Q23157 (INX11_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Innexin-11

Alternative name(s):
Protein opu-11

Gene names

Name:	inx-11
Synonyms:	opu-11
ORF Names:	W04D2.3

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Structural components of the gap junctions By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential. Cell junction › gap junction By similarity.
Sequence similarities	Belongs to the pannexin family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Gap junction Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	gap junction Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	gap junction hemi-channel activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Innexin-11		PRO_0000208512
Regions
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	105 – 125	21	Helical; Potential
	Transmembrane	195 – 215	21	Helical; Potential
	Transmembrane	286 – 306	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q23157 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 467F2E009F721A43	FASTA	465	54,576
	10 20 30 40 50 60 MVMIETFLGM AKYLSPREDD DWSDRLNYLM TPNILLAFSV LISFKQFGGR PIECMFPNKF 70 80 90 100 110 120 PGSWEQYAEN YCWSQDTYFV EPTQDVSLLK KEERYTPDRQ LSYYQWVPFF LLLQAAFFRA 130 140 150 160 170 180 PSYLWKYFSN HSGIRIHEVV EKAKDSANVE EEVREKNILI LKRHLSSALR FQANMERKKV 190 200 210 220 230 240 QVHKTVTFLN FQYSSGFISW IYLFTKVLYF LNVFAQLYLM NYFLGTNRHH WYGFGVVQDI 250 260 270 280 290 300 VQGEPWERSG YFPRAAVCDF EVRQVANIQR YSVQCVLVIN IFNEKIFVLL WFWYVILLLS 310 320 330 340 350 360 STVSLVQWFI VLVFPCFSKW FVKQHLALST LQNFNQRNSR REDSDVSKFV TQYLHKDGVF 370 380 390 400 410 420 VLRMVSSHAG IIFATDLVQA LYEAYDFQDK NKDVQGSPVS DDLQTISTGA ESSIRQRKTR 430 440 450 460 KGSRIEYKAG FPISTSLMPD KDDIESSSTS SEEDQKRVSN VITNI

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z75552 Genomic DNA. Translation: CAA99940.1.
PIR	T26146.
RefSeq	NP_001256426.1. NM_001269497.1.
3D structure databases
ModBase	Search...
Proteomic databases
PaxDb	Q23157.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	W04D2.3a; W04D2.3a; W04D2.3.
GeneID	179710.
KEGG	cel:CELE_W04D2.3.
UCSC	W04D2.3. c. elegans.
Organism-specific databases
CTD	179710.
WormBase	W04D2.3a; CE06538; WBGene00002133; inx-11.
Phylogenomic databases
eggNOG	NOG39377.
GeneTree	ENSGT00530000064205.
HOGENOM	HOG000017412.
InParanoid	Q23157.
Gene expression databases
ArrayExpress	Q23157.
Family and domain databases
InterPro	IPR000990. Innexin. [Graphical view]
PANTHER	PTHR11893. PTHR11893. 1 hit.
Pfam	PF00876. Innexin. 1 hit. [Graphical view]
PRINTS	PR01262. INNEXIN.
PROSITE	PS51013. PANNEXIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	906546.

Entry information

Entry name

INX11_CAEEL

Accession

Primary (citable) accession number: Q23157

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project