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Protein

Leucine-rich repeat protein soc-2

Gene

soc-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a Ras effector and participates in MAPK pathway activation (PubMed:9674433, PubMed:9618511). Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulates Raf activity at specialized signaling complexes upon Ras activation (PubMed:10521400, PubMed:14685271). Required for vulval development (PubMed:10521400). Involved in fluid homeostasis (PubMed:11689700). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870).6 Publications

GO - Molecular functioni

  • Ras GTPase binding Source: WormBase

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: WormBase
  • muscle organ development Source: WormBase
  • positive regulation of Ras protein signal transduction Source: UniProtKB
  • regulation of cell projection organization Source: WormBase
  • vulval development Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ22875.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat protein soc-2
Alternative name(s):
Suppressor of Clr protein 2
Suppressor of activated let-60 Ras protein 8
Gene namesi
Name:soc-2
Synonyms:sur-8
ORF Names:AC7.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiAC7.2a; CE25736; WBGene00004929; soc-2.
AC7.2b; CE31275; WBGene00004929; soc-2.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi233 – 2331C → Y in ku242; suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations. Abolishes interaction with let-60. 1 Publication
Mutagenesisi430 – 4301E → K in ku167; suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations. Moderate increase in resistance to nicotine-induced paralysis. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Leucine-rich repeat protein soc-2PRO_0000385631Add
BLAST

Proteomic databases

EPDiQ22875.
PaxDbiQ22875.
PRIDEiQ22875.

Expressioni

Gene expression databases

ExpressionAtlasiQ22875. baseline.

Interactioni

Subunit structurei

Interacts with let-60.1 Publication

GO - Molecular functioni

  • Ras GTPase binding Source: WormBase

Protein-protein interaction databases

BioGridi42412. 3 interactions.
IntActiQ22875. 1 interaction.
MINTiMINT-115544.
STRINGi6239.AC7.2a.2.

Structurei

3D structure databases

ProteinModelPortaliQ22875.
SMRiQ22875. Positions 11-536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati74 – 9522LRR 1Add
BLAST
Repeati97 – 11822LRR 2Add
BLAST
Repeati120 – 14223LRR 3Add
BLAST
Repeati143 – 16422LRR 4Add
BLAST
Repeati166 – 18722LRR 5Add
BLAST
Repeati189 – 21022LRR 6Add
BLAST
Repeati212 – 23322LRR 7Add
BLAST
Repeati235 – 25622LRR 8Add
BLAST
Repeati258 – 27922LRR 9Add
BLAST
Repeati281 – 30222LRR 10Add
BLAST
Repeati305 – 32622LRR 11Add
BLAST
Repeati329 – 35022LRR 12Add
BLAST
Repeati353 – 37422LRR 13Add
BLAST
Repeati376 – 39722LRR 14Add
BLAST
Repeati399 – 42022LRR 15Add
BLAST
Repeati422 – 44322LRR 16Add
BLAST
Repeati445 – 46622LRR 17Add
BLAST
Repeati468 – 48922LRR 18Add
BLAST
Repeati491 – 51323LRR 19Add
BLAST
Repeati515 – 53622LRR 20Add
BLAST

Sequence similaritiesi

Belongs to the SHOC2 family.Curated
Contains 20 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000116557.
InParanoidiQ22875.
OMAiCHKLEEF.
PhylomeDBiQ22875.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 17 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 17 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q22875-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METSKEFEFR PAKETSRSKS PGGIVGRLSN FARNKARHSL SEKGSNSVGG
60 70 80 90 100
SGGAGFDKPR KDLLKEFHKC KEAQDQRLDL SSIEITSIPS PIKELTQLTE
110 120 130 140 150
LFLYKNKLTC LPTEIGQLVN LKKLGLSENA LTSLPDSLAS LESLETLDLR
160 170 180 190 200
HNKLTEVPSV IYKIGSLETL WLRYNRIVAV DEQIGNLSKL KMLDVRENKI
210 220 230 240 250
RELPSAIGKL TSLVVCLVSY NHLTRVPEEI GDCHSLTQLD LQHNDLSELP
260 270 280 290 300
YSIGKLVNLV RIGIRYNKIR CIPSELESCQ QLEEFIVESN HLQLLPPNLL
310 320 330 340 350
TMLPKIHTVN LSRNELTAFP AGGPQQFVST VTINMEHNQI SKIPIGIFSK
360 370 380 390 400
ATRLTKLNLK ENELVSLPLD MGSWTSITEL NLSTNQLKVL PEDIEKLVNL
410 420 430 440 450
EILVLSNNQL KKLPNQIGNL NKLRELDLEE NELETVPTEI GFLQHLTKLW
460 470 480 490 500
VQSNKILTLP RSIGNLCSLQ DLRLGENNLT AIPEEIGHLD SLKSLYLNDN
510 520 530 540 550
SSLHNLPFEL ALCQSLEIMS IENSPLSQIP PEITAGGPSL VIQYLKMQGP

YRGVVMNSQ
Length:559
Mass (Da):62,483
Last modified:December 1, 2001 - v3
Checksum:iED68F9771998C456
GO
Isoform b (identifier: Q22875-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: METSKEFEFR...SGGAGFDKPR → MRVLQKLGFC...NMRNNKGHAE

Note: No experimental confirmation available.
Show »
Length:558
Mass (Da):62,862
Checksum:iE48886B4ABD10412
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6060METSK…FDKPR → MRVLQKLGFCLEKQKRETPP TTANTGVSATKRVSVIATDR DRAYFLRQKNMRNNKGHAE in isoform b. CuratedVSP_038198Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068919 mRNA. Translation: AAC39129.1.
AF054827 mRNA. Translation: AAC25697.1.
FO080091 Genomic DNA. Translation: CCD61151.1.
FO080091 Genomic DNA. Translation: CCD61152.1.
PIRiB88684.
T30947.
T42998.
RefSeqiNP_001021259.1. NM_001026088.3. [Q22875-1]
NP_741391.2. NM_171332.3. [Q22875-2]
UniGeneiCel.18171.

Genome annotation databases

EnsemblMetazoaiAC7.2a.1; AC7.2a.1; WBGene00004929. [Q22875-1]
AC7.2a.2; AC7.2a.2; WBGene00004929. [Q22875-1]
GeneIDi177286.
UCSCiAC7.2b. c. elegans. [Q22875-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068919 mRNA. Translation: AAC39129.1.
AF054827 mRNA. Translation: AAC25697.1.
FO080091 Genomic DNA. Translation: CCD61151.1.
FO080091 Genomic DNA. Translation: CCD61152.1.
PIRiB88684.
T30947.
T42998.
RefSeqiNP_001021259.1. NM_001026088.3. [Q22875-1]
NP_741391.2. NM_171332.3. [Q22875-2]
UniGeneiCel.18171.

3D structure databases

ProteinModelPortaliQ22875.
SMRiQ22875. Positions 11-536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42412. 3 interactions.
IntActiQ22875. 1 interaction.
MINTiMINT-115544.
STRINGi6239.AC7.2a.2.

Proteomic databases

EPDiQ22875.
PaxDbiQ22875.
PRIDEiQ22875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAC7.2a.1; AC7.2a.1; WBGene00004929. [Q22875-1]
AC7.2a.2; AC7.2a.2; WBGene00004929. [Q22875-1]
GeneIDi177286.
UCSCiAC7.2b. c. elegans. [Q22875-1]

Organism-specific databases

CTDi177286.
WormBaseiAC7.2a; CE25736; WBGene00004929; soc-2.
AC7.2b; CE31275; WBGene00004929; soc-2.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000116557.
InParanoidiQ22875.
OMAiCHKLEEF.
PhylomeDBiQ22875.

Enzyme and pathway databases

SignaLinkiQ22875.

Miscellaneous databases

NextBioi896124.
PROiQ22875.

Gene expression databases

ExpressionAtlasiQ22875. baseline.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 17 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans."
    Sieburth D.S., Sun Q., Han M.
    Cell 94:119-130(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, INTERACTION WITH LET-60, MUTAGENESIS OF CYS-233 AND GLU-430.
    Tissue: Vulva.
  2. "Soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling."
    Selfors L.M., Schutzman J.L., Borland C.Z., Stern M.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:6903-6908(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION.
    Strain: Bristol N2.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS A AND B).
    Strain: Bristol N2.
  4. "A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction."
    Sieburth D.S., Sundaram M., Howard R.M., Han M.
    Genes Dev. 13:2562-2569(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction."
    Schutzman J.L., Borland C.Z., Newman J.C., Robinson M.K., Kokel M., Stern M.J.
    Mol. Cell. Biol. 21:8104-8116(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: Bristol N2.
  6. "Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase."
    Yoder J.H., Chong H., Guan K.-L., Han M.
    EMBO J. 23:111-119(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans."
    Gottschalk A., Almedom R.B., Schedletzky T., Anderson S.D., Yates J.R. III, Schafer W.R.
    EMBO J. 24:2566-2578(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF GLU-430.

Entry informationi

Entry nameiSHOC2_CAEEL
AccessioniPrimary (citable) accession number: Q22875
Secondary accession number(s): O77472, Q8MPP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.