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Q22H00

- Q22H00_TETTS

UniProt

Q22H00 - Q22H00_TETTS

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Protein

Superoxide dismutase [Cu-Zn]

Gene

TTHERM_00655520

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Binds 1 copper ion per subunit.UniRule annotation
Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. copper ion binding Source: RefGenome
  2. superoxide dismutase activity Source: RefGenome
  3. zinc ion binding Source: RefGenome

GO - Biological processi

  1. removal of superoxide radicals Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
ORF Names:TTHERM_00655520Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5911.XP_001032187.

Structurei

3D structure databases

ProteinModelPortaliQ22H00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

InParanoidiQ22H00.
KOiK04565.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22H00-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQHAPVYAI CLLKNETNTV SAVVRLVEKF ENNKFVTHLK ATFKGLPAGL
60 70 80 90 100
HGFHVHQYGD LSNGCATAGP HFNPFNKQHG GPNDENRHVG DLGNVTAVDG
110 120 130 140 150
QDTNFEFQSD LIRLSGENTI VGRSFVIHAD EDDLGKGNFE DSKTTGHAGA
160
RLACGIIALA APFENF
Length:166
Mass (Da):17,900
Last modified:April 18, 2006 - v1
Checksum:i742B4B90762A8AB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662502 Genomic DNA. Translation: EAR84524.1.
RefSeqiXP_001032187.1. XM_001032187.2.
UniGeneiTth.445.

Genome annotation databases

EnsemblProtistsiEAR84524; EAR84524; TTHERM_00655520.
GeneIDi7823633.
KEGGitet:TTHERM_00655520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662502 Genomic DNA. Translation: EAR84524.1 .
RefSeqi XP_001032187.1. XM_001032187.2.
UniGenei Tth.445.

3D structure databases

ProteinModelPortali Q22H00.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5911.XP_001032187.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi EAR84524 ; EAR84524 ; TTHERM_00655520 .
GeneIDi 7823633.
KEGGi tet:TTHERM_00655520.

Phylogenomic databases

InParanoidi Q22H00.
KOi K04565.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210Imported.

Entry informationi

Entry nameiQ22H00_TETTS
AccessioniPrimary (citable) accession number: Q22H00
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3