modified:October 1, 2001 - v2
Checksum:iDCE8B129219A498C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080346 Genomic DNA. Translation: CCD63046.1.
PIRiT27918.
RefSeqiNP_508585.1. NM_076184.4.
UniGeneiCel.9217.

Genome annotation databases

EnsemblMetazoaiZK563.6.1; ZK563.6.1; WBGene00022770.
ZK563.6.2; ZK563.6.2; WBGene00022770.
GeneIDi180627.
KEGGicel:CELE_ZK563.6.
UCSCiZK563.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080346 Genomic DNA. Translation: CCD63046.1.
PIRiT27918.
RefSeqiNP_508585.1. NM_076184.4.
UniGeneiCel.9217.

3D structure databases

ProteinModelPortaliQ23534.
SMRiQ23534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ23534. 1 interactor.
STRINGi6239.ZK563.6.2.

Proteomic databases

EPDiQ23534.
PaxDbiQ23534.
PeptideAtlasiQ23534.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK563.6.1; ZK563.6.1; WBGene00022770.
ZK563.6.2; ZK563.6.2; WBGene00022770.
GeneIDi180627.
KEGGicel:CELE_ZK563.6.
UCSCiZK563.6.1. c. elegans.

Organism-specific databases

CTDi180627.
WormBaseiZK563.6; CE28192; WBGene00022770; acp-1.

Phylogenomic databases

eggNOGiKOG3720. Eukaryota.
ENOG410ZVBQ. LUCA.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000115658.
InParanoidiQ23534.
OMAiVERCLMT.
OrthoDBiEOG091G0AF7.
PhylomeDBiQ23534.

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ23534.

Gene expression databases

BgeeiWBGene00022770.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACP1_CAEEL
AccessioniPrimary (citable) accession number: Q23534
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.