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Q23240

- CYC22_CAEEL

UniProt

Q23240 - CYC22_CAEEL

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Protein

Probable cytochrome c 2.2

Gene

cyc-2.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301Heme (covalent)PROSITE-ProRule annotation
Binding sitei33 – 331Heme (covalent)PROSITE-ProRule annotation
Metal bindingi34 – 341Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi95 – 951Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_184548. Detoxification of Reactive Oxygen Species.
REACT_208473. Release of apoptotic factors from the mitochondria.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c 2.2
Gene namesi
Name:cyc-2.2
ORF Names:ZC116.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiZC116.2; CE06565; WBGene00013854; cyc-2.2.

Subcellular locationi

Mitochondrion intermembrane space By similarity
Note: Loosely associated with the inner membrane.By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 123123Probable cytochrome c 2.2PRO_0000108272Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.By similarity

Proteomic databases

PaxDbiQ23240.
PRIDEiQ23240.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZC116.2.

Structurei

3D structure databases

ProteinModelPortaliQ23240.
SMRiQ23240. Positions 17-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
InParanoidiQ23240.
KOiK08738.
OMAiACNTELA.
OrthoDBiEOG761BWX.
PhylomeDBiQ23240.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23240-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKKKSDTAS GGAIPEGDNE KGKKIFKQRC EQCHVVNSLQ TKTGPTLNGV
60 70 80 90 100
IGRQSGQVAG FDYSAANKNK GVVWDRQTLF DYLADPKKYI PGTKMVFAGL
110 120
KKADERADLI KFIEVEAAKK PSA
Length:123
Mass (Da):13,362
Last modified:November 1, 1996 - v1
Checksum:i6FBC24AF847F596C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z74046 Genomic DNA. Translation: CAA98555.1.
PIRiT27492.
RefSeqiNP_506156.1. NM_073755.3.
UniGeneiCel.1420.

Genome annotation databases

EnsemblMetazoaiZC116.2; ZC116.2; WBGene00013854.
GeneIDi179728.
KEGGicel:CELE_ZC116.2.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z74046 Genomic DNA. Translation: CAA98555.1 .
PIRi T27492.
RefSeqi NP_506156.1. NM_073755.3.
UniGenei Cel.1420.

3D structure databases

ProteinModelPortali Q23240.
SMRi Q23240. Positions 17-114.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.ZC116.2.

Proteomic databases

PaxDbi Q23240.
PRIDEi Q23240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZC116.2 ; ZC116.2 ; WBGene00013854 .
GeneIDi 179728.
KEGGi cel:CELE_ZC116.2.

Organism-specific databases

CTDi 179728.
WormBasei ZC116.2 ; CE06565 ; WBGene00013854 ; cyc-2.2.

Phylogenomic databases

eggNOGi COG3474.
GeneTreei ENSGT00390000009405.
InParanoidi Q23240.
KOi K08738.
OMAi ACNTELA.
OrthoDBi EOG761BWX.
PhylomeDBi Q23240.

Enzyme and pathway databases

Reactomei REACT_184548. Detoxification of Reactive Oxygen Species.
REACT_208473. Release of apoptotic factors from the mitochondria.

Miscellaneous databases

NextBioi 906616.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view ]
PANTHERi PTHR11961. PTHR11961. 1 hit.
Pfami PF00034. Cytochrom_C. 1 hit.
[Graphical view ]
PRINTSi PR00604. CYTCHRMECIAB.
SUPFAMi SSF46626. SSF46626. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCYC22_CAEEL
AccessioniPrimary (citable) accession number: Q23240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3