Reviewed, UniProtKB/Swiss-Prot Q23381 (MUTA_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable methylmalonyl-CoA mutase, mitochondrial
    EC=5.4.99.2
Alternative name(s):
    MethylmalonylCoA mutase homolog 1
      Short name=MCM

Gene names

Name:	mmcm-1
ORF Names:	ZK1058.1

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	744 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved, in man, in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species By similarity.
Catalytic activity	(R)-methylmalonyl-CoA = succinyl-CoA.
Cofactor	Adenosylcobalamin By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the methylmalonyl-CoA mutase family. Contains 1 B12-binding domain.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Cobalamin Cobalt Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cobalamin binding Inferred from electronic annotation. Source: UniProtKB-KW cobalt ion binding Inferred from electronic annotation. Source: UniProtKB-KW methylmalonyl-CoA mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 744		Probable methylmalonyl-CoA mutase, mitochondrial		PRO_0000019297
Regions
	Domain	605 – 737	133	B12-binding
Sites
	Metal binding	618	1	Cobalt (cobalamin axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q23381-1 [UniParc]. Last modified June 20, 2002. Version 2. Checksum: 599E22008D8FBAEC	FASTA	744	81,683
	10 20 30 40 50 60 MYLQLLKPTL LRCSTRPSSS GAYTRSPIDQ KWAAMAKKAM KGREADTLTW NTPEGIPIKP 70 80 90 100 110 120 LYLRSDRDCD AQRSVELPGQ FPFTRGPYPT MYTQRPWTIR QYAGFSTVEE SNKFYKENIK 130 140 150 160 170 180 AGQQGLSVAF DLATHRGYDS DNPRVFGDVG MAGVAVDSVE DMRQLFDGIN LEKMSVSMTM 190 200 210 220 230 240 NGAVVPVLAM YVVAAEEAGV SRKLLAGTIQ NDILKEFMVR NTYIYPPEPS MRIIGDIFAY 250 260 270 280 290 300 TSREMPKFNS ISISGYHMQE AGADAVLEMA FTIADGIQYC ETGLNAGLTI DAFAPRLSFF 310 320 330 340 350 360 WGISMNFYME IAKMRAARRL WANLIKERFS PKSDKSMMLR THSQTSGWSL TEQDPYNNII 370 380 390 400 410 420 RTTIEAMASV FGGTQSLHTN SFDEALGLPT KFSARIARNT QIIIQEESGI CNVADPWGGS 430 440 450 460 470 480 YMMESLTDEI YEKALAVIKE IDELGGMAKA VASGMTKLKI EEAAAKKQAR IDAGKDVIVG 490 500 510 520 530 540 VNKYRLDHEQ QVEVLKIDNA KVREEQCAKL NHIRATRDAE KAQKALDAIT EGARGNGNLM 550 560 570 580 590 600 ELAIEAARAR CTVGEISDAM EKVFNRHAAV NRLVSGAYKS EFGETSEMSQ VLERVKSFAD 610 620 630 640 650 660 RDGRQPRIMV AKMGQDGHDR GAKVIATGFA DLGFDVDVGP LFQTPLEAAQ QAVDADVHVI 670 680 690 700 710 720 GASSLAAGHL TLIPQLIGEL KKLGRPDILV VAGGVIPPQD YKELYDAGVA LVFGPGTRLP 730 740 ACANQILEKL EANLPEAPGK AASR

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z35604 Genomic DNA. Translation: CAA84676.2.
PIR	T27674.
RefSeq	NP_497786.2.
UniGene	Cel.17830
3D structure databases
HSSP	HSSP built from PDB template 1REQ based on UniProtKB P11653.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q23381. 1 interaction.
Genome annotation databases
Ensembl	ZK1058.1. Caenorhabditis elegans. [Contig view]
GeneID	175503.
KEGG	cel:ZK1058.1.
Organism-specific databases
WormBase	WBGene00014202. mmcm-1.
WormPep	ZK1058.1. CE30404. [WorfDB]
Phylogenomic databases
OMA	Q23381. IDSGSEV.
Enzyme and pathway databases
BRENDA	5.4.99.2. 672.
Gene expression databases
ArrayExpress	Q23381.
Family and domain databases
InterPro	IPR006159. Acid_CoA_mut_C. IPR014348. Cbl-dep_enz_cat-sub. IPR006158. Cobalamin-bd. IPR006099. MMCoA_mutase_a/b_cat. IPR006098. MMCoA_mutase_a_cat. [Graphical view]
Gene3D	G3DSA:3.40.50.280. B12_bd. 1 hit. G3DSA:3.20.20.240. Cobalamin-dep_enz_cat. 1 hit.
Pfam	PF02310. B12-binding. 1 hit. PF01642. MM_CoA_mutase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00640. acid_CoA_mut_C. 1 hit. TIGR00641. acid_CoA_mut_N. 1 hit.
PROSITE	PS51332. B12_BINDING. 1 hit. PS00544. METMALONYL_COA_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	888440.

Entry information

Entry name

MUTA_CAEEL

Accession

Primary (citable) accession number: Q23381

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	June 20, 2002
Last modified:	June 16, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project