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Protein

Double-strand break repair protein mre-11

Gene

mre-11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in DNA double-strand break repair (DSBR) (PubMed:11238374). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11238374). Also involved in meiotic DSB processing (PubMed:11238374). In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites (PubMed:16628214).2 Publications
Required for meiotic crossing over and chiasma formation. Pachytene morphology and homolog pairing are normal. Vital in long term for maintenance of reproductive capacity of subsequent generations.1 Publication

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei182Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Exonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair, Meiosis
LigandManganese

Enzyme and pathway databases

ReactomeiR-CEL-1834949 Cytosolic sensors of pathogen-associated DNA
R-CEL-2559586 DNA Damage/Telomere Stress Induced Senescence
R-CEL-5693548 Sensing of DNA Double Strand Breaks
R-CEL-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Names & Taxonomyi

Protein namesi
Recommended name:
Double-strand break repair protein mre-11
Gene namesi
Name:mre-11Imported
ORF Names:ZC302.1Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiZC302.1 ; CE37459 ; WBGene00003405 ; mre-11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in DNA damage repair defects following ionizing radiation with reduced ubiquitination at DNA damage sites.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi95E → K in mre-11-ME41; defective in meiotic chromosome degradation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001386781 – 728Double-strand break repair protein mre-11Add BLAST728

Proteomic databases

EPDiQ23255
PaxDbiQ23255
PeptideAtlasiQ23255
PRIDEiQ23255

PTM databases

iPTMnetiQ23255

Expressioni

Gene expression databases

BgeeiWBGene00003405

Interactioni

Subunit structurei

Forms a complex with rad-50.By similarity

Protein-protein interaction databases

BioGridi44517, 5 interactors
IntActiQ23255, 3 interactors
MINTiQ23255
STRINGi6239.ZC302.1.2

Structurei

3D structure databases

ProteinModelPortaliQ23255
SMRiQ23255
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MRE11/RAD32 family.UniRule annotation1 Publication

Phylogenomic databases

eggNOGiKOG2310 Eukaryota
COG0420 LUCA
GeneTreeiENSGT00390000017288
HOGENOMiHOG000018843
InParanoidiQ23255
KOiK10865
OMAiPSREVQH
OrthoDBiEOG091G06P4
PhylomeDBiQ23255

Family and domain databases

Gene3Di3.30.110.110, 1 hit
3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR003701 Mre11
IPR007281 Mre11_DNA-bd
IPR038487 Mre11_DNA-bd_sf
PANTHERiPTHR10139 PTHR10139, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF04152 Mre11_DNA_bind, 1 hit
PIRSFiPIRSF000882 DSB_repair_MRE11, 1 hit
SMARTiView protein in SMART
SM01347 Mre11_DNA_bind, 1 hit
TIGRFAMsiTIGR00583 mre11, 1 hit

Sequencei

Sequence statusi: Complete.

Q23255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGSDDSFDD FVPDSQEPAS SRTRNQDHLD DDEVPCSQRP DAANDTMVED
60 70 80 90 100
LDEGDEPAHD ESEDIIKILV ATDIHCGYGE NKANIHMDAV NTFEEVLQIA
110 120 130 140 150
TEQKVDMILL GGDLFHENNP SREVQHRVTQ LLRQYCLNGN PIALEFLSDA
160 170 180 190 200
SVNFNQSVFG HVNYYDQNLN VGLPIFTIHG NHDDLSGKGL TALDLLHESG
210 220 230 240 250
LVNLFGKHSN IQEFIVSPIL LRKGETRLAL YGIGSQRDDR LVRAFKNNSI
260 270 280 290 300
SFLRPNAGAE DWFNLFVLHQ NRPRRAMHRS TGNFLPESLI PQFFDLLIWG
310 320 330 340 350
HEHECKPDPQ YVASSEAVGD GFYILQPGST VATSLTPEEA LQKNAFLIKI
360 370 380 390 400
KGRKFASKPI PLQTVRPMVC DELLLDKIPP GSRPILKTDR PKHTDGRYID
410 420 430 440 450
EIAIEAKINE MITTAKAKRR PRQPELPLIR LKVIYDGDWL NITPANAKRI
460 470 480 490 500
GLRYENVVAN AVDMVFIKKN NKPKEGKLQT ENEKNITEMA DEMGQVSATN
510 520 530 540 550
LQTIINDYFI NQPLVDQMTV LKPIGIGRAL EQYSAIEEGG LATSANRNFD
560 570 580 590 600
SCLMHQIDVV RKTLKKMPLP PINDPSDLDK FRDLITKDLY DMKKADSERF
610 620 630 640 650
KNPVADVEME EDEDDPQYYM PPQSTSRTNY ASGSEDEVAN SDEEMGSSIS
660 670 680 690 700
RHSKQPTTRG RGRGARGAGA SRETTRGRSN KVVSTRQIDS DGFEIINDSP
710 720
SPPPASRSTR GKARGKSAPS KKRDLSFF
Length:728
Mass (Da):81,559
Last modified:May 10, 2005 - v2
Checksum:iE86C5BEF81216DC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73978 Genomic DNA Translation: CAA98292.2
PIRiT27512
RefSeqiNP_505736.2, NM_073335.4
UniGeneiCel.2948

Genome annotation databases

EnsemblMetazoaiZC302.1.1; ZC302.1.1; WBGene00003405
ZC302.1.2; ZC302.1.2; WBGene00003405
ZC302.1.3; ZC302.1.3; WBGene00003405
GeneIDi179488
KEGGicel:CELE_ZC302.1
UCSCiZC302.1.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiMRE11_CAEEL
AccessioniPrimary (citable) accession number: Q23255
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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