Q22949 (PLSB_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glycerol-3-phosphate acyltransferase, mitochondrial
Short name=GPAT
EC=2.3.1.15

Gene names

Name:	acl-6
ORF Names:	F08F3.2

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	718 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.
Subcellular location	Mitochondrion membrane; Single-pass membrane protein Potential.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the GPAT/DAPAT family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane Mitochondrion
Domain	Transit peptide Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 718		Probable glycerol-3-phosphate acyltransferase, mitochondrial		PRO_0000024693
Regions
	Transmembrane	409 – 425	17	Helical; Potential
	Motif	167 – 172	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	Q22949 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E0A36A4A86FC138D	FASTA	718	82,072
	10 20 30 40 50 60 MELDVESTSI TQLRSHCETC FPLMEEVVPR RERYVDLLEF SNFNGIPYPV VDPSRKPRRF 70 80 90 100 110 120 LADFRYSWSI PLIHHYPNVE KDVLSSKRVH RVISKLKEQN DEQKNRAVQF FTEISARLSK 130 140 150 160 170 180 FICKCCSYVL YKVFRRLMDK LLVCKEEMEV LYEAEQTGIP MVYLPLHRSH LDYLLITWCN 190 200 210 220 230 240 WHFGLKLPHI ASGDNLNLSG LGWLLRATGA FFIRRRVDPD DERGKDQLYR AILHSYIEQV 250 260 270 280 290 300 LSKDMPIEFF LEGTRSRFGK ALTPKNGLIS NVVEAVQHGF IKDCYLVPVS YTYDAVVEGI 310 320 330 340 350 360 FLHELMGIPK VRESVLGVFR GIFSGFSKSK QCGVVRMHYG RPIRLTEYLA TITASLSSNH 370 380 390 400 410 420 RTRPVRMTKL STSFSYRELV PWHRTHSETV DDRTMIRAIG FHVVYEAQMM CSISPVAVVS 430 440 450 460 470 480 CLLLAKWRGK VSRSTFERDC EWLCEKIIAE GGDVVGYQSK KTKGSALVKY AFEKLESCVE 490 500 510 520 530 540 VTDEYVSPKE SHSSFITLAY NKNSVICRFS IKSVIALTIV SRPSGTKLSI DQIVEDALSL 550 560 570 580 590 600 CDWLQFEFMF CRPCDSLREL VHNVLGQKEW SDPIHGFLRS EIEDDGFLDA GGALNSGTLR 610 620 630 640 650 660 VRDAKSRETL QFFANLVRPF VQSLYLISSF VVSEKCPTEP TSDNNIIRQL CQQSLAGDID 670 680 690 700 710 LPFAPLLESI NSDSFKNALR VLKDKGLLQR STPNSTARSG NSRLAELISN LERVLEVK

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080663 Genomic DNA. Translation: CCD65590.1.
PIR	T29448.
RefSeq	NP_001023769.1. NM_001028598.2.
UniGene	Cel.4218.
3D structure databases
ProteinModelPortal	Q22949.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-26239N.
MINT	MINT-1078489.
STRING	Q22949.
Proteomic databases
PRIDE	Q22949.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F08F3.2a.1; F08F3.2a.1; F08F3.2. F08F3.2a.2; F08F3.2a.2; F08F3.2.
GeneID	178928.
KEGG	cel:F08F3.2.
UCSC	F08F3.2a.1. c. elegans.
Organism-specific databases
CTD	178928.
WormBase	F08F3.2a; CE09258; WBGene00017261; acl-6.
Phylogenomic databases
eggNOG	meNOG06397.
HOGENOM	HBG385928.
InParanoid	Q22949.
OMA	EQNDEQK.
PhylomeDB	Q22949.
Gene expression databases
ArrayExpress	Q22949.
Family and domain databases
InterPro	IPR002123. Acyltransferase. IPR022284. G3P_O-AcylTrfase. [Graphical view]
KO	K00629.
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
PIRSF	PIRSF000437. GPAT_DHAPAT. 1 hit.
SMART	SM00563. PlsC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	903158.

Entry information

Entry name

PLSB_CAEEL

Accession

Primary (citable) accession number: Q22949

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project