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Q22943

- PAFA_CAEEL

UniProt

Q22943 - PAFA_CAEEL

Protein

Platelet-activating factor acetylhydrolase homolog 2

Gene

paf-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei238 – 2381NucleophileBy similarity
    Active sitei261 – 2611Charge relay systemBy similarity
    Active sitei316 – 3161Charge relay systemBy similarity

    GO - Molecular functioni

    1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: WormBase

    GO - Biological processi

    1. embryo development ending in birth or egg hatching Source: WormBase
    2. embryonic body morphogenesis Source: WormBase
    3. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    BRENDAi3.1.1.47. 1045.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet-activating factor acetylhydrolase homolog 2 (EC:3.1.1.47)
    Gene namesi
    Name:paf-2
    ORF Names:C52B9.7
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiC52B9.7a; CE30264; WBGene00003907; paf-2.
    C52B9.7b; CE30265; WBGene00003907; paf-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Platelet-activating factor acetylhydrolase homolog 2PRO_0000090381Add
    BLAST

    Proteomic databases

    PaxDbiQ22943.
    PRIDEiQ22943.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.C52B9.7a.

    Structurei

    3D structure databases

    ProteinModelPortaliQ22943.
    SMRiQ22943. Positions 16-358.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.Curated

    Phylogenomic databases

    eggNOGiNOG286523.
    GeneTreeiENSGT00390000005233.
    HOGENOMiHOG000008053.
    InParanoidiQ22943.
    KOiK01062.
    OMAiQFRCAVA.
    OrthoDBiEOG7MSMQ5.
    PhylomeDBiQ22943.

    Family and domain databases

    Gene3Di3.40.50.1820. 3 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR005065. PAF_acetylhydro.
    IPR016715. PAF_acetylhydro_eukaryote.
    [Graphical view]
    PANTHERiPTHR10272. PTHR10272. 1 hit.
    PfamiPF03403. PAF-AH_p_II. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
    SUPFAMiSSF53474. SSF53474. 3 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q22943-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSYISSPQV LTRQVSGQFQ VGCKDLMIDG TVLGDRGLFM RLYFPTDSQA    50
    ADISSYPLWL PKPQYAHGLG EYLGQSSQKM NVITSTVVGE KREDCIENAQ 100
    MSTKCDKWPI VVFSHGLGGS RTFYSTYCTS LASHGYVVAA VEHKDHSACW 150
    TYQLTEKNGE LVEQPIKIKL IEKNEKNEFK IRNQQVGKRV TECVKALNVL 200
    EQLNLGTVPE KVLIGNDYNW AQFKNKLVMS SASVIGHSFG GATSLASSAY 250
    TTDFQKAIVF DGWMYPLDST QQEQAKQPTL FLNVGDWQWN ENLDVMKKII 300
    SHNDGNLALT LNGAVHQCFS DFPFIFPSWL AKKFGVQGRT EPSLCMQAAI 350
    ELSLAFLENG KDGAQKLKDE KFSSFISNEI YGREKYKL 388
    Length:388
    Mass (Da):43,418
    Last modified:June 6, 2002 - v2
    Checksum:i98B71A8ADA43E701
    GO
    Isoform b (identifier: Q22943-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         187-190: GKRV → SVKV
         191-388: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:190
    Mass (Da):21,294
    Checksum:iEF7FDDD124BCF0F3
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei187 – 1904GKRV → SVKV in isoform b. CuratedVSP_003132
    Alternative sequencei191 – 388198Missing in isoform b. CuratedVSP_003133Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF386745 mRNA. Translation: AAL57290.1.
    FO080644 Genomic DNA. Translation: CCD65415.1.
    FO080644 Genomic DNA. Translation: CCD65416.1.
    RefSeqiNP_741768.1. NM_171668.6. [Q22943-1]
    NP_741769.1. NM_171669.3. [Q22943-2]
    UniGeneiCel.9185.

    Genome annotation databases

    EnsemblMetazoaiC52B9.7a; C52B9.7a; WBGene00003907. [Q22943-1]
    GeneIDi180704.
    KEGGicel:CELE_C52B9.7.
    UCSCiC52B9.7a. c. elegans. [Q22943-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF386745 mRNA. Translation: AAL57290.1 .
    FO080644 Genomic DNA. Translation: CCD65415.1 .
    FO080644 Genomic DNA. Translation: CCD65416.1 .
    RefSeqi NP_741768.1. NM_171668.6. [Q22943-1 ]
    NP_741769.1. NM_171669.3. [Q22943-2 ]
    UniGenei Cel.9185.

    3D structure databases

    ProteinModelPortali Q22943.
    SMRi Q22943. Positions 16-358.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.C52B9.7a.

    Proteomic databases

    PaxDbi Q22943.
    PRIDEi Q22943.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C52B9.7a ; C52B9.7a ; WBGene00003907 . [Q22943-1 ]
    GeneIDi 180704.
    KEGGi cel:CELE_C52B9.7.
    UCSCi C52B9.7a. c. elegans. [Q22943-1 ]

    Organism-specific databases

    CTDi 180704.
    WormBasei C52B9.7a ; CE30264 ; WBGene00003907 ; paf-2.
    C52B9.7b ; CE30265 ; WBGene00003907 ; paf-2.

    Phylogenomic databases

    eggNOGi NOG286523.
    GeneTreei ENSGT00390000005233.
    HOGENOMi HOG000008053.
    InParanoidi Q22943.
    KOi K01062.
    OMAi QFRCAVA.
    OrthoDBi EOG7MSMQ5.
    PhylomeDBi Q22943.

    Enzyme and pathway databases

    BRENDAi 3.1.1.47. 1045.

    Miscellaneous databases

    NextBioi 910542.

    Family and domain databases

    Gene3Di 3.40.50.1820. 3 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR005065. PAF_acetylhydro.
    IPR016715. PAF_acetylhydro_eukaryote.
    [Graphical view ]
    PANTHERi PTHR10272. PTHR10272. 1 hit.
    Pfami PF03403. PAF-AH_p_II. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018169. PAF_acetylhydrolase. 1 hit.
    SUPFAMi SSF53474. SSF53474. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "A short-chain acyl hydrolase is required for early epithelial morphogenesis in Caenorhabditis elegans."
      Inoue T., Suzuki Y., Aoki J., Sugimoto A., Yamamoto M., Tsujimoto M., Inoue K., Arai H.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPAFA_CAEEL
    AccessioniPrimary (citable) accession number: Q22943
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3