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Protein

TWiK family of potassium channels protein 9

Gene

twk-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel protein that may be component of regulatory network that controls ray development and function.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Protein family/group databases

TCDBi1.A.1.9.8. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
TWiK family of potassium channels protein 9
Gene namesi
Name:twk-9
ORF Names:ZK1251.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiZK1251.8a; CE40540; WBGene00006664; twk-9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence analysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Intramembranei163 – 18321Pore-forming; Name=Pore-forming 1Sequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Topological domaini212 – 316105CytoplasmicSequence analysisAdd
BLAST
Transmembranei317 – 33721HelicalSequence analysisAdd
BLAST
Intramembranei343 – 36321Pore-forming; Name=Pore-forming 2Sequence analysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence analysisAdd
BLAST
Topological domaini391 – 568178CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568TWiK family of potassium channels protein 9PRO_0000101772Add
BLAST

Proteomic databases

PaxDbiQ23435.

Expressioni

Tissue specificityi

Expressed in ray A-type neurons and cell bodies. Also seen in head, pharyngeal and phasmid neurons, and in coelomocytes.1 Publication

Gene expression databases

BgeeiWBGene00006664.
ExpressionAtlasiQ23435. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK1251.8.

Structurei

3D structure databases

ProteinModelPortaliQ23435.
SMRiQ23435. Positions 161-212, 316-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000022314.
InParanoidiQ23435.
KOiK05323.
OMAiLSMQWLE.
PhylomeDBiQ23435.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.

Sequencei

Sequence statusi: Complete.

Q23435-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCSFHIPEK YQWASTLFVH VALIAGVAVY TVFGALSMQW LESPDRVRAL
60 70 80 90 100
LKRELKPVES LPPPPSISGL PDRITRVYLG EELAILDPGV HECLERTILT
110 120 130 140 150
LFHDTKCDPY SFEHLNIELI DRCYAEANVP IPEGYGGQPR KKIKNKEEEK
160 170 180 190 200
DVIDETPAEK WSIGNSVIFA FTVITTIGYG HVAPETFEGR LFLIFYGVIG
210 220 230 240 250
VPFTLLTIAD LGMFLTRFLK NLLTMARRFA HYLVKLYQKA KKQRNKSQKT
260 270 280 290 300
SPVMPDSERS EVWNTGKEMK EMSMRTAREP GEGDEIEVIE NGNDENGKEE
310 320 330 340 350
DEEEPENNEP RKTEESIALG ITFTCYLVAG AKILSVYEPE MDFFKALYFN
360 370 380 390 400
FVTLTTIGLG DFVPKSFDYL LITLIYIGIG LALTTMAIEI AADLLKKLHY
410 420 430 440 450
IGRKMENVGQ AVVWFGGKKM TMKSLVKHLG DQFNIPEEEL ANFDMSAFVD
460 470 480 490 500
NAIKVEKGEI ATLRKPPTPP VVFRERAFSF SNVRNSSESA LKYVDDNRFS
510 520 530 540 550
KTTQPTIYTV IIHETTRTID TLHNLADAIR RDPSIPRLDL DVHYLTDMSA
560
PTSFDENYLR TYTNARRK
Length:568
Mass (Da):64,533
Last modified:July 10, 2007 - v2
Checksum:i6C47ED7AC4EEADA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68222 Genomic DNA. Translation: CAA92504.2.
PIRiT27725.
RefSeqiNP_501724.2. NM_069323.2.
UniGeneiCel.12254.

Genome annotation databases

EnsemblMetazoaiZK1251.8a; ZK1251.8a; WBGene00006664.
GeneIDi177803.
KEGGicel:CELE_ZK1251.8.
UCSCiZK1251.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68222 Genomic DNA. Translation: CAA92504.2.
PIRiT27725.
RefSeqiNP_501724.2. NM_069323.2.
UniGeneiCel.12254.

3D structure databases

ProteinModelPortaliQ23435.
SMRiQ23435. Positions 161-212, 316-405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK1251.8.

Protein family/group databases

TCDBi1.A.1.9.8. the voltage-gated ion channel (vic) superfamily.

Proteomic databases

PaxDbiQ23435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1251.8a; ZK1251.8a; WBGene00006664.
GeneIDi177803.
KEGGicel:CELE_ZK1251.8.
UCSCiZK1251.8. c. elegans.

Organism-specific databases

CTDi177803.
WormBaseiZK1251.8a; CE40540; WBGene00006664; twk-9.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000022314.
InParanoidiQ23435.
KOiK05323.
OMAiLSMQWLE.
PhylomeDBiQ23435.

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Miscellaneous databases

PROiQ23435.

Gene expression databases

BgeeiWBGene00006664.
ExpressionAtlasiQ23435. baseline.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
ProtoNetiSearch...

Entry informationi

Entry nameiTWK9_CAEEL
AccessioniPrimary (citable) accession number: Q23435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.