Q23240 (CYC22_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cytochrome c 2.2

Gene names

Name:	cyc-2.2
ORF Names:	ZC116.2

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	123 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain By similarity.
Subcellular location	Mitochondrion intermembrane space By similarity. Note: Loosely associated with the inner membrane By similarity.
Post-translational modification	Binds 1 heme group per subunit By similarity.
Sequence similarities	Belongs to the cytochrome c family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 123	123	Probable cytochrome c 2.2		PRO_0000108272
Sites
	Metal binding	34	1	Iron (heme axial ligand) By similarity
	Metal binding	95	1	Iron (heme axial ligand) By similarity
	Binding site	30	1	Heme (covalent) By similarity
	Binding site	33	1	Heme (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q23240 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 6FBC24AF847F596C	FASTA	123	13,362
	10 20 30 40 50 60 MGKKKSDTAS GGAIPEGDNE KGKKIFKQRC EQCHVVNSLQ TKTGPTLNGV IGRQSGQVAG 70 80 90 100 110 120 FDYSAANKNK GVVWDRQTLF DYLADPKKYI PGTKMVFAGL KKADERADLI KFIEVEAAKK PSA

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z74046 Genomic DNA. Translation: CAA98555.1.
PIR	T27492.
RefSeq	NP_506156.1. NM_073755.3.
3D structure databases
ProteinModelPortal	Q23240.
SMR	Q23240. Positions 17-114.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.ZC116.2.
Proteomic databases
PaxDb	Q23240.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZC116.2; ZC116.2; ZC116.2.
GeneID	179728.
KEGG	cel:CELE_ZC116.2.
Organism-specific databases
CTD	179728.
WormBase	ZC116.2; CE06565; WBGene00013854; cyc-2.2.
Phylogenomic databases
eggNOG	COG3474.
GeneTree	ENSGT00390000009405.
InParanoid	Q23240.
KO	K08738.
OMA	KMIYAGL.
Family and domain databases
InterPro	IPR002327. Cyt_c_1A/1B. IPR009056. Cyt_c_dom. IPR003088. Cyt_c_I. [Graphical view]
PANTHER	PTHR11961. PTHR11961. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
SUPFAM	SSF46626. Cytochrome_c. 1 hit.
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	906616.

Entry information

Entry name

CYC22_CAEEL

Accession

Primary (citable) accession number: Q23240

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project