ID   CYC22_CAEEL             Reviewed;         123 AA.
AC   Q23240;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 165.
DE   RecName: Full=Probable cytochrome c 2.2;
GN   Name=cyc-2.2; ORFNames=ZC116.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Electron carrier protein. The oxidized form of the cytochrome
CC       c heme group can accept an electron from the heme group of the
CC       cytochrome c1 subunit of cytochrome reductase. Cytochrome c then
CC       transfers this electron to the cytochrome oxidase complex, the final
CC       protein carrier in the mitochondrial electron-transport chain (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}.
CC       Note=Loosely associated with the inner membrane. {ECO:0000250}.
CC   -!- PTM: Binds 1 heme c group covalently per subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Life shuttle - Issue 76 of
CC       November 2006;
CC       URL="https://web.expasy.org/spotlight/back_issues/076";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z74046; CAA98555.1; -; Genomic_DNA.
DR   PIR; T27492; T27492.
DR   RefSeq; NP_506156.1; NM_073755.3.
DR   AlphaFoldDB; Q23240; -.
DR   SMR; Q23240; -.
DR   BioGRID; 44748; 12.
DR   STRING; 6239.ZC116.2.1; -.
DR   EPD; Q23240; -.
DR   PaxDb; 6239-ZC116-2; -.
DR   PeptideAtlas; Q23240; -.
DR   EnsemblMetazoa; ZC116.2.1; ZC116.2.1; WBGene00013854.
DR   GeneID; 179728; -.
DR   KEGG; cel:CELE_ZC116.2; -.
DR   AGR; WB:WBGene00013854; -.
DR   WormBase; ZC116.2; CE06565; WBGene00013854; cyc-2.2.
DR   eggNOG; KOG3453; Eukaryota.
DR   GeneTree; ENSGT00940000168884; -.
DR   HOGENOM; CLU_060944_3_1_1; -.
DR   InParanoid; Q23240; -.
DR   OMA; MPAPYKK; -.
DR   OrthoDB; 4150at2759; -.
DR   PhylomeDB; Q23240; -.
DR   Reactome; R-CEL-111457; Release of apoptotic factors from the mitochondria.
DR   Reactome; R-CEL-3299685; Detoxification of Reactive Oxygen Species.
DR   Reactome; R-CEL-5620971; Pyroptosis.
DR   Reactome; R-CEL-611105; Respiratory electron transport.
DR   PRO; PR:Q23240; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00013854; Expressed in adult organism and 1 other cell type or tissue.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
DR   GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IBA:GO_Central.
DR   Gene3D; 1.10.760.10; Cytochrome c-like domain; 1.
DR   InterPro; IPR009056; Cyt_c-like_dom.
DR   InterPro; IPR036909; Cyt_c-like_dom_sf.
DR   InterPro; IPR002327; Cyt_c_1A/1B.
DR   PANTHER; PTHR11961; CYTOCHROME C; 1.
DR   PANTHER; PTHR11961:SF12; CYTOCHROME C; 1.
DR   Pfam; PF00034; Cytochrom_C; 1.
DR   PRINTS; PR00604; CYTCHRMECIAB.
DR   SUPFAM; SSF46626; Cytochrome c; 1.
DR   PROSITE; PS51007; CYTC; 1.
PE   3: Inferred from homology;
KW   Electron transport; Heme; Iron; Metal-binding; Mitochondrion;
KW   Reference proteome; Respiratory chain; Transport.
FT   CHAIN           1..123
FT                   /note="Probable cytochrome c 2.2"
FT                   /id="PRO_0000108272"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         30
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /note="covalent"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
FT   BINDING         33
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /note="covalent"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
FT   BINDING         34
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
FT   BINDING         95
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
SQ   SEQUENCE   123 AA;  13362 MW;  6FBC24AF847F596C CRC64;
     MGKKKSDTAS GGAIPEGDNE KGKKIFKQRC EQCHVVNSLQ TKTGPTLNGV IGRQSGQVAG
     FDYSAANKNK GVVWDRQTLF DYLADPKKYI PGTKMVFAGL KKADERADLI KFIEVEAAKK
     PSA
//