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Protein
Submitted name:

Leucyl Amino-acyl tRNA Synthetase

Gene

lars-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Leucyl Amino-acyl tRNA SynthetaseImported
Gene namesi
Name:lars-2Imported
ORF Names:CELE_ZK524.3Imported, ZK524.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiZK524.3a; CE35160; WBGene00003074; lars-2.

PTM / Processingi

Proteomic databases

EPDiQ23511.
PaxDbiQ23511.
PRIDEiQ23511.

Expressioni

Gene expression databases

ExpressionAtlasiQ23511. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-24547N.
MINTiMINT-1088627.
STRINGi6239.ZK524.3a.1.

Structurei

3D structure databases

ProteinModelPortaliQ23511.
SMRiQ23511. Positions 27-743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini388 – 528141tRNA-synt_1InterPro annotationAdd
BLAST
Domaini701 – 74343Anticodon_1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0435. Eukaryota.
COG0495. LUCA.
GeneTreeiENSGT00390000015114.
HOGENOMiHOG000200747.
InParanoidiQ23511.
KOiK01869.
OMAiKMQGLTN.
PhylomeDBiQ23511.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWGTIQQI RRIGSALQWP LKDIRISENT KMLEKHWSKS LVDSFESSKN
60 70 80 90 100
KPSNLNGKKY ILSMFPYPSG RLHIGHMRVY TISDATARYY RLNGYEVIHP
110 120 130 140 150
IGWDSFGLPA ENAARDKGVD PREWTINNIE SMKQQLLKTK ILFDWEKEIS
160 170 180 190 200
TCEPEFFRWT QWIFCKLFEY GLVKRTSSEV NWDPIDKTVL AAEQIDNDGK
210 220 230 240 250
SWRSGAKAEK KKLSQWMIET PKYAKRLQEG LRKMSEQWGE VADIQANWIG
260 270 280 290 300
KCDVYRFMLP VMKDGSNDEI IDLRIKDIFE ISNAEFLVLK QSHSLADKDA
310 320 330 340 350
TQFPYKLPFQ VLNGVTGRQI PVIVVEDTYQ PDVTSFLNSR IGNFQKDKIL
360 370 380 390 400
VEKFAIAEPK HKRKLTKNDI QEMASFGGYG GYETSRTLTD WVVSRQRGWG
410 420 430 440 450
TPIPMIQTKD GKRVAVQLNK LPVLGSDRGQ EVDKERFGES GVFDTDTLDT
460 470 480 490 500
FFDSAWYYLR YLDNKNKSEL ISKGAMKNMP VDVYVGGIEH AAVHMFFARF
510 520 530 540 550
VAYFLKDINV IQTAEPFTDL IPQGIVRGKT FIEKETGKYL GSEDVQQSGD
560 570 580 590 600
KLTLKNDSSV EVDAVYEKMS KSKNNGVDLA AILDSEGVDM TRLRLLEAAA
610 620 630 640 650
PRAPINWGET DLKGIKKLLD RIAAINSQIV DARDNGKPIE LKKEIDGSIK
660 670 680 690 700
ETYNFFVRNV GMCLEVLHLH NTALMRIQGF TNALKKVDPI YLAHSPEGQR
710 720 730 740 750
AVKSLIIMLQ VFCPHVASEM WSALANDGSL VSDQKWPEVD KDADIEFLLM
760 770 780 790 800
IDGVSGGRPS LDRRIIEEMS MDQLWERATF YEHADILRMM KEDGMKLKNS
810 820 830 840 850
SYISRKGFHV TLSCSLEGDK EENRKKIGKI LDRIQAEKRK LEIGKKGGKR

KKEKKIVNK
Length:859
Mass (Da):98,278
Last modified:October 1, 2003 - v4
Checksum:iC22CB6A0B1136F01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAA98144.4.
PIRiB87833.
T27887.
RefSeqiNP_001021875.1. NM_001026704.4.
UniGeneiCel.16138.

Genome annotation databases

EnsemblMetazoaiZK524.3a; ZK524.3a; WBGene00003074.
GeneIDi172499.
KEGGicel:CELE_ZK524.3.
UCSCiZK524.3b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAA98144.4.
PIRiB87833.
T27887.
RefSeqiNP_001021875.1. NM_001026704.4.
UniGeneiCel.16138.

3D structure databases

ProteinModelPortaliQ23511.
SMRiQ23511. Positions 27-743.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-24547N.
MINTiMINT-1088627.
STRINGi6239.ZK524.3a.1.

Proteomic databases

EPDiQ23511.
PaxDbiQ23511.
PRIDEiQ23511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK524.3a; ZK524.3a; WBGene00003074.
GeneIDi172499.
KEGGicel:CELE_ZK524.3.
UCSCiZK524.3b. c. elegans.

Organism-specific databases

CTDi172499.
WormBaseiZK524.3a; CE35160; WBGene00003074; lars-2.

Phylogenomic databases

eggNOGiKOG0435. Eukaryota.
COG0495. LUCA.
GeneTreeiENSGT00390000015114.
HOGENOMiHOG000200747.
InParanoidiQ23511.
KOiK01869.
OMAiKMQGLTN.
PhylomeDBiQ23511.

Gene expression databases

ExpressionAtlasiQ23511. baseline.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ23511_CAEEL
AccessioniPrimary (citable) accession number: Q23511
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 140 of the entry and version 4 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.