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Protein

TWiK family of potassium channels protein 9

Gene

twk-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potassium channel protein that may be component of regulatory network that controls ray development and function.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-CEL-1299344 TWIK-related spinal cord K+ channel (TRESK)
R-CEL-5576886 Phase 4 - resting membrane potential

Protein family/group databases

TCDBi1.A.1.9.8 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
TWiK family of potassium channels protein 9
Gene namesi
Name:twk-9
ORF Names:ZK1251.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiZK1251.8a ; CE40540 ; WBGene00006664 ; twk-9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Intramembranei163 – 183Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 316CytoplasmicSequence analysisAdd BLAST105
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Intramembranei343 – 363Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST21
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 568CytoplasmicSequence analysisAdd BLAST178

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017721 – 568TWiK family of potassium channels protein 9Add BLAST568

Proteomic databases

PaxDbiQ23435

Expressioni

Tissue specificityi

Expressed in ray A-type neurons and cell bodies. Also seen in head, pharyngeal and phasmid neurons, and in coelomocytes.1 Publication

Gene expression databases

BgeeiWBGene00006664
ExpressionAtlasiQ23435 baseline

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK1251.8

Structurei

3D structure databases

ProteinModelPortaliQ23435
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00700000104522
HOGENOMiHOG000022314
InParanoidiQ23435
KOiK05323
OMAiCLERTIL
PhylomeDBiQ23435

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL

Sequencei

Sequence statusi: Complete.

Q23435-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCSFHIPEK YQWASTLFVH VALIAGVAVY TVFGALSMQW LESPDRVRAL
60 70 80 90 100
LKRELKPVES LPPPPSISGL PDRITRVYLG EELAILDPGV HECLERTILT
110 120 130 140 150
LFHDTKCDPY SFEHLNIELI DRCYAEANVP IPEGYGGQPR KKIKNKEEEK
160 170 180 190 200
DVIDETPAEK WSIGNSVIFA FTVITTIGYG HVAPETFEGR LFLIFYGVIG
210 220 230 240 250
VPFTLLTIAD LGMFLTRFLK NLLTMARRFA HYLVKLYQKA KKQRNKSQKT
260 270 280 290 300
SPVMPDSERS EVWNTGKEMK EMSMRTAREP GEGDEIEVIE NGNDENGKEE
310 320 330 340 350
DEEEPENNEP RKTEESIALG ITFTCYLVAG AKILSVYEPE MDFFKALYFN
360 370 380 390 400
FVTLTTIGLG DFVPKSFDYL LITLIYIGIG LALTTMAIEI AADLLKKLHY
410 420 430 440 450
IGRKMENVGQ AVVWFGGKKM TMKSLVKHLG DQFNIPEEEL ANFDMSAFVD
460 470 480 490 500
NAIKVEKGEI ATLRKPPTPP VVFRERAFSF SNVRNSSESA LKYVDDNRFS
510 520 530 540 550
KTTQPTIYTV IIHETTRTID TLHNLADAIR RDPSIPRLDL DVHYLTDMSA
560
PTSFDENYLR TYTNARRK
Length:568
Mass (Da):64,533
Last modified:July 10, 2007 - v2
Checksum:i6C47ED7AC4EEADA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68222 Genomic DNA Translation: CAA92504.2
PIRiT27725
RefSeqiNP_501724.2, NM_069323.2
UniGeneiCel.12254

Genome annotation databases

EnsemblMetazoaiZK1251.8a; ZK1251.8a; WBGene00006664
GeneIDi177803
KEGGicel:CELE_ZK1251.8
UCSCiZK1251.8 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTWK9_CAEEL
AccessioniPrimary (citable) accession number: Q23435
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 10, 2007
Last modified: February 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome