ID   Q234S0_TETTS            Unreviewed;       522 AA.
AC   Q234S0;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 87.
DE   SubName: Full=Cytochrome P450 family monooxygenase {ECO:0000313|EMBL:EAR91933.1};
GN   ORFNames=TTHERM_00101290 {ECO:0000313|EMBL:EAR91933.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR91933.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617}.
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DR   EMBL; GG662767; EAR91933.1; -; Genomic_DNA.
DR   RefSeq; XP_001012178.1; XM_001012178.3.
DR   AlphaFoldDB; Q234S0; -.
DR   SMR; Q234S0; -.
DR   STRING; 312017.Q234S0; -.
DR   EnsemblProtists; EAR91933; EAR91933; TTHERM_00101290.
DR   GeneID; 7841193; -.
DR   KEGG; tet:TTHERM_00101290; -.
DR   eggNOG; KOG0157; Eukaryota.
DR   HOGENOM; CLU_001570_5_1_1; -.
DR   InParanoid; Q234S0; -.
DR   OMA; NIFFAGH; -.
DR   OrthoDB; 3041391at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   CDD; cd20621; CYP5011A1-like; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR24291:SF189; CYTOCHROME P450 4V2; 1.
DR   PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
PE   3: Inferred from homology;
KW   Monooxygenase {ECO:0000313|EMBL:EAR91933.1};
KW   Oxidoreductase {ECO:0000313|EMBL:EAR91933.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168}.
SQ   SEQUENCE   522 AA;  60685 MW;  1E4C5AB7CADB119A CRC64;
     MIGYIAIALV LLFVYRFIIK NLMIYFTYKS KFGDKVVFMF YPLLGNFGIS RKSFRQYGDS
     LHILKTIQRT KPDVKAVMVF NGFIIQIIII DTQLQKVFLQ NTKPYYKVEG PFGARDAFGQ
     GLVVAEEKVW TRQRNFLSNS FHFNALKNRV PIIKEITKEF LSTLPSDGKT PITIIEELQN
     ITSEVVIQTF FGENLKGMTV NGLQPSVEIS KIIGDGFSYK ANSFAYFLKL MVFGQEKASR
     VLNTTFEKNF LKRVENYNQF IEGIVDKRLS ELEKLTDTSK VDENFLNLYL LEYIKQQKAL
     KENPKIYADY EIIPKREIVH QFTTFFFAGM DTTANQTGIC LWVLAQHPEL QQKIRAEIDS
     VIQTFDDLKH EDLNKLEYFN AFFKESLRVY PTAPQVIPRV SARDHMVDDF PIPKGAFVSN
     LTIQYNEQKF PLLCKDIDTF NPDRFLDKNI IQDHFSFIPY SAGPRNCIGQ HLALIEAKIM
     IAYILKNYVV LPNEEHQKVR FNHLFLYTSY ERDIIKLKKL TA
//