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Q23500 (ACOC_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytoplasmic aconitate hydratase
Short name=Aconitase
EC=4.2.1.3
Alternative name(s):
Citrate hydro-lyase
Gex-3-interacting protein 22
Gene names
Name:aco-1
Synonyms:gei-22
ORF Names:ZK455.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length887 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate By similarity.

Catalytic activity

Citrate = isocitrate.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Subunit structure

Interacts with gex-3. Ref.3

Subcellular location

Cytoplasm Ref.2.

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 887887Probable cytoplasmic aconitate hydratase
PRO_0000076650

Regions

Region204 – 2063Substrate binding By similarity
Region777 – 7782Substrate binding By similarity

Sites

Metal binding4361Iron-sulfur (4Fe-4S) By similarity
Metal binding5021Iron-sulfur (4Fe-4S) By similarity
Metal binding5051Iron-sulfur (4Fe-4S) By similarity
Binding site841Substrate By similarity
Binding site5351Substrate By similarity
Binding site5401Substrate By similarity
Binding site6971Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q23500 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AB53EF890EBC88C4

FASTA88796,660
        10         20         30         40         50         60 
MAFNNLIRNL AIGDNVYKYF DLNGLNDARY NELPISIKYL LEAAVRHCDE FHVLKKDVET 

        70         80         90        100        110        120 
ILDWKNSQRN QAEIPFKPAR VILQDFTGVP AVVDLAAMRD AVQNMGADPA KINPVCPVDL 

       130        140        150        160        170        180 
VIDHSVQVDH YGNLEALAKN QSIEFERNRE RFNFLKWGSK AFDNLLIVPP GSGIVHQVNL 

       190        200        210        220        230        240 
EYLARTVFVG KDGVLYPDSV VGTDSHTTMI DGSGVLGWGV GGIEAEAVML GQPISMVIPE 

       250        260        270        280        290        300 
VIGYELVGTL SDTVTSTDLV LTITKNLRDL GVVGKFVEFF GTGVASLSIA DRATIANMCP 

       310        320        330        340        350        360 
EYGATIGFFP VDSRTIDYLT QTGRDTDYTQ RVEQYLKSVG MFVNFTDDSY RPTYTTTLKL 

       370        380        390        400        410        420 
DLGSVVPSVS GPKRPHDRVE LASLAQDFSK GLTDKISFKA FGLKPEDATK SVTITNHGRT 

       430        440        450        460        470        480 
AELTHGSVVI AAITSCTNTS NPSVMLAAGL VAKKAVELGL NVQPYVKTSL SPGSGVVTKY 

       490        500        510        520        530        540 
LEASGLLPYL EKIGFNIAGY GCMTCIGNSG PLDEPVTKAI EENNLVVAGV LSGNRNFEGR 

       550        560        570        580        590        600 
IHPHVRANYL ASPPLAVLYS IIGNVNVDIN GVLAVTPDGK EIRLADIWPT RKEVAKFEEE 

       610        620        630        640        650        660 
FVKPQFFREV YANIELGSTE WQQLECPAVK LYPWDDASTY IKKVPFFDGM TSELPSQSDI 

       670        680        690        700        710        720 
VNAHVLLNLG DSVTTDHISP AGSISKTSPA ARFLAGRGVT PRDFNTYGAR RGNDEIMARG 

       730        740        750        760        770        780 
TFANIRLVNK LASKVGPITL HVPSGEELDI FDAAQKYKDA GIPAIILAGK EYGCGSSRDW 

       790        800        810        820        830        840 
AAKGPFLQGV KAVIAESFER IHRSNLIGMG IIPFQYQAGQ NADSLGLTGK EQFSIGVPDD 

       850        860        870        880 
LKPGQLIDVN VSNGSVFQVI CRFDTEVELT YYRNGGILQY MIRKLIQ

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans."
Gourley B.L., Parker S.B., Jones B.J., Zumbrennen K.B., Leibold E.A.
J. Biol. Chem. 278:3227-3234(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
[3]"Isolation of the interacting molecules with GEX-3 by a novel functional screening."
Tsuboi D., Qadota H., Kasuya K., Amano M., Kaibuchi K.
Biochem. Biophys. Res. Commun. 292:697-701(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GEX-3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z66567 Genomic DNA. Translation: CAA91491.1.
PIRT27868.
RefSeqNP_509898.1. NM_077497.3.
UniGeneCel.17233.

3D structure databases

ProteinModelPortalQ23500.
SMRQ23500. Positions 18-885.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-26479N.
IntActQ23500. 1 interaction.
MINTMINT-1039639.
STRING6239.ZK455.1.1.

Proteomic databases

PaxDbQ23500.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK455.1.1; ZK455.1.1; ZK455.1.
ZK455.1.2; ZK455.1.2; ZK455.1.
GeneID181324.
KEGGcel:CELE_ZK455.1.
UCSCZK455.1.1. c. elegans.

Organism-specific databases

CTD181324.
WormBaseZK455.1; CE03812; WBGene00000040; aco-1.

Phylogenomic databases

eggNOGCOG1048.
GeneTreeENSGT00530000063060.
HOGENOMHOG000025704.
InParanoidQ23500.
KOK01681.
OMARNCDGKK.

Enzyme and pathway databases

BRENDA4.2.1.3. 1045.

Family and domain databases

Gene3D3.20.19.10. 1 hit.
3.30.499.10. 3 hits.
3.40.1060.10. 1 hit.
InterProIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR006249. Aconitase/Fe_reg_prot_2.
IPR015934. Aconitase/Fe_reg_prot_2/AcnD.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF1. PTHR11670:SF1. 1 hit.
PfamPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSPR00415. ACONITASE.
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
SSF53732. Aconitase_N. 1 hit.
TIGRFAMsTIGR01341. aconitase_1. 1 hit.
PROSITEPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio913448.

Entry information

Entry nameACOC_CAEEL
AccessionPrimary (citable) accession number: Q23500
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 29, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

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