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Q23126

- TRMB_CAEEL

UniProt

Q23126 - TRMB_CAEEL

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

W02B12.10

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei152 – 1521S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Active sitei155 – 1551UniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA (guanine-N7)-methylation Source: GOC
  2. tRNA modification Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
ORF Names:W02B12.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiW02B12.10; CE03770; WBGene00012205.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256tRNA (guanine-N(7)-)-methyltransferasePRO_0000171433Add
BLAST

Proteomic databases

PaxDbiQ23126.
PRIDEiQ23126.

Interactioni

Protein-protein interaction databases

STRINGi6239.W02B12.10.

Structurei

3D structure databases

ProteinModelPortaliQ23126.
SMRiQ23126. Positions 37-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 982S-adenosyl-L-methionine bindingUniRule annotation
Regioni132 – 1332S-adenosyl-L-methionine bindingUniRule annotation
Regioni230 – 2323S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
GeneTreeiENSGT00390000017840.
HOGENOMiHOG000260965.
InParanoidiQ23126.
KOiK03439.
OMAiRAHSNPI.
OrthoDBiEOG7PS1GC.
PhylomeDBiQ23126.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q23126-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDITPALTEM ELDHKPTCET VPGLPQKKHY RQRAHSNPHS DHDIEYPLTP
60 70 80 90 100
NHMDWTKYYG DYTKGRQVDF ADIGCGYGGL LMRLSPKYPD NLMIGMEIRV
110 120 130 140 150
KVSDYVNEKI QALRKHHAEA GHYRNVAVLR SNAMKYMPNY FHKGQLSKMF
160 170 180 190 200
FLFPDPHFKN KKHKWRIITP TLLSEYAYVL REGGIIYTIT DVKDLHEWMV
210 220 230 240 250
KHLSEHPLFE RLTEEEMKKD PIVEMLFEST EEGQKVTRND GGKWPAIFRR

LPNPAL
Length:256
Mass (Da):30,041
Last modified:November 1, 1996 - v1
Checksum:i4F4FAF58CB25FD24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z66521 Genomic DNA. Translation: CAA91400.1.
PIRiT26090.
RefSeqiNP_496448.1. NM_064047.3.
UniGeneiCel.14230.

Genome annotation databases

EnsemblMetazoaiW02B12.10; W02B12.10; WBGene00012205.
GeneIDi174753.
KEGGicel:CELE_W02B12.10.
UCSCiW02B12.10. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z66521 Genomic DNA. Translation: CAA91400.1 .
PIRi T26090.
RefSeqi NP_496448.1. NM_064047.3.
UniGenei Cel.14230.

3D structure databases

ProteinModelPortali Q23126.
SMRi Q23126. Positions 37-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.W02B12.10.

Proteomic databases

PaxDbi Q23126.
PRIDEi Q23126.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai W02B12.10 ; W02B12.10 ; WBGene00012205 .
GeneIDi 174753.
KEGGi cel:CELE_W02B12.10.
UCSCi W02B12.10. c. elegans.

Organism-specific databases

CTDi 174753.
WormBasei W02B12.10 ; CE03770 ; WBGene00012205 .

Phylogenomic databases

eggNOGi COG0220.
GeneTreei ENSGT00390000017840.
HOGENOMi HOG000260965.
InParanoidi Q23126.
KOi K03439.
OMAi RAHSNPI.
OrthoDBi EOG7PS1GC.
PhylomeDBi Q23126.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Miscellaneous databases

NextBioi 885350.
PROi Q23126.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiTRMB_CAEEL
AccessioniPrimary (citable) accession number: Q23126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3