ID   Q233G4_TETTS            Unreviewed;       555 AA.
AC   Q233G4;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=ATP-dependent DNA ligase {ECO:0000313|EMBL:EAR91616.1};
GN   ORFNames=TTHERM_00392850 {ECO:0000313|EMBL:EAR91616.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR91616.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|EMBL:EAR91616.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SB210 {ECO:0000313|EMBL:EAR91616.1};
RA   Eisen J.A., Wu M., Wu D., Nierman W.C., Orias E., Delcher A.L.,
RA   Salzberg S.L.;
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAR91616.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SB210 {ECO:0000313|EMBL:EAR91616.1};
RA   Bidwell S., Michalis H.M., Zafar N., Joardar V., Miao W., Russ C.,
RA   Eisen J., Wu M., Wu D., Nierman W., Orias E., Delcher A., Salzberg S.,
RA   Coyne R.;
RT   "Annotation update of Tetrahymena thermophila SB210.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|ARBA:ARBA00001968};
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DR   EMBL; GG662770; EAR91616.1; -; Genomic_DNA.
DR   RefSeq; XP_001011861.1; XM_001011861.1.
DR   AlphaFoldDB; Q233G4; -.
DR   SMR; Q233G4; -.
DR   STRING; 312017.Q233G4; -.
DR   EnsemblProtists; EAR91616; EAR91616; TTHERM_00392850.
DR   GeneID; 7847151; -.
DR   KEGG; tet:TTHERM_00392850; -.
DR   eggNOG; ENOG502QTYC; Eukaryota.
DR   HOGENOM; CLU_021047_2_0_1; -.
DR   InParanoid; Q233G4; -.
DR   OMA; LSANQCK; -.
DR   OrthoDB; 5489531at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd07896; Adenylation_kDNA_ligase_like; 1.
DR   CDD; cd08041; OBF_kDNA_ligase_like; 1.
DR   Gene3D; 3.30.1490.70; -; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 2.20.140.10; WGR domain; 1.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR029319; DNA_ligase_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR47810; DNA LIGASE; 1.
DR   PANTHER; PTHR47810:SF1; DNA LIGASE B; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF14743; DNA_ligase_OB_2; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000313|EMBL:EAR91616.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT   DOMAIN          389..505
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
FT   REGION          231..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        237..262
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   555 AA;  63068 MW;  18799FAFAC545C87 CRC64;
     MIKIDLTKPV FLNFNQSKFW EISLLDGNKS QIRYGKLVQG EEIEEKTQIV QKQHKDTDSC
     LDYIIRVIEN KKLKGYSGDI PMKKNEPQII IPANNASGFS IQISAPKSVE NNANDDKDSK
     VDSNTQAYLQ ENKTWSSQFV ILTLSGNEVE EIIGKLGIKK TWEKSSTILS ANQCKLYFKN
     QIEEYERKGY VRDDSQYNFQ LNEVNKHFSA QNGSSNNNQL DLNQKGKKKN FNKDSGLYDD
     SHSNISGISD QSDLTARSGG SQLDLSFDKG DDDDGNSSVV VTGEIKKGSL GANGSMDSGV
     LLAQAMPDEM DPTGWYASEK MDGVRAVWTG KTFYSRNGNE FYPPPFFIQN FPNCTLDGEL
     FTKRDDFQRC VGIVKTKNGN EEKDERWKDI VYLVYDCPKL LKPFKDRIKA LQEQIPKLGN
     KYIKVLPHKI VESREQLESE LDRVLKNNGE GLMLRDPNSM YECRRSKTLL KVKTFTDEEA
     TVIGSERGEG RCADMMGALV CRMKNGKEFK IGSGFNDDQR RRPPKKGSVI TFKYQNLTKD
     GKPRFPIFLR IKEDE
//