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Protein
Submitted name:

AcetylCholine Receptor

Gene

acr-8

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
AcetylCholine ReceptorImported
Gene namesi
Name:acr-8Imported
ORF Names:CELE_ZC504.2Imported, ZC504.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiZC504.2; CE36679; WBGene00000047; acr-8.

Subcellular locationi

  • Cell junctionsynapsepostsynaptic cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation
  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei251 – 27525HelicalSequence analysisAdd
BLAST
Transmembranei281 – 30323HelicalSequence analysisAdd
BLAST
Transmembranei315 – 33723HelicalSequence analysisAdd
BLAST
Transmembranei457 – 47519HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 537516Sequence analysisPRO_5004201394Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ23355.

Expressioni

Gene expression databases

ExpressionAtlasiQ23355. baseline.

Interactioni

Protein-protein interaction databases

IntActiQ23355. 2 interactions.
MINTiMINT-3383737.
STRINGi6239.ZC504.2.

Structurei

3D structure databases

ProteinModelPortaliQ23355.
SMRiQ23355. Positions 22-365, 424-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 250225Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini257 – 473217Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
InParanoidiQ23355.
KOiK05312.
OMAiHITIMSD.
OrthoDBiEOG7J183P.
PhylomeDBiQ23355.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFAFLLRIF VYAGLFFYVN PNRYADQMYE DLLYYYNKNV RPIKNASESV
60 70 80 90 100
KVKFGSSLIR IIDVDEVNQV LTTNLWLEMQ WFDYRLMWDP GRWGKIRKLH
110 120 130 140 150
VPVDQIWIPD ILLYNNADGE PHITIMSDAI VYYNGLVVWK PPSIYKSFCS
160 170 180 190 200
IDIEYFPYDT QTCWMKFGGW TYNGFLLDVR QLPVEEWTLV VTTRKLQVCA
210 220 230 240 250
HASSISFFFR SLEWDLMELN SARHEKIYAG CCGQDFYIDI TFKIEIRRKT
260 270 280 290 300
LFYTINLMIP CTMFAILTSI VFYVPPIEHK MTFSISILVT LTVFYLILID
310 320 330 340 350
LVPPTSLVIP LIGKYLLFTM FLVSISIMLS VISLNFYRRD GSSFPMPHWM
360 370 380 390 400
KVVFIHTLPR YICIKTAEED DGSDRGSSIS DIGPFMDSRR PSPFFITVNE
410 420 430 440 450
RQLNGRLSEL KKKGMHPDLI RNMIQNVEFI AEYFNSLKKE DKVSEDWSYV
460 470 480 490 500
ANVIDRIFLI IFSIMNVVGT WVILLNSPAL FDNRTPLFIN SVARPLSGDT
510 520 530
FEHFINENFT QLAWWASTIK NSTTDVSDSD LCPIKYQ
Length:537
Mass (Da):62,755
Last modified:September 13, 2004 - v3
Checksum:i8F99AD84D5FE06A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA90341.3.
PIRiT27619.
RefSeqiNP_509745.2. NM_077344.4.
UniGeneiCel.11549.

Genome annotation databases

EnsemblMetazoaiZC504.2; ZC504.2; WBGene00000047.
GeneIDi181246.
KEGGicel:CELE_ZC504.2.
UCSCiZC504.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA90341.3.
PIRiT27619.
RefSeqiNP_509745.2. NM_077344.4.
UniGeneiCel.11549.

3D structure databases

ProteinModelPortaliQ23355.
SMRiQ23355. Positions 22-365, 424-477.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ23355. 2 interactions.
MINTiMINT-3383737.
STRINGi6239.ZC504.2.

Proteomic databases

PaxDbiQ23355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZC504.2; ZC504.2; WBGene00000047.
GeneIDi181246.
KEGGicel:CELE_ZC504.2.
UCSCiZC504.2. c. elegans.

Organism-specific databases

CTDi181246.
WormBaseiZC504.2; CE36679; WBGene00000047; acr-8.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
InParanoidiQ23355.
KOiK05312.
OMAiHITIMSD.
OrthoDBiEOG7J183P.
PhylomeDBiQ23355.

Gene expression databases

ExpressionAtlasiQ23355. baseline.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ23355_CAEEL
AccessioniPrimary (citable) accession number: Q23355
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: September 13, 2004
Last modified: July 6, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.