Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q22943

- PAFA_CAEEL

UniProt

Q22943 - PAFA_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Platelet-activating factor acetylhydrolase homolog 2

Gene

paf-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei238 – 2381NucleophileBy similarity
Active sitei261 – 2611Charge relay systemBy similarity
Active sitei316 – 3161Charge relay systemBy similarity

GO - Molecular functioni

  1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: WormBase

GO - Biological processi

  1. embryo development ending in birth or egg hatching Source: WormBase
  2. embryonic body morphogenesis Source: WormBase
  3. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.47. 1045.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase homolog 2 (EC:3.1.1.47)
Gene namesi
Name:paf-2
ORF Names:C52B9.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC52B9.7a; CE30264; WBGene00003907; paf-2.
C52B9.7b; CE30265; WBGene00003907; paf-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Platelet-activating factor acetylhydrolase homolog 2PRO_0000090381Add
BLAST

Proteomic databases

PaxDbiQ22943.
PRIDEiQ22943.

Interactioni

Protein-protein interaction databases

STRINGi6239.C52B9.7a.

Structurei

3D structure databases

ProteinModelPortaliQ22943.
SMRiQ22943. Positions 16-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Phylogenomic databases

eggNOGiNOG286523.
GeneTreeiENSGT00390000005233.
HOGENOMiHOG000008053.
InParanoidiQ22943.
KOiK01062.
OMAiQFRCAVA.
OrthoDBiEOG7MSMQ5.
PhylomeDBiQ22943.

Family and domain databases

Gene3Di3.40.50.1820. 3 hits.
InterProiIPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERiPTHR10272. PTHR10272. 1 hit.
PfamiPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q22943) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSYISSPQV LTRQVSGQFQ VGCKDLMIDG TVLGDRGLFM RLYFPTDSQA
60 70 80 90 100
ADISSYPLWL PKPQYAHGLG EYLGQSSQKM NVITSTVVGE KREDCIENAQ
110 120 130 140 150
MSTKCDKWPI VVFSHGLGGS RTFYSTYCTS LASHGYVVAA VEHKDHSACW
160 170 180 190 200
TYQLTEKNGE LVEQPIKIKL IEKNEKNEFK IRNQQVGKRV TECVKALNVL
210 220 230 240 250
EQLNLGTVPE KVLIGNDYNW AQFKNKLVMS SASVIGHSFG GATSLASSAY
260 270 280 290 300
TTDFQKAIVF DGWMYPLDST QQEQAKQPTL FLNVGDWQWN ENLDVMKKII
310 320 330 340 350
SHNDGNLALT LNGAVHQCFS DFPFIFPSWL AKKFGVQGRT EPSLCMQAAI
360 370 380
ELSLAFLENG KDGAQKLKDE KFSSFISNEI YGREKYKL
Length:388
Mass (Da):43,418
Last modified:June 6, 2002 - v2
Checksum:i98B71A8ADA43E701
GO
Isoform b (identifier: Q22943-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-190: GKRV → SVKV
     191-388: Missing.

Note: No experimental confirmation available.

Show »
Length:190
Mass (Da):21,294
Checksum:iEF7FDDD124BCF0F3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei187 – 1904GKRV → SVKV in isoform b. CuratedVSP_003132
Alternative sequencei191 – 388198Missing in isoform b. CuratedVSP_003133Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF386745 mRNA. Translation: AAL57290.1.
FO080644 Genomic DNA. Translation: CCD65415.1.
FO080644 Genomic DNA. Translation: CCD65416.1.
RefSeqiNP_741768.1. NM_171668.6. [Q22943-1]
NP_741769.1. NM_171669.3. [Q22943-2]
UniGeneiCel.9185.

Genome annotation databases

EnsemblMetazoaiC52B9.7a; C52B9.7a; WBGene00003907. [Q22943-1]
GeneIDi180704.
KEGGicel:CELE_C52B9.7.
UCSCiC52B9.7a. c. elegans. [Q22943-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF386745 mRNA. Translation: AAL57290.1 .
FO080644 Genomic DNA. Translation: CCD65415.1 .
FO080644 Genomic DNA. Translation: CCD65416.1 .
RefSeqi NP_741768.1. NM_171668.6. [Q22943-1 ]
NP_741769.1. NM_171669.3. [Q22943-2 ]
UniGenei Cel.9185.

3D structure databases

ProteinModelPortali Q22943.
SMRi Q22943. Positions 16-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.C52B9.7a.

Proteomic databases

PaxDbi Q22943.
PRIDEi Q22943.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C52B9.7a ; C52B9.7a ; WBGene00003907 . [Q22943-1 ]
GeneIDi 180704.
KEGGi cel:CELE_C52B9.7.
UCSCi C52B9.7a. c. elegans. [Q22943-1 ]

Organism-specific databases

CTDi 180704.
WormBasei C52B9.7a ; CE30264 ; WBGene00003907 ; paf-2.
C52B9.7b ; CE30265 ; WBGene00003907 ; paf-2.

Phylogenomic databases

eggNOGi NOG286523.
GeneTreei ENSGT00390000005233.
HOGENOMi HOG000008053.
InParanoidi Q22943.
KOi K01062.
OMAi QFRCAVA.
OrthoDBi EOG7MSMQ5.
PhylomeDBi Q22943.

Enzyme and pathway databases

BRENDAi 3.1.1.47. 1045.

Miscellaneous databases

NextBioi 910542.

Family and domain databases

Gene3Di 3.40.50.1820. 3 hits.
InterProi IPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view ]
PANTHERi PTHR10272. PTHR10272. 1 hit.
Pfami PF03403. PAF-AH_p_II. 1 hit.
[Graphical view ]
PIRSFi PIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMi SSF53474. SSF53474. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A short-chain acyl hydrolase is required for early epithelial morphogenesis in Caenorhabditis elegans."
    Inoue T., Suzuki Y., Aoki J., Sugimoto A., Yamamoto M., Tsujimoto M., Inoue K., Arai H.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiPAFA_CAEEL
AccessioniPrimary (citable) accession number: Q22943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: October 1, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3