Q23400 (RCL1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable RNA 3'-terminal phosphate cyclase-like protein

Gene names

ORF Names:

ZK1127.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA interference Inferred from mutant phenotype. Source: WormBase RNA processing Inferred from electronic annotation. Source: InterPro body morphogenesis Inferred from mutant phenotype. Source: WormBase cytokinesis Inferred from mutant phenotype. Source: WormBase determination of adult lifespan Inferred from mutant phenotype. Source: WormBase embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase gamete generation Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase oviposition Inferred from mutant phenotype. Source: WormBase positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Probable RNA 3'-terminal phosphate cyclase-like protein		PRO_0000156441

Sequences

	Sequence		Length	Mass (Da)
	Q23400 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: A6AAE4C90EA1D516	FASTA	379	41,597
	10 20 30 40 50 60 MSSETLEFSG CNFFRIRLAY SILSGRPIRI INIRKNDDRP GIRDFESKLI GLLEKVTNGT 70 80 90 100 110 120 KVEISRTGTQ VIFRPGMITG GVVNLDCGTE RCISYFLEPL LLLSPFCKVP MVIKLKGVTN 130 140 150 160 170 180 APGEISVDGM KASWLKVYNK FVLNDEKLDI KIQARGLKPE GGGVVVFTAP IVKTLRPVKR 190 200 210 220 230 240 QQVGKVCKIR GQAYVTKVTP SLAYRMIDAA KKAMHGYISD VYITVDQRKG DAGGASPGYG 250 260 270 280 290 300 LFLTAETTEG VIYQAEAISR PKGESGVPIL PEDIGIEAGH ALLQQIYMGG ALDSSAQILA 310 320 330 340 350 360 STFMTLCPKD VSHFLYGPLP MYSVHALRHL KQFFEIEFKM EDFKKTLKEE EADLKTGSAD 370 KAMVTAVGVG YSNLNKTIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea." Genschik P., Billy E., Swianiewicz M., Filipowicz W. EMBO J. 16:2955-2967(1997) [PubMed: 9184239] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081697 Genomic DNA. Translation: CCD73717.1.
PIR	G88196.
RefSeq	NP_495445.2. NM_063044.4.
UniGene	Cel.13718.
3D structure databases
ProteinModelPortal	Q23400.
SMR	Q23400. Positions 3-373.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q23400. 7 interactions.
STRING	Q23400.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZK1127.5.1; ZK1127.5.1; ZK1127.5. ZK1127.5.2; ZK1127.5.2; ZK1127.5.
GeneID	174151.
KEGG	cel:ZK1127.5.
NMPDR	fig|6239.3.peg.6113.
UCSC	ZK1127.5. c. elegans.
Organism-specific databases
CTD	174151.
WormBase	ZK1127.5; CE32083; WBGene00022852.
Phylogenomic databases
eggNOG	meNOG05747.
GeneTree	EMGT00050000015984.
HOGENOM	HBG381263.
InParanoid	Q23400.
OMA	GEVFFSC.
PhylomeDB	Q23400.
Gene expression databases
ArrayExpress	Q23400.
Family and domain databases
InterPro	IPR023797. RNA3'_phos_cyclase_dom. IPR000228. RNA3'_term_phos_cyc. IPR016443. RNA3'_term_phos_cyc_type_2. IPR020719. RNA3'_term_phos_cycl-like_CS. IPR013796. RNA3'_term_phos_cycl_insert. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.20. RNA3'_term_phos_cycl. 1 hit.
KO	K11108.
PANTHER	PTHR11096. RNA3'_term_phos_cycl. 1 hit.
Pfam	PF01137. RTC. 1 hit. PF05189. RTC_insert. 1 hit. [Graphical view]
PIRSF	PIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR03400. 18S_RNA_Rcl1p. 1 hit.
PROSITE	PS01287. RTC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	882755.

Entry information

Entry name

RCL1_CAEEL

Accession

Primary (citable) accession number: Q23400

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project