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Protein

Epoxide hydrolase

Gene

CELE_W01A11.1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-(4-methoxyphenyl)-N-methyl-N-((3-methyloxetan-3-yl)methyl)methanamine + H2O = 2-((((4-methoxyphenyl)methyl)(methyl)amino)methyl)-2-methylpropane-1,3-diol.UniRule annotation
Cis-stilbene oxide + H2O = (1R,2R)-1,2-diphenylethane-1,2-diol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227NucleophileUniRule annotation1
Active sitei375Proton donorUniRule annotation1
Active sitei430Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processAromatic hydrocarbons catabolismUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-211945 Phase I - Functionalization of compounds

Protein family/group databases

ESTHERicaeel-W01A11.1 Epoxide_hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxide hydrolaseUniRule annotation (EC:3.3.2.9UniRule annotation)
Gene namesi
ORF Names:CELE_W01A11.1Imported, W01A11.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiW01A11.1a ; CE14390 ; WBGene00020909

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, MembraneUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500420179119 – 452Epoxide hydrolaseSequence analysisAdd BLAST434

Proteomic databases

EPDiQ23068
PaxDbiQ23068
PeptideAtlasiQ23068

Expressioni

Gene expression databases

BgeeiWBGene00020909
ExpressionAtlasiQ23068 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi6239.W01A11.1

Structurei

3D structure databases

ProteinModelPortaliQ23068
SMRiQ23068
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 158EHNInterPro annotationAdd BLAST110

Sequence similaritiesi

Belongs to the peptidase S33 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2565 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00390000002210
HOGENOMiHOG000132894
InParanoidiQ23068
KOiK01253
OMAiYSLMRES
OrthoDBiEOG091G0B5A
PhylomeDBiQ23068

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000639 Epox_hydrolase-like
IPR010497 Epoxide_hydro_N
IPR016292 Epoxide_hydrolase
PfamiView protein in Pfam
PF06441 EHN, 1 hit
PIRSFiPIRSF001112 Epoxide_hydrolase, 1 hit
PRINTSiPR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q23068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILKLILVP VAIGVLAAAV WNLLPEKEIN VEENNYYGSG KAKPDNTEIK
60 70 80 90 100
PFKVNVEQSV IDDLKHRLQN ARISHSVLED SDDFYYGFNS KQLLKLRDYW
110 120 130 140 150
LNKYDWRKQE ATINQFPQFK TEIEGLQVHF LHVKPPKSYK NVKPILVAHG
160 170 180 190 200
WPGNVFEFYK FIPLLTDPKK HGIDSDFAFE VIAPSIPGYG WSDQPKKTGF
210 220 230 240 250
SQLACARVFR KLMLRLGYNK FYLQGGDWGA IITSLLTKVY PQNVMALHLN
260 270 280 290 300
MMPAMPGANA LGTFYDILGW LIPSTLSSKE IQKTHNPFSK FGLLIVETGY
310 320 330 340 350
MHLQATKPDT AGTSLNDSPI GLAAYIIEKF STWTNTENRA LPDGGLNKRF
360 370 380 390 400
TNDELLTIVM IYWTNGNIVS SQRFYREMFL DRRCEALGKR YVSTPTAHAS
410 420 430 440 450
GLNELYDRTP IEVSRHSYNI THYTEIDMGH FAAFEAPKPL AQSVFKFVKD

LN
Length:452
Mass (Da):51,460
Last modified:November 1, 1996 - v1
Checksum:iCCA16D0ECE54385E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD74260.1
PIRiD89073
T29648
T33960
RefSeqiNP_504650.1, NM_072249.6
UniGeneiCel.2059

Genome annotation databases

EnsemblMetazoaiW01A11.1a; W01A11.1a; WBGene00020909
GeneIDi179036
KEGGicel:CELE_W01A11.1
UCSCiW01A11.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ23068_CAEEL
AccessioniPrimary (citable) accession number: Q23068
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health