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Protein

26S proteasome non-ATPase regulatory subunit 8

Gene

rpn-12

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-195253. Degradation of beta-catenin by the destruction complex.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4608870. Asymmetric localization of PCP proteins.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 8
Alternative name(s):
26S proteasome regulatory subunit rpn-12
Gene namesi
Name:rpn-12
ORF Names:ZK20.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK20.5; CE06608; WBGene00004468; rpn-12.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • nucleus Source: GO_Central
  • proteasome regulatory particle Source: WormBase
  • proteasome regulatory particle, lid subcomplex Source: GO_Central

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738481 – 25026S proteasome non-ATPase regulatory subunit 8Add BLAST250

Proteomic databases

EPDiQ23449.
PaxDbiQ23449.
PeptideAtlasiQ23449.
PRIDEiQ23449.

2D gel databases

World-2DPAGEi0020:Q23449.

Expressioni

Gene expression databases

BgeeiWBGene00004468.

Interactioni

Protein-protein interaction databases

BioGridi40091. 2 interactors.
IntActiQ23449. 2 interactors.
MINTiMINT-210917.
STRINGi6239.ZK20.5.1.

Structurei

3D structure databases

ProteinModelPortaliQ23449.
SMRiQ23449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the proteasome subunit S14 family.Curated

Phylogenomic databases

eggNOGiKOG3151. Eukaryota.
ENOG410XXP2. LUCA.
GeneTreeiENSGT00390000014682.
HOGENOMiHOG000196008.
InParanoidiQ23449.
KOiK03031.
OMAiYAGLHTR.
OrthoDBiEOG091G0G73.
PhylomeDBiQ23449.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR006746. 26S_Psome_Rpn12.
IPR033464. CSN8_PSD8_EIF3K.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR12387. PTHR12387. 1 hit.
PfamiView protein in Pfam
PF10075. CSN8_PSD8_EIF3K. 1 hit.

Sequencei

Sequence statusi: Complete.

Q23449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAHKNLLA VWAKEPKDLV AVEKALNELT KVLSASSDLN DKQSALASKD
60 70 80 90 100
LYEISVLLAI LKHDFETFDD YINQMHTYYT MAPENSENKH LMTGLHLMFL
110 120 130 140 150
LAANRLSDFH MLLEQIPQKE QTSNAYISTP VRIEQSLMEG AYNKVVLTEK
160 170 180 190 200
NIPSPFYTIF IRIMLDTIRR EIATSIEKSF KVLTAKDATV MLLFDNDEQM
210 220 230 240 250
KKFGQERKWH LDGERYVFEI EVAQEKPVNL DTVRVATQTL FYAKQLEQIV
Length:250
Mass (Da):28,795
Last modified:November 1, 1996 - v1
Checksum:i7406538A0CE1B2DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69904 Genomic DNA. Translation: CAA93778.1.
PIRiT27772.
RefSeqiNP_496489.1. NM_064088.7.
UniGeneiCel.14571.

Genome annotation databases

EnsemblMetazoaiZK20.5.1; ZK20.5.1; WBGene00004468.
ZK20.5.2; ZK20.5.2; WBGene00004468.
GeneIDi174786.
KEGGicel:CELE_ZK20.5.
UCSCiZK20.5.1. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPSMD8_CAEEL
AccessioniPrimary (citable) accession number: Q23449
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families