Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

HIStone

Gene

his-39

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Submitted name:
HIStoneImported
Gene namesi
Name:his-39Imported
ORF Names:CELE_F45F2.2Imported, F45F2.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF45F2.2; CE36851; WBGene00001913; his-39.

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleosome coreSAAS annotation, NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ22979.
PeptideAtlasiQ22979.

Expressioni

Gene expression databases

BgeeiWBGene00001913.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.SAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.F45F2.2.

Structurei

3D structure databases

ProteinModelPortaliQ22979.
SMRiQ22979.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 83HistoneInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the histone H2B family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00870000136414.
HOGENOMiHOG000231213.
InParanoidiQ22979.
KOiK11252.
OMAiANFMAVQ.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ22979.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00621. HISTONEH2B.
SMARTiView protein in SMART
SM00427. H2B. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCCKIFKYL TPNFLHKESY SLYIFRVLKQ VHPDTGVSSK AMSIMNSFVN
60 70 80 90 100
DVFERIAAEA SRLAHYNKRS TISSREIQTA VRLILPGELA KNAVSEGTNA

VTKYTSSK
Length:108
Mass (Da):12,164
Last modified:August 16, 2004 - v2
Checksum:iEB1D79C36513C6F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD70019.1.
PIRiT28965.
RefSeqiNP_505201.2. NM_072800.2.
UniGeneiCel.28729.

Genome annotation databases

EnsemblMetazoaiF45F2.2; F45F2.2; WBGene00001913.
GeneIDi191681.
KEGGicel:CELE_F45F2.2.
UCSCiF45F2.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD70019.1.
PIRiT28965.
RefSeqiNP_505201.2. NM_072800.2.
UniGeneiCel.28729.

3D structure databases

ProteinModelPortaliQ22979.
SMRiQ22979.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F45F2.2.

Proteomic databases

PaxDbiQ22979.
PeptideAtlasiQ22979.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF45F2.2; F45F2.2; WBGene00001913.
GeneIDi191681.
KEGGicel:CELE_F45F2.2.
UCSCiF45F2.2. c. elegans.

Organism-specific databases

CTDi191681.
WormBaseiF45F2.2; CE36851; WBGene00001913; his-39.

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00870000136414.
HOGENOMiHOG000231213.
InParanoidiQ22979.
KOiK11252.
OMAiANFMAVQ.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ22979.

Gene expression databases

BgeeiWBGene00001913.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00621. HISTONEH2B.
SMARTiView protein in SMART
SM00427. H2B. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ22979_CAEEL
AccessioniPrimary (citable) accession number: Q22979
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: August 16, 2004
Last modified: May 10, 2017
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.