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Protein
Submitted name:

AcetylCholine Receptor

Gene

acr-8

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-629587. Highly sodium permeable acetylcholine nicotinic receptors.
R-CEL-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-CEL-629597. Highly calcium permeable nicotinic acetylcholine receptors.
R-CEL-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
AcetylCholine ReceptorImported
Gene namesi
Name:acr-8Imported
ORF Names:CELE_ZC504.2Imported, ZC504.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiZC504.2; CE36679; WBGene00000047; acr-8.

Subcellular locationi

  • Cell junctionsynapsepostsynaptic cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation
  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei251 – 275HelicalSequence analysisAdd BLAST25
Transmembranei281 – 303HelicalSequence analysisAdd BLAST23
Transmembranei315 – 337HelicalSequence analysisAdd BLAST23
Transmembranei457 – 475HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500420139422 – 537Sequence analysisAdd BLAST516

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ23355.

Expressioni

Gene expression databases

BgeeiWBGene00000047.

Interactioni

Protein-protein interaction databases

IntActiQ23355. 2 interactors.
MINTiMINT-3383737.
STRINGi6239.ZC504.2.

Structurei

3D structure databases

ProteinModelPortaliQ23355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 250Neur_chan_LBDInterPro annotationAdd BLAST225
Domaini257 – 473Neur_chan_membInterPro annotationAdd BLAST217

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
InParanoidiQ23355.
KOiK05312.
OMAiHITIMSD.
OrthoDBiEOG091G0R20.
PhylomeDBiQ23355.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFAFLLRIF VYAGLFFYVN PNRYADQMYE DLLYYYNKNV RPIKNASESV
60 70 80 90 100
KVKFGSSLIR IIDVDEVNQV LTTNLWLEMQ WFDYRLMWDP GRWGKIRKLH
110 120 130 140 150
VPVDQIWIPD ILLYNNADGE PHITIMSDAI VYYNGLVVWK PPSIYKSFCS
160 170 180 190 200
IDIEYFPYDT QTCWMKFGGW TYNGFLLDVR QLPVEEWTLV VTTRKLQVCA
210 220 230 240 250
HASSISFFFR SLEWDLMELN SARHEKIYAG CCGQDFYIDI TFKIEIRRKT
260 270 280 290 300
LFYTINLMIP CTMFAILTSI VFYVPPIEHK MTFSISILVT LTVFYLILID
310 320 330 340 350
LVPPTSLVIP LIGKYLLFTM FLVSISIMLS VISLNFYRRD GSSFPMPHWM
360 370 380 390 400
KVVFIHTLPR YICIKTAEED DGSDRGSSIS DIGPFMDSRR PSPFFITVNE
410 420 430 440 450
RQLNGRLSEL KKKGMHPDLI RNMIQNVEFI AEYFNSLKKE DKVSEDWSYV
460 470 480 490 500
ANVIDRIFLI IFSIMNVVGT WVILLNSPAL FDNRTPLFIN SVARPLSGDT
510 520 530
FEHFINENFT QLAWWASTIK NSTTDVSDSD LCPIKYQ
Length:537
Mass (Da):62,755
Last modified:September 13, 2004 - v3
Checksum:i8F99AD84D5FE06A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA90341.3.
PIRiT27619.
RefSeqiNP_509745.2. NM_077344.4.
UniGeneiCel.11549.

Genome annotation databases

EnsemblMetazoaiZC504.2; ZC504.2; WBGene00000047.
GeneIDi181246.
KEGGicel:CELE_ZC504.2.
UCSCiZC504.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA90341.3.
PIRiT27619.
RefSeqiNP_509745.2. NM_077344.4.
UniGeneiCel.11549.

3D structure databases

ProteinModelPortaliQ23355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ23355. 2 interactors.
MINTiMINT-3383737.
STRINGi6239.ZC504.2.

Proteomic databases

PaxDbiQ23355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZC504.2; ZC504.2; WBGene00000047.
GeneIDi181246.
KEGGicel:CELE_ZC504.2.
UCSCiZC504.2. c. elegans.

Organism-specific databases

CTDi181246.
WormBaseiZC504.2; CE36679; WBGene00000047; acr-8.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
InParanoidiQ23355.
KOiK05312.
OMAiHITIMSD.
OrthoDBiEOG091G0R20.
PhylomeDBiQ23355.

Enzyme and pathway databases

ReactomeiR-CEL-629587. Highly sodium permeable acetylcholine nicotinic receptors.
R-CEL-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-CEL-629597. Highly calcium permeable nicotinic acetylcholine receptors.
R-CEL-6798695. Neutrophil degranulation.

Gene expression databases

BgeeiWBGene00000047.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ23355_CAEEL
AccessioniPrimary (citable) accession number: Q23355
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.