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Q23240

- CYC22_CAEEL

UniProt

Q23240 - CYC22_CAEEL

Protein

Probable cytochrome c 2.2

Gene

cyc-2.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei30 – 301Heme (covalent)PROSITE-ProRule annotation
    Binding sitei33 – 331Heme (covalent)PROSITE-ProRule annotation
    Metal bindingi34 – 341Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi95 – 951Iron (heme axial ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_184548. Detoxification of Reactive Oxygen Species.
    REACT_208473. Release of apoptotic factors from the mitochondria.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c 2.2
    Gene namesi
    Name:cyc-2.2
    ORF Names:ZC116.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiZC116.2; CE06565; WBGene00013854; cyc-2.2.

    Subcellular locationi

    Mitochondrion intermembrane space By similarity
    Note: Loosely associated with the inner membrane.By similarity

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 123123Probable cytochrome c 2.2PRO_0000108272Add
    BLAST

    Post-translational modificationi

    Binds 1 heme group per subunit.By similarity

    Proteomic databases

    PaxDbiQ23240.
    PRIDEiQ23240.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.ZC116.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ23240.
    SMRiQ23240. Positions 17-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c family.Curated

    Phylogenomic databases

    eggNOGiCOG3474.
    GeneTreeiENSGT00390000009405.
    InParanoidiQ23240.
    KOiK08738.
    OMAiACNTELA.
    OrthoDBiEOG761BWX.
    PhylomeDBiQ23240.

    Family and domain databases

    Gene3Di1.10.760.10. 1 hit.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view]
    PANTHERiPTHR11961. PTHR11961. 1 hit.
    PfamiPF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    PRINTSiPR00604. CYTCHRMECIAB.
    SUPFAMiSSF46626. SSF46626. 1 hit.
    PROSITEiPS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q23240-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKKKSDTAS GGAIPEGDNE KGKKIFKQRC EQCHVVNSLQ TKTGPTLNGV    50
    IGRQSGQVAG FDYSAANKNK GVVWDRQTLF DYLADPKKYI PGTKMVFAGL 100
    KKADERADLI KFIEVEAAKK PSA 123
    Length:123
    Mass (Da):13,362
    Last modified:November 1, 1996 - v1
    Checksum:i6FBC24AF847F596C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z74046 Genomic DNA. Translation: CAA98555.1.
    PIRiT27492.
    RefSeqiNP_506156.1. NM_073755.3.
    UniGeneiCel.1420.

    Genome annotation databases

    EnsemblMetazoaiZC116.2; ZC116.2; WBGene00013854.
    GeneIDi179728.
    KEGGicel:CELE_ZC116.2.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Life shuttle - Issue 76 of November 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z74046 Genomic DNA. Translation: CAA98555.1 .
    PIRi T27492.
    RefSeqi NP_506156.1. NM_073755.3.
    UniGenei Cel.1420.

    3D structure databases

    ProteinModelPortali Q23240.
    SMRi Q23240. Positions 17-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.ZC116.2.

    Proteomic databases

    PaxDbi Q23240.
    PRIDEi Q23240.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZC116.2 ; ZC116.2 ; WBGene00013854 .
    GeneIDi 179728.
    KEGGi cel:CELE_ZC116.2.

    Organism-specific databases

    CTDi 179728.
    WormBasei ZC116.2 ; CE06565 ; WBGene00013854 ; cyc-2.2.

    Phylogenomic databases

    eggNOGi COG3474.
    GeneTreei ENSGT00390000009405.
    InParanoidi Q23240.
    KOi K08738.
    OMAi ACNTELA.
    OrthoDBi EOG761BWX.
    PhylomeDBi Q23240.

    Enzyme and pathway databases

    Reactomei REACT_184548. Detoxification of Reactive Oxygen Species.
    REACT_208473. Release of apoptotic factors from the mitochondria.

    Miscellaneous databases

    NextBioi 906616.

    Family and domain databases

    Gene3Di 1.10.760.10. 1 hit.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view ]
    PANTHERi PTHR11961. PTHR11961. 1 hit.
    Pfami PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00604. CYTCHRMECIAB.
    SUPFAMi SSF46626. SSF46626. 1 hit.
    PROSITEi PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiCYC22_CAEEL
    AccessioniPrimary (citable) accession number: Q23240
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3