Q22799 (DYL1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynein light chain 1, cytoplasmic

Gene names

Name:	dlc-1
ORF Names:	T26A5.9

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	89 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a non-catalytic accessory component of a dynein complex By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Belongs to the dynein light chain family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Dynein Microtubule
Molecular function	Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from mutant phenotype. Source: WormBase apoptotic process Inferred from mutant phenotype. Source: WormBase body morphogenesis Inferred from mutant phenotype. Source: WormBase embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase microtubule-based process Inferred from electronic annotation. Source: InterPro morphogenesis of an epithelium Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase oogenesis Inferred from mutant phenotype. Source: WormBase positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase pronuclear migration Inferred from mutant phenotype. Source: WormBase receptor-mediated endocytosis Inferred from mutant phenotype. Source: WormBase regulation of cell proliferation Inferred from mutant phenotype. Source: WormBase regulation of meiosis Inferred from mutant phenotype. Source: WormBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW dynein complex Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	motor activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
egal-1	Q17902	6	EBI-328324,EBI-328330
R10D12.14	Q1ZXT3	3	EBI-328324,EBI-2007498
spat-1	O45243	3	EBI-328324,EBI-328382
unc-83	Q23064-3	2	EBI-328324,EBI-2902257

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 89	89	Dynein light chain 1, cytoplasmic		PRO_0000195130

Sequences

	Sequence		Length	Mass (Da)
	Q22799 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 72831C3103C2294E	FASTA	89	10,344
	10 20 30 40 50 60 MVDRKAVIKN ADMSDDMQQD AIDCATQALE KYNIEKDIAA YIKKEFDKKY NPTWHCIVGR 70 80 NFGSYVTHET KHFIYFYLGQ VAILLFKSG

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080366 Genomic DNA. Translation: CCD63216.1.
PIR	T34388.
RefSeq	NP_498422.1. NM_066021.3.
UniGene	Cel.18125.
3D structure databases
ProteinModelPortal	Q22799.
SMR	Q22799. Positions 3-89.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-25449N.
IntAct	Q22799. 31 interactions.
MINT	MINT-1043486.
STRING	Q22799.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	T26A5.9.1; T26A5.9.1; T26A5.9. T26A5.9.2; T26A5.9.2; T26A5.9. T26A5.9.3; T26A5.9.3; T26A5.9.
GeneID	175922.
KEGG	cel:T26A5.9.
UCSC	T26A5.9.1. c. elegans.
Organism-specific databases
CTD	175922.
WormBase	T26A5.9; CE00788; WBGene00001005; dlc-1.
Phylogenomic databases
eggNOG	meNOG20124.
GeneTree	EMGT00050000002335.
HOGENOM	HBG627578.
InParanoid	Q22799.
OMA	FVTHETK.
PhylomeDB	Q22799.
Gene expression databases
ArrayExpress	Q22799.
Family and domain databases
InterPro	IPR019763. Dynein_light_1/2_CS. IPR001372. Dynein_light_chain_typ-1/2. [Graphical view]
Gene3D	G3DSA:3.30.740.10. Dynein_light1. 1 hit.
KO	K10418.
PANTHER	PTHR11886. Dynein_light1. 1 hit.
Pfam	PF01221. Dynein_light. 1 hit. [Graphical view]
SUPFAM	SSF54648. Dynein_light_chain_typ-1/2. 1 hit.
PROSITE	PS01239. DYNEIN_LIGHT_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	890322.

Entry information

Entry name

DYL1_CAEEL

Accession

Primary (citable) accession number: Q22799

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project