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Protein

Homeobox protein ceh-39

Gene

ceh-39

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable DNA-binding regulatory protein involved in cell-fate specification.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi205 – 291CUTAdd BLAST87
DNA bindingi315 – 374HomeoboxAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • negative regulation of transcription from RNA polymerase II promoter Source: WormBase
  • primary sex determination Source: WormBase
  • system development Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ceh-39
Gene namesi
Name:ceh-39
ORF Names:T26C11.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT26C11.7; CE05026; WBGene00000460; ceh-39.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024101 – 399Homeobox protein ceh-39Add BLAST399

Proteomic databases

EPDiQ22812.
PaxDbiQ22812.

Expressioni

Gene expression databases

BgeeiWBGene00000460.

Interactioni

Protein-protein interaction databases

IntActiQ22812. 2 interactors.
STRINGi6239.T26C11.7.

Structurei

3D structure databases

ProteinModelPortaliQ22812.
SMRiQ22812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252. Eukaryota.
ENOG410YWY4. LUCA.
GeneTreeiENSGT00530000063019.
InParanoidiQ22812.
PhylomeDBiQ22812.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR003350. CUT_dom.
IPR009057. Homeobox-like_sf.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom_sf.
PfamiView protein in Pfam
PF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
SMARTiView protein in SMART
SM01109. CUT. 1 hit.
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFSNTYRNY GEVVDFPEDF LSDYVPTVKS EPEPAAIAPS VCEPPISTTR
60 70 80 90 100
NYGTDFGRAS SMCGSSSSSS SSSYSSGSSP NYLTENGGDT EEPRFEELVS
110 120 130 140 150
RKMSFDSENV AQVSNQMDYA RDTYADSRIP FASIDSNDAL LPYPVNNYVA
160 170 180 190 200
ALPVPVPAKK SRGRTAPRTP KSLETSKPGR GVKRPASKEI DAKDLGIGDL
210 220 230 240 250
SAHMNRQIGD DEELDTQLIA HRILDELKEQ CIPQASLAVK VLGRSQGTLS
260 270 280 290 300
DLLRKPKPWG IMKNGRGTFQ RMANWLDLDP VVRRALCFMK KEDVARITGM
310 320 330 340 350
AEPTPAKRAR QTTPSDERIR RFTFTQTQLD SLHTVFQQQD RPNREMQQAL
360 370 380 390
SATLKLNRST VGNFFMNARR RLPKAAPVSQ NLVAEHAIDH NQPGPSHHY
Length:399
Mass (Da):44,331
Last modified:November 1, 1996 - v1
Checksum:iDC5AAD2EE0C8E87F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080541 Genomic DNA. Translation: CCD64529.1.
PIRiT28913.
RefSeqiNP_508342.1. NM_075941.4.
UniGeneiCel.22768.

Genome annotation databases

EnsemblMetazoaiT26C11.7; T26C11.7; WBGene00000460.
GeneIDi180505.
KEGGicel:CELE_T26C11.7.
UCSCiT26C11.7. c. elegans.

Entry informationi

Entry nameiHM39_CAEEL
AccessioniPrimary (citable) accession number: Q22812
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families