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Protein
Submitted name:

HIStone

Gene

his-39

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-212300. PRC2 methylates histones and DNA.
R-CEL-2299718. Condensation of Prophase Chromosomes.
R-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-3214815. HDACs deacetylate histones.
R-CEL-3214847. HATs acetylate histones.
R-CEL-427359. SIRT1 negatively regulates rRNA expression.
R-CEL-5578749. Transcriptional regulation by small RNAs.
R-CEL-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-CEL-8936459. RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.

Names & Taxonomyi

Protein namesi
Submitted name:
HIStoneImported
Gene namesi
Name:his-39Imported
ORF Names:CELE_F45F2.2Imported, F45F2.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF45F2.2; CE52308; WBGene00001913; his-39.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreSAAS annotation, NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ22979.
PeptideAtlasiQ22979.

Expressioni

Gene expression databases

BgeeiWBGene00001913.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.SAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.F45F2.2.

Structurei

3D structure databases

ProteinModelPortaliQ22979.
SMRiQ22979.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 42HistoneInterPro annotationAdd BLAST42

Sequence similaritiesi

Belongs to the histone H2B family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00760000118976.
HOGENOMiHOG000231213.
InParanoidiQ22979.
KOiK11252.
OMAiNSERWAV.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ22979.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00621. HISTONEH2B.
SMARTiView protein in SMART
SM00427. H2B. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIMNSFVND VFERIAAEAS RLAHYNKRST ISSREIQTAV RLILPGELAK
60
NAVSEGTNAV TKYTSSK
Length:67
Mass (Da):7,374
Last modified:December 20, 2017 - v3
Checksum:i9BAE292B100A6D0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD70019.2.
PIRiT28965.
RefSeqiNP_505201.2. NM_072800.2.

Genome annotation databases

EnsemblMetazoaiF45F2.2; F45F2.2; WBGene00001913.
GeneIDi191681.
KEGGicel:CELE_F45F2.2.
UCSCiF45F2.2. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ22979_CAEEL
AccessioniPrimary (citable) accession number: Q22979
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: December 20, 2017
Last modified: March 28, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported