Reviewed, UniProtKB/Swiss-Prot Q22795 (SET1_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable histone-lysine N-methyltransferase set-1
    EC=2.1.1.43

Gene names

Name:	set-1
ORF Names:	T26A5.7

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable histone methyltransferase involved in chromatin modification and/or regulation By similarity.
Catalytic activity	S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subcellular location	Nucleus. Ref.2
Tissue specificity	In embryos, it is expressed ubiquitously. In late embryos, it is expressed in hypodermal seam cells. In L3 and L4 larvae and thereafter, it is expressed in vulval precursor cells. In adult males, it is also expressed in 6 unidentified posterior cells. Ref.2
Developmental stage	Highly expressed in eggs, then decreases. Ref.2
Sequence similarities	Belongs to the histone-lysine methyltransferase family. PR/SET subfamily. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosomal protein Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW embryonic development ending in birth or egg hatching Ref.2 Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW reproduction Inferred from mutant phenotype. Source: WormBase transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Probable histone-lysine N-methyltransferase set-1		PRO_0000097694
Regions
	Domain	103 – 230	128	SET
	Region	114 – 116	3	S-adenosyl-L-methionine binding By similarity
	Region	186 – 187	2	S-adenosyl-L-methionine binding By similarity
	Compositional bias	18 – 21	4	Poly-Ala
	Compositional bias	38 – 43	6	Poly-Ser
Sites
	Binding site	159	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q22795-1 [UniParc]. Last modified January 1, 1999. Version 2. Checksum: 0F752B79505AFA99	FASTA	242	27,568
	10 20 30 40 50 60 MKVAAKKLAT SRMRKDRAAA ASPSSDIENS ENPSSLASHS SSSGRMTPSK NTRSRKGVSV 70 80 90 100 110 120 KDVSNHKITE FFQVRRSNRK TSKQISDEAK HALRDTVLKG TNERLLEVYK DVVKGRGIRT 130 140 150 160 170 180 KVNFEKGDFV VEYRGVMMEY SEAKVIEEQY SNDEEIGSYM YFFEHNNKKW CIDATKESPW 190 200 210 220 230 240 KGRLINHSVL RPNLKTKVVE IDGSHHLILV ARRQIAQGEE LLYDYGDRSA ETIAKNPWLV NT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Characterisation of set-1, a conserved PR/SET domain gene in Caenorhabditis elegans." Terranova R., Pujol N., Fasano L., Djabali M. Gene 292:33-41(2002) [PubMed: 12119097] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00043 Genomic DNA. Translation: AAC77512.1.
PIR	T34384.
RefSeq	NP_001022796.1.
UniGene	Cel.7462
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q22795. 1 interaction.
Proteomic databases
PRIDE	Q22795.
Genome annotation databases
Ensembl	T26A5.7. Caenorhabditis elegans. [Contig view]
GeneID	175918.
KEGG	cel:T26A5.7.
NMPDR	fig|6239.3.peg.10206.
Organism-specific databases
WormBase	WBGene00004781. set-1.
WormPep	T26A5.7. CE19602. [WorfDB]
Phylogenomic databases
OMA	Q22795. RRSNRKT.
Enzyme and pathway databases
BRENDA	2.1.1.43. 672.
Gene expression databases
ArrayExpress	Q22795.
Family and domain databases
InterPro	IPR016858. Hist_H4-K20_MeTrfase. IPR001214. SET. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
PIRSF	PIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMART	SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	890302.

Entry information

Entry name

SET1_CAEEL

Accession

Primary (citable) accession number: Q22795

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	January 1, 1999
Last modified:	June 16, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project