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Protein

Leucine-rich repeat protein soc-2

Gene

soc-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a Ras effector and participates in MAPK pathway activation (PubMed:9674433, PubMed:9618511). Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulates Raf activity at specialized signaling complexes upon Ras activation (PubMed:10521400, PubMed:14685271). Required for vulval development (PubMed:10521400). Involved in fluid homeostasis (PubMed:11689700). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870).6 Publications

GO - Molecular functioni

  • Ras GTPase binding Source: WormBase

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: WormBase
  • muscle organ development Source: WormBase
  • positive regulation of Ras protein signal transduction Source: UniProtKB
  • regulation of cell projection organization Source: WormBase
  • vulval development Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ22875.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat protein soc-2
Alternative name(s):
Suppressor of Clr protein 2
Suppressor of activated let-60 Ras protein 8
Gene namesi
Name:soc-2
Synonyms:sur-8
ORF Names:AC7.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiAC7.2a; CE25736; WBGene00004929; soc-2.
AC7.2b; CE31275; WBGene00004929; soc-2.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi233C → Y in ku242; suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations. Abolishes interaction with let-60. 1 Publication1
Mutagenesisi430E → K in ku167; suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations. Moderate increase in resistance to nicotine-induced paralysis. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003856311 – 559Leucine-rich repeat protein soc-2Add BLAST559

Proteomic databases

EPDiQ22875.
PaxDbiQ22875.
PRIDEiQ22875.

Expressioni

Gene expression databases

BgeeiWBGene00004929.
ExpressionAtlasiQ22875. differential.

Interactioni

Subunit structurei

Interacts with let-60.1 Publication

GO - Molecular functioni

  • Ras GTPase binding Source: WormBase

Protein-protein interaction databases

BioGridi42412. 3 interactors.
IntActiQ22875. 1 interactor.
MINTiMINT-115544.
STRINGi6239.AC7.2a.2.

Structurei

3D structure databases

ProteinModelPortaliQ22875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati74 – 95LRR 1Add BLAST22
Repeati97 – 118LRR 2Add BLAST22
Repeati120 – 142LRR 3Add BLAST23
Repeati143 – 164LRR 4Add BLAST22
Repeati166 – 187LRR 5Add BLAST22
Repeati189 – 210LRR 6Add BLAST22
Repeati212 – 233LRR 7Add BLAST22
Repeati235 – 256LRR 8Add BLAST22
Repeati258 – 279LRR 9Add BLAST22
Repeati281 – 302LRR 10Add BLAST22
Repeati305 – 326LRR 11Add BLAST22
Repeati329 – 350LRR 12Add BLAST22
Repeati353 – 374LRR 13Add BLAST22
Repeati376 – 397LRR 14Add BLAST22
Repeati399 – 420LRR 15Add BLAST22
Repeati422 – 443LRR 16Add BLAST22
Repeati445 – 466LRR 17Add BLAST22
Repeati468 – 489LRR 18Add BLAST22
Repeati491 – 513LRR 19Add BLAST23
Repeati515 – 536LRR 20Add BLAST22

Sequence similaritiesi

Belongs to the SHOC2 family.Curated
Contains 20 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000116557.
InParanoidiQ22875.
OMAiCHKLEEF.
PhylomeDBiQ22875.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 17 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 17 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q22875-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METSKEFEFR PAKETSRSKS PGGIVGRLSN FARNKARHSL SEKGSNSVGG
60 70 80 90 100
SGGAGFDKPR KDLLKEFHKC KEAQDQRLDL SSIEITSIPS PIKELTQLTE
110 120 130 140 150
LFLYKNKLTC LPTEIGQLVN LKKLGLSENA LTSLPDSLAS LESLETLDLR
160 170 180 190 200
HNKLTEVPSV IYKIGSLETL WLRYNRIVAV DEQIGNLSKL KMLDVRENKI
210 220 230 240 250
RELPSAIGKL TSLVVCLVSY NHLTRVPEEI GDCHSLTQLD LQHNDLSELP
260 270 280 290 300
YSIGKLVNLV RIGIRYNKIR CIPSELESCQ QLEEFIVESN HLQLLPPNLL
310 320 330 340 350
TMLPKIHTVN LSRNELTAFP AGGPQQFVST VTINMEHNQI SKIPIGIFSK
360 370 380 390 400
ATRLTKLNLK ENELVSLPLD MGSWTSITEL NLSTNQLKVL PEDIEKLVNL
410 420 430 440 450
EILVLSNNQL KKLPNQIGNL NKLRELDLEE NELETVPTEI GFLQHLTKLW
460 470 480 490 500
VQSNKILTLP RSIGNLCSLQ DLRLGENNLT AIPEEIGHLD SLKSLYLNDN
510 520 530 540 550
SSLHNLPFEL ALCQSLEIMS IENSPLSQIP PEITAGGPSL VIQYLKMQGP

YRGVVMNSQ
Length:559
Mass (Da):62,483
Last modified:December 1, 2001 - v3
Checksum:iED68F9771998C456
GO
Isoform b (identifier: Q22875-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: METSKEFEFR...SGGAGFDKPR → MRVLQKLGFC...NMRNNKGHAE

Note: No experimental confirmation available.
Show »
Length:558
Mass (Da):62,862
Checksum:iE48886B4ABD10412
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0381981 – 60METSK…FDKPR → MRVLQKLGFCLEKQKRETPP TTANTGVSATKRVSVIATDR DRAYFLRQKNMRNNKGHAE in isoform b. CuratedAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068919 mRNA. Translation: AAC39129.1.
AF054827 mRNA. Translation: AAC25697.1.
FO080091 Genomic DNA. Translation: CCD61151.1.
FO080091 Genomic DNA. Translation: CCD61152.1.
PIRiB88684.
T30947.
T42998.
RefSeqiNP_001021259.1. NM_001026088.3. [Q22875-1]
NP_741391.2. NM_171332.3. [Q22875-2]
UniGeneiCel.18171.

Genome annotation databases

EnsemblMetazoaiAC7.2a.1; AC7.2a.1; WBGene00004929. [Q22875-1]
AC7.2a.2; AC7.2a.2; WBGene00004929. [Q22875-1]
GeneIDi177286.
UCSCiAC7.2b. c. elegans.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068919 mRNA. Translation: AAC39129.1.
AF054827 mRNA. Translation: AAC25697.1.
FO080091 Genomic DNA. Translation: CCD61151.1.
FO080091 Genomic DNA. Translation: CCD61152.1.
PIRiB88684.
T30947.
T42998.
RefSeqiNP_001021259.1. NM_001026088.3. [Q22875-1]
NP_741391.2. NM_171332.3. [Q22875-2]
UniGeneiCel.18171.

3D structure databases

ProteinModelPortaliQ22875.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42412. 3 interactors.
IntActiQ22875. 1 interactor.
MINTiMINT-115544.
STRINGi6239.AC7.2a.2.

Proteomic databases

EPDiQ22875.
PaxDbiQ22875.
PRIDEiQ22875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAC7.2a.1; AC7.2a.1; WBGene00004929. [Q22875-1]
AC7.2a.2; AC7.2a.2; WBGene00004929. [Q22875-1]
GeneIDi177286.
UCSCiAC7.2b. c. elegans.

Organism-specific databases

CTDi177286.
WormBaseiAC7.2a; CE25736; WBGene00004929; soc-2.
AC7.2b; CE31275; WBGene00004929; soc-2.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000116557.
InParanoidiQ22875.
OMAiCHKLEEF.
PhylomeDBiQ22875.

Enzyme and pathway databases

SignaLinkiQ22875.

Miscellaneous databases

PROiQ22875.

Gene expression databases

BgeeiWBGene00004929.
ExpressionAtlasiQ22875. differential.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 17 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 17 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHOC2_CAEEL
AccessioniPrimary (citable) accession number: Q22875
Secondary accession number(s): O77472, Q8MPP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.