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Protein

Double-strand break repair protein mre-11

Gene

mre-11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.1 Publication
Required for meiotic crossing over and chiasma formation. Pachytene morphology and homolog pairing are normal. Vital in long term for maintenance of reproductive capacity of subsequent generations.1 Publication

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821Proton donorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair, Meiosis

Keywords - Ligandi

Manganese

Enzyme and pathway databases

ReactomeiR-CEL-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-CEL-5693548. Sensing of DNA Double Strand Breaks.
R-CEL-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Names & Taxonomyi

Protein namesi
Recommended name:
Double-strand break repair protein mre-11
Gene namesi
Name:mre-11
ORF Names:ZC302.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiZC302.1; CE37459; WBGene00003405; mre-11.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • Mre11 complex Source: InterPro
  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi95 – 951E → K in mre-11-ME41; defective in meiotic chromosome degradation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Double-strand break repair protein mre-11PRO_0000138678Add
BLAST

Proteomic databases

EPDiQ23255.
PaxDbiQ23255.

PTM databases

iPTMnetiQ23255.

Interactioni

Subunit structurei

Forms a complex with rad-50.By similarity

Protein-protein interaction databases

BioGridi44517. 5 interactions.
IntActiQ23255. 3 interactions.
MINTiMINT-226668.
STRINGi6239.ZC302.1.2.

Structurei

3D structure databases

ProteinModelPortaliQ23255.
SMRiQ23255. Positions 64-465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MRE11/RAD32 family.UniRule annotation1 Publication

Phylogenomic databases

eggNOGiKOG2310. Eukaryota.
COG0420. LUCA.
GeneTreeiENSGT00390000017288.
HOGENOMiHOG000018843.
InParanoidiQ23255.
KOiK10865.
OMAiPSREVQH.
PhylomeDBiQ23255.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR003701. Mre11.
IPR007281. Mre11_DNA-bd.
[Graphical view]
PANTHERiPTHR10139:SF1. PTHR10139:SF1. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
PF04152. Mre11_DNA_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF000882. DSB_repair_MRE11. 1 hit.
SMARTiSM01347. Mre11_DNA_bind. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
TIGRFAMsiTIGR00583. mre11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q23255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGSDDSFDD FVPDSQEPAS SRTRNQDHLD DDEVPCSQRP DAANDTMVED
60 70 80 90 100
LDEGDEPAHD ESEDIIKILV ATDIHCGYGE NKANIHMDAV NTFEEVLQIA
110 120 130 140 150
TEQKVDMILL GGDLFHENNP SREVQHRVTQ LLRQYCLNGN PIALEFLSDA
160 170 180 190 200
SVNFNQSVFG HVNYYDQNLN VGLPIFTIHG NHDDLSGKGL TALDLLHESG
210 220 230 240 250
LVNLFGKHSN IQEFIVSPIL LRKGETRLAL YGIGSQRDDR LVRAFKNNSI
260 270 280 290 300
SFLRPNAGAE DWFNLFVLHQ NRPRRAMHRS TGNFLPESLI PQFFDLLIWG
310 320 330 340 350
HEHECKPDPQ YVASSEAVGD GFYILQPGST VATSLTPEEA LQKNAFLIKI
360 370 380 390 400
KGRKFASKPI PLQTVRPMVC DELLLDKIPP GSRPILKTDR PKHTDGRYID
410 420 430 440 450
EIAIEAKINE MITTAKAKRR PRQPELPLIR LKVIYDGDWL NITPANAKRI
460 470 480 490 500
GLRYENVVAN AVDMVFIKKN NKPKEGKLQT ENEKNITEMA DEMGQVSATN
510 520 530 540 550
LQTIINDYFI NQPLVDQMTV LKPIGIGRAL EQYSAIEEGG LATSANRNFD
560 570 580 590 600
SCLMHQIDVV RKTLKKMPLP PINDPSDLDK FRDLITKDLY DMKKADSERF
610 620 630 640 650
KNPVADVEME EDEDDPQYYM PPQSTSRTNY ASGSEDEVAN SDEEMGSSIS
660 670 680 690 700
RHSKQPTTRG RGRGARGAGA SRETTRGRSN KVVSTRQIDS DGFEIINDSP
710 720
SPPPASRSTR GKARGKSAPS KKRDLSFF
Length:728
Mass (Da):81,559
Last modified:May 10, 2005 - v2
Checksum:iE86C5BEF81216DC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73978 Genomic DNA. Translation: CAA98292.2.
PIRiT27512.
RefSeqiNP_505736.2. NM_073335.4.
UniGeneiCel.2948.

Genome annotation databases

EnsemblMetazoaiZC302.1.1; ZC302.1.1; WBGene00003405.
ZC302.1.2; ZC302.1.2; WBGene00003405.
GeneIDi179488.
KEGGicel:CELE_ZC302.1.
UCSCiZC302.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73978 Genomic DNA. Translation: CAA98292.2.
PIRiT27512.
RefSeqiNP_505736.2. NM_073335.4.
UniGeneiCel.2948.

3D structure databases

ProteinModelPortaliQ23255.
SMRiQ23255. Positions 64-465.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44517. 5 interactions.
IntActiQ23255. 3 interactions.
MINTiMINT-226668.
STRINGi6239.ZC302.1.2.

PTM databases

iPTMnetiQ23255.

Proteomic databases

EPDiQ23255.
PaxDbiQ23255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZC302.1.1; ZC302.1.1; WBGene00003405.
ZC302.1.2; ZC302.1.2; WBGene00003405.
GeneIDi179488.
KEGGicel:CELE_ZC302.1.
UCSCiZC302.1.1. c. elegans.

Organism-specific databases

CTDi179488.
WormBaseiZC302.1; CE37459; WBGene00003405; mre-11.

Phylogenomic databases

eggNOGiKOG2310. Eukaryota.
COG0420. LUCA.
GeneTreeiENSGT00390000017288.
HOGENOMiHOG000018843.
InParanoidiQ23255.
KOiK10865.
OMAiPSREVQH.
PhylomeDBiQ23255.

Enzyme and pathway databases

ReactomeiR-CEL-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-CEL-5693548. Sensing of DNA Double Strand Breaks.
R-CEL-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Miscellaneous databases

NextBioi905614.
PROiQ23255.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR003701. Mre11.
IPR007281. Mre11_DNA-bd.
[Graphical view]
PANTHERiPTHR10139:SF1. PTHR10139:SF1. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
PF04152. Mre11_DNA_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF000882. DSB_repair_MRE11. 1 hit.
SMARTiSM01347. Mre11_DNA_bind. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
TIGRFAMsiTIGR00583. mre11. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "C. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G(2) DNA damage checkpoint."
    Chin G.M., Villeneuve A.M.
    Genes Dev. 15:522-534(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLU-95.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMRE11_CAEEL
AccessioniPrimary (citable) accession number: Q23255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.