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Protein
Submitted name:

HIStone

Gene

his-39

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Submitted name:
HIStoneImported
Gene namesi
Name:his-39Imported
ORF Names:CELE_F45F2.2Imported, F45F2.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF45F2.2; CE36851; WBGene00001913; his-39.

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome coreSAAS annotation, NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ22979.
PRIDEiQ22979.

Expressioni

Gene expression databases

BgeeiWBGene00001913.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.SAAS annotation

Protein-protein interaction databases

STRINGi6239.F45F2.2.

Structurei

3D structure databases

ProteinModelPortaliQ22979.
SMRiQ22979. Positions 17-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 8367HistoneInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone H2B family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00840000129751.
HOGENOMiHOG000231213.
InParanoidiQ22979.
KOiK11252.
OMAiANFMAVQ.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ22979.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCCKIFKYL TPNFLHKESY SLYIFRVLKQ VHPDTGVSSK AMSIMNSFVN
60 70 80 90 100
DVFERIAAEA SRLAHYNKRS TISSREIQTA VRLILPGELA KNAVSEGTNA

VTKYTSSK
Length:108
Mass (Da):12,164
Last modified:August 16, 2004 - v2
Checksum:iEB1D79C36513C6F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD70019.1.
PIRiT28965.
RefSeqiNP_505201.2. NM_072800.2.
UniGeneiCel.28729.

Genome annotation databases

EnsemblMetazoaiF45F2.2; F45F2.2; WBGene00001913.
GeneIDi191681.
KEGGicel:CELE_F45F2.2.
UCSCiF45F2.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD70019.1.
PIRiT28965.
RefSeqiNP_505201.2. NM_072800.2.
UniGeneiCel.28729.

3D structure databases

ProteinModelPortaliQ22979.
SMRiQ22979. Positions 17-108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F45F2.2.

Proteomic databases

PaxDbiQ22979.
PRIDEiQ22979.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF45F2.2; F45F2.2; WBGene00001913.
GeneIDi191681.
KEGGicel:CELE_F45F2.2.
UCSCiF45F2.2. c. elegans.

Organism-specific databases

CTDi191681.
WormBaseiF45F2.2; CE36851; WBGene00001913; his-39.

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00840000129751.
HOGENOMiHOG000231213.
InParanoidiQ22979.
KOiK11252.
OMAiANFMAVQ.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ22979.

Gene expression databases

BgeeiWBGene00001913.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ22979_CAEEL
AccessioniPrimary (citable) accession number: Q22979
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.