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Q22943 (PAFA_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Platelet-activating factor acetylhydrolase homolog 2
EC=3.1.1.47
Gene names
Name:paf-2
ORF Names:C52B9.7
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q22943-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b (identifier: Q22943-2)

The sequence of this isoform differs from the canonical sequence as follows:
     187-190: GKRV → SVKV
     191-388: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Platelet-activating factor acetylhydrolase homolog 2
PRO_0000090381

Sites

Active site2381Nucleophile By similarity
Active site2611Charge relay system By similarity
Active site3161Charge relay system By similarity

Natural variations

Alternative sequence187 – 1904GKRV → SVKV in isoform b.
VSP_003132
Alternative sequence191 – 388198Missing in isoform b.
VSP_003133

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: 98B71A8ADA43E701

FASTA38843,418
        10         20         30         40         50         60 
MGSYISSPQV LTRQVSGQFQ VGCKDLMIDG TVLGDRGLFM RLYFPTDSQA ADISSYPLWL 

        70         80         90        100        110        120 
PKPQYAHGLG EYLGQSSQKM NVITSTVVGE KREDCIENAQ MSTKCDKWPI VVFSHGLGGS 

       130        140        150        160        170        180 
RTFYSTYCTS LASHGYVVAA VEHKDHSACW TYQLTEKNGE LVEQPIKIKL IEKNEKNEFK 

       190        200        210        220        230        240 
IRNQQVGKRV TECVKALNVL EQLNLGTVPE KVLIGNDYNW AQFKNKLVMS SASVIGHSFG 

       250        260        270        280        290        300 
GATSLASSAY TTDFQKAIVF DGWMYPLDST QQEQAKQPTL FLNVGDWQWN ENLDVMKKII 

       310        320        330        340        350        360 
SHNDGNLALT LNGAVHQCFS DFPFIFPSWL AKKFGVQGRT EPSLCMQAAI ELSLAFLENG 

       370        380 
KDGAQKLKDE KFSSFISNEI YGREKYKL

« Hide

Isoform b [UniParc].

Checksum: EF7FDDD124BCF0F3
Show »

FASTA19021,294

References

« Hide 'large scale' references
[1]"A short-chain acyl hydrolase is required for early epithelial morphogenesis in Caenorhabditis elegans."
Inoue T., Suzuki Y., Aoki J., Sugimoto A., Yamamoto M., Tsujimoto M., Inoue K., Arai H.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF386745 mRNA. Translation: AAL57290.1.
FO080644 Genomic DNA. Translation: CCD65415.1.
FO080644 Genomic DNA. Translation: CCD65416.1.
RefSeqNP_741768.1. NM_171668.6.
NP_741769.1. NM_171669.3.
UniGeneCel.9185.

3D structure databases

ProteinModelPortalQ22943.
SMRQ22943. Positions 16-358.
ModBaseSearch...

Protein-protein interaction databases

STRING6239.C52B9.7a.

Proteomic databases

PaxDbQ22943.
PRIDEQ22943.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC52B9.7a; C52B9.7a; C52B9.7.
GeneID180704.
KEGGcel:CELE_C52B9.7.
UCSCC52B9.7a. c. elegans.

Organism-specific databases

CTD180704.
WormBaseC52B9.7a; CE30264; WBGene00003907; paf-2.
C52B9.7b; CE30265; WBGene00003907; paf-2.

Phylogenomic databases

eggNOGNOG286523.
GeneTreeENSGT00390000005233.
HOGENOMHOG000008053.
InParanoidQ22943.
KOK01062.
OMAREDCIEN.

Enzyme and pathway databases

BRENDA3.1.1.47. 1045.

Family and domain databases

InterProIPR016715. Ac_Ohase_PAF.
IPR005065. PAF_acetylhydro.
[Graphical view]
PANTHERPTHR10272. PTHR10272. 1 hit.
PfamPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFPIRSF018169. PAF_acetylhydrolase. 1 hit.
PROSITEPS00120. LIPASE_SER. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio910542.

Entry information

Entry namePAFA_CAEEL
AccessionPrimary (citable) accession number: Q22943
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

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