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Q23534

- ACP1_CAEEL

UniProt

Q23534 - ACP1_CAEEL

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Protein

Putative acid phosphatase 1

Gene

apc-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei29 – 291NucleophileBy similarity
Active sitei276 – 2761Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acid phosphatase 1 (EC:3.1.3.2)
Gene namesi
Name:apc-1
ORF Names:ZK563.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiZK563.6; CE28192; WBGene00022770; acp-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 388370ExtracellularSequence AnalysisAdd
BLAST
Transmembranei389 – 40921HelicalSequence AnalysisAdd
BLAST
Topological domaini410 – 42617CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 426408Putative acid phosphatase 1PRO_0000248567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)2 Publications
Disulfide bondi133 ↔ 369By similarity
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ23534.

Interactioni

Protein-protein interaction databases

IntActiQ23534. 1 interaction.
STRINGi6239.ZK563.6.1.

Structurei

3D structure databases

ProteinModelPortaliQ23534.
SMRiQ23534. Positions 24-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG306642.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000115658.
InParanoidiQ23534.
OMAiVERCLMT.
PhylomeDBiQ23534.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q23534-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVLFYVSIL VIIASVHTQL ISVHVIFRHG ARAPVLNVTS EEAKSYFYRG
60 70 80 90 100
LGQLTDEGFE QARLMGKVLR DRYVNSFVDA RMLSSQLLFR SSPVERCLMT
110 120 130 140 150
LQTVGNTMFP NATPPVQTVA KPDDFLLVPK LDCDFQLGEW DNYFNLTESD
160 170 180 190 200
KKMARKNPWF VSDKALRKAV TKTDFLQDRG GENLPALILE KEAGLAVPSW
210 220 230 240 250
FNEGAYKESL HVFYSALAVM SSVGEYKSSK GIRIKSGLLM EKVFNDIQEK
260 270 280 290 300
VRCHEKKEVS NIKCDIHKLQ VFSSHDLLIL PILETLGIRE EVLGKDMPPE
310 320 330 340 350
FMSTIIIETM IVDNSPVVKV LFRKNPREIT LRDVTGFVKN CPPGQPLCPV
360 370 380 390 400
QRFTSCCNEF ITSDPKSECY AETTVEKQSE WVMTPLSWII VAIAILLLIA
410 420
LILMTYFVIR YKNRSIVNIK KLSLEN
Length:426
Mass (Da):48,431
Last modified:October 1, 2001 - v2
Checksum:iDCE8B129219A498C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080346 Genomic DNA. Translation: CCD63046.1.
PIRiT27918.
RefSeqiNP_508585.1. NM_076184.4.
UniGeneiCel.9217.

Genome annotation databases

EnsemblMetazoaiZK563.6.1; ZK563.6.1; WBGene00022770.
ZK563.6.2; ZK563.6.2; WBGene00022770.
GeneIDi180627.
KEGGicel:CELE_ZK563.6.
UCSCiZK563.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080346 Genomic DNA. Translation: CCD63046.1 .
PIRi T27918.
RefSeqi NP_508585.1. NM_076184.4.
UniGenei Cel.9217.

3D structure databases

ProteinModelPortali Q23534.
SMRi Q23534. Positions 24-108.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q23534. 1 interaction.
STRINGi 6239.ZK563.6.1.

Proteomic databases

PaxDbi Q23534.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZK563.6.1 ; ZK563.6.1 ; WBGene00022770 .
ZK563.6.2 ; ZK563.6.2 ; WBGene00022770 .
GeneIDi 180627.
KEGGi cel:CELE_ZK563.6.
UCSCi ZK563.6.1. c. elegans.

Organism-specific databases

CTDi 180627.
WormBasei ZK563.6 ; CE28192 ; WBGene00022770 ; acp-1.

Phylogenomic databases

eggNOGi NOG306642.
GeneTreei ENSGT00530000062956.
HOGENOMi HOG000115658.
InParanoidi Q23534.
OMAi VERCLMT.
PhylomeDBi Q23534.

Miscellaneous databases

NextBioi 910178.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins."
    Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J., Kasai K., Takahashi N., Isobe T.
    Nat. Biotechnol. 21:667-672(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.
  3. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiACP1_CAEEL
AccessioniPrimary (citable) accession number: Q23534
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2001
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3