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Protein
Submitted name:

HIStone

Gene

his-39

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-212300. PRC2 methylates histones and DNA.
R-CEL-2299718. Condensation of Prophase Chromosomes.
R-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-427359. SIRT1 negatively regulates rRNA expression.
R-CEL-5578749. Transcriptional regulation by small RNAs.
R-CEL-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-CEL-8936459. RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.

Names & Taxonomyi

Protein namesi
Submitted name:
HIStoneImported
Gene namesi
Name:his-39Imported
ORF Names:CELE_F45F2.2Imported, F45F2.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF45F2.2; CE52308; WBGene00001913; his-39.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreSAAS annotation, NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ22979.
PeptideAtlasiQ22979.

Expressioni

Gene expression databases

BgeeiWBGene00001913.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.SAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.F45F2.2.

Structurei

3D structure databases

ProteinModelPortaliQ22979.
SMRiQ22979.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 42HistoneInterPro annotationAdd BLAST42

Sequence similaritiesi

Belongs to the histone H2B family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00760000118976.
HOGENOMiHOG000231213.
InParanoidiQ22979.
KOiK11252.
OMAiEVARACT.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ22979.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00621. HISTONEH2B.
SMARTiView protein in SMART
SM00427. H2B. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIMNSFVND VFERIAAEAS RLAHYNKRST ISSREIQTAV RLILPGELAK
60
NAVSEGTNAV TKYTSSK
Length:67
Mass (Da):7,374
Last modified:December 20, 2017 - v3
Checksum:i9BAE292B100A6D0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD70019.2.
PIRiT28965.
RefSeqiNP_505201.2. NM_072800.2.

Genome annotation databases

EnsemblMetazoaiF45F2.2; F45F2.2; WBGene00001913.
GeneIDi191681.
KEGGicel:CELE_F45F2.2.
UCSCiF45F2.2. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ22979_CAEEL
AccessioniPrimary (citable) accession number: Q22979
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: December 20, 2017
Last modified: January 31, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported