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Protein

Platelet-activating factor acetylhydrolase homolog 2

Gene

paf-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei238NucleophileBy similarity1
Active sitei261Charge relay systemBy similarity1
Active sitei316Charge relay systemBy similarity1

GO - Molecular functioni

  • 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: WormBase

GO - Biological processi

  • lipid catabolic process Source: WormBase
  • morphogenesis of embryonic epithelium Source: WormBase

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.47 1045
ReactomeiR-CEL-418346 Platelet homeostasis

Protein family/group databases

ESTHERicaeel-pafa PAF-Acetylhydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase homolog 2 (EC:3.1.1.47)
Gene namesi
Name:paf-2
ORF Names:C52B9.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC52B9.7a ; CE30264 ; WBGene00003907 ; paf-2
C52B9.7b ; CE30265 ; WBGene00003907 ; paf-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000903811 – 388Platelet-activating factor acetylhydrolase homolog 2Add BLAST388

Proteomic databases

EPDiQ22943
PaxDbiQ22943
PeptideAtlasiQ22943
PRIDEiQ22943

Expressioni

Gene expression databases

BgeeiWBGene00003907

Interactioni

Protein-protein interaction databases

STRINGi6239.C52B9.7a

Structurei

3D structure databases

ProteinModelPortaliQ22943
SMRiQ22943
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Phylogenomic databases

eggNOGiKOG3847 Eukaryota
ENOG4111FH0 LUCA
GeneTreeiENSGT00390000005233
HOGENOMiHOG000008053
InParanoidiQ22943
KOiK01062
OMAiCMELASR
OrthoDBiEOG091G08C2
PhylomeDBiQ22943

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR005065 PAF_acetylhydro-like
IPR016715 PAF_acetylhydro_eukaryote
PANTHERiPTHR10272 PTHR10272, 1 hit
PfamiView protein in Pfam
PF03403 PAF-AH_p_II, 1 hit
PIRSFiPIRSF018169 PAF_acetylhydrolase, 1 hit
SUPFAMiSSF53474 SSF53474, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q22943-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSYISSPQV LTRQVSGQFQ VGCKDLMIDG TVLGDRGLFM RLYFPTDSQA
60 70 80 90 100
ADISSYPLWL PKPQYAHGLG EYLGQSSQKM NVITSTVVGE KREDCIENAQ
110 120 130 140 150
MSTKCDKWPI VVFSHGLGGS RTFYSTYCTS LASHGYVVAA VEHKDHSACW
160 170 180 190 200
TYQLTEKNGE LVEQPIKIKL IEKNEKNEFK IRNQQVGKRV TECVKALNVL
210 220 230 240 250
EQLNLGTVPE KVLIGNDYNW AQFKNKLVMS SASVIGHSFG GATSLASSAY
260 270 280 290 300
TTDFQKAIVF DGWMYPLDST QQEQAKQPTL FLNVGDWQWN ENLDVMKKII
310 320 330 340 350
SHNDGNLALT LNGAVHQCFS DFPFIFPSWL AKKFGVQGRT EPSLCMQAAI
360 370 380
ELSLAFLENG KDGAQKLKDE KFSSFISNEI YGREKYKL
Length:388
Mass (Da):43,418
Last modified:June 6, 2002 - v2
Checksum:i98B71A8ADA43E701
GO
Isoform b (identifier: Q22943-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-190: GKRV → SVKV
     191-388: Missing.

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):21,294
Checksum:iEF7FDDD124BCF0F3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003132187 – 190GKRV → SVKV in isoform b. Curated4
Alternative sequenceiVSP_003133191 – 388Missing in isoform b. CuratedAdd BLAST198

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF386745 mRNA Translation: AAL57290.1
FO080644 Genomic DNA Translation: CCD65415.1
FO080644 Genomic DNA Translation: CCD65416.1
RefSeqiNP_741768.1, NM_171668.6 [Q22943-1]
NP_741769.1, NM_171669.3 [Q22943-2]
UniGeneiCel.9185

Genome annotation databases

EnsemblMetazoaiC52B9.7a.1; C52B9.7a.1; WBGene00003907 [Q22943-1]
C52B9.7a.2; C52B9.7a.2; WBGene00003907 [Q22943-1]
GeneIDi180704
KEGGicel:CELE_C52B9.7
UCSCiC52B9.7a c. elegans [Q22943-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPAFA_CAEEL
AccessioniPrimary (citable) accession number: Q22943
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: March 28, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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